MX2023008245A - Molécula de ácido nucleico que contiene un gen incorporado que codifica una proteína fusionada de ligando y proteína que tiene actividad fisiológica. - Google Patents

Molécula de ácido nucleico que contiene un gen incorporado que codifica una proteína fusionada de ligando y proteína que tiene actividad fisiológica.

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Publication number
MX2023008245A
MX2023008245A MX2023008245A MX2023008245A MX2023008245A MX 2023008245 A MX2023008245 A MX 2023008245A MX 2023008245 A MX2023008245 A MX 2023008245A MX 2023008245 A MX2023008245 A MX 2023008245A MX 2023008245 A MX2023008245 A MX 2023008245A
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Mexico
Prior art keywords
protein
nucleic acid
acid molecule
gene encoding
ligand
Prior art date
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MX2023008245A
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English (en)
Inventor
Hiroyuki Sonoda
Masafumi Kinoshita
Shunsuke Iizuka
Atsushi Imakiire
Haruna Takagi
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Japan Chem Res
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Publication date
Application filed by Japan Chem Res filed Critical Japan Chem Res
Publication of MX2023008245A publication Critical patent/MX2023008245A/es

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Abstract

La invención provee una molécula de ácido nucleico que comprende un gen que codifica una proteína de fusión de un ligando y una proteína que tiene actividad fisiológica, para utilizarse para expresar la proteína de fusión en células, tejido o el organismo. La invención además provee una molécula de ácido nucleico que comprende el gen que codifica la proteína de fusión, que se encuentra en forma de un plásmido, en una forma encapsulada en un virión de virus recombinante, o en una forma encapsulada en liposomas o nanopartículas lipídicas. La invención se refiere además al uso de un medicamento, el cual es una molécula de ácido nucleico que comprende el gen que codifica la proteína de fusión.
MX2023008245A 2021-01-12 2022-01-11 Molécula de ácido nucleico que contiene un gen incorporado que codifica una proteína fusionada de ligando y proteína que tiene actividad fisiológica. MX2023008245A (es)

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US8053569B2 (en) 2005-10-07 2011-11-08 Armagen Technologies, Inc. Nucleic acids encoding and methods of producing fusion proteins
EP2182980A4 (en) 2007-07-27 2012-04-18 Armagen Technologies Inc METHOD AND COMPOSITIONS FOR INCREASED ALPHA IDURONIDASE ACTIVITY IN THE CNS
EP3533467B1 (en) 2009-10-09 2023-07-26 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
CA2990785A1 (en) 2015-06-24 2016-12-29 Jcr Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody permeating blood-brain barrier
AU2017385288B9 (en) 2016-12-26 2022-01-13 Jcr Pharmaceuticals Co., Ltd. Novel anti-human transferrin receptor antibody capable of penetrating blood-brain barrier
JP2021513355A (ja) * 2018-02-14 2021-05-27 ジェネレーション バイオ カンパニー 非ウイルス性ｄｎａベクター、ならびに抗体および融合タンパク質の産生のためのその使用
US20210261645A1 (en) * 2018-05-23 2021-08-26 Manysmart Therapeutics, Inc. Bispecific t cell engager and uses thereof
EP4019958A4 (en) 2019-08-23 2023-08-02 JCR Pharmaceuticals Co., Ltd. METHOD FOR QUANTIFYING HEX4, LYSO-GM1, FUC-GLCNAC-ASN, AND LYSO-SULFATAIDE INCLUDED IN CEREPO-SPINAL FLUID

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JP2022108271A (ja) 2022-07-25
AU2022207244A1 (en) 2023-08-24
KR20230131223A (ko) 2023-09-12
CN116981774A (zh) 2023-10-31
IL304409A (en) 2023-09-01
EP4265715A1 (en) 2023-10-25
WO2022153957A1 (ja) 2022-07-21
CA3208107A1 (en) 2022-07-21
US20240066149A1 (en) 2024-02-29
TW202242103A (zh) 2022-11-01
BR112023013864A2 (pt) 2023-10-03

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