MX2012006490A - Inhibidores azociclicos de hidrolasa de amidas de acidos grasos. - Google Patents

Inhibidores azociclicos de hidrolasa de amidas de acidos grasos.

Info

Publication number
MX2012006490A
MX2012006490A MX2012006490A MX2012006490A MX2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A
Authority
MX
Mexico
Prior art keywords
fatty acid
acid amide
azocyclic
inhibitors
amide hydrolase
Prior art date
Application number
MX2012006490A
Other languages
English (en)
Inventor
Robert James Pasteris
Mei H Dung
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of MX2012006490A publication Critical patent/MX2012006490A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Se describe compuestos de la Fórmula 1 que incluyen todos los estereoisómeros, N-óxidos y sales de estos, (Ver Formula) en donde: A, W, X, G, R1, R2, R3, R4, m y n son como se definen en la descripción. Además, se describe composiciones farmacéuticas que contienen los compuestos de la Fórmula 1 y métodos para tratar una enfermedad o afección mediada por la actividad de la hidrolasa de amidas de ácidos grasos; los métodos comprenden aplicar una cantidad con eficacia terapéutica de un compuesto o una composición de la invención.
MX2012006490A 2009-12-11 2010-12-10 Inhibidores azociclicos de hidrolasa de amidas de acidos grasos. MX2012006490A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28560009P 2009-12-11 2009-12-11
PCT/US2010/059850 WO2011072207A1 (en) 2009-12-11 2010-12-10 Azocyclic inhibitors of fatty acid amide hydrolase

Publications (1)

Publication Number Publication Date
MX2012006490A true MX2012006490A (es) 2012-07-03

Family

ID=43478289

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012006490A MX2012006490A (es) 2009-12-11 2010-12-10 Inhibidores azociclicos de hidrolasa de amidas de acidos grasos.

Country Status (12)

Country Link
US (1) US20130045948A1 (es)
EP (1) EP2509978A1 (es)
JP (1) JP2013513615A (es)
KR (1) KR20120093425A (es)
CN (1) CN102652135A (es)
AU (1) AU2010328049A1 (es)
BR (1) BR112012013801A2 (es)
CA (1) CA2780905A1 (es)
IL (1) IL219659A0 (es)
MX (1) MX2012006490A (es)
WO (1) WO2011072207A1 (es)
ZA (1) ZA201203371B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759527B2 (en) * 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
MX352307B (es) * 2011-02-01 2017-11-17 Bayer Ip Gmbh Derivados de heteroarilpiperidina y -piperazina como fungicidas.
BR112014016101B1 (pt) 2011-12-27 2020-03-10 Bayer Intellectual Property Gmbh Compostos derivados da heteroarilpiperidina e heteroarilpiperazina, método e composição para controlar microorganismos indesejados, suas utilizações e semente tratada
CN105473585B (zh) * 2013-06-24 2018-04-13 拜耳作物科学股份公司 作为杀真菌剂的哌啶羧酸衍生物
US20170137417A1 (en) 2014-03-24 2017-05-18 Bayer Cropscience Aktiengesellschaft Phenylpiperidinecarboxamide derivatives as fungicides
DK3148993T3 (da) * 2014-05-28 2019-05-20 Bayer Cropscience Ag Fremgangsmåde til fremstilling af thiazolderivater
MX2016016398A (es) 2014-06-11 2017-04-06 Bayer Cropscience Ag Preparacion de piperidin-4-carbotioamida.
ES2749900T3 (es) 2015-03-05 2020-03-24 Bayer Cropscience Ag Procedimiento de preparación de derivados de fenilisoxazolina sustituidos
MX2017011391A (es) 2015-03-05 2018-01-15 Bayer Cropscience Ag Procedimiento para la preparacion de clorhidrato de piperidina-4-carbotioamida.
AU2016261325A1 (en) * 2015-05-08 2017-11-16 Vertellus Holdings Llc Processes for converting carboxamides to thiocarboxamides
CN107602550B (zh) * 2017-10-25 2018-10-23 磐安县宸熙工艺品有限公司 一种脂肪酰胺水解酶抑制剂及其制备方法
CN110804048A (zh) * 2019-11-08 2020-02-18 暨南大学 恶唑酮类化合物及其应用、faah的正电子药物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557089A (en) 1968-12-27 1971-01-19 Du Pont Preparation of l-(carbamoyl)-n-(carbamoyloxy) thioformimidates from acetoacetamides
GB9416364D0 (en) 1994-08-12 1994-10-05 Fine Organics Ltd Preparation of thioamides
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2007005510A1 (en) * 2005-06-30 2007-01-11 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
CA2665804A1 (en) * 2006-08-23 2008-02-28 Astellas Pharma Inc. Urea compound or salt thereof
EP2402332A3 (en) * 2008-01-25 2014-10-29 E.I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds

Also Published As

Publication number Publication date
ZA201203371B (en) 2013-08-28
KR20120093425A (ko) 2012-08-22
BR112012013801A2 (pt) 2019-09-24
AU2010328049A1 (en) 2012-05-31
US20130045948A1 (en) 2013-02-21
EP2509978A1 (en) 2012-10-17
CA2780905A1 (en) 2011-06-16
IL219659A0 (en) 2012-07-31
WO2011072207A1 (en) 2011-06-16
JP2013513615A (ja) 2013-04-22
CN102652135A (zh) 2012-08-29

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