AR110586A1 - Anticuerpo de receptor antitransferrina humana que penetra la barrera hematoencefálica - Google Patents

Anticuerpo de receptor antitransferrina humana que penetra la barrera hematoencefálica

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Publication number
AR110586A1
AR110586A1 ARP170103680A ARP170103680A AR110586A1 AR 110586 A1 AR110586 A1 AR 110586A1 AR P170103680 A ARP170103680 A AR P170103680A AR P170103680 A ARP170103680 A AR P170103680A AR 110586 A1 AR110586 A1 AR 110586A1
Authority
AR
Argentina
Prior art keywords
seq
receptor antibody
amino acid
acid sequence
set forth
Prior art date
Application number
ARP170103680A
Other languages
English (en)
Original Assignee
Japan Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Chem Res filed Critical Japan Chem Res
Publication of AR110586A1 publication Critical patent/AR110586A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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Abstract

Se proporciona un medio para convertir compuestos que tienen actividad fisiológica o farmacológica, ya que son incapaces de pasar a través de la barrera hematoencefálica, en una forma en la cual pueden pasar a través de la barrera hematoencefálica, y compuestos convertidos por dicho método. Un anticuerpo de receptor antitransferrina humana, donde en la región variable de cadena pesada del anticuerpo, (a) CDR1 comprende la secuencia de aminoácidos expuesta como SEQ ID Nº 62 o SEQ ID Nº 63, (b) CDR2 comprende la secuencia de aminoácidos expuesta como SEQ ID Nº 13 o SEQ ID Nº 14, y (c) CDR3 comprende la secuencia de aminoácidos expuesta como SEQ ID Nº 15 o SEQ ID Nº 16, y uno de sus análogos. Fragmento de ADN, vector, célula transformada.
ARP170103680A 2016-12-26 2017-12-26 Anticuerpo de receptor antitransferrina humana que penetra la barrera hematoencefálica AR110586A1 (es)

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