PE20230036A1 - Variantes de progranulina - Google Patents
Variantes de progranulinaInfo
- Publication number
- PE20230036A1 PE20230036A1 PE2022001166A PE2022001166A PE20230036A1 PE 20230036 A1 PE20230036 A1 PE 20230036A1 PE 2022001166 A PE2022001166 A PE 2022001166A PE 2022001166 A PE2022001166 A PE 2022001166A PE 20230036 A1 PE20230036 A1 PE 20230036A1
- Authority
- PE
- Peru
- Prior art keywords
- progranulin
- variants
- proteins
- ftd
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Se proporcionan en la presente variantes de progranulina y proteinas de fusion que comprenden una variante de progranulina y un polipeptido Fc. Tambien se proporcionan en la presente metodos para el uso de dichas proteinas para el tratamiento de trastornos asociados con la progranulina (por ejemplo, una enfermedad neurodegenerativa, tal como demencia frontotemporal (FTD))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962953099P | 2019-12-23 | 2019-12-23 | |
US202063091819P | 2020-10-14 | 2020-10-14 | |
PCT/US2020/066831 WO2021133907A1 (en) | 2019-12-23 | 2020-12-23 | Progranulin variants |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20230036A1 true PE20230036A1 (es) | 2023-01-10 |
Family
ID=76437806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022001166A PE20230036A1 (es) | 2019-12-23 | 2020-12-23 | Variantes de progranulina |
Country Status (12)
Country | Link |
---|---|
US (4) | US20210188925A1 (es) |
EP (1) | EP4081536A1 (es) |
JP (1) | JP2023507846A (es) |
KR (1) | KR20220130678A (es) |
CN (1) | CN114981297A (es) |
AU (1) | AU2020411480B2 (es) |
BR (1) | BR112022012230A2 (es) |
CA (1) | CA3165846A1 (es) |
CO (1) | CO2022008648A2 (es) |
IL (1) | IL293994A (es) |
MX (1) | MX2022007486A (es) |
PE (1) | PE20230036A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ756763A (en) | 2017-02-17 | 2023-04-28 | Denali Therapeutics Inc | Engineered transferrin receptor binding polypeptides |
SG11202002730XA (en) | 2017-10-02 | 2020-04-29 | Denali Therapeutics Inc | Fusion proteins comprising enzyme replacement therapy enzymes |
IL293994A (en) | 2019-12-23 | 2022-08-01 | Denali Therapeutics Inc | Variants of progranulin, preparations containing them and their uses |
CR20230178A (es) | 2020-10-14 | 2023-07-26 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas sulfoglucosamina sulfohidrolasa y métodos de estas |
CN116121306A (zh) * | 2023-03-27 | 2023-05-16 | 迦进生物医药(上海)有限公司 | 一种human TfR1高表达的稳转细胞株及其构建方法和应用 |
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US6743893B2 (en) | 2000-11-30 | 2004-06-01 | The Uab Research Foundation | Receptor-mediated uptake of peptides that bind the human transferrin receptor |
PT2279753E (pt) | 2001-10-10 | 2016-01-15 | Novo Nordisk As | Remodelação e glicoconjugação de péptidos |
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DE102007033359B4 (de) | 2007-07-16 | 2010-12-02 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Verwendung eines Granulins oder einer Granulin-ähnlichen Verbindung zur Therapie oder Prophylaxe von chronischen Schmerzen |
EP2249861B1 (en) | 2008-01-16 | 2016-07-06 | Neurodyn Life Sciences Inc. | Progranulin for use in treating parkinson's disease or alzheimer's disease |
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CA2758542A1 (en) | 2009-04-17 | 2010-10-21 | New York University | Peptides targeting tnf family receptors and antagonizing tnf action, compositions, methods and uses thereof |
US20150352185A1 (en) | 2010-11-16 | 2015-12-10 | Denis G. Kay | Method for increasing neprilysin expression and activity |
CN110251668A (zh) | 2010-11-30 | 2019-09-20 | 霍夫曼-拉罗奇有限公司 | 低亲和力血脑屏障受体抗体及其用途 |
RU2013140685A (ru) | 2011-02-04 | 2015-03-10 | Дженентек, Инк. | ВАРИАНТЫ Fc, СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
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EP3539982A3 (en) | 2011-12-23 | 2020-01-15 | Pfizer Inc | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
