|
GB9718972D0
(en)
*
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
EP1676845B1
(en)
|
1999-11-05 |
2008-06-11 |
AstraZeneca AB |
New quinazoline derivatives
|
|
GB0008269D0
(en)
*
|
2000-04-05 |
2000-05-24 |
Astrazeneca Ab |
Combination chemotherapy
|
|
ES2267748T3
(es)
|
2000-04-07 |
2007-03-16 |
Astrazeneca Ab |
Compuestos de quinazolina.
|
|
GB0126879D0
(en)
*
|
2001-11-08 |
2002-01-02 |
Astrazeneca Ab |
Combination therapy
|
|
US20050163781A1
(en)
*
|
2002-01-29 |
2005-07-28 |
Philippe Koninckx |
Tissue adhesion formation control
|
|
RU2365588C2
(ru)
|
2002-02-01 |
2009-08-27 |
Астразенека Аб |
Хиназолиновые соединения
|
|
US6924285B2
(en)
|
2002-03-30 |
2005-08-02 |
Boehringer Ingelheim Pharma Gmbh & Co. |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
|
|
US7576074B2
(en)
*
|
2002-07-15 |
2009-08-18 |
Rice Kenneth D |
Receptor-type kinase modulators and methods of use
|
|
EP1534287A1
(en)
*
|
2002-08-09 |
2005-06-01 |
Astrazeneca AB |
Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer
|
|
DE10237423A1
(de)
|
2002-08-16 |
2004-02-19 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
|
|
GB0223380D0
(en)
*
|
2002-10-09 |
2002-11-13 |
Astrazeneca Ab |
Combination therapy
|
|
CA2503371C
(en)
*
|
2002-11-04 |
2011-01-11 |
Astrazeneca Ab |
Quinazoline derivatives as src tyrosine kinase inhibitors
|
|
GB0303289D0
(en)
*
|
2003-02-13 |
2003-03-19 |
Astrazeneca Ab |
Combination therapy
|
|
SI1592423T1
(sl)
*
|
2003-02-13 |
2011-07-29 |
Astrazeneca Ab |
Kombinacijska terapija ZD6474 s 5-FU in/ali CPT-11
|
|
US20050043233A1
(en)
*
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
|
WO2005004870A1
(en)
*
|
2003-07-10 |
2005-01-20 |
Astrazeneca Ab |
Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
|
|
GB0316176D0
(en)
*
|
2003-07-10 |
2003-08-13 |
Astrazeneca Ab |
Combination therapy
|
|
CA2532027C
(en)
|
2003-07-18 |
2016-06-14 |
Amgen Inc. |
Specific binding agents to hepatocyte growth factor
|
|
GB0317665D0
(en)
|
2003-07-29 |
2003-09-03 |
Astrazeneca Ab |
Qinazoline derivatives
|
|
GB0318423D0
(en)
*
|
2003-08-06 |
2003-09-10 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2005026150A1
(en)
*
|
2003-09-16 |
2005-03-24 |
Astrazeneca Ab |
Quinazoline derivatives as tyrosine kinase inhibitors
|
|
KR20060100388A
(ko)
*
|
2003-09-25 |
2006-09-20 |
아스트라제네카 아베 |
퀴나졸린 유도체
|
|
GB0330002D0
(en)
*
|
2003-12-24 |
2004-01-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
ES2315834T3
(es)
|
2004-02-03 |
2009-04-01 |
Astrazeneca Ab |
Derivados de quinazolina.
