BR9712544B1 - Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos - Google Patents

Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos

Info

Publication number
BR9712544B1
BR9712544B1 BRPI9712544-0B1A BR9712544A BR9712544B1 BR 9712544 B1 BR9712544 B1 BR 9712544B1 BR 9712544 A BR9712544 A BR 9712544A BR 9712544 B1 BR9712544 B1 BR 9712544B1
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
same
protease inhibitors
serine protease
composition understanding
Prior art date
Application number
BRPI9712544-0B1A
Other languages
English (en)
Portuguese (pt)
Other versions
BR9712544A (pt
Inventor
Roger D Tung
Scott L Harbeson
David D Deininger
Mark A Murcko
Govinda Rao Bhisetti
Luc J Farmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR9712544A publication Critical patent/BR9712544A/pt
Publication of BR9712544B1 publication Critical patent/BR9712544B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
BRPI9712544-0B1A 1996-10-18 1997-10-17 Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos BR9712544B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2829096P 1996-10-18 1996-10-18
PCT/US1997/018968 WO1998017679A1 (en) 1996-10-18 1997-10-17 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (2)

Publication Number Publication Date
BR9712544A BR9712544A (pt) 1999-10-19
BR9712544B1 true BR9712544B1 (pt) 2013-10-22

Family

ID=21842625

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9712544-0B1A BR9712544B1 (pt) 1996-10-18 1997-10-17 Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos

Country Status (33)

Country Link
US (5) US6265380B1 (https=)
EP (3) EP2409985A3 (https=)
JP (3) JP4080541B2 (https=)
KR (1) KR100509388B1 (https=)
CN (1) CN1133649C (https=)
AP (1) AP1019A (https=)
AT (1) ATE212037T1 (https=)
BG (1) BG103392A (https=)
BR (1) BR9712544B1 (https=)
CA (1) CA2268391A1 (https=)
CZ (1) CZ298749B6 (https=)
DE (1) DE69709671T2 (https=)
DK (1) DK0932617T3 (https=)
EA (1) EA001915B1 (https=)
EE (1) EE04023B1 (https=)
ES (1) ES2169880T3 (https=)
GE (1) GEP20012471B (https=)
HU (1) HU227742B1 (https=)
ID (1) ID21649A (https=)
IL (3) IL129407A0 (https=)
IN (1) IN183120B (https=)
IS (1) IS5028A (https=)
MX (1) MXPA05003026A (https=)
NO (2) NO329751B1 (https=)
NZ (1) NZ335276A (https=)
PL (2) PL192280B1 (https=)
PT (1) PT932617E (https=)
SK (1) SK286105B6 (https=)
TR (1) TR199901602T2 (https=)
TW (1) TW530065B (https=)
UA (2) UA79749C2 (https=)
WO (1) WO1998017679A1 (https=)
ZA (1) ZA979327B (https=)

Families Citing this family (354)

* Cited by examiner, † Cited by third party
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