CN107209118A - 在自体荧光存在下生物材料中目标荧光团的成像 - Google Patents
在自体荧光存在下生物材料中目标荧光团的成像 Download PDFInfo
- Publication number
- CN107209118A CN107209118A CN201580064648.8A CN201580064648A CN107209118A CN 107209118 A CN107209118 A CN 107209118A CN 201580064648 A CN201580064648 A CN 201580064648A CN 107209118 A CN107209118 A CN 107209118A
- Authority
- CN
- China
- Prior art keywords
- biomaterial
- fluorescent emission
- porphyrin
- fluorescent
- autofluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012620 biological material Substances 0.000 title claims abstract description 105
- 238000003384 imaging method Methods 0.000 title claims description 16
- 238000000034 method Methods 0.000 claims abstract description 56
- 150000004032 porphyrins Chemical group 0.000 claims description 51
- 230000005284 excitation Effects 0.000 claims description 19
- 238000012545 processing Methods 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 11
- 230000003287 optical effect Effects 0.000 claims description 9
- 230000006698 induction Effects 0.000 claims description 8
- 238000001228 spectrum Methods 0.000 claims description 8
- 238000002189 fluorescence spectrum Methods 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- NCAJWYASAWUEBY-UHFFFAOYSA-N 3-[20-(2-carboxyethyl)-9,14-diethyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(21),2,4,6(24),7,9,11,13,15,17,19-undecaen-4-yl]propanoic acid Chemical compound N1C2=C(C)C(CC)=C1C=C(N1)C(C)=C(CC)C1=CC(C(C)=C1CCC(O)=O)=NC1=CC(C(CCC(O)=O)=C1C)=NC1=C2 NCAJWYASAWUEBY-UHFFFAOYSA-N 0.000 claims description 3
- MOTVYDVWODTRDF-UHFFFAOYSA-N 3-[7,12,17-tris(2-carboxyethyl)-3,8,13,18-tetrakis(carboxymethyl)-21,22-dihydroporphyrin-2-yl]propanoic acid Chemical compound N1C(C=C2C(=C(CC(O)=O)C(=CC=3C(=C(CC(O)=O)C(=C4)N=3)CCC(O)=O)N2)CCC(O)=O)=C(CC(O)=O)C(CCC(O)=O)=C1C=C1C(CC(O)=O)=C(CCC(=O)O)C4=N1 MOTVYDVWODTRDF-UHFFFAOYSA-N 0.000 claims description 3
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 claims description 3
- 238000003745 diagnosis Methods 0.000 claims description 3
- 239000007850 fluorescent dye Substances 0.000 claims description 3
- 229950003776 protoporphyrin Drugs 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 2
- 238000004364 calculation method Methods 0.000 claims description 2
- 210000003850 cellular structure Anatomy 0.000 claims description 2
- 238000003364 immunohistochemistry Methods 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 230000003211 malignant effect Effects 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- OOOQNKMJLOLMHC-UHFFFAOYSA-N 5-[[3,4-diethyl-5-[[5-formyl-3-(3-hydroxypropyl)-4-methyl-1h-pyrrol-2-yl]methyl]-1h-pyrrol-2-yl]methyl]-4-(3-hydroxypropyl)-3-methyl-1h-pyrrole-2-carbaldehyde Chemical class N1C(CC2=C(C(C)=C(C=O)N2)CCCO)=C(CC)C(CC)=C1CC=1NC(C=O)=C(C)C=1CCCO OOOQNKMJLOLMHC-UHFFFAOYSA-N 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 150000004033 porphyrin derivatives Chemical class 0.000 claims 2
- 230000036541 health Effects 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 abstract description 3
- 210000002700 urine Anatomy 0.000 description 16
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 8
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 8
- 210000000245 forearm Anatomy 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical class CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000000799 fluorescence microscopy Methods 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 102000016942 Elastin Human genes 0.000 description 3
- 108010014258 Elastin Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 229920002549 elastin Polymers 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000000295 emission spectrum Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000006651 lactation Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- RKCAIXNGYQCCAL-UHFFFAOYSA-N porphin Chemical compound N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 RKCAIXNGYQCCAL-UHFFFAOYSA-N 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 108010005094 Advanced Glycation End Products Proteins 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003875 Ferrochelatase Human genes 0.000 description 1
- 108010057394 Ferrochelatase Proteins 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013079 data visualisation Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000012632 fluorescent imaging Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 239000005337 ground glass Substances 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011503 in vivo imaging Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
- A61B1/00009—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T5/00—Image enhancement or restoration
- G06T5/50—Image enhancement or restoration using two or more images, e.g. averaging or subtraction
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
- G06T7/0014—Biomedical image inspection using an image reference approach
- G06T7/0016—Biomedical image inspection using an image reference approach involving temporal comparison
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10064—Fluorescence image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10141—Special mode during image acquisition
- G06T2207/10152—Varying illumination
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/20—Special algorithmic details
- G06T2207/20212—Image combination
- G06T2207/20224—Image subtraction
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Theoretical Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Quality & Reliability (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Signal Processing (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Endoscopes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims (36)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462056830P | 2014-09-29 | 2014-09-29 | |
US62/056830 | 2014-09-29 | ||
PCT/CA2015/050973 WO2016049756A1 (en) | 2014-09-29 | 2015-09-28 | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107209118A true CN107209118A (zh) | 2017-09-26 |
CN107209118B CN107209118B (zh) | 2021-05-28 |
Family
ID=55629196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201580064648.8A Active CN107209118B (zh) | 2014-09-29 | 2015-09-28 | 在自体荧光存在下生物材料中目标荧光团的成像 |
Country Status (9)
Country | Link |
---|---|
US (2) | US9816930B2 (zh) |
EP (1) | EP3201607B1 (zh) |
JP (1) | JP6549705B2 (zh) |
KR (2) | KR102068776B1 (zh) |
CN (1) | CN107209118B (zh) |
AU (1) | AU2015327665B2 (zh) |
CA (1) | CA2963987A1 (zh) |
HK (1) | HK1244873A1 (zh) |
WO (1) | WO2016049756A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112424588A (zh) * | 2018-07-24 | 2021-02-26 | 索尼公司 | 从样本的自体荧光分离出荧光试剂的荧光的信息处理装置及显微镜 |
TWI726614B (zh) * | 2020-02-12 | 2021-05-01 | 財團法人國家實驗研究院 | 生物螢光影像的檢測方法 |
CN113508289A (zh) * | 2019-02-01 | 2021-10-15 | 埃森仪器公司Dba埃森生物科学公司 | 光谱分解 |
WO2022041331A1 (en) * | 2020-08-28 | 2022-03-03 | Hong Kong Applied Science and Technology Research Institute Company Limited | Forensic detector and the system thereof |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location |
US20080161744A1 (en) * | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes |
US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
EP3372250B1 (en) | 2008-05-02 | 2019-12-25 | Novadaq Technologies ULC | Methods for production and use of substance-loaded erythrocytes for observation and treatment of microvascular hemodynamics |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
US10278585B2 (en) | 2012-06-21 | 2019-05-07 | Novadaq Technologies ULC | Quantification and analysis of angiography and perfusion |
