WO2008024139A3 - Inhibitors of fatty acid amide hydrolase - Google Patents

Inhibitors of fatty acid amide hydrolase Download PDF

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Publication number
WO2008024139A3
WO2008024139A3 PCT/US2007/009434 US2007009434W WO2008024139A3 WO 2008024139 A3 WO2008024139 A3 WO 2008024139A3 US 2007009434 W US2007009434 W US 2007009434W WO 2008024139 A3 WO2008024139 A3 WO 2008024139A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
inhibitors
acid amide
amide hydrolase
faah
Prior art date
Application number
PCT/US2007/009434
Other languages
French (fr)
Other versions
WO2008024139B1 (en
WO2008024139A2 (en
Inventor
David Putman
Jeff Parrott
Timothy R Compton
Olivier Dasse
Original Assignee
Organon Nv
David Putman
Jeff Parrott
Timothy R Compton
Olivier Dasse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/561,774 external-priority patent/US20070155707A1/en
Priority claimed from PCT/US2006/049485 external-priority patent/WO2007079180A2/en
Application filed by Organon Nv, David Putman, Jeff Parrott, Timothy R Compton, Olivier Dasse filed Critical Organon Nv
Publication of WO2008024139A2 publication Critical patent/WO2008024139A2/en
Publication of WO2008024139A3 publication Critical patent/WO2008024139A3/en
Publication of WO2008024139B1 publication Critical patent/WO2008024139B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity. Described herein are processes for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.
PCT/US2007/009434 2006-08-18 2007-04-17 Inhibitors of fatty acid amide hydrolase WO2008024139A2 (en)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US82287706P 2006-08-18 2006-08-18
US60/822,877 2006-08-18
US82307606P 2006-08-21 2006-08-21
US60/823,076 2006-08-21
US82488706P 2006-09-07 2006-09-07
US60/824,887 2006-09-07
US82786106P 2006-10-02 2006-10-02
US60/827,861 2006-10-02
US82875306P 2006-10-09 2006-10-09
US60/828,753 2006-10-09
US86656806P 2006-11-20 2006-11-20
US60/866,568 2006-11-20
US11/561,774 US20070155707A1 (en) 2005-12-29 2006-11-20 Ionizable inhibitors of fatty acid amide hydrolase
US11/561,774 2006-11-20
PCT/US2006/049485 WO2007079180A2 (en) 2005-12-29 2006-12-28 Inhibitors of fatty acid amide hydrolase
USPCT/US2020/06/049 2006-12-28

Publications (3)

Publication Number Publication Date
WO2008024139A2 WO2008024139A2 (en) 2008-02-28
WO2008024139A3 true WO2008024139A3 (en) 2008-10-02
WO2008024139B1 WO2008024139B1 (en) 2008-12-04

Family

ID=39110473

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009434 WO2008024139A2 (en) 2006-08-18 2007-04-17 Inhibitors of fatty acid amide hydrolase

Country Status (1)

Country Link
WO (1) WO2008024139A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY29321A1 (en) 2004-12-30 2006-03-31 Janssen Pharmaceutica Nv PIPERAZINILUREAS AND PIPERIDINILUREAS AS AMID HYDROLASSES MODULATORS OF FATTY ACIDS
MX2009004233A (en) 2006-10-18 2009-08-12 Pfizer Prod Inc Biaryl ether urea compounds.
TW200942549A (en) 2007-12-17 2009-10-16 Janssen Pharmaceutica Nv Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
US8461159B2 (en) 2008-11-25 2013-06-11 Jannsen Pharmaceutica BV Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
WO2010068452A1 (en) 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
US8901111B2 (en) 2009-06-05 2014-12-02 Janssen Pharmaceutica Nv Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase
WO2010141817A1 (en) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
UA108233C2 (en) 2010-05-03 2015-04-10 Fatty acid amide hydrolysis activity modulators
WO2013180698A1 (en) * 2012-05-30 2013-12-05 Alcon Research, Ltd. Use of faah antagonists for treating dry eye and ocular pain
US11096909B2 (en) 2016-04-06 2021-08-24 University Of Oulu Compounds for use in the treatment of cancer
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
CN110354110B (en) * 2019-06-11 2021-03-12 江南大学 Lipase inhibitor and application thereof
CN116332818B (en) * 2021-12-22 2023-12-15 王喆明 Tetrahydropyrrole derivatives and their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067517B2 (en) * 2001-12-14 2006-06-27 Nero Nordisk A/S Use of compounds for decreasing activity of hormone-sensitive lipase
US20080089845A1 (en) * 2006-09-07 2008-04-17 N.V. Organon Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067517B2 (en) * 2001-12-14 2006-06-27 Nero Nordisk A/S Use of compounds for decreasing activity of hormone-sensitive lipase
US20080089845A1 (en) * 2006-09-07 2008-04-17 N.V. Organon Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo

Also Published As

Publication number Publication date
WO2008024139B1 (en) 2008-12-04
WO2008024139A2 (en) 2008-02-28

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