CN103975245A - 用于试样输送系统的磁阻尼 - Google Patents

用于试样输送系统的磁阻尼 Download PDF

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CN103975245A
CN103975245A CN201280060884.9A CN201280060884A CN103975245A CN 103975245 A CN103975245 A CN 103975245A CN 201280060884 A CN201280060884 A CN 201280060884A CN 103975245 A CN103975245 A CN 103975245A
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sample
sample carriers
magnet
transfer arm
carriers
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查尔斯·W·约翰
塞缪尔·H·里佐特
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Beckman Coulter Inc
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Beckman Instruments Inc
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Abstract

本发明公开了一种利用磁阻尼的试样输送系统和利用磁阻尼输送试样的方法。传送装置输送被配置为携带试样容器的样本载体。一个以上的样本载体包含磁体。该系统还可以包含具有磁体的转移臂。当第一样本载体被朝向第二样本载体输送时,耦接到第一样本载体的第一样本载体磁体排斥耦接到第二样本载体的第二样本载体磁体。当样本载体被朝向转移臂输送时,转移臂的转移臂磁体排斥样本载体的样本载体磁体。

Description

用于试样输送系统的磁阻尼
涉及申请的交叉引用
本申请要求2011年11月7日提交的题为“用于处理样本的分析系统和方法”的美国临时专利申请第61/556,667号的优先权,通过引用将其全部在此结合用于各种用途。这个申请还要求2012年3月28日提交的题为“用于处理样本的分析系统和方法”的美国临时专利申请第61/616,994号的优先权,通过引用将其全部在此结合用于各种用途。这个申请进一步要求2012年8月6日提交的题为“用于处理样本的分析系统和方法”的美国临时专利申请第61/680,066号的优先权,通过引用将其全部结合在此用于各种用途。
背景技术
试样输送系统可以用于传送实验室分析系统之内的试样。试样可以是要对其进行实验室分析的血液或者其他体液的样本。用于分析的样本的制备可以要求将样本输送到用于等分处理、离心处理或者其他处理的各种各样的台。然后样本可以被输送到要进行分析的地点和用于存储或者废弃的输出台。各种各样的输送系统可以用于在实验室分析系统的台之间输送样本。
输送机输送系统可以使用输送带或者输送机轨道来在台之间输送样本试管。典型地,样本试管被插入样本载体中,该样本载体将试样保持在固定的竖直位置中,用于传送机系统的输送。诸如转移臂的规定路线机构可以用于将样本载体从一个传送机转移到另一个传送机(例如,从主要传送机到辅助的传送机)。
传送机系统可以以低速被操作,从而避免潜在的样本载体碰撞的出现。随着它们在障碍物后面形成队列,当第一个样本载体遇到障碍物并且接着第一个样本载体的样本载体碰撞时,冲击可能发生在样本载体之间。当样本载体遇到轨道上的转移臂时,冲击同样可能出现。这些冲击可能使得样本试管的容纳物从样本载体飞溅出去。通过使得由离心分离所分离的流体层再混合,冲击同样可能影响样本质量。
本发明的实施例解决这些及其他问题。
发明内容
技术的实施例涉及用于有效地处理为了实验室分析而采集的样本的系统和方法。更具体地,描述了具有磁阻尼部件的样本载体输送系统。
一个实施例针对一种试样输送系统。第一样本载体磁体被耦接到配置为输送至少一个试样容器的第一样本载体,以及第二样本载体磁体被耦接到配置为输送至少一个试样容器的第二样本载体。传送装置输送多个样本容器。第一样本载体磁体被配置为排斥所述第二样本载体磁体,以致在所述第一样本载体被朝向所述第二样本载体输送时,在所述第一样本载体和所述第二样本载体之间没有出现接触。