WO2016049756A1 (en) * | 2014-09-29 | 2016-04-07 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
KR101955134B1 (ko) | 2014-10-09 | 2019-03-06 | 노바다크 테크놀러지즈 유엘씨 | 형광-조정 광전용적맥파 측정기를 사용한 조직 내의 절대적인 혈류의 정량화 |
CN108369734B (zh) * | 2015-12-10 | 2022-04-26 | 凯杰有限公司 | 数字图像中的对象分类方法、系统及计算机可读介质 |
TWI583952B (zh) * | 2016-01-21 | 2017-05-21 | 威力暘電子股份有限公司 | 排泄物之潛血檢測方法及潛血檢測裝置 |
CA3049922A1 (en) | 2017-02-10 | 2018-08-16 | Novadaq Technologies ULC | Open-field handheld fluorescence imaging systems and methods |
CN110741242B (zh) * | 2017-04-07 | 2023-07-07 | 艾维拉斯生物科学公司 | 比率荧光成像方法 |
US10969384B2 (en) | 2017-05-04 | 2021-04-06 | Vector Laboratories, Inc. | Immunofluorescence assays |
EP3654020B1 (en) * | 2017-07-11 | 2023-06-21 | Hamamatsu Photonics K.K. | Sample observation device and sample observation method |
CN111565620A (zh) * | 2017-12-27 | 2020-08-21 | 爱惜康有限责任公司 | 缺光环境中的荧光成像 |
EP3788345A1 (en) | 2018-05-03 | 2021-03-10 | Akoya Biosciences, Inc. | Multispectral sample imaging |
US10753875B1 (en) * | 2019-01-31 | 2020-08-25 | Rarecyte, Inc. | Spectral unmixing of spectroscopic emission images |
JP7227389B2 (ja) * | 2019-02-13 | 2023-02-21 | ベンタナ メディカル システムズ, インコーポレイテッド | マルチチャネル画像における自己蛍光の寄与を算出するシステムおよび方法 |
WO2022010519A1 (en) * | 2020-07-09 | 2022-01-13 | Axon Imaging, Llc | Tissue imaging system |
WO2022011276A1 (en) | 2020-07-09 | 2022-01-13 | Axon Imaging, Llc | Advanced nervous tissue imaging system |
KR102655200B1 (ko) * | 2020-08-25 | 2024-04-08 | 한국과학기술원 | 반복색분리를 통한 분자 다중 이미징 방법 및 장치 |
EP3961194B1 (en) * | 2020-08-25 | 2023-11-08 | Korea Advanced Institute of Science and Technology | Method and apparatus for multiplexed imaging of biomolecules through iterative unmixing of fluorophore signals |
US20220079447A1 (en) * | 2020-09-15 | 2022-03-17 | Sensors Unlimited, Inc. | Visualization for fluorescent guided imaging |
EP4283282A1 (en) * | 2021-01-22 | 2023-11-29 | Toho University | Autofluorescence quenching device |
WO2023059956A1 (en) * | 2021-10-05 | 2023-04-13 | Mazel Charles H | Method and system for distinguishing a fluorescent subject of interest from other fluorescent subjects or fluorescent background |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1636506A (zh) * | 2003-12-12 | 2005-07-13 | 强生消费者公司 | 评估皮肤与个体之整体健康的方法 |
CN1678239A (zh) * | 2002-08-01 | 2005-10-05 | 约翰霍普金斯大学 | 利用荧光鉴定分子结构和使体腔起皱的细胞类型的技术 |
WO2007012301A1 (de) * | 2005-07-29 | 2007-02-01 | Biocam Gmbh | Verfahren sowie messsystem zur ermittlung der sauerstoffpartialdruckverteilung in zumindest einem gewebeflächenabschnitt, insbesondere hautgewebeflächenabschnitt |
CN101451953A (zh) * | 2008-12-31 | 2009-06-10 | 聚光科技(杭州)有限公司 | 一种生物毒性的检测方法 |
CN101484067A (zh) * | 2006-07-07 | 2009-07-15 | 皇家飞利浦电子股份有限公司 | 光学成像系统和方法 |
CN102026668A (zh) * | 2008-05-14 | 2011-04-20 | 诺瓦达克技术公司 | 用于神经成像的包括与病毒组分结合的荧光染料的成像法和组合物 |
CN102288589A (zh) * | 2011-06-23 | 2011-12-21 | 深圳大学 | 单个荧光探针的定位方法、装置及超分辨成像方法、系统 |
WO2012038824A1 (en) * | 2010-09-20 | 2012-03-29 | Novadaq Technologies Inc. | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
CN102405212A (zh) * | 2009-02-18 | 2012-04-04 | 康奈尔大学 | 在体内外使用的偶联识别/检测系统 |
CN102436648A (zh) * | 2011-08-11 | 2012-05-02 | 上海交通大学 | 基于背景荧光消除的目标荧光光谱解混方法 |
CN103608662A (zh) * | 2011-06-29 | 2014-02-26 | 京都府公立大学法人 | 肿瘤部位的识别装置以及识别方法 |
Family Cites Families (355)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5854822B2 (ja) | 1975-09-11 | 1983-12-06 | ミノルタ株式会社 | コウデンシキセイタイケイソクキ |
US4109647A (en) | 1977-03-16 | 1978-08-29 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare | Method of and apparatus for measurement of blood flow using coherent light |
US4263916A (en) | 1978-03-27 | 1981-04-28 | University Of Southern California | Image averaging for angiography by registration and combination of serial images |
US4162405A (en) | 1978-05-23 | 1979-07-24 | Britton Chance | Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide |
US4200801A (en) | 1979-03-28 | 1980-04-29 | The United States Of America As Represented By The United States Department Of Energy | Portable spotter for fluorescent contaminants on surfaces |
US4394199A (en) | 1981-09-08 | 1983-07-19 | Agnus Chemical Company | Explosive emulsion composition |
JPS58141135A (ja) | 1981-10-20 | 1983-08-22 | 富士写真フイルム株式会社 | 固体イメ−ジセンサを用いた内視鏡の画像伝送方式 |
EP0091805B1 (en) | 1982-04-08 | 1989-07-26 | Olympus Optical Co., Ltd. | Endoscope focus state detectors |
JPS58222331A (ja) | 1982-06-21 | 1983-12-24 | Sony Corp | 文字情報再生装置 |
JPS5940830A (ja) | 1982-08-31 | 1984-03-06 | 浜松ホトニクス株式会社 | レ−ザ光パルスを用いた癌の診断装置 |
JPS5969721A (ja) | 1982-10-15 | 1984-04-20 | Olympus Optical Co Ltd | 内視鏡計測装置 |
JPS5970903A (ja) | 1982-10-15 | 1984-04-21 | Olympus Optical Co Ltd | 内視鏡自動計測装置 |
US4541438A (en) | 1983-06-02 | 1985-09-17 | The Johns Hopkins University | Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light |
US4532918A (en) | 1983-10-07 | 1985-08-06 | Welch Allyn Inc. | Endoscope signal level control |
JPS60256443A (ja) | 1984-05-31 | 1985-12-18 | オムロン株式会社 | 画像計測装置 |
US4559557A (en) | 1984-06-01 | 1985-12-17 | General Electric Company | Region-of-interest digital subtraction angiography |
SE455646B (sv) | 1984-10-22 | 1988-07-25 | Radians Innova Ab | Fluorescensanordning |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
US4718417A (en) | 1985-03-22 | 1988-01-12 | Massachusetts Institute Of Technology | Visible fluorescence spectral diagnostic for laser angiosurgery |
US5125404A (en) | 1985-03-22 | 1992-06-30 | Massachusetts Institute Of Technology | Apparatus and method for obtaining spectrally resolved spatial images of tissue |
DE3511255A1 (de) | 1985-03-28 | 1986-10-02 | Grün Optik Wetzlar GmbH, 6330 Wetzlar | Anordnung zur individuellen regelung der intensitaet mehrer spektrallampen |
CN85100424B (zh) | 1985-04-01 | 1986-10-29 | 上海医疗器械研究所 | 恶性肿瘤固有荧光诊断仪 |
US4619249A (en) | 1985-07-24 | 1986-10-28 | Kim Landry | Transcutaneous intravenous illuminator |
AT387860B (de) | 1985-09-16 | 1989-03-28 | Optical Sensing Technology | Verfahren und vorrichtung zur tumordiagnose mittels sera |
US4719508A (en) | 1985-10-02 | 1988-01-12 | Olympus Optical Co., Ltd. | Endoscopic photographing apparatus |
US5134662A (en) | 1985-11-04 | 1992-07-28 | Cell Analysis Systems, Inc. | Dual color camera microscope and methodology for cell staining and analysis |
US5042494A (en) | 1985-11-13 | 1991-08-27 | Alfano Robert R | Method and apparatus for detecting cancerous tissue using luminescence excitation spectra |
US4930516B1 (en) | 1985-11-13 | 1998-08-04 | Laser Diagnostic Instr Inc | Method for detecting cancerous tissue using visible native luminescence |
US4774568A (en) | 1986-01-27 | 1988-09-27 | Kabushiki Kaisha Toshiba | Endoscopic apparatus |
JPS62247232A (ja) | 1986-04-21 | 1987-10-28 | Agency Of Ind Science & Technol | 蛍光測定装置 |
GB2203831B (en) | 1986-07-07 | 1991-02-06 | Academy Of Applied Sciences | Apparatus and method for the diagnosis of malignant tumours |
JPH0763443B2 (ja) | 1986-09-30 | 1995-07-12 | 株式会社東芝 | 電子内視鏡 |
JPS63122421A (ja) | 1986-11-12 | 1988-05-26 | 株式会社東芝 | 内視鏡装置 |
US5255087A (en) | 1986-11-29 | 1993-10-19 | Olympus Optical Co., Ltd. | Imaging apparatus and endoscope apparatus using the same |
JP2572394B2 (ja) | 1987-03-19 | 1997-01-16 | オリンパス光学工業株式会社 | 電子内視鏡 |
JPH0783B2 (ja) | 1987-03-30 | 1995-01-11 | 株式会社東芝 | 電子内視鏡装置 |
US4986262A (en) | 1987-03-31 | 1991-01-22 | Kabushiki Kaisha Toshiba | Measuring endoscope |
US4852579A (en) | 1987-04-20 | 1989-08-01 | Karl Storz Endoscopy Gmbh And Company | Photocharacterization and treatment of normal abnormal and ectopic endometrium |
