BR112022012230A2 - Variantes de progranulina - Google Patents

Variantes de progranulina

Info

Publication number
BR112022012230A2
BR112022012230A2 BR112022012230A BR112022012230A BR112022012230A2 BR 112022012230 A2 BR112022012230 A2 BR 112022012230A2 BR 112022012230 A BR112022012230 A BR 112022012230A BR 112022012230 A BR112022012230 A BR 112022012230A BR 112022012230 A2 BR112022012230 A2 BR 112022012230A2
Authority
BR
Brazil
Prior art keywords
progranulin
variants
proteins
ftd
polypeptide
Prior art date
Application number
BR112022012230A
Other languages
English (en)
Inventor
Maxwell Cherf Gerald
Kannan Gunasekaran
W Lexa Katrina
L Y Low Ray
Prorok Rachel
Srivastava Ankita
Original Assignee
Denali Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Priority claimed from PCT/US2020/066831 external-priority patent/WO2021133907A1/en
Publication of BR112022012230A2 publication Critical patent/BR112022012230A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

VARIANTES DE PROGRANULINA. A presente invenção refere-se a variantes de progranulina e proteínas de fusão que compreendem uma variante de progranulina e um polipeptídeo Fc. Métodos de uso de tais proteínas para tratar distúrbios associados à progranulina (por exemplo, uma doença neurodegenerativa, como demência frontotemporal (FTD)) também são fornecidos neste documento.
BR112022012230A 2019-12-23 2020-12-23 Variantes de progranulina BR112022012230A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962953099P 2019-12-23 2019-12-23
US202063091819P 2020-10-14 2020-10-14
PCT/US2020/066831 WO2021133907A1 (en) 2019-12-23 2020-12-23 Progranulin variants

Publications (1)

Publication Number Publication Date
BR112022012230A2 true BR112022012230A2 (pt) 2022-08-30

Family

ID=76437806

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012230A BR112022012230A2 (pt) 2019-12-23 2020-12-23 Variantes de progranulina

Country Status (12)

Country Link
US (4) US20210188925A1 (pt)
EP (1) EP4081536A1 (pt)
JP (1) JP2023507846A (pt)
KR (1) KR20220130678A (pt)
CN (1) CN114981297A (pt)
AU (1) AU2020411480B2 (pt)
BR (1) BR112022012230A2 (pt)
CA (1) CA3165846A1 (pt)
CO (1) CO2022008648A2 (pt)
IL (1) IL293994A (pt)
MX (1) MX2022007486A (pt)
PE (1) PE20230036A1 (pt)

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Also Published As

Publication number Publication date
MX2022007486A (es) 2022-06-29
AU2020411480A1 (en) 2022-06-30
CA3165846A1 (en) 2021-07-01
US11643446B2 (en) 2023-05-09
PE20230036A1 (es) 2023-01-10
IL293994A (en) 2022-08-01
US20230265137A1 (en) 2023-08-24
CN114981297A (zh) 2022-08-30
JP2023507846A (ja) 2023-02-27
US20220220172A1 (en) 2022-07-14
EP4081536A1 (en) 2022-11-02
KR20220130678A (ko) 2022-09-27
CO2022008648A2 (es) 2022-06-30
AU2020411480B2 (en) 2023-12-21
US20210188925A1 (en) 2021-06-24
US20220213155A1 (en) 2022-07-07

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