|
|
GB0421438D0
(en)
*
|
2004-09-27 |
2004-10-27 |
Astrazeneca Ab |
Combination therapy
|
|
GB0411378D0
(en)
*
|
2004-05-21 |
2004-06-23 |
Astrazeneca Ab |
Pharmaceutical compositions
|
|
JP2008504292A
(ja)
*
|
2004-06-24 |
2008-02-14 |
ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド |
免疫増強用の化合物
|
|
CA2578956A1
(en)
*
|
2004-09-27 |
2006-04-06 |
Astrazeneca Ab |
Combination comprising zd6474 and an imatinib
|
|
GB0424339D0
(en)
*
|
2004-11-03 |
2004-12-08 |
Astrazeneca Ab |
Combination therapy
|
|
US7652009B2
(en)
|
2004-11-30 |
2010-01-26 |
Amgem Inc. |
Substituted heterocycles and methods of use
|
|
PT1838733E
(pt)
|
2004-12-21 |
2011-12-13 |
Medimmune Ltd |
Anticorpos direccionados a angiopoietina-2 e respectivos usos
|
|
CN1854130B
(zh)
*
|
2005-04-15 |
2011-04-20 |
中国医学科学院药物研究所 |
喹唑啉衍生物、及其制法和药物组合物与用途
|
|
EP1967516B1
(en)
|
2005-05-18 |
2009-11-04 |
Array Biopharma, Inc. |
4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases
|
|
GB0519879D0
(en)
*
|
2005-09-30 |
2005-11-09 |
Astrazeneca Ab |
Chemical process
|
|
AU2011203358B2
(en)
*
|
2005-09-30 |
2013-05-30 |
Genzyme Corporation |
Chemical process
|
|
GB0519878D0
(en)
*
|
2005-09-30 |
2005-11-09 |
Astrazeneca Ab |
Chemical compound
|
|
US20080108664A1
(en)
|
2005-12-23 |
2008-05-08 |
Liu Belle B |
Solid-state form of AMG 706 and pharmaceutical compositions thereof
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
AR059066A1
(es)
*
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
|
|
WO2007092178A1
(en)
|
2006-02-10 |
2007-08-16 |
Amgen Inc. |
Hydrate forms of amg706
|
|
TW200808739A
(en)
|
2006-04-06 |
2008-02-16 |
Novartis Vaccines & Diagnostic |
Quinazolines for PDK1 inhibition
|
|
TW200813091A
(en)
|
2006-04-10 |
2008-03-16 |
Amgen Fremont Inc |
Targeted binding agents directed to uPAR and uses thereof
|
|
RU2008145225A
(ru)
|
2006-04-19 |
2010-05-27 |
Новартис АГ (CH) |
Соединения индазола и способы ингибирования cd7
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
CL2007002225A1
(es)
|
2006-08-03 |
2008-04-18 |
Astrazeneca Ab |
Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un
|
|
WO2008016192A2
(en)
|
2006-08-04 |
2008-02-07 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic derivative and use thereof
|
|
PT2057156T
(pt)
|
2006-08-23 |
2017-05-04 |
Kudos Pharm Ltd |
Derivados de 2-metilmorfolina pirido-, pirazo- e pirimidopirimidina como inibidores de mtor
|
|
US20100092466A1
(en)
*
|
2006-09-29 |
2010-04-15 |
Anderson Joseph Ryan |
Combination of zd6474 and bevacizumab for cancer therapy
|
|
JP5528807B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
|
JP5528806B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
|
WO2008046242A1
(fr)
*
|
2006-10-16 |
2008-04-24 |
Institute Of Mataria Medica, Chinese Academy Of Medical Sciences |
Nouveaux dérivés quinazolines, leurs procédés de préparation et leurs utilisations
|
|
EP1921070A1
(de)
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
|
|
US7687522B2
(en)
|
2006-12-20 |
2010-03-30 |
Amgen Inc. |
Substituted pyridines and pyrimidines and their use in treatment of cancer
|
|
CA2673652A1
(en)
|
2007-01-09 |
2008-07-17 |
Amgen Inc. |
Bis-aryl amide derivatives and methods of use
|
|
BRPI0807234A2
(pt)
|
2007-02-06 |
2014-06-03 |
Boehringer Ingelheim Int |
Heterociclos bicíclicos, composições farmacêuticas que contêm estes compostos, o uso dos mesmos e processos para a preparação dos mesmos
|
|
US20080190689A1
(en)
*
|
2007-02-12 |
2008-08-14 |
Ballard Ebbin C |
Inserts for engine exhaust systems
|
|
EP2114898A2
(en)
|
2007-02-16 |
2009-11-11 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
|
|
AR065784A1
(es)
|
2007-03-20 |
2009-07-01 |
