BRPI0213207B1 - Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação - Google Patents

Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação Download PDF

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Publication number
BRPI0213207B1
BRPI0213207B1 BRPI0213207-9A BR0213207A BRPI0213207B1 BR PI0213207 B1 BRPI0213207 B1 BR PI0213207B1 BR 0213207 A BR0213207 A BR 0213207A BR PI0213207 B1 BRPI0213207 B1 BR PI0213207B1
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Brazil
Prior art keywords
peptide
glycosyl
contacting
element selected
process according
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BRPI0213207-9A
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English (en)
Portuguese (pt)
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BR0213207A (pt
Inventor
Shawn De Frees
David Hakes
Xi Chen
Caryn Bowe
Robert Bayer
David Zopf
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Novo Nordisk A/S
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Publication of BR0213207A publication Critical patent/BR0213207A/pt
Publication of BRPI0213207B1 publication Critical patent/BRPI0213207B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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BRPI0213207-9A 2001-10-10 2002-10-09 Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação BRPI0213207B1 (pt)

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US32852301P 2001-10-10 2001-10-10
US60/328,523 2001-10-10
US34469201P 2001-10-19 2001-10-19
US60/344,692 2001-10-19
US33423301P 2001-11-28 2001-11-28
US33430101P 2001-11-28 2001-11-28
US38729202P 2002-06-07 2002-06-07
US60/387,292 2002-06-07
US39177702P 2002-06-25 2002-06-25
US39659402P 2002-07-17 2002-07-17
US60/396,594 2002-07-17
US40424902P 2002-08-16 2002-08-16
US60/404,249 2002-08-16
US40752702P 2002-08-28 2002-08-28
PCT/US2002/032263 WO2003031464A2 (en) 2001-10-10 2002-10-09 Remodeling and glycoconjugation of peptides

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