CL2009000870A1 - Compuestos derivados de acidos p-1,3,4-oxadiazolil-2-il-fenilboronicos, inhibidores de amida hidrolasa de acido graso (faah); composicion farmaceutica, utiles para tratar una afeccion, enfermedad o trastorno doloroso, inflamatorio, inmunologico, entre otros. - Google Patents
Compuestos derivados de acidos p-1,3,4-oxadiazolil-2-il-fenilboronicos, inhibidores de amida hidrolasa de acido graso (faah); composicion farmaceutica, utiles para tratar una afeccion, enfermedad o trastorno doloroso, inflamatorio, inmunologico, entre otros.Info
- Publication number
- CL2009000870A1 CL2009000870A1 CL2009000870A CL2009000870A CL2009000870A1 CL 2009000870 A1 CL2009000870 A1 CL 2009000870A1 CL 2009000870 A CL2009000870 A CL 2009000870A CL 2009000870 A CL2009000870 A CL 2009000870A CL 2009000870 A1 CL2009000870 A1 CL 2009000870A1
- Authority
- CL
- Chile
- Prior art keywords
- disorder
- disease
- fatty acid
- acid amide
- painful
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 230000001354 painful effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101150042613 FA2H gene Proteins 0.000 title 1
- 101150008770 FAAH gene Proteins 0.000 title 1
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 title 1
- 230000001900 immune effect Effects 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940122746 Fatty acid amide hydrolase inhibitor Drugs 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 239000003940 fatty acid amidase inhibitor Substances 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 208000004371 toothache Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
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- Diabetes (AREA)
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
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- Psychology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4368608P | 2008-04-09 | 2008-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009000870A1 true CL2009000870A1 (es) | 2010-06-25 |
Family
ID=40912141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009000870A CL2009000870A1 (es) | 2008-04-09 | 2009-04-09 | Compuestos derivados de acidos p-1,3,4-oxadiazolil-2-il-fenilboronicos, inhibidores de amida hidrolasa de acido graso (faah); composicion farmaceutica, utiles para tratar una afeccion, enfermedad o trastorno doloroso, inflamatorio, inmunologico, entre otros. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8957049B2 (enExample) |
| EP (1) | EP2282742A1 (enExample) |
| JP (1) | JP5637982B2 (enExample) |
| CN (1) | CN102046179B (enExample) |
| AR (1) | AR072249A1 (enExample) |
| AU (1) | AU2009233711B2 (enExample) |
| CA (1) | CA2721060A1 (enExample) |
| CL (1) | CL2009000870A1 (enExample) |
| IL (1) | IL208536A0 (enExample) |
| PE (1) | PE20091838A1 (enExample) |
| TW (1) | TW201000107A (enExample) |
| WO (1) | WO2009126691A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| AU2009233711B2 (en) | 2008-04-09 | 2015-02-12 | Infinity Pharmaceuticals, Inc | Inhibitors of fatty acid amide hydrolase |
| WO2010118155A1 (en) * | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| WO2010118159A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| WO2010124113A1 (en) | 2009-04-23 | 2010-10-28 | Infinity Pharmaceuticals, Inc. | Anti-fatty acid amide hydrolase-2 antibodies and uses thereof |
| US8927551B2 (en) | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US9149465B2 (en) | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| CN102030770B (zh) * | 2009-09-25 | 2012-10-31 | 北京大学 | 一种芳香硼酸酯化合物的制备方法 |
| PH12012500778A1 (en) | 2009-10-30 | 2012-11-26 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| US20130150346A1 (en) | 2010-01-08 | 2013-06-13 | Quest Ventures Ltd. | Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome |
| BR112012019120A2 (pt) | 2010-02-03 | 2016-06-28 | Infinity Pharmaceuticais Inc | forma sólida, composição farmacêutica, método de preparação do composto 1, método de tratamento de uma condição mediada por faah |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| CA2789950C (en) | 2010-02-18 | 2018-09-04 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| WO2011123719A2 (en) | 2010-03-31 | 2011-10-06 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating abdominal, visceral and pelvic pain |
| CN102958933B (zh) | 2010-06-24 | 2016-02-03 | 吉里德科学公司 | 作为抗病毒药的吡唑并[1,5-a]嘧啶类 |
| KR101594002B1 (ko) | 2010-10-06 | 2016-02-15 | 글락소스미스클라인 엘엘씨 | Pi3 키나제 억제제로서의 벤즈이미다졸 유도체 |
| WO2012087833A1 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Hepatitis c inhibitors and uses thereof |
| JP2012232924A (ja) * | 2011-04-28 | 2012-11-29 | Tosoh Corp | 新規なナフチルボロン酸化合物及びその製造法 |
| JP6115962B2 (ja) | 2011-06-27 | 2017-04-19 | ヤンセン ファーマシューティカ エヌ.ベー. | 1−アリール−4−メチル−[1,2,4]トリアゾロ[4,3−a]キノキサリン誘導体 |
| CN103889987B (zh) * | 2011-07-19 | 2016-09-14 | 默沙东有限责任公司 | 作为btk抑制剂的选择的咪唑并吡嗪类 |
| JP6105594B2 (ja) | 2011-09-30 | 2017-03-29 | エンドゥ ファーマシューティカルズ,インコーポレイティド | 癌処置用cyp17阻害剤としてのイミダゾール誘導体 |
| ES2647486T3 (es) | 2011-12-22 | 2017-12-21 | Gilead Sciences, Inc. | Pirazolo[1,5-a]pirimidinas como agentes antivirales |
| EA027855B1 (ru) | 2012-04-17 | 2017-09-29 | Гайлид Сайэнсиз, Инк. | Соединения и способы для противовирусной терапии |
| WO2014001314A1 (en) | 2012-06-26 | 2014-01-03 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| AU2013289284B2 (en) | 2012-07-09 | 2017-03-30 | Janssen Pharmaceutica Nv | Inhibitors of phosphodiesterase 10 enzyme |
| MX2015006715A (es) | 2012-12-03 | 2015-08-14 | Hoffmann La Roche | Compuestos de acido triazolboronico sustituido. |
| US8987461B2 (en) | 2012-12-06 | 2015-03-24 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| US9353122B2 (en) | 2013-02-15 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9353123B2 (en) | 2013-02-20 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| KR20160099084A (ko) | 2013-11-01 | 2016-08-19 | 칼라 파마슈티컬스, 인크. | 치료 화합물의 결정질 형태 및 그의 용도 |
| EP3134418A4 (en) * | 2014-04-23 | 2018-01-03 | The Research Foundation for The State University of New York | A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith |
| US9828351B2 (en) | 2014-06-26 | 2017-11-28 | Monash University | Enzyme interacting agents |
| WO2016004166A1 (en) * | 2014-07-02 | 2016-01-07 | Xavier University Of Louisiana | Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least one phenol (or aromatic hydroxyl) group |
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-
2009
- 2009-04-08 AU AU2009233711A patent/AU2009233711B2/en not_active Ceased
- 2009-04-08 EP EP09729529A patent/EP2282742A1/en not_active Withdrawn
- 2009-04-08 PE PE2009000498A patent/PE20091838A1/es not_active Application Discontinuation
- 2009-04-08 JP JP2011504146A patent/JP5637982B2/ja not_active Expired - Fee Related
- 2009-04-08 CN CN200980119527.3A patent/CN102046179B/zh not_active Expired - Fee Related
- 2009-04-08 CA CA2721060A patent/CA2721060A1/en not_active Abandoned
- 2009-04-08 TW TW098111651A patent/TW201000107A/zh unknown
- 2009-04-08 AR ARP090101257A patent/AR072249A1/es unknown
- 2009-04-08 WO PCT/US2009/039872 patent/WO2009126691A1/en not_active Ceased
- 2009-04-09 CL CL2009000870A patent/CL2009000870A1/es unknown
-
2010
- 2010-10-07 IL IL208536A patent/IL208536A0/en unknown
- 2010-10-08 US US12/901,421 patent/US8957049B2/en not_active Expired - Fee Related
-
2015
- 2015-01-16 US US14/599,192 patent/US20150368278A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2282742A1 (en) | 2011-02-16 |
| TW201000107A (en) | 2010-01-01 |
| IL208536A0 (en) | 2010-12-30 |
| JP5637982B2 (ja) | 2014-12-10 |
| CA2721060A1 (en) | 2009-10-15 |
| PE20091838A1 (es) | 2009-12-18 |
| AU2009233711A1 (en) | 2009-10-15 |
| CN102046179B (zh) | 2015-01-14 |
| AR072249A1 (es) | 2010-08-18 |
| US20110172186A1 (en) | 2011-07-14 |
| AU2009233711B2 (en) | 2015-02-12 |
| US20150368278A1 (en) | 2015-12-24 |
| US8957049B2 (en) | 2015-02-17 |
| WO2009126691A1 (en) | 2009-10-15 |
| JP2011516564A (ja) | 2011-05-26 |
| CN102046179A (zh) | 2011-05-04 |
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