CA2889044A1 - Anti apob antisense conjugate compounds - Google Patents

Anti apob antisense conjugate compounds Download PDF

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Publication number
CA2889044A1
CA2889044A1 CA2889044A CA2889044A CA2889044A1 CA 2889044 A1 CA2889044 A1 CA 2889044A1 CA 2889044 A CA2889044 A CA 2889044A CA 2889044 A CA2889044 A CA 2889044A CA 2889044 A1 CA2889044 A1 CA 2889044A1
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CA
Canada
Prior art keywords
region
conjugate
group
oligomer
lna
Prior art date
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Abandoned
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CA2889044A
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English (en)
French (fr)
Inventor
Nanna ALBÆK
Henrik Frydenlund Hansen
Susanne KAMMLER
Jacob Ravn
Henrik Orum
Mark Turner
Marie Lindholm
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Roche Innovation Center Copenhagen AS
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Roche Innovation Center Copenhagen AS
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Application filed by Roche Innovation Center Copenhagen AS filed Critical Roche Innovation Center Copenhagen AS
Publication of CA2889044A1 publication Critical patent/CA2889044A1/en
Abandoned legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P35/00—Antineoplastic agents
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/3517—Marker; Tag
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CA2889044A 2012-11-15 2013-11-14 Anti apob antisense conjugate compounds Abandoned CA2889044A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP12192773 2012-11-15
EP12192773.5 2012-11-15
EP13153296 2013-01-30
EP13153296.2 2013-01-30
EP13157237 2013-02-28
EP13157237.2 2013-02-28
EP13174092.0 2013-06-27
EP13174092 2013-06-27
PCT/EP2013/073859 WO2014076196A1 (en) 2012-11-15 2013-11-14 Anti apob antisense conjugate compounds

Publications (1)

Publication Number Publication Date
CA2889044A1 true CA2889044A1 (en) 2014-05-22

Family

ID=49584733

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2889044A Abandoned CA2889044A1 (en) 2012-11-15 2013-11-14 Anti apob antisense conjugate compounds
CA2889596A Active CA2889596C (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2889596A Active CA2889596C (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates

Country Status (22)

Country Link
US (4) US20150291958A1 (OSRAM)
EP (3) EP2920307B1 (OSRAM)
JP (3) JP2016503300A (OSRAM)
KR (2) KR20150083920A (OSRAM)
CN (3) CN104884618A (OSRAM)
AU (2) AU2013346767B2 (OSRAM)
BR (2) BR112015010116A2 (OSRAM)
CA (2) CA2889044A1 (OSRAM)
DK (2) DK2920304T3 (OSRAM)
ES (1) ES2724853T3 (OSRAM)
HK (2) HK1214297A1 (OSRAM)
HR (1) HRP20190826T1 (OSRAM)
IL (2) IL238448B (OSRAM)
MX (2) MX363068B (OSRAM)
MY (1) MY173826A (OSRAM)
NZ (1) NZ708171A (OSRAM)
PL (1) PL2920304T3 (OSRAM)
RU (3) RU2015119411A (OSRAM)
SG (2) SG10201804331TA (OSRAM)
SI (1) SI2920304T1 (OSRAM)
WO (2) WO2014076196A1 (OSRAM)
ZA (1) ZA201503375B (OSRAM)

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