Dainippon Sumitomo Pharma Co |
Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
|
|
EP2138497A4
(en)
|
2007-03-20 |
2012-01-04 |
Dainippon Sumitomo Pharma Co |
NEW ADENINE CONNECTION
|
|
US8914063B2
(en)
|
2007-05-15 |
2014-12-16 |
Lg Electronics Inc. |
Mobile terminal equipped with mode setting key and method of controlling the mobile terminal
|
|
EP2162445B1
(en)
|
2007-06-05 |
2013-11-27 |
Takeda Pharmaceutical Company Limited |
Heterobicyclic compounds as kinase inhibitors
|
|
RS56743B1
(sr)
|
2007-08-21 |
2018-03-30 |
Amgen Inc |
Humani c-fms antigen vezujući proteini
|
|
JP5270553B2
(ja)
|
2007-08-23 |
2013-08-21 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
AU2008309383B2
(en)
|
2007-10-11 |
2012-04-19 |
Astrazeneca Ab |
Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors
|
|
BRPI0819529A2
(pt)
|
2007-12-19 |
2015-05-26 |
Genentech Inc |
"composto de fórmula i, composição farmacêutica, método para inibir o crescimento celular anormal ou tratar um distúrbio hiperproliferativo em um mamífero e método para tratar uma doença inflamatória em um mamífero"
|
|
CA2710122A1
(en)
|
2007-12-20 |
2009-07-02 |
Novartis Ag |
Thiazole derivatives used as pi 3 kinase inhibitors
|
|
CA2708176A1
(en)
|
2007-12-21 |
2009-07-02 |
Genentech, Inc. |
Azaindolizines and methods of use
|
|
US8609673B2
(en)
*
|
2008-01-22 |
2013-12-17 |
Concert Pharmaceuticals, Inc. |
Vandetanib derivatives
|
|
DK2245026T3
(da)
|
2008-02-07 |
2012-10-15 |
Boehringer Ingelheim Int |
Spirocycliske heterocycler, lægemiddel indeholdende disse forbindelser, deres anvendelse og fremgangsmåde til deres fremstilling
|
|
BRPI0908100A2
(pt)
*
|
2008-02-21 |
2015-10-06 |
Astrazeneca Ab |
produto combinação, uso de um composto, e, método de tratar câncer
|
|
MY183041A
(en)
|
2008-05-13 |
2021-02-08 |
Astrazeneca Ab |
Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- {[1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy}quinazoline
|
|
JP2011526892A
(ja)
|
2008-06-30 |
2011-10-20 |
アンジオブラスト システムズ,インコーポレーテッド |
併用療法を使用した眼疾患及び過剰血管新生の治療
|
|
US8648191B2
(en)
|
2008-08-08 |
2014-02-11 |
Boehringer Ingelheim International Gmbh |
Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
|
|
WO2010032060A1
(en)
|
2008-09-19 |
2010-03-25 |
Medimmune Llc |
Antibodies directed to dll4 and uses thereof
|
|
JP5579619B2
(ja)
|
2008-12-01 |
2014-08-27 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
JO3101B1
(ar)
|
2008-12-02 |
2017-09-20 |
Takeda Pharmaceuticals Co |
مشتقات بنزوثيازول كعوامل مضادة للسرطان
|
|
TW201028410A
(en)
|
2008-12-22 |
2010-08-01 |
Astrazeneca Ab |
Chemical compounds 610
|
|
JP2012513194A
(ja)
|
2008-12-23 |
2012-06-14 |
アストラゼネカ アクチボラグ |
α5β1に向けられた標的結合剤およびその使用
|
|
BRPI1008749B8
(pt)
|
2009-02-05 |
2021-05-25 |
Immunogen Inc |
compostos derivados de benzodiazepina, seus conjugados, composição farmacêutica, seu uso e seus processos de preparação
|
|
ES2529205T3
(es)
|
2009-03-13 |
2015-02-17 |
Cellzome Limited |
Derivados de pirimidina como inhibidores de mTOR
|
|
WO2010108503A1
(en)
|
2009-03-24 |
2010-09-30 |
Life & Brain Gmbh |
Promotion of neuronal integration in neural stem cell grafts
|
|
EP2419423A1
(en)
|
2009-04-14 |
2012-02-22 |
Cellzome Limited |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
|
CA2771675A1
(en)
|
2009-09-11 |
2011-03-17 |
Cellzome Limited |
Ortho substituted pyrimidine compounds as jak inhibitors
|
|
WO2011048082A1
(en)
|
2009-10-20 |
2011-04-28 |
Cellzome Limited |
Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors
|
|
CN102070608A
(zh)
*
|
2009-11-19 |
2011-05-25 |
天津药物研究院 |
4-取代苯胺基-7-取代烷氧基-喹唑啉衍生物、其制备方法和用途
|
|
LT2504364T
(lt)
|
2009-11-24 |
2017-11-10 |
Medimmune Limited |
