BRPI1015135B1 - Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos - Google Patents

Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos Download PDF

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BRPI1015135B1
BRPI1015135B1 BRPI1015135-4A BRPI1015135A BRPI1015135B1 BR PI1015135 B1 BRPI1015135 B1 BR PI1015135B1 BR PI1015135 A BRPI1015135 A BR PI1015135A BR PI1015135 B1 BRPI1015135 B1 BR PI1015135B1
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pyrimidin
methyl
thiazolo
ethyl
purin
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BRPI1015135-4A
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English (en)
Portuguese (pt)
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Yun-Long Li
Brian W. Metcalf
Andrew P. Combs
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Incyte Holdings Corporation
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Application filed by Incyte Holdings Corporation filed Critical Incyte Holdings Corporation
Publication of BRPI1015135A2 publication Critical patent/BRPI1015135A2/pt
Publication of BRPI1015135B1 publication Critical patent/BRPI1015135B1/pt

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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI1015135-4A 2009-06-29 2010-06-28 Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos BRPI1015135B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22116009P 2009-06-29 2009-06-29
US61/221,160 2009-06-29
US25976509P 2009-11-10 2009-11-10
US61/259,765 2009-11-10
PCT/US2010/040150 WO2011008487A1 (en) 2009-06-29 2010-06-28 Pyrimidinones as pi3k inhibitors

Publications (2)

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BRPI1015135A2 BRPI1015135A2 (pt) 2019-07-09
BRPI1015135B1 true BRPI1015135B1 (pt) 2021-08-03

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BRPI1015135-4A BRPI1015135B1 (pt) 2009-06-29 2010-06-28 Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos

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US (6) US8940752B2 (cg-RX-API-DMAC10.html)
EP (2) EP2448938B9 (cg-RX-API-DMAC10.html)
JP (2) JP5677425B2 (cg-RX-API-DMAC10.html)
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AR (1) AR077280A1 (cg-RX-API-DMAC10.html)
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BR (1) BRPI1015135B1 (cg-RX-API-DMAC10.html)
CA (1) CA2766100C (cg-RX-API-DMAC10.html)
CL (1) CL2011003346A1 (cg-RX-API-DMAC10.html)
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WO2015192761A1 (zh) * 2014-06-17 2015-12-23 辰欣药业股份有限公司 作为mTOR/PI3K抑制剂的吡啶并[1,2-a]嘧啶酮类似物
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