另一个实施例针对一种试样输送系统,该试样输送系统具有耦接到样本载体的样本载体磁体和耦接到转移臂的转移臂磁体。一种传送装置输送样本载体,以使样本载体被朝向转移臂输送。所述转移臂磁体被配置为排斥所述样本载体磁体,以致在所述样本载体被朝向所述转移臂输送时,在所述样本载体和所述转移臂之间没有出现接触。
进一步的实施例针对用于输送试样的方法。传送装置输送多个样本载体。第一样本载体的第一样本载体磁体排斥第二样本载体的第二样本载体磁体,以致在所述第一样本载体被朝向所述第二样本载体输送时,在所述第一样本载体和所述第二样本载体之间没有出现接触。
附加的实施例针对样本载体组件。样本载体组件包含样本载体。样本载体被配置为输送至少一个试样容器。该样本载体组件还包含耦接到样本载体的样本载体磁体。
以下进一步详细描述该技术的这些及其他实施例。
附图说明
可以通过参考以下附图来了解不同的实施例的本质和优点的进一步的理解。
图1显示在用于处理患者样本的实验室自动化系统中用于输送样本载体的传送机系统的说明性的实施例。
图2(a)-(d)描绘可以用于传送机输送系统的转移和合并功能的说明性的实例。
图3显示现有技术的传送机输送系统。
图4显示根据实施例的具有磁阻尼部件的试样输送系统的说明性的样本载体。
图5显示具有转移臂磁体的说明性的转移臂的俯视图。
图6是图解两个样本载体环形磁体的磁化的图。
图7是图解样本载体环形磁体和转移臂的磁化的图。
图8是显示磁阻尼可以如何用于传送机输送系统的说明性的实例的流程图。
具体实施方式
本技术的实施例涉及用于在医疗实验室分析的试样输送系统中使用的样本载体的磁阻尼的系统和方法。
实验室自动化系统可以具有将试样载体从系统之内的一个地点输送到另一个地点的一个以上的手段。例如,具有传送带或者轨道的传送机系统可以用于移动试样载体。
试样载体可以是任何器皿,该任何器皿用于包含诸如血液的体液,或者需要实验室分析的任何其他的流体。试样载体可以是样本试管。在一些实施例中,样本在分析之前被离心处理。例如,通过离心处理,血液可以被分离到组分材料及其他材料(例如,等离子体、红细胞、白细胞层、凝胶体)的层中。
一个以上的试样容器可以被放置在样本载体中,试样容器用于经由输送系统在位置之间输送试样。在一些实施例中,样本载体具有诸如带弹簧的钳子等弹性元件,以容纳具有不同尺寸的样本试管。一旦试样容器被插入到样本载体中,该样本载体较佳地将该试样容器相对于该样本载体保持在固定位置中。当样本载体到达对于试样容器的指定目的地时,可以从样本载体去除该试样容器。样本载体可以包含允许样本载体独立移动的马达。可独立移动的样本载体的示范性的实施例在2012年5月11日提交的题为“包含实验室产品输送元件的系统和方法”的PCT专利申请第PCT/US2012/037585号中,通过引用将其全部结合在此用于各种用途。
在样本载体中引入磁体,以致第一个样本载体的磁体排斥相邻样本载体的磁体,可以防止在样本载体互相碰撞的时候可能出现的不利影响。结果,样本载体可以在对于样本质量有少许到没有有害影响的情况下以增加的速度行进。
在一些实施例中,一个以上的磁性元件可以耦接到定向闸(directional gate)。定向闸可以用于将样本载体从一个轨道移动到另一个轨道。现有的定向闸可以使得样本载体由于样本载体和之间的摩擦而减速。当磁体被耦接到定向闸时,磁体可以排斥样本载体上的样本载体磁体,以致在样本载体和定向闸之间没有接触。如此,样本载体能够穿过定向闸的速度可以增加。
用于样本载体和定向闸的磁体可以由产生磁场的任何材料或装置组成,任何材料或装置诸如是金属磁体、陶瓷磁体,或者电磁体。
图1显示在用于处理患者样本的实验室自动化系统中用于输送样本容器的传送机系统的说明性的实施例。该实验室自动化系统可以使用传送机轨道以在实验室自动化系统的各个区域之间输送样本载体。例如,传送机轨道102可以用于在一个以上的例如试样容器输入和分配区域106、等分试样区域108、离心区域110、输出区域112、分析区域114和后分析样本处理区域116之间输送样本载体104。
定向闸可以用于引导样本载体沿着传送机系统行进。例如,定向闸可以是转移臂,该转移臂用于将样本载体从一个轨道转移到相邻轨道。在一些实施例中,可以在一个以上的处理器的控制下操作定向闸。例如,传送机输送系统的控制器可以被通信地耦接到用于实验室自动化系统的主控制器。传送机输送系统控制器可以响应于从主控制器接收的指令来操作该定向闸,以便将样本载体转移到希望的传送机轨道或者样本载体目的地。图2(a)-(d)描绘可以用于传送机输送系统的转移和合并功能的说明性的实例。
