BR0313059A - Método para tratar ou prevenir uma doença auto-imune e/ou um ou mais sintomas associados com a mesma - Google Patents

Método para tratar ou prevenir uma doença auto-imune e/ou um ou mais sintomas associados com a mesma

Info

Publication number
BR0313059A
BR0313059A BR0313059-2A BR0313059A BR0313059A BR 0313059 A BR0313059 A BR 0313059A BR 0313059 A BR0313059 A BR 0313059A BR 0313059 A BR0313059 A BR 0313059A
Authority
BR
Brazil
Prior art keywords
treating
preventing
symptoms associated
autoimmune disease
symptoms
Prior art date
Application number
BR0313059-2A
Other languages
English (en)
Other versions
BR0313059B8 (pt
BRPI0313059B1 (pt
Inventor
Rajinder Singh
Ankush Argade
Donald G Payan
Jeffrey Clough
Holger Keim
Catherine Sylvain
Somasekhar Bhamidipati
Hui Li
Original Assignee
Rigel Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31721742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0313059(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rigel Pharmaceuticals filed Critical Rigel Pharmaceuticals
Publication of BR0313059A publication Critical patent/BR0313059A/pt
Publication of BRPI0313059B1 publication Critical patent/BRPI0313059B1/pt
Publication of BR0313059B8 publication Critical patent/BR0313059B8/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)

Abstract

"MéTODO PARA TRATAR OU PREVENIR UMA DOENçA AUTO-IMUNE E/OU UM OU MAIS SINTOMAS ASSOCIADOS COM A MESMA". A presente invenção promove métodos para tratar ou prevenir doenças auto-imunes com compostos de 2,4-diamino-pirimidina, assim como também, métodos para tratar, prevenir ou aliviar sintomas associados com tais doenças. Exemplos específicos das doenças auto-imunes que podem ser tratados ou prevenidos com os compostos que incluem artrite reumatóide e/ou seus sintomas associados, lupus eritematoso sistêmico e/ou seus sintomas associados e a esclerose múltipla e/ou seus sintomas associados.
BRPI0313059A 2002-07-29 2003-07-29 composto, e, composição farmacêutica BR0313059B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39967302P 2002-07-29 2002-07-29
US44394903P 2003-01-31 2003-01-31
US45233903P 2003-03-06 2003-03-06
US10/631,029 US7517886B2 (en) 2002-07-29 2003-07-29 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
PCT/US2003/024087 WO2004014382A1 (en) 2002-07-29 2003-07-29 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds

Publications (3)

Publication Number Publication Date
BR0313059A true BR0313059A (pt) 2005-07-05
BRPI0313059B1 BRPI0313059B1 (pt) 2018-05-08
BR0313059B8 BR0313059B8 (pt) 2021-07-27

Family

ID=31721742

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0313059A BR0313059B8 (pt) 2002-07-29 2003-07-29 composto, e, composição farmacêutica

Country Status (25)

Country Link
US (5) US7517886B2 (pt)
EP (1) EP1534286B1 (pt)
JP (2) JP2006514989A (pt)
CN (2) CN103169708B (pt)
AT (1) ATE451104T1 (pt)
AU (1) AU2003265336B8 (pt)
BR (1) BR0313059B8 (pt)
CA (1) CA2492325C (pt)
CY (1) CY1110292T1 (pt)
DE (1) DE60330466D1 (pt)
DK (1) DK1534286T3 (pt)
ES (2) ES2337782T3 (pt)
HK (2) HK1079978A1 (pt)
HR (1) HRP20050089B1 (pt)
IL (3) IL166241A0 (pt)
IS (1) IS2923B (pt)
MX (1) MXPA05001096A (pt)
NO (1) NO332550B1 (pt)
NZ (1) NZ537752A (pt)
PL (1) PL216744B1 (pt)
RS (1) RS51752B (pt)
RU (1) RU2659777C9 (pt)
SE (1) SE0500203L (pt)
SG (1) SG176311A1 (pt)
WO (1) WO2004014382A1 (pt)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
ATE451104T1 (de) 2002-07-29 2009-12-15 Rigel Pharmaceuticals Inc Verfahren zur behandlung oder pruvention von autoimmunkrankheiten mit 2,4-pyrimidindiamin- verbindungen
EA200500721A1 (ru) * 2002-11-28 2005-12-29 Шеринг Акциенгезельшафт Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств
UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
CL2004000306A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa.
PL1656372T3 (pl) * 2003-07-30 2013-08-30 Rigel Pharmaceuticals Inc Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym
JP2007500179A (ja) * 2003-07-30 2007-01-11 サイクラセル・リミテッド キナーゼ阻害剤としての２−アミノフェニル−４−フェニルピリミジン
US20050113398A1 (en) * 2003-08-07 2005-05-26 Ankush Argade 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents
CA2533320A1 (en) * 2003-08-15 2006-02-24 Novartis Ag 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
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