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AU2013352812B2 (en) | 2012-11-27 | 2019-06-20 | Ajou University Industry-Academic Cooperation Foundation | CH3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof |
BR112015012014A2 (pt) | 2012-12-04 | 2017-07-11 | Abbvie Inc | proteínas de ligação específicas duais penetrando a barreira hematoencefálica (bbb) |
CA3166758A1 (en) | 2013-05-14 | 2014-11-20 | California Institute Of Technology | Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier |
PL3594240T3 (pl) | 2013-05-20 | 2024-04-02 | F. Hoffmann-La Roche Ag | Przeciwciała przeciwko receptorowi transferyny i sposoby ich zastosowania |
SG10201800982QA (en) | 2013-07-05 | 2018-03-28 | Genmab As | Humanized or chimeric cd3 antibodies |
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NZ756763A (en) | 2017-02-17 | 2023-04-28 | Denali Therapeutics Inc | Engineered transferrin receptor binding polypeptides |
CN110520440A (zh) | 2017-02-17 | 2019-11-29 | 戴纳立制药公司 | 抗τ抗体及其使用方法 |
CN111148757A (zh) | 2017-08-10 | 2020-05-12 | 戴纳立制药公司 | 工程改造的转铁蛋白受体结合多肽 |
SG11202002730XA (en) | 2017-10-02 | 2020-04-29 | Denali Therapeutics Inc | Fusion proteins comprising enzyme replacement therapy enzymes |
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BR112020025306A2 (pt) | 2018-06-18 | 2021-03-09 | Denali Therapeutics Inc. | Proteínas de fusão compreendendo progranulina |
JP7397063B2 (ja) | 2018-08-16 | 2023-12-12 | デナリ セラピューティクス インコーポレイテッド | 操作された二重特異性タンパク質 |
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IL293994A (en) | 2019-12-23 | 2022-08-01 | Denali Therapeutics Inc | Variants of progranulin, preparations containing them and their uses |
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US20230092681A1 (en) | 2020-02-07 | 2023-03-23 | Denali Therapeutics Inc. | Methods for the treatment of hunter syndrome |
CR20230178A (es) | 2020-10-14 | 2023-07-26 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas sulfoglucosamina sulfohidrolasa y métodos de estas |
AU2021362487A1 (en) | 2020-10-14 | 2023-06-08 | Denali Therapeutics Inc. | Methods for treating and monitoring frontotemporal dementia |
-
2020
- 2020-12-23 IL IL293994A patent/IL293994A/en unknown
- 2020-12-23 CN CN202080089731.1A patent/CN114981297A/zh active Pending
- 2020-12-23 KR KR1020227022284A patent/KR20220130678A/ko unknown
- 2020-12-23 JP JP2022538728A patent/JP2023507846A/ja active Pending
- 2020-12-23 AU AU2020411480A patent/AU2020411480B2/en active Active
- 2020-12-23 CA CA3165846A patent/CA3165846A1/en active Pending
- 2020-12-23 EP EP20842153.7A patent/EP4081536A1/en active Pending
- 2020-12-23 BR BR112022012230A patent/BR112022012230A2/pt unknown
- 2020-12-23 PE PE2022001166A patent/PE20230036A1/es unknown
- 2020-12-23 MX MX2022007486A patent/MX2022007486A/es unknown
-
2021
- 2021-01-26 US US17/159,038 patent/US20210188925A1/en not_active Abandoned
-
2022
- 2022-03-17 US US17/697,771 patent/US11643446B2/en active Active
- 2022-03-18 US US17/698,456 patent/US20220220172A1/en not_active Abandoned
- 2022-06-21 CO CONC2022/0008648A patent/CO2022008648A2/es unknown
-
2023
- 2023-03-24 US US18/189,413 patent/US20230265137A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CO2022008648A2 (es) | 2022-06-30 |
IL293994A (en) | 2022-08-01 |
JP2023507846A (ja) | 2023-02-27 |
CN114981297A (zh) | 2022-08-30 |
MX2022007486A (es) | 2022-06-29 |
EP4081536A1 (en) | 2022-11-02 |
AU2020411480B2 (en) | 2023-12-21 |
US20230265137A1 (en) | 2023-08-24 |
US20220213155A1 (en) | 2022-07-07 |
US11643446B2 (en) | 2023-05-09 |
BR112022012230A2 (pt) | 2022-08-30 |
AU2020411480A1 (en) | 2022-06-30 |
US20220220172A1 (en) | 2022-07-14 |
US20210188925A1 (en) | 2021-06-24 |
CA3165846A1 (en) | 2021-07-01 |
KR20220130678A (ko) | 2022-09-27 |
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