图2(a)显示能够将样本载体202从一个轨道204转移到相邻的平行轨道206的传送机输送系统。当传送机输送系统控制器指示转移臂208移动到使得样本试管可以被转移到平行传送线的位置时,样本试管可以被转移。
如图2(b)所示,传送机输送系统同样可以合并互相平行的两个传送轨道。来自第一个传送机轨道212的样本载体202可以与从第二传送机轨道214下来的样本试管合并。在一些实施例中,诸如传送机输送系统控制器的控制器可以协调样本载体202进入传送机轨道212、214的时刻和/或转移臂208的操作,以使样本载体不会彼此撞上和/或在线上变得被堵塞。
如图2(c)所示,传送机输送系统同样能够将行进的样本载体从第一传送线222转移到第二传送线224,第二传送线224垂直于第一传送线。通过转移臂208,沿着传送机222行进的样本载体可以被转移90°。将认识到,传送机轨道222和224可以以90°角度以外的角度相交。
如图2(d)所示,传送机输送系统同样可能能够将样本试管从垂直的第二传送线234合并到第一传送线232之上。第一传送机轨道232可以垂直于第二传送机轨道234。将认识到,传送机轨道可以以除了90°角度以外的角度相交。沿着第二传送机234行进的样本载体可以被合并到第一传送机232之上。在一些实施例中,诸如传送机输送系统控制器的控制器可以协调样本载体202进入传送机轨道232、234的时刻和/或转移臂208的操作,以使样本载体不会彼此撞上和/或在线上变得被堵塞。
图3显示现有技术的传送机输送系统,在现有技术的传送机输送系统中,试样容器302、304和306分别沿着传送机轨道314被样本载体308、310和312输送。在说明性的现有技术系统中,样本载体308已经沿着传送机轨道314行进,直到样本载体遇到障碍物316。在样本载体308被障碍物316截停之后,在样本载体308后面行进的样本载体310已经与样本载体308碰撞。样本载体312同样已经与样本载体310碰撞。这种碰撞会使得样本材料飞溅到样本载体之外。如果样本材料已经被分离到层中(例如,通过离心处理被分离到它的构件中的血液),那么该碰撞可能干扰该层,使得分离的样本材料再结合。现有技术的输送系统必须以足够缓慢的速率运行,以防止样本的溢出和干扰。
在利用磁阻尼的改进的试样输送系统的各个实施例中,磁体被耦接到样本载体。例如,环形磁体可以被结合到样本载体中或者另外附着到样本载体。在一些实施例中,环形磁体被耦接到样本载体,以使环形磁体环绕样本载体。当具有环形磁体的样本载体遇到具有环形磁体的另一个样本载体时,各个环形磁体排斥另一个,以使各个样本载体减速。如此,碰撞可以被防止或者抑制。
图4显示根据实施例的具有磁阻尼部件的试样输送系统的说明性的样本载体。第一样本载体磁体402、第二样本载体磁体404和第三样本载体磁体406分别被耦接到第一样本载体408、第二样本载体410和第三样本载体412。试样容器(诸如参考图3描述的试样容器302-306)可以被插入每个样本载体中。
样本载体磁体402-406可以是环形的磁体。在一些实施例中,环形磁体可以被耦接到样本载体的底部(例如,在接收试样容器的试样容器的部分下方)。可以安装环形磁体,以使环形磁体的外部与样本载体的外表面同样高。环形磁体可以被径向地磁化,以使磁体的第一极是环的外表面,并且磁体的第二极是环的内表面。较佳地,每个样本载体环形磁体的外表面的极被匹配,以使样本载体磁体互相排斥。因此,如果第一样本载体磁体的外表面是北极,那么第二样本载体磁体和第三样本载体磁体的外表面同样被磁化,以使环形磁体的外表面是北极。
在图4中,第一样本载体磁体402排斥第二样本载体磁体404,使得在样本载体408和410之间维持间隔。类似地,第二样本载体磁体404排斥第三样本载体磁体406,使得在样本容器410和之间维持间隔。如此,通过耦接到样本容器的磁体的各个磁场的排斥效应,来防止相邻的样本容器之间的碰撞。
在一些实施例中,转移臂磁体被耦接到转移臂,以使转移臂磁体排斥接近该转移臂的任何样本载体的样本载体磁体。
图5显示具有转移臂磁体的说明性的转移臂的俯视图。一个以上的转移臂磁体502可以被耦接到转移臂504。在一些实施例中,转移臂504由磁化的材料构成,以致不必将分开的磁性部件502耦接到转移臂504。试样容器506被插入具有样本载体磁体510的样本载体508中。样本载体508被第一传送机轨道512朝向转移臂504输送。