US4900934A (en) | 1987-07-15 | 1990-02-13 | University Of Utah | Apparatus for simultaneous visualization and measurement of fluorescence from fluorescent dye-treated cell preparations and solutions |
JPH0824668B2 (ja) | 1987-09-14 | 1996-03-13 | オリンパス光学工業株式会社 | 電子内視鏡装置 |
US4858001A (en) | 1987-10-08 | 1989-08-15 | High-Tech Medical Instrumentation, Inc. | Modular endoscopic apparatus with image rotation |
JPH01160525A (ja) | 1987-12-17 | 1989-06-23 | Olympus Optical Co Ltd | 内視鏡 |
DE3906860A1 (de) | 1988-03-08 | 1989-09-28 | Fraunhofer Ges Forschung | Vorrichtung zum herstellen einer angiographie |
JPH01236879A (ja) | 1988-03-17 | 1989-09-21 | Canon Inc | 画像符号化装置 |
JPH06105190B2 (ja) | 1988-03-31 | 1994-12-21 | 工業技術院長 | 信号解析装置 |
US4998972A (en) | 1988-04-28 | 1991-03-12 | Thomas J. Fogarty | Real time angioscopy imaging system |
US5078150A (en) | 1988-05-02 | 1992-01-07 | Olympus Optical Co., Ltd. | Spectral diagnosing apparatus with endoscope |
IL90188A0 (en) | 1988-05-18 | 1989-12-15 | Cryopharm Corp | Process and medium for the lyophilization of erythrocytes |
US4938205A (en) | 1988-05-27 | 1990-07-03 | The University Of Connecticut | Endoscope with traced raster and elemental photodetectors |
US5178616A (en) | 1988-06-06 | 1993-01-12 | Sumitomo Electric Industries, Ltd. | Method and apparatus for intravascular laser surgery |
US4995396A (en) | 1988-12-08 | 1991-02-26 | Olympus Optical Co., Ltd. | Radioactive ray detecting endoscope |
US5353799A (en) | 1991-01-22 | 1994-10-11 | Non Invasive Technology, Inc. | Examination of subjects using photon migration with high directionality techniques |
WO1990006718A1 (en) | 1988-12-21 | 1990-06-28 | Massachusetts Institute Of Technology | A method for laser induced fluorescence of tissue |
JP2987816B2 (ja) | 1989-01-30 | 1999-12-06 | オリンパス光学工業株式会社 | 蛍光観察装置 |
DE3903019A1 (de) | 1989-02-02 | 1990-08-09 | Hell Rudolf Dr Ing Gmbh | Optische farbteiler-anordnung |
SE8900612D0 (sv) * | 1989-02-22 | 1989-02-22 | Jonas Johansson | Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium |
WO1990012536A1 (en) | 1989-04-14 | 1990-11-01 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
KR100190423B1 (ko) | 1989-06-06 | 1999-06-01 | 기타지마 요시도시 | 에멀젼마스크 등의결함 수정방법 및 장치 |
US4993404A (en) | 1989-06-26 | 1991-02-19 | Lane Timothy G | Fluoroscopy switching device |
CN1049781A (zh) | 1989-09-02 | 1991-03-13 | 住友电气工业株式会社 | 用于血管外科的激光手术器械 |
JPH0614921B2 (ja) | 1989-09-29 | 1994-03-02 | 浜松ホトニクス株式会社 | 生体組織螢光観察装置 |
US5150292A (en) | 1989-10-27 | 1992-09-22 | Arch Development Corporation | Method and system for determination of instantaneous and average blood flow rates from digital angiograms |
EP0439018B1 (en) | 1990-01-08 | 1995-11-08 | Ernest Feiler, M.D. | Diagnostic method for checking the blood flow |
US5091652A (en) | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
US5420628A (en) | 1990-01-16 | 1995-05-30 | Research Development Foundation | Video densitometer with determination of color composition |
US5131398A (en) | 1990-01-22 | 1992-07-21 | Mediscience Technology Corp. | Method and apparatus for distinguishing cancerous tissue from benign tumor tissue, benign tissue or normal tissue using native fluorescence |
US4995398A (en) | 1990-04-30 | 1991-02-26 | Turnidge Patrick A | Coronary angiography imaging system |
US5071417A (en) | 1990-06-15 | 1991-12-10 | Rare Earth Medical Lasers, Inc. | Laser fusion of biological materials |
US5465718A (en) | 1990-08-10 | 1995-11-14 | Hochman; Daryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
US6671540B1 (en) | 1990-08-10 | 2003-12-30 | Daryl W. Hochman | Methods and systems for detecting abnormal tissue using spectroscopic techniques |
US5845639A (en) | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
US6196226B1 (en) | 1990-08-10 | 2001-03-06 | University Of Washington | Methods and apparatus for optically imaging neuronal tissue and activity |
US5438989A (en) | 1990-08-10 | 1995-08-08 | Hochman; Darryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
US5699798A (en) | 1990-08-10 | 1997-12-23 | University Of Washington | Method for optically imaging solid tumor tissue |
US5997844A (en) | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
JPH04297236A (ja) | 1991-03-26 | 1992-10-21 | Toshiba Corp | ディジタルフルオログラフィ装置 |
JPH04307024A (ja) | 1991-04-02 | 1992-10-29 | Olympus Optical Co Ltd | 電子内視鏡装置 |
US5377676A (en) | 1991-04-03 | 1995-01-03 | Cedars-Sinai Medical Center | Method for determining the biodistribution of substances using fluorescence spectroscopy |
US5318023A (en) | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US5117466A (en) | 1991-04-30 | 1992-05-26 | The United States Of America As Represented By The United States Department Of Energy | Integrated fluorescence analysis system |
CA2042075C (en) | 1991-05-08 | 2001-01-23 | Branko Palcic | Endoscopic imaging system |
US5225883A (en) | 1991-06-05 | 1993-07-06 | The Babcock & Wilcox Company | Video temperature monitor |
SE468925B (sv) | 1991-08-22 | 1993-04-19 | Gert Nilsson | En metod och en anordning foer att reducera den avstaandsberoende foerstaerkningsfaktorn vid maetning av stroemningsroerelser med en bildgivande laser-doppler teknik, i synnerhet vid maetning av blodperfusion genom en vaevnad |
US5377686A (en) | 1991-10-11 | 1995-01-03 | The University Of Connecticut | Apparatus for detecting leakage from vascular tissue |
JP3297725B2 (ja) | 1991-12-09 | 2002-07-02 | 国立循環器病センター総長 | 造影血管高精度管径計測装置 |
US5214503A (en) | 1992-01-31 | 1993-05-25 | The United States Of America As Represented By The Secretary Of The Army | Color night vision camera system |
US5235984A (en) | 1992-03-30 | 1993-08-17 | Hewlett-Packard Company | On-line acoustic densitometry tool for use with an ultrasonic imaging system |
US6096289A (en) | 1992-05-06 | 2000-08-01 | Immunomedics, Inc. | Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy |
DE4220633C1 (de) | 1992-06-24 | 1994-02-03 | Wolf Gmbh Richard | Vorrichtung zur Lichtversorgung von Endoskopen |
US5279298A (en) | 1992-11-20 | 1994-01-18 | The Johns Hopkins University | Method and apparatus to identify and treat neovascular membranes in the eye |
US5733721A (en) * | 1992-11-20 | 1998-03-31 | The Board Of Regents Of The University Of Oklahoma | Cell analysis method using quantitative fluorescence image analysis |
GB2275198B (en) | 1993-02-18 | 1997-03-26 | Central Research Lab Ltd | Apparatus for irradiating an area with a controllable pattern of light |
US5437274A (en) | 1993-02-25 | 1995-08-01 | Gholam A. Peyman | Method of visualizing submicron-size vesicles and particles in blood circulation |
JP3228627B2 (ja) | 1993-03-19 | 2001-11-12 | オリンパス光学工業株式会社 | 内視鏡用画像処理装置 |
US5431161A (en) | 1993-04-15 | 1995-07-11 | Adac Laboratories | Method and apparatus for information acquistion, processing, and display within a medical camera system |
US5421339A (en) | 1993-05-12 | 1995-06-06 | Board Of Regents, The University Of Texas System | Diagnosis of dysplasia using laser induced fluoroescence |
US5394199A (en) | 1993-05-17 | 1995-02-28 | The Johns Hopkins University | Methods and apparatus for improved visualization of choroidal blood flow and aberrant vascular structures in the eye using fluorescent dye angiography |
WO1996009792A1 (en) | 1993-05-17 | 1996-04-04 | The Johns Hopkins University | Improved visualization of choroidal blood flow and aberrant vascular structures in the eye |
US5424841A (en) | 1993-05-28 | 1995-06-13 | Molecular Dynamics | Apparatus for measuring spatial distribution of fluorescence on a substrate |
US5673701A (en) | 1994-10-07 | 1997-10-07 | Non Invasive Technology, Inc. | Optical techniques for examination of biological tissue |
