BR112019009316A2 - anticorpo antirreceptor de transferrina humana, proteína de fusão, fragmento de dna, vetor de expressão, célula de mamífero, complexo de composto farmacologicamente ativo e de anticorpo antirreceptor de transferrina humana, usos do anticorpo antirreceptor de transferrina humana e da proteína de fusão, e, métodos para tratamento de um distúrbio do sistema nervoso central e de uma doença do sistema nervoso central que acompanha a doença de pompe, a síndrome de hurler ou a síndrome de hurler-scheie. - Google Patents
anticorpo antirreceptor de transferrina humana, proteína de fusão, fragmento de dna, vetor de expressão, célula de mamífero, complexo de composto farmacologicamente ativo e de anticorpo antirreceptor de transferrina humana, usos do anticorpo antirreceptor de transferrina humana e da proteína de fusão, e, métodos para tratamento de um distúrbio do sistema nervoso central e de uma doença do sistema nervoso central que acompanha a doença de pompe, a síndrome de hurler ou a síndrome de hurler-scheie.Info
- Publication number
- BR112019009316A2 BR112019009316A2 BR112019009316A BR112019009316A BR112019009316A2 BR 112019009316 A2 BR112019009316 A2 BR 112019009316A2 BR 112019009316 A BR112019009316 A BR 112019009316A BR 112019009316 A BR112019009316 A BR 112019009316A BR 112019009316 A2 BR112019009316 A2 BR 112019009316A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antibody
- human transferrin
- fusion protein
- nervous system
- central nervous
- Prior art date
Links
- 101000766306 Homo sapiens Serotransferrin Proteins 0.000 title abstract 4
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 title abstract 4
- 206010056886 Mucopolysaccharidosis I Diseases 0.000 title 2
- 208000012902 Nervous system disease Diseases 0.000 title 2
- 208000015114 central nervous system disease Diseases 0.000 title 2
- 108020001507 fusion proteins Proteins 0.000 title 2
- 102000037865 fusion proteins Human genes 0.000 title 2
- 208000032007 Glycogen storage disease due to acid maltase deficiency Diseases 0.000 title 1
- 206010053185 Glycogen storage disease type II Diseases 0.000 title 1
- 208000015178 Hurler syndrome Diseases 0.000 title 1
- 208000015204 Hurler-Scheie syndrome Diseases 0.000 title 1
- 102100033448 Lysosomal alpha-glucosidase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 201000004502 glycogen storage disease II Diseases 0.000 title 1
- 210000004962 mammalian cell Anatomy 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
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- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
Abstract
a presente invenção provê um anticorpo antirreceptor de transferrina humana ou um análogo do mesmo, em que, na região variável de cadeia pesada do anticorpo, (a) cdr1 compreende a sequência de aminoácidos apresentada como seq id no: 62 ou seq id no: 63, (b) cdr2 compreende a sequência de aminoácidos apresentada como seq id no: 13 ou seq id no: 14, e (c) cdr3 compreende a sequência de aminoácidos apresentada como seq id no: 15 ou seq id no: 16.
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JP2016252148 | 2016-12-26 | ||
PCT/JP2017/046762 WO2018124121A1 (ja) | 2016-12-26 | 2017-12-26 | 血液脳関門を通過する新規な抗ヒトトランスフェリン受容体抗体 |
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