转移臂磁体502可以被磁化,以致转移臂磁体502面对样本载体508的极与样本载体磁体510的外表面的极相同。例如,如果转移臂磁体502具有面对样本载体磁体510的北极,那么样本载体磁体510的外表面可以被磁化,以使环形磁体的外表面是北极。如此,当样本载体508接近转移臂504时,转移臂磁体502排斥样本载体磁体510,以使转移臂504和样本载体508之间的碰撞被减少或者避免。当转移臂504处于使得转移臂504延伸穿过第一传送机轨道512的第一位置时,样品容器508通过第一传送机轨道512和转移臂504被推动到第二传送机轨道514之上。当转移臂504处于使得转移臂504没有延伸穿过第一传送机轨道512的第二位置(没有图示)时,样品容器508将继续沿着未转移的第一传送机轨道512。
图6是与第一样本载体(没有显示)的第一环形磁体和与第二样本载体(没有显示)关联的第二环形磁体的图。第一环形磁体602可以被径向地磁化,以使磁体的第一极是环的外表面604,并且磁体的第二极是环的内表面606。第二环形磁体608可以被径向地磁化,以使磁体的第一极在环的外表面610,并且磁体的第二极在环的内表面612。因为第一环形磁体和第二环形磁体在环的外表面具有相同的极(如图6所示,诸如北极),所以第一环形磁体排斥第二环形磁体。只要驱动第一样本载体朝向第二样本载体(或者相反)的力小于磁场的力,就防止第一样本载体与第二样本载体接触。
第一环形磁体、第二环形磁体和/或转移臂的磁场可以是在离开磁体的外表面10毫米的距离处测量时的150-300高斯的范围,诸如在离开磁体的外表面10毫米的距离处测量时的200-260高斯,例如,在离开磁体的外表面10毫米的距离处测量时的242高斯。
图7是一个以上的与转移臂关联的转移臂磁体和与样本载体关联的环形磁体的图。转移臂702可以被枢轴地耦接到传送机系统,使得它在枢轴点714周围枢轴旋转。转移臂702可以包含一个以上的磁体,诸如第一转移臂磁体710和第二转移臂磁体712。有利地,在具有两个磁体的转移臂中,第一转移臂磁体710可以排斥接近转移臂的第一面704的样本载体的样本载体磁体,并且第二转移臂磁体712可以排斥接近转移臂的第二面706的样本载体的样本载体磁体。例如,在图2D中,由传送机轨道232输送的样本载体可以接近转移臂208的第一面,并且由传送机轨道234输送的样本载体可以接近转移臂208的第二面。
第一转移臂磁体710和第二转移臂磁体712可以通过现有技术中已知的各种手段被耦接到转移臂702。例如,转移臂磁体710、712可以利用粘合剂被耦接到表面转移臂702。在一些实施例中,转移臂磁体710和第二转移臂磁体712可以被内置在转移臂702之内。在其他实施例中,转移臂磁体710和第二转移臂磁体712可以被分别耦接到转移臂702的第一面和第二面。转移臂702的第一面可以是样本载体接触的面,而且转移臂702的第二面可以是与第一面相反的。
较佳地,在转移臂702的将面对样本载体的外表面处的极和在样本载体磁体708的外表面处的极是一样的。例如,如果第一转移臂磁体710具有面对样本载体磁体708的北极,如图7所示,那么样本载体磁体708的外表面714较佳地被磁化,以致环形磁体708的外表面714是北极并且环形磁体708的内表面716是南极。如此,当样本载体708接近转移臂702时,转移臂磁体702排斥样本载体磁体708,以致转移臂702和样本载体708之间的摩擦被减少或者避免。
在一些实施例中,转移臂702具有单个磁体,该单个磁体可以被轴向地磁化,以致第一极在转移臂702的面对环形磁体708的第一表面704处,以及第二极在转移臂702的第二表面706处。
因为通过将磁体结合到样本载体中可以防止或者避免样本载体之间的碰撞,所以可以在减少干扰样本的风险的情况下,以高轨道速度输送样本载体。在一些实施例中,将样本载体磁体和转移臂磁体结合到试样输送系统中允许试样以100mm/s到200mm/s的速度被输送,诸如130mm/s到170mm/s,例如150mm/s。
图8显示传送机输送系统中的磁阻尼的说明性的流程图。在操作802,诸如传送机轨道的传送机装置输送多个样本载体。如果第一样本载体遇到障碍物,如在804指示的,那么第二样本载体被朝向第一样本载体输送,如在操作806指示的。耦接到第一样本载体的第一样本载体磁体排斥耦接到第二样本载体的第二样本载体磁体,以使第二样本载体不与第一样本载体碰撞,如在操作808指示的。如果第一样本载体遇到转移臂,如在810指示的,那么转移臂的转移臂磁体排斥第一样本载体的第一样本载体磁体,以使第一样本载体不与转移臂碰撞,如在操作812指示的。