DK75593D0 (zh) | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
US5365057A (en) | 1993-07-02 | 1994-11-15 | Litton Systems, Inc. | Light-weight night vision device |
JP3224640B2 (ja) * | 1993-07-30 | 2001-11-05 | 三菱重工業株式会社 | Lifによる濃度計測装置及び方法 |
US5371355A (en) | 1993-07-30 | 1994-12-06 | Litton Systems, Inc. | Night vision device with separable modular image intensifier assembly |
JPH0765154A (ja) | 1993-08-31 | 1995-03-10 | Toshiba Corp | 血管像の定量解析装置及びその定量解析方法 |
JPH0779955A (ja) | 1993-09-14 | 1995-03-28 | Toshiba Corp | X線撮影装置 |
JP3487933B2 (ja) | 1993-12-03 | 2004-01-19 | オリンパス株式会社 | 蛍光観察装置 |
JP3194660B2 (ja) | 1993-12-03 | 2001-07-30 | オリンパス光学工業株式会社 | 蛍光観察装置 |
JPH07155290A (ja) | 1993-12-03 | 1995-06-20 | Olympus Optical Co Ltd | 内視鏡装置 |
JPH07155291A (ja) | 1993-12-03 | 1995-06-20 | Olympus Optical Co Ltd | 蛍光観察装置 |
JP3283128B2 (ja) | 1993-12-03 | 2002-05-20 | オリンパス光学工業株式会社 | 蛍光観察内視鏡装置 |
JP3285265B2 (ja) | 1993-12-03 | 2002-05-27 | オリンパス光学工業株式会社 | 蛍光観察装置 |
JPH07222712A (ja) | 1994-02-10 | 1995-08-22 | Olympus Optical Co Ltd | 蛍光内視鏡装置 |
US5453448A (en) | 1993-12-09 | 1995-09-26 | Pdt Cardiovascular, Inc. | In vivo method for estimating the lipid contant of an atheromatous lesion |
JP3275159B2 (ja) | 1993-12-17 | 2002-04-15 | 日本光電工業株式会社 | 循環血液量測定装置 |
US5496369A (en) | 1994-02-09 | 1996-03-05 | University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic |
EP0668013B1 (en) | 1994-02-22 | 2005-04-20 | Nippon Telegraph And Telephone Corporation | Freeze-dried blood cells, stem cells and platelets and manufacturing method for the same |
US5707986A (en) | 1994-03-14 | 1998-01-13 | Miller; Joan W. | Angiographic method using green porphyrins in primate eyes |
JPH07250812A (ja) | 1994-03-15 | 1995-10-03 | Olympus Optical Co Ltd | 蛍光診断装置 |
JPH07250804A (ja) | 1994-03-15 | 1995-10-03 | Olympus Optical Co Ltd | 蛍光観察装置 |
US5491343A (en) * | 1994-03-25 | 1996-02-13 | Brooker; Gary | High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
CA2189366A1 (en) | 1994-05-03 | 1995-11-09 | Kenneth J. Widder | Composition for ultrasonically quantitating myocardial perfusion |
US5519534A (en) | 1994-05-25 | 1996-05-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane |
JP3641495B2 (ja) | 1994-07-19 | 2005-04-20 | 株式会社日立メディコ | 医用画像診断装置 |
CA2141181A1 (en) | 1994-09-21 | 1996-03-22 | Kimberly-Clark Worldwide, Inc. | Wet-resilient webs |
DE69433413T2 (de) | 1994-09-26 | 2004-10-14 | The Johns Hopkins University | Optische darstellung des blutkreislaufs und von abnormalen gefässstrukturen in der aderhaut des auges |
US5627907A (en) | 1994-12-01 | 1997-05-06 | University Of Pittsburgh | Computerized detection of masses and microcalcifications in digital mammograms |
US5935942A (en) | 1994-12-14 | 1999-08-10 | Zeimer; Ran | Selective and non-invasive visualization or treatment of vasculature |
US5951980A (en) | 1995-01-06 | 1999-09-14 | Leuven Research & Development Vzw | Identification, production and use of new staphylokinase derivatives with reduced immunogenicity |
GB9502065D0 (en) | 1995-02-02 | 1995-03-22 | Nycomed Imaging As | Contrast media |
JPH08224240A (ja) | 1995-02-22 | 1996-09-03 | Olympus Optical Co Ltd | 蛍光診断装置 |
JPH08224208A (ja) | 1995-02-22 | 1996-09-03 | Olympus Optical Co Ltd | 蛍光観察内視鏡装置 |
JP3560671B2 (ja) | 1995-02-23 | 2004-09-02 | オリンパス株式会社 | 蛍光観察装置 |
JP3411737B2 (ja) | 1995-03-03 | 2003-06-03 | ペンタックス株式会社 | 生体の蛍光診断装置 |
US7236815B2 (en) | 1995-03-14 | 2007-06-26 | The Board Of Regents Of The University Of Texas System | Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy |
US5576013A (en) | 1995-03-21 | 1996-11-19 | Eastern Virginia Medical School | Treating vascular and neoplastic tissues |
WO1996031237A2 (en) | 1995-04-04 | 1996-10-10 | Wound Healing Of Oklahoma | Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant |
US5689241A (en) | 1995-04-24 | 1997-11-18 | Clarke, Sr.; James Russell | Sleep detection and driver alert apparatus |
US5743266A (en) | 1995-04-25 | 1998-04-28 | Molecular Biosystems, Inc. | Method for processing real-time contrast enhanced ultrasonic images |
US5623930A (en) | 1995-05-02 | 1997-04-29 | Acuson Corporation | Ultrasound system for flow measurement |
US6032070A (en) | 1995-06-07 | 2000-02-29 | University Of Arkansas | Method and apparatus for detecting electro-magnetic reflection from biological tissue |
CN1200174A (zh) | 1995-08-24 | 1998-11-25 | 普渡研究基金会 | 基于荧光寿命的人体组织及其它无规则介质成象技术和光谱技术 |
US5836311A (en) | 1995-09-20 | 1998-11-17 | Medtronic, Inc. | Method and apparatus for temporarily immobilizing a local area of tissue |
US5647368A (en) | 1996-02-28 | 1997-07-15 | Xillix Technologies Corp. | Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract |
US5756541A (en) | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
DE19613342A1 (de) | 1996-04-03 | 1997-10-09 | Philips Patentverwaltung | Automatisches Bildauswertungsverfahren |
US5766127A (en) | 1996-04-15 | 1998-06-16 | Ohmeda Inc. | Method and apparatus for improved photoplethysmographic perfusion-index monitoring |
JPH09305845A (ja) | 1996-05-13 | 1997-11-28 | Shibaura Eng Works Co Ltd | 温蔵自動販売機 |
US5662644A (en) | 1996-05-14 | 1997-09-02 | Mdlt, Inc. | Dermatological laser apparatus and method |
US5785965A (en) | 1996-05-15 | 1998-07-28 | The Board Of Trustees Of The Leland Stanford Junior Univ. | VEGF gene transfer into endothelial cells for vascular prosthesis |
JP3896176B2 (ja) | 1996-05-21 | 2007-03-22 | 浜松ホトニクス株式会社 | 近赤外線蛍光トレーサーおよび蛍光イメージング方法 |
GB9610700D0 (en) | 1996-05-22 | 1996-07-31 | Moor Instr Ltd | Apparatus for imaging microvascular blood flow |
JPH09308609A (ja) | 1996-05-24 | 1997-12-02 | Canon Inc | 眼科用画像処理装置 |
DE19635038A1 (de) | 1996-08-29 | 1998-03-12 | Pulsion Verwaltungs Gmbh & Co | Verfahren zur nicht invasiven Bestimmung des zerebralen Blutflusses mittels Nah-Infrarot-Spektroskopie |
US5851181A (en) | 1996-08-30 | 1998-12-22 | Esc Medical Systems Ltd. | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
JP3177635B2 (ja) | 1996-09-30 | 2001-06-18 | 株式会社応用光電研究室 | 周波数標準器および選択標準周波数生成方法 |
JP2793989B2 (ja) | 1996-09-30 | 1998-09-03 | オリンパス光学工業株式会社 | 内視鏡用光源装置の回転フィルタ |
US6013265A (en) | 1996-10-22 | 2000-01-11 | University Of Maryland, Baltimore | Vaccine composition for herpes simplex virus and methods of using |
JP3962122B2 (ja) | 1996-11-20 | 2007-08-22 | オリンパス株式会社 | 内視鏡装置 |
US6293911B1 (en) | 1996-11-20 | 2001-09-25 | Olympus Optical Co., Ltd. | Fluorescent endoscope system enabling simultaneous normal light observation and fluorescence observation in infrared spectrum |
JP3713347B2 (ja) | 1996-11-25 | 2005-11-09 | オリンパス株式会社 | 蛍光内視鏡装置 |
DE19648935B4 (de) | 1996-11-26 | 2008-05-15 | IMEDOS Intelligente Optische Systeme der Medizin- und Messtechnik GmbH | Vorrichtung und Verfahren zur Untersuchung von Gefäßen |
CA2192036A1 (en) | 1996-12-04 | 1998-06-04 | Harvey Lui | Fluorescence scope system for dermatologic diagnosis |
US6086539A (en) | 1996-12-04 | 2000-07-11 | Acuson Corporation | Methods and apparatus for ultrasound image quantification |
US6200310B1 (en) | 1997-01-08 | 2001-03-13 | Biosense, Inc. | Monitoring of myocardial revascularization |
JPH10210367A (ja) | 1997-01-20 | 1998-08-07 | Olympus Optical Co Ltd | 電子的撮像装置 |
JP3771985B2 (ja) | 1997-01-20 | 2006-05-10 | オリンパス株式会社 | 蛍光観察内視鏡装置 |
US5965356A (en) | 1997-01-31 | 1999-10-12 | University Of Maryland, Baltimore | Herpes simplex virus type specific seroassay |
US6122042A (en) | 1997-02-07 | 2000-09-19 | Wunderman; Irwin | Devices and methods for optically identifying characteristics of material objects |
US6466687B1 (en) | 1997-02-12 | 2002-10-15 | The University Of Iowa Research Foundation | Method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology |
US6081612A (en) | 1997-02-28 | 2000-06-27 | Electro Optical Sciences Inc. | Systems and methods for the multispectral imaging and characterization of skin tissue |
US6008889A (en) | 1997-04-16 | 1999-12-28 | Zeng; Haishan | Spectrometer system for diagnosis of skin disease |
AU737530B2 (en) | 1997-04-17 | 2001-08-23 | Avimo Group Limited | Ocular microcirculation examination and treatment apparatus |
GB9710049D0 (en) | 1997-05-19 | 1997-07-09 | Nycomed Imaging As | Method |
US6280386B1 (en) | 1997-06-16 | 2001-08-28 | The Research Foundation Of The City University Of New York | Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same |
AU7934498A (en) | 1997-06-27 | 1999-01-19 | Toa Medical Electronics Co., Ltd. | Living body inspecting apparatus and noninvasive blood analyzer using the same |
US6342611B1 (en) | 1997-10-10 | 2002-01-29 | Cytovia, Inc. | Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof |
DE19747172C2 (de) | 1997-10-24 | 2000-04-13 | Pulsion Verwaltungs Gmbh & Co | Vorrichtung zur Feststellung eines Perikardergusses |
JP3370912B2 (ja) | 1997-11-14 | 2003-01-27 | 松下電器産業株式会社 | 撮像装置 |
US6306642B1 (en) | 1997-11-24 | 2001-10-23 | Quidel Corporation | Enzyme substrate delivery and product registration in one step enzyme immunoassays |
JPH11155812A (ja) | 1997-12-02 | 1999-06-15 | Olympus Optical Co Ltd | 蛍光観察装置 |
US5919616A (en) | 1997-12-12 | 1999-07-06 | Aurx, Inc. | Serological assay for herpes |
JPH11183358A (ja) | 1997-12-25 | 1999-07-09 | Kowa Co | 蛍光粒子撮像用容器 |
DE19800312A1 (de) | 1998-01-07 | 1999-07-08 | Wolf Gmbh Richard | Diagnosegerät zur bildgebenden Aufnahme fluoreszierender biologischer Gewebebereiche |
US6054131A (en) | 1998-01-16 | 2000-04-25 | University Of Maryland Baltimore | Vaccine composition for herpes simplex virus and method of using |
WO1999040840A1 (en) | 1998-02-11 | 1999-08-19 | Non-Invasive Technology, Inc. | Detection, imaging and characterization of breast tumors |
US6113588A (en) | 1998-03-13 | 2000-09-05 | Corvascular, Inc. | Transillumination catheter and method |
JP2002507438A (ja) | 1998-03-18 | 2002-03-12 | メディ−フィジックス・インコーポレイテッド | 溶解化した極性化129Xeを用いる肺および心臓脈管構造の映像化および血流を上昇するMR方法 |
US6462770B1 (en) | 1998-04-20 | 2002-10-08 | Xillix Technologies Corp. | Imaging system with automatic gain control for reflectance and fluorescence endoscopy |
US6399354B1 (en) | 1998-07-31 | 2002-06-04 | President And Fellows Of Harvard College | Replication-competent virus expressing a detectable fusion protein |
US6178340B1 (en) | 1998-08-24 | 2001-01-23 | Eduardo Svetliza | Three-dimensional infrared imager for subcutaneous puncture and study of vascular network |
CA2413033A1 (en) | 1998-09-18 | 2000-03-30 | Schering Aktiengesellschaft | Near infrared fluorescent contrast agent and fluorescence imaging |
US6162242A (en) | 1999-01-21 | 2000-12-19 | Peyman; Gholam A. | Selective photodynamic treatment |
ATE309739T1 (de) | 1999-01-26 | 2005-12-15 | Newton Lab Inc | Vorrichtung zur autofluoreszensbildgebung für ein endoskop |
GB9903394D0 (en) | 1999-02-15 | 1999-04-07 | Avimo Group Limited | Treatment of neovascularization and other eye diseases |
US6331703B1 (en) | 1999-03-12 | 2001-12-18 | Ethicon Endo-Surgery, Inc. | Guidance method for radiation detection |
US6167297A (en) | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
US6217848B1 (en) | 1999-05-20 | 2001-04-17 | Mallinckrodt Inc. | Cyanine and indocyanine dye bioconjugates for biomedical applications |
US6186628B1 (en) | 1999-05-23 | 2001-02-13 | Jozek F. Van de Velde | Scanning laser ophthalmoscope for selective therapeutic laser |
WO2001008552A1 (en) | 1999-08-03 | 2001-02-08 | Biophysica, Llc | Spectroscopic systems and methods for detecting tissue properties |
US6944493B2 (en) | 1999-09-10 | 2005-09-13 | Akora, Inc. | Indocyanine green (ICG) compositions and related methods of use |
US6351663B1 (en) | 1999-09-10 | 2002-02-26 | Akorn, Inc. | Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation |
WO2001017561A1 (en) | 1999-09-10 | 2001-03-15 | Akorn, Inc. | Fluorescent dye angiography and dye-enhanced photocoagulation |
DE60036781T2 (de) | 1999-09-24 | 2008-07-24 | National Research Council Of Canada, Ottawa | Vorrichtung zur durchführung von intra-operativer angiographie |
US20050182434A1 (en) | 2000-08-11 | 2005-08-18 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US6915154B1 (en) | 1999-09-24 | 2005-07-05 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US7581191B2 (en) | 1999-11-15 | 2009-08-25 | Xenogen Corporation | Graphical user interface for 3-D in-vivo imaging |
JP2001147387A (ja) | 1999-11-22 | 2001-05-29 | Asahi Optical Co Ltd | 走査光学装置 |
WO2001037717A2 (en) | 1999-11-26 | 2001-05-31 | Applied Spectral Imaging Ltd. | System and method for functional brain mapping |
US6443976B1 (en) | 1999-11-30 | 2002-09-03 | Akorn, Inc. | Methods for treating conditions and illnesses associated with abnormal vasculature |
AT409451B (de) | 1999-12-14 | 2002-08-26 | Hoffmann La Roche | Vorrichtung zur bestimmung der örtlichen verteilung einer messgrösse |
US6319273B1 (en) | 1999-12-16 | 2001-11-20 | Light Sciences Corporation | Illuminating device for treating eye disease |
US6603552B1 (en) | 1999-12-22 | 2003-08-05 | Xillix Technologies Corp. | Portable system for detecting skin abnormalities based on characteristic autofluorescence |
AUPQ514600A0 (en) | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
US6447443B1 (en) | 2001-01-13 | 2002-09-10 | Medtronic, Inc. | Method for organ positioning and stabilization |
JP2001198079A (ja) * | 2000-01-19 | 2001-07-24 | Fuji Photo Film Co Ltd | 蛍光診断装置 |
CA2401270A1 (en) | 2000-03-10 | 2001-09-20 | Jeff W. Lichtman | Method for labeling individual cells |
JP2001299676A (ja) | 2000-04-25 | 2001-10-30 | Fuji Photo Film Co Ltd | センチネルリンパ節検出方法および検出システム |
GB0010123D0 (en) | 2000-04-27 | 2000-06-14 | Univ Nottingham | Planar light sheet anemometers |
AU2001259435A1 (en) | 2000-05-03 | 2001-11-12 | Stephen T Flock | Optical imaging of subsurface anatomical structures and biomolecules |
GB0011278D0 (en) | 2000-05-10 | 2000-06-28 | Univ London | Repair of nerve damage |
DE10028233A1 (de) | 2000-06-07 | 2002-01-24 | Cobra Electronic Gmbh | Farbkameraanordnung mit einem photosensitiven,Iv ladungsgekoppelten Bildwandler (CCD) |
US7482318B2 (en) | 2000-07-26 | 2009-01-27 | University Of Maryland, Baltimore | Protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp 10pk) has anti-apoptotic activity |
US6669926B1 (en) | 2000-10-16 | 2003-12-30 | Mallinckrodt, Inc. | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients |
US6869437B1 (en) | 2000-11-13 | 2005-03-22 | Cardica, Inc. | Method and system for performing closed-chest bypass |
DE10059070C1 (de) | 2000-11-28 | 2002-02-14 | Pulsion Medical Sys Ag | Vorrichtung zur Bestimmung von Gewebeperfusion und intraoperative Verwendung |
WO2002061390A2 (en) | 2001-01-31 | 2002-08-08 | Mayo Foundation For Medical Education And Research | Detection of herpes simplex virus |
US20020181752A1 (en) | 2001-03-14 | 2002-12-05 | Warren Wallo | Method for measuring changes in portions of a human body |
EP1377938B1 (en) | 2001-04-02 | 2018-12-26 | Koninklijke Philips N.V. | Heart modeling using a template |
AU2002305148A1 (en) | 2001-04-05 | 2002-10-21 | Johns Hopkins University | Imaging systems for in vivo protocols |