以上描述是说明性的而不是限制性的。一旦查看本公开,该技术的许多变化对那些本领域的技术人员来说就变得显而易见了。因此,本技术的范围应当不是参考以上描述被确定,而是应当参考未决的权利要求书连通它们的全部范围或等效物一起被确定。
在不背离该技术的范围的情况下,来自任何实施例的一个以上的特征可以与任何其他实施例的一个以上的特征相结合。
“一”、“一个”、“该”的叙述打算意指“一个以上”,除非具体地有相反的指示。
以上提及的所有的专利、专利申请、公报和描述通过引用将其全部结合在此,用于各种用途。都不认为是现有技术。

Claims (20)

1.一种试样输送系统,其特征在于,包括:
配置为输送至少一个试样容器的第一样本载体,
耦接到所述第一样本载体的第一样本载体磁体;
配置为输送至少一个试样容器的第二样本载体;
耦接到所述第二样本载体的第二样本载体磁体;和
其中,所述第一样本载体磁体被配置为排斥所述第二样本载体磁体,以致在所述第一样本载体朝向所述第二样本载体被输送时,在所述第一样本载体和所述第二样本载体之间不发生接触。
2.如权利要求1所述的试样输送系统,其特征在于,进一步包括耦接到转移臂的转移臂磁体,其中,所述转移臂磁体被配置为排斥样本载体的样本载体磁体。
3.如权利要求2所述的试样输送系统,其特征在于,所述转移臂磁体被轴向地磁化。
4.如权利要求1所述的试样输送系统,其特征在于,进一步包括转移臂,其中所述转移臂包括:
第一转移臂磁体,所述第一转移臂磁体被配置为排斥接近所述转移臂的所述第一面的样本载体的样本载体磁体,
第二转移臂磁体,所述第二转移臂磁体被配置为排斥接近所述转移臂的所述第二面的样本载体的样本载体磁体。
5.如权利要求1所述的试样输送系统,其特征在于,所述样本载体磁体是环形磁体。
6.如权利要求5所述的试样输送系统,其特征在于,所述环形磁体被径向地磁化。
7.如权利要求5所述的试样输送系统,其特征在于,所述环形磁体被耦接到所述样本载体,以致所述环形磁体的外部与所述样本载体的外表面同样高。
8.如权利要求1所述的试样输送系统,其特征在于,所述第一样本载体以150毫米每秒的速率朝向所述第二样本载体被输送。
9.一种试样输送系统,其特征在于,包括:
配置为输送试样容器的样本载体;
耦接到所述样本载体的样本载体磁体;
耦接到转移臂的转移臂磁体;以及
其中,所述转移臂磁体被配置为排斥所述样本载体磁体,以致在所述样本载体朝向所述转移臂被输送时,在所述样本载体和所述转移臂之间不发生接触。
10.如权利要求9所述的试样输送系统,其特征在于,所述转移臂磁体被轴向地磁化。
11.如权利要求9所述的试样输送系统,其特征在于,所述样本载体磁体是环形磁体。
12.如权利要求11所述的试样输送系统,其特征在于,所述环形磁体被径向地磁化。
13.如权利要求11所述的试样输送系统,其特征在于,所述环形磁体被耦接到所述样本载体,以致所述环形磁体的外部与所述样本载体的外表面同样高。
14.如权利要求9所述的试样输送系统,其特征在于,所述样本载体以150毫米每秒的速率朝向所述转移臂被输送。
15.一种用于输送试样的方法,其特征在于,所述方法包括:
通过传送装置输送多个样本载体;
通过第一样本载体的第一样本载体磁体、第二样本载体的第二样本载体磁体进行排斥,以致在所述第一样本载体朝向所述第二样本载体被输送时,在所述第一样本载体和所述第二样本载体之间不发生接触。
16.如权利要求15所述的方法,其特征在于,所述方法进一步包括:
通过转移臂的转移臂磁体、所述第一样本载体磁体进行排斥,以致在所述第一样本载体朝向所述转移臂被输送时,在所述第一样本载体和所述转移臂之间不发生接触。
17.如权利要求15所述的方法,其特征在于,所述传送装置以150毫米每秒的速率输送所述多个样本载体。
18.一种样本载体组件,其特征在于,包括:
配置为输送至少一个试样容器的样本载体;和
耦接到所述样本载体的样本载体磁体。
19.权利要求18所述的样本载体组件,其特征在于,所述磁体是环的形状,并且环绕所述样本载体。
20.权利要求18所述的样本载体组件,其特征在于,所述样本载体组件包括马达,并且可以独立移动。
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