DE10120980B4 (de) | 2001-05-01 | 2009-12-03 | Pulsion Medical Systems Ag | Verfahren, Vorrichtung und Computerprogramm zur Bestimmung des Blutflusses in einer Gewebe- oder Organregion |
US6757554B2 (en) | 2001-05-22 | 2004-06-29 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution |
US6609794B2 (en) | 2001-06-05 | 2003-08-26 | Adaptive Optics Associates, Inc. | Method of treating the human eye with a wavefront sensor-based ophthalmic instrument |
EP1406081A4 (en) | 2001-07-03 | 2011-10-05 | Hitachi Ltd | METHOD FOR OPTICALLY MEASURING BIOLOGICAL SAMPLING AND OPTICAL MEASURING APPARATUS FOR BIOLOGICAL SAMPLING |
WO2003006658A1 (en) | 2001-07-13 | 2003-01-23 | The General Hospital Corporation | Mutant herpes simplex virus that expresses yeast cytosine deaminase |
US6544183B2 (en) | 2001-08-02 | 2003-04-08 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Method for imaging skin surface intercellular and intracellular structure using a compound to enhance contrast |
DE10143995A1 (de) | 2001-09-07 | 2003-04-03 | Pulsion Medical Sys Ag | System und Computerprogramm zur Bestimmung von Kreislaufgrößen eines Patienten |
US7113817B1 (en) | 2001-10-04 | 2006-09-26 | Wintec, Llc | Optical imaging of blood circulation velocities |
WO2003039333A2 (en) | 2001-10-19 | 2003-05-15 | Innovative Retinal Products Llc | Macula cover and method |
US6942655B2 (en) | 2001-11-13 | 2005-09-13 | Minu, Llc | Method to treat age-related macular degeneration |
US6936043B2 (en) | 2001-11-13 | 2005-08-30 | Minu, Llc | Method to treat age-related macular degeneration |
JP3753650B2 (ja) | 2001-11-14 | 2006-03-08 | 株式会社島津製作所 | 血流測定装置 |
SE0103827D0 (sv) | 2001-11-16 | 2001-11-16 | Mikael Wiberg | Nerve repair unit and method of producing it |
JP3820979B2 (ja) | 2001-12-17 | 2006-09-13 | ブラザー工業株式会社 | パッチ形成装置およびプログラム |
US6899675B2 (en) | 2002-01-15 | 2005-05-31 | Xillix Technologies Corp. | Fluorescence endoscopy video systems with no moving parts in the camera |
EP1332718A1 (en) | 2002-02-01 | 2003-08-06 | Stichting Voor De Technische Wetenschappen | Laser doppler perfusion imaging using a CMOS image sensor |
US7214495B2 (en) | 2002-02-14 | 2007-05-08 | Takeda Pharmaceutical Company Limited | Screening method |
ES2406697T3 (es) | 2002-03-12 | 2013-06-07 | Beth Israel Deaconess Medical Center | Sistema de obtención de imágenes médicas |
US20030187349A1 (en) | 2002-03-29 | 2003-10-02 | Olympus Optical Co., Ltd. | Sentinel lymph node detecting method |
US20030232016A1 (en) | 2002-04-17 | 2003-12-18 | Russell Heinrich | Nerve identification and sparing method |
US7404640B2 (en) | 2002-06-14 | 2008-07-29 | Physical Sciences, Inc. | Monitoring blood flow in the retina using a line-scanning laser ophthalmoscope |
JP4515721B2 (ja) | 2002-06-21 | 2010-08-04 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 灌流画像を分析するための方法、装置及びソフトウェア |
US20060134001A1 (en) | 2002-07-12 | 2006-06-22 | Frangioni John V | Conjugated infrared fluorescent substances for detection of cell death |
EP1539067B1 (en) | 2002-07-17 | 2011-11-30 | Novadaq Technologies Inc. | Combined photocoagulation and photodynamic therapy |
EP1560924A4 (en) | 2002-08-16 | 2006-05-31 | Wayne John Cancer Inst | MOLECULAR LYMPHATIC MAPPING OF VIRCHOV LYMPHOTIC NODES |
JP2004163413A (ja) | 2002-08-28 | 2004-06-10 | Carl-Zeiss-Stiftung Trading As Carl Zeiss | 顕微鏡システムおよび顕微鏡検査方法 |
US20040077952A1 (en) | 2002-10-21 | 2004-04-22 | Rafter Patrick G. | System and method for improved diagnostic image displays |
US7005518B2 (en) | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
WO2004049899A2 (en) | 2002-12-02 | 2004-06-17 | Yeda Research And Development Co. Ltd. | Characterization of arteriosclerosis by optical imaging |
DE10257743B4 (de) | 2002-12-10 | 2006-11-23 | Irmgard Zerrle | Vorrichtung zur Bestimmung der Perfusion in einem Gewebebereich und des Blutflusses durch einzelne Blutgefäße |
US20040156782A1 (en) | 2003-02-12 | 2004-08-12 | Akorn, Inc. | Methods of using indocyanine green (ICG) dye |
JP2004325200A (ja) * | 2003-04-24 | 2004-11-18 | Hitachi Ltd | 組織内物質濃度測定装置 |
WO2005002425A2 (en) | 2003-07-02 | 2005-01-13 | U.S. Government As Represented By The Secretary Of The Army | Wearable tissue viability diagnostic unit |
US20050019744A1 (en) | 2003-07-25 | 2005-01-27 | La Jolla Bioengineering Institute | Ultrasound-assisted ischemic reperfusion |
WO2005026319A2 (en) | 2003-08-06 | 2005-03-24 | The Regents Of Teh University Of California | Erythrocytic cells and method for loading solutes |
US8473035B2 (en) | 2003-09-15 | 2013-06-25 | Beth Israel Deaconess Medical Center | Medical imaging systems |
JP4634304B2 (ja) | 2003-10-10 | 2011-02-16 | 浜松ホトニクス株式会社 | 蛍光色素の濃度を定量する方法およびシステム |
US7512436B2 (en) | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
WO2006014334A2 (en) | 2004-07-06 | 2006-02-09 | Advanced Biophotonics, Inc. | Systems and methods for localizing vascular architecture, and evaluation and monitoring of functional behavior of same |
US7381400B2 (en) | 2004-07-13 | 2008-06-03 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Injection of a radioactive dye for sentinel lymph node identification |
US7394053B2 (en) | 2004-09-09 | 2008-07-01 | Beth Israel Deaconess Medical Center, Inc. | Systems and methods for multi-modal imaging having a spatial relationship in three dimensions between first and second image data |
US7899271B1 (en) | 2004-09-15 | 2011-03-01 | Raytheon Company | System and method of moving target based calibration of non-uniformity compensation for optical imagers |
US8103331B2 (en) * | 2004-12-06 | 2012-01-24 | Cambridge Research & Instrumentation, Inc. | Systems and methods for in-vivo optical imaging and measurement |
JP4937991B2 (ja) * | 2004-12-08 | 2012-05-23 | オリンパス株式会社 | 蛍光内視鏡装置及びそれに用いる撮像ユニット |
JP5028008B2 (ja) | 2004-12-08 | 2012-09-19 | オリンパス株式会社 | 蛍光内視鏡装置 |
US20090005693A1 (en) | 2004-12-22 | 2009-01-01 | Biotree Systems, Inc. | Medical Imaging Methods and Apparatus for Diagnosis and Monitoring of Diseases and Uses Therefor |
US7729750B2 (en) | 2005-01-20 | 2010-06-01 | The Regents Of The University Of California | Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography |
FR2882147B1 (fr) * | 2005-02-14 | 2007-10-05 | Commissariat Energie Atomique | Dispositif d'imagerie de fluorescence par reflexion a deux longueurs d'onde |
DE202005003411U1 (de) | 2005-02-24 | 2006-07-06 | Karl Storz Gmbh & Co. Kg | Multifunktionales Fluoreszenzdiagnosesystem |
AU2006234326B2 (en) | 2005-04-14 | 2011-06-16 | Bracco Suisse S.A. | Perfusion assessment based on animated perfusion imaging |
WO2006111909A1 (en) | 2005-04-20 | 2006-10-26 | Cvl Cosmetics S.A. | Instrument and method for high-speed perfusion imaging |
US20130296715A1 (en) | 2005-04-20 | 2013-11-07 | Ecole Polytechnique Federale De Lausanne (Epfl) | Instrument and method for high-speed perfusion imaging |
US20060239921A1 (en) | 2005-04-26 | 2006-10-26 | Novadaq Technologies Inc. | Real time vascular imaging during solid organ transplant |
US8185176B2 (en) | 2005-04-26 | 2012-05-22 | Novadaq Technologies, Inc. | Method and apparatus for vasculature visualization with applications in neurosurgery and neurology |
RU2288633C1 (ru) | 2005-04-29 | 2006-12-10 | ГОУ ВПО "Красноярская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ определения границ резекции при закрытой травме поджелудочной железы с разрывом главного панкреатического протока |
EP1883354A2 (en) | 2005-04-29 | 2008-02-06 | Novadaq Technologies Inc. | Choroid and retinal imaging and treatment system |
US8460191B2 (en) | 2005-05-20 | 2013-06-11 | Hitachi Medical Corporation | Ultrasonic medical diagnostic device for imaging changes with time |
US7400755B2 (en) | 2005-06-02 | 2008-07-15 | Accuray Incorporated | Inverse planning using optimization constraints derived from image intensity |
JP2007021006A (ja) | 2005-07-20 | 2007-02-01 | Hitachi Medical Corp | X線ct装置 |
WO2007016790A1 (en) | 2005-08-10 | 2007-02-15 | Novadaq Technologies, Inc. | Intra-operative head & neck nerve mapping |
US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location |
DE102005044531A1 (de) | 2005-09-16 | 2007-03-22 | Myrenne Gmbh | Verfahren zur Bestimmung einer Perfusionsverteilung |
JP5236489B2 (ja) | 2005-12-15 | 2013-07-17 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 再現性がありかつ比較可能な流れ取得のための装置および方法 |
WO2007122602A1 (en) | 2006-04-26 | 2007-11-01 | Seng Enterprises Ltd. | A method and system for measuring membrane potential based on fluorescence polarization |
DE102006025423A1 (de) | 2006-05-31 | 2007-12-06 | Siemens Ag | Röntgenanlage mit dual energy Betrieb und Auswertungsverfahren für im dual energy Betrieb erfasste Projektionsbilder |
WO2007143141A2 (en) * | 2006-06-01 | 2007-12-13 | The General Hospital Corporation | In-vivo optical imaging method including analysis of dynamic images |
US20080025918A1 (en) | 2006-07-03 | 2008-01-31 | Beth Israel Deaconess Medical Center, Inc. | Invisible light fluorescent platelets for intraoperative detection of vascular thrombosis |
CA2692923A1 (en) | 2006-07-03 | 2008-06-26 | Beth Israel Deaconess Medical Center, Inc. | Intraoperative imaging methods |
US7450243B2 (en) | 2006-07-10 | 2008-11-11 | The Board Of Trustees Of The University Of Illinois | Volumetric endoscopic coherence microscopy using a coherent fiber bundle |
US9089601B2 (en) | 2006-07-10 | 2015-07-28 | University Of Rochester | Pre- and intra-operative imaging of bladder cancer |
US8078265B2 (en) | 2006-07-11 | 2011-12-13 | The General Hospital Corporation | Systems and methods for generating fluorescent light images |
JP4936812B2 (ja) | 2006-07-21 | 2012-05-23 | 株式会社日本色材工業研究所 | 化粧料の成型装置および成型方法 |
US8725225B2 (en) | 2006-08-10 | 2014-05-13 | University Of Rochester | Intraoperative imaging of renal cortical tumors and cysts |
US20080161744A1 (en) | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes |
WO2008039968A2 (en) | 2006-09-28 | 2008-04-03 | The Research Foundation Of State University Of New York | Apparatus, system, kit and method for heart mapping |
US11540720B2 (en) | 2006-10-06 | 2023-01-03 | Stryker European Operations Limited | Methods, software and systems for imaging |
KR100867977B1 (ko) | 2006-10-11 | 2008-11-10 | 한국과학기술원 | 인도시아닌 그린 혈중 농도 역학을 이용한 조직 관류 분석장치 및 그를 이용한 조직 관류 분석방법 |
US8498695B2 (en) * | 2006-12-22 | 2013-07-30 | Novadaq Technologies Inc. | Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy |
JP4954699B2 (ja) * | 2006-12-28 | 2012-06-20 | オリンパス株式会社 | 蛍光内視鏡システム |
JP5489469B2 (ja) | 2007-01-16 | 2014-05-14 | オリンパス株式会社 | 蛍光信号解析装置および蛍光信号解析方法 |
KR100818669B1 (ko) | 2007-03-09 | 2008-04-02 | 한국과학기술원 | 하지 관류정도 측정장치 |
WO2008116838A2 (de) | 2007-03-23 | 2008-10-02 | Enverdis Gmbh | Verfahren zum ermitteln mikrovaskulärer schädigungen |
DE102007014133B4 (de) | 2007-03-23 | 2015-10-29 | Siemens Aktiengesellschaft | Verfahren zur Visualisierung einer Sequenz tomographischer Volumendatensätze der medizinischen Bildgebung |
DE102007018641B8 (de) | 2007-04-19 | 2009-10-08 | Carl Zeiss Surgical Gmbh | Navigationssystem für Gehirnoperationen |
CN101784227B (zh) | 2007-07-06 | 2013-12-04 | 工业研究有限公司 | 激光散斑成像系统和方法 |
US8073224B2 (en) | 2007-07-09 | 2011-12-06 | Siemens Aktiengesellschaft | System and method for two-dimensional visualization of temporal phenomena and three dimensional vessel reconstruction |
DE102007048362B9 (de) | 2007-10-09 | 2017-08-17 | Carl Zeiss Meditec Ag | System und Verfahren zum Untersuchen eines Objekts |
AU2009204461A1 (en) | 2008-01-10 | 2009-07-16 | Pacific Biosciences Of California, Inc. | Methods and systems for analysis of fluorescent reactions with modulated excitation |
EP3733055A1 (en) | 2008-01-25 | 2020-11-04 | Novadaq Technologies ULC | Method for evaluating blush in myocardial tissue |
US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
US20140316262A1 (en) | 2008-02-26 | 2014-10-23 | Novadaq Technologies Inc. | Preoperative identification of perforator vessels in flaps to be used in reconstructive surgery |
EP2268194B1 (en) * | 2008-03-18 | 2016-08-31 | Novadaq Technologies Inc. | Imaging system for combined full-color reflectance and near-infrared imaging |
JP5074256B2 (ja) * | 2008-03-24 | 2012-11-14 | オリンパス株式会社 | 蛍光観察装置 |
CN102083362B (zh) | 2008-04-14 | 2015-04-22 | 诺瓦达克技术公司 | 定位和分析用于整形和重建手术的穿支皮瓣 |
EP3372250B1 (en) | 2008-05-02 | 2019-12-25 | Novadaq Technologies ULC | Methods for production and use of substance-loaded erythrocytes for observation and treatment of microvascular hemodynamics |
US8150127B2 (en) | 2008-05-28 | 2012-04-03 | Siemens Medical Solutions Usa, Inc. | Method for automatically synchronizing the review of two DSA scenes |
JP5389382B2 (ja) * | 2008-06-09 | 2014-01-15 | オリンパス株式会社 | 蛍光内視鏡装置 |
DE102008040804B4 (de) | 2008-07-28 | 2021-07-29 | Carl Zeiss Meditec Ag | Verfahren, Operationsmikroskop und Analysesystem zur quantitativen Darstellung des Blutflusses |
DE102008040803A1 (de) | 2008-07-28 | 2010-02-04 | Carl Zeiss Surgical Gmbh | Verfahren zur quantitativen Darstellung des Blutflusses |
US8144958B2 (en) | 2008-09-11 | 2012-03-27 | Carl Zeiss Meditec Ag | Medical systems and methods |
US20110266462A1 (en) * | 2009-01-09 | 2011-11-03 | Mitsui Engineering & Shipbuilding Co., Ltd | Fluorescence detecting device and fluorescence detecting method |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
FR2944104A1 (fr) * | 2009-08-25 | 2010-10-08 | Commissariat Energie Atomique | Extinction de l'autofluorescence des tissus biologiques en tomographie resolue en temps |
US20110071403A1 (en) | 2009-09-21 | 2011-03-24 | Board Of Regents Of The University Of Texas System | Functional near-infrared fluorescence lymphatic mapping for diagnosing, accessing, monitoring and directing therapy of lymphatic disorders |
US9091903B2 (en) | 2010-07-29 | 2015-07-28 | Logitech Europe S.A. | Optimized movable IR filter in cameras |
US20130203082A1 (en) * | 2010-09-02 | 2013-08-08 | Tohoku University | Method for determining cancer onset or cancer onset risk |
EP2618154B1 (en) * | 2010-09-17 | 2016-12-14 | Tohoku University | Method for determining effectiveness of medicine containing antibody as component |
JP5371946B2 (ja) * | 2010-12-24 | 2013-12-18 | 富士フイルム株式会社 | 内視鏡診断装置 |
CA2824134C (en) | 2011-01-10 | 2019-05-14 | East Carolina University | Methods, systems and computer program products for noninvasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling |
US9226673B2 (en) | 2011-01-10 | 2016-01-05 | East Carolina University | Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling |
US9179843B2 (en) | 2011-04-21 | 2015-11-10 | Hassan Ghaderi MOGHADDAM | Method and system for optically evaluating proximity to the inferior alveolar nerve in situ |
KR101325054B1 (ko) * | 2011-10-19 | 2013-11-20 | 유인성 | 형광 영상을 촬영하는 장치 및 방법 |
US10278585B2 (en) | 2012-06-21 | 2019-05-07 | Novadaq Technologies ULC | Quantification and analysis of angiography and perfusion |
US9575304B2 (en) * | 2012-06-25 | 2017-02-21 | Huron Technologies International Inc. | Pathology slide scanners for fluorescence and brightfield imaging and method of operation |
US9449377B2 (en) * | 2012-10-09 | 2016-09-20 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Imaging methods and computer-readable media |
JP6198426B2 (ja) * | 2013-03-29 | 2017-09-20 | 浜松ホトニクス株式会社 | 蛍光観察装置及び蛍光観察方法 |
JP6310550B2 (ja) | 2013-06-14 | 2018-04-11 | ノバダック テクノロジーズ インコーポレイテッド | 蛍光媒介フォトプレチスモグラフィを用いた組織の絶対血流の定量化 |
US9779500B2 (en) * | 2013-07-03 | 2017-10-03 | Konica Minolta, Inc. | Image processing device, pathological diagnosis support system, image processing program, and pathological diagnosis support method |
CN106455942B (zh) * | 2014-06-05 | 2018-07-06 | 奥林巴斯株式会社 | 处理装置、内窥镜装置及系统、图像处理装置的工作方法 |
WO2016049756A1 (en) * | 2014-09-29 | 2016-04-07 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
KR101955134B1 (ko) | 2014-10-09 | 2019-03-06 | 노바다크 테크놀러지즈 유엘씨 | 형광-조정 광전용적맥파 측정기를 사용한 조직 내의 절대적인 혈류의 정량화 |
CA3049922A1 (en) | 2017-02-10 | 2018-08-16 | Novadaq Technologies ULC | Open-field handheld fluorescence imaging systems and methods |
-
2015
- 2015-09-28 WO PCT/CA2015/050973 patent/WO2016049756A1/en active Application Filing
- 2015-09-28 CN CN201580064648.8A patent/CN107209118B/zh active Active
- 2015-09-28 KR KR1020197031200A patent/KR102068776B1/ko active IP Right Grant
- 2015-09-28 CA CA2963987A patent/CA2963987A1/en not_active Abandoned
- 2015-09-28 AU AU2015327665A patent/AU2015327665B2/en not_active Ceased
- 2015-09-28 KR KR1020177011565A patent/KR20170067803A/ko active Application Filing
- 2015-09-28 EP EP15846111.1A patent/EP3201607B1/en active Active
- 2015-09-28 JP JP2017516925A patent/JP6549705B2/ja active Active
- 2015-09-28 US US14/868,369 patent/US9816930B2/en active Active
-
2017
- 2017-10-31 US US15/799,727 patent/US10488340B2/en active Active
-
2018
- 2018-03-23 HK HK18104021.5A patent/HK1244873A1/zh unknown
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1678239A (zh) * | 2002-08-01 | 2005-10-05 | 约翰霍普金斯大学 | 利用荧光鉴定分子结构和使体腔起皱的细胞类型的技术 |
CN1636506A (zh) * | 2003-12-12 | 2005-07-13 | 强生消费者公司 | 评估皮肤与个体之整体健康的方法 |
WO2007012301A1 (de) * | 2005-07-29 | 2007-02-01 | Biocam Gmbh | Verfahren sowie messsystem zur ermittlung der sauerstoffpartialdruckverteilung in zumindest einem gewebeflächenabschnitt, insbesondere hautgewebeflächenabschnitt |
CN101484067A (zh) * | 2006-07-07 | 2009-07-15 | 皇家飞利浦电子股份有限公司 | 光学成像系统和方法 |
CN102026668A (zh) * | 2008-05-14 | 2011-04-20 | 诺瓦达克技术公司 | 用于神经成像的包括与病毒组分结合的荧光染料的成像法和组合物 |
CN101451953A (zh) * | 2008-12-31 | 2009-06-10 | 聚光科技(杭州)有限公司 | 一种生物毒性的检测方法 |
CN102405212A (zh) * | 2009-02-18 | 2012-04-04 | 康奈尔大学 | 在体内外使用的偶联识别/检测系统 |
WO2012038824A1 (en) * | 2010-09-20 | 2012-03-29 | Novadaq Technologies Inc. | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
CN102288589A (zh) * | 2011-06-23 | 2011-12-21 | 深圳大学 | 单个荧光探针的定位方法、装置及超分辨成像方法、系统 |
CN103608662A (zh) * | 2011-06-29 | 2014-02-26 | 京都府公立大学法人 | 肿瘤部位的识别装置以及识别方法 |
CN102436648A (zh) * | 2011-08-11 | 2012-05-02 | 上海交通大学 | 基于背景荧光消除的目标荧光光谱解混方法 |
Non-Patent Citations (1)
Title |
---|
R. BAUMGARTNER 等: ""A FLUORESCENCE IMAGING DEVICE FOR ENDOSCOPIC DETECTION OF EARLY STAGE CANCER – INSTRUMENTAL and EXPERIMENTAL STUDIES"", 《PHOTOCHEMISTRY AND PHOTOBIOLOGY》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112424588A (zh) * | 2018-07-24 | 2021-02-26 | 索尼公司 | 从样本的自体荧光分离出荧光试剂的荧光的信息处理装置及显微镜 |
CN113508289A (zh) * | 2019-02-01 | 2021-10-15 | 埃森仪器公司Dba埃森生物科学公司 | 光谱分解 |
TWI726614B (zh) * | 2020-02-12 | 2021-05-01 | 財團法人國家實驗研究院 | 生物螢光影像的檢測方法 |
WO2022041331A1 (en) * | 2020-08-28 | 2022-03-03 | Hong Kong Applied Science and Technology Research Institute Company Limited | Forensic detector and the system thereof |
US11408825B2 (en) | 2020-08-28 | 2022-08-09 | Hong Kong Applied Science and Technology Research Institute Company Limited | Forensic detector and the system thereof |
Also Published As
Publication number | Publication date |
---|---|
US20180120230A1 (en) | 2018-05-03 |
US9816930B2 (en) | 2017-11-14 |
EP3201607B1 (en) | 2020-12-30 |
WO2016049756A1 (en) | 2016-04-07 |
HK1244873A1 (zh) | 2018-08-17 |
US10488340B2 (en) | 2019-11-26 |
KR20170067803A (ko) | 2017-06-16 |
AU2015327665B2 (en) | 2018-09-27 |
EP3201607A1 (en) | 2017-08-09 |
KR102068776B1 (ko) | 2020-01-21 |
KR20190122890A (ko) | 2019-10-30 |
CA2963987A1 (en) | 2016-04-07 |
US20160110870A1 (en) | 2016-04-21 |
EP3201607A4 (en) | 2018-08-15 |
AU2015327665A1 (en) | 2017-04-13 |
JP6549705B2 (ja) | 2019-07-24 |
JP2017533415A (ja) | 2017-11-09 |
CN107209118B (zh) | 2021-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107209118A (zh) | 在自体荧光存在下生物材料中目标荧光团的成像 | |
US11656448B2 (en) | Method and apparatus for quantitative hyperspectral fluorescence and reflectance imaging for surgical guidance | |
JP5991975B2 (ja) | 腫瘍部位の識別装置及び識別方法 | |
JP5028008B2 (ja) | 蛍光内視鏡装置 | |
JP2009148568A (ja) | 蛍光画像の分析処理方法 | |
US20110042580A1 (en) | Fluorescence quantification and image acquisition in highly turbid media | |
EP2347703B1 (en) | Cancerous or pre-cancerous tissue visualization method and device | |
JP2003102672A (ja) | 病変等の対象部位を自動的に検知かつ治療または採取する方法およびその装置 | |
JP2011115658A (ja) | 周辺光条件下のインビボ誘導信号の光学画像化 | |
JP2022517422A (ja) | 創傷および組織標本の3次元画像化、測定、および表示のためのシステム、方法、および装置 | |
JP7221285B2 (ja) | 切除縁を術中に評価するための画像化方法およびシステム | |
JP2006340796A (ja) | センチネルリンパ節検出システム | |
Koizumi et al. | Highly sensitive fluorescence detection of metastatic lymph nodes of gastric cancer with photo-oxidation of protoporphyrin IX | |
US20230280577A1 (en) | Method and apparatus for quantitative hyperspectral fluorescence and reflectance imaging for surgical guidance | |
EP3785019B1 (en) | Device and method for determining depth and concentration of a subsurface fluorescent object | |
JP2005195379A (ja) | 腫瘍画像検出方法とその装置 | |
EP1203944B1 (de) | Tumorzellenidentifizierungsverfahren | |
US20090214440A1 (en) | Method and device for examining a biological tissue | |
Becker et al. | First results of computer-enhanced optical diagnosis of bladder cancer | |
WO2024099594A1 (en) | Imaging device and method | |
Xie et al. | Computer-assisted image processing for lung cancer localization | |
CN116106275A (zh) | 肿瘤部位的判定装置、肿瘤部位的判定方法以及存储介质 | |
Themelis et al. | Advancing the technology and applications of surgical fluorescence imaging with targeted fluorochromes | |
Lin et al. | Clinical translation of ultraviolet autofluorescence microscopy towards endomicroscopy for early detection of cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1244873 Country of ref document: HK |
|
TA01 | Transfer of patent application right |
Address after: Delaware, USA Applicant before: Stryker Europe Holdings Ltd. Effective date of registration: 20210118 Effective date of registration: 20210118 Address after: Delaware, USA Applicant after: Stryker Europe Holdings Ltd. Address before: Delaware, USA Applicant before: Stryker Europe Holdings Ltd. Effective date of registration: 20210118 Address after: Ai Erlankekejun Applicant after: Stryker Europe Operations Ltd. Address before: Delaware, USA Applicant before: Stryker Europe Holdings Ltd. Effective date of registration: 20210118 Address after: Delaware, USA Applicant after: Stryker Europe Holdings Ltd. Address before: michigan Applicant before: Stryker Europe holding LLC Effective date of registration: 20210118 Address after: michigan Applicant after: Stryker Europe holding LLC Address before: Ontario, Canada Applicant before: NOVADAQ TECHNOLOGIES ULC Effective date of registration: 20210118 Address after: Ontario, Canada Applicant after: NOVADAQ TECHNOLOGIES ULC Address before: Ontario, Canada Applicant before: NOVADAQ TECHNOLOGIES Inc. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240423 Address after: michigan Patentee after: STRYKER Corp. Country or region after: U.S.A. Address before: Ai Erlankekejun Patentee before: Stryker Europe Operations Ltd. Country or region before: Ireland |
|
TR01 | Transfer of patent right |