Tiksliniai surišantys agentai prieš b7-h1
|
|
WO2011068233A1
(en)
|
2009-12-03 |
2011-06-09 |
Dainippon Sumitomo Pharma Co., Ltd. |
Imidazoquinolines which act via toll - like receptors (tlr)
|
|
JP5841072B2
(ja)
|
2010-02-10 |
2016-01-06 |
イミュノジェン・インコーポレーテッド |
Cd20抗体およびその使用
|
|
WO2011107585A1
(en)
|
2010-03-04 |
2011-09-09 |
Cellzome Limited |
Morpholino substituted urea derivatives as mtor inhibitors
|
|
EP2566867A1
(en)
|
2010-04-30 |
2013-03-13 |
Cellzome Limited |
Pyrazole compounds as jak inhibitors
|
|
SA111320519B1
(ar)
|
2010-06-11 |
2014-07-02 |
Astrazeneca Ab |
مركبات بيريميدينيل للاستخدام كمثبطات atr
|
|
WO2011161217A2
(en)
|
2010-06-23 |
2011-12-29 |
Palacký University in Olomouc |
Targeting of vegfr2
|
|
EP2588105A1
(en)
|
2010-07-01 |
2013-05-08 |
Cellzome Limited |
Triazolopyridines as tyk2 inhibitors
|
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
|
WO2012022681A2
(en)
|
2010-08-20 |
2012-02-23 |
Cellzome Limited |
Heterocyclyl pyrazolopyrimidine analogues as selective jak inhibitors
|
|
JP2013537966A
(ja)
|
2010-08-31 |
2013-10-07 |
ジェネンテック, インコーポレイテッド |
バイオマーカー及び治療の方法
|
|
JP2014500254A
(ja)
|
2010-11-09 |
2014-01-09 |
セルゾーム リミティッド |
Tyk2阻害剤としてのピリジン化合物およびそのアザ類似体
|
|
CN102532103B
(zh)
*
|
2010-12-20 |
2014-07-09 |
天津药物研究院 |
喹唑啉芳基脲衍生物及其制备方法和用途
|
|
SG192193A1
(en)
|
2011-01-31 |
2013-09-30 |
Novartis Ag |
Novel heterocyclic derivatives
|
|
UA120696C2
(uk)
|
2011-02-15 |
2020-01-27 |
Імуноген, Інк. |
Спосіб одержання кон'югатів
|
|
US9174946B2
(en)
|
2011-02-17 |
2015-11-03 |
Cancer Therapeutics Crc Pty Ltd |
Selective FAK inhibitors
|
|
ES2691673T3
(es)
|
2011-02-17 |
2018-11-28 |
Cancer Therapeutics Crc Pty Limited |
Inhibidores de Fak
|
|
EP2688887B1
(en)
|
2011-03-23 |
2015-05-13 |
Amgen Inc. |
Fused tricyclic dual inhibitors of cdk 4/6 and flt3
|
|
JP2014510122A
(ja)
|
2011-04-04 |
2014-04-24 |
セルゾーム リミテッド |
mTOR阻害剤としてのジヒドロピロロピリミジン誘導体
|
|
WO2012143320A1
(en)
|
2011-04-18 |
2012-10-26 |
Cellzome Limited |
(7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
|
|
AU2012288892B2
(en)
|
2011-07-28 |
2016-04-21 |
Cellzome Limited |
Heterocyclyl pyrimidine analogues as JAK inhibitors
|
|
WO2013017480A1
(en)
|
2011-07-29 |
2013-02-07 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
|
|
WO2013017479A1
(en)
|
2011-07-29 |
2013-02-07 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
|
|
WO2013025939A2
(en)
|
2011-08-16 |
2013-02-21 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
|
CN103874699A
(zh)
|
2011-09-20 |
2014-06-18 |
赛尔佐姆有限公司 |
吡唑并[4,3-c]吡啶衍生物作为激酶抑制剂
|
|
BR112014006743A8
(pt)
|
2011-09-21 |
2018-01-09 |
Cellzome Ltd |
composto, uso de um composto, e, método para tratar, controlar, retardar ou impedir uma ou mais condições
|
|
ES2592219T3
(es)
|
2011-10-07 |
2016-11-28 |
Cellzome Limited |
Derivados de {(4-(4-morfolino-dihidrotieno[3,4-d]pirimidin-2-il)aril}urea o carbamato como inhibidores de mTOR
|
|
AP2014007601A0
(en)
|
2011-10-28 |
2014-04-30 |
Novartis Ag |
Novel purine derivatives and their use in the treatment of disease
|
|
RU2014130214A
(ru)
|
2011-12-23 |
2016-02-10 |
Целльзом Лимитид |
Пиримидин-2, 4-диаминовые производные в качестве ингибиторов киназы
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
MX360892B
(es)
|
2012-05-16 |
2018-11-20 |
Novartis Ag |
Régimen de dosificación para un inhibidor de cinasa pi-3.
|
|
HUE043552T2
(hu)
|
2012-06-08 |
2019-09-30 |
Sutro Biopharma Inc |
Antitestek, amelyek tartalmaznak helyspecifikus nem természetes aminosav maradékokat, eljárások elõállításukra és eljárások használatukra
|
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
HK1209105A1
(en)
|
2012-08-17 |
2016-03-24 |
Cancer Therapeutics Crc Pty Limited |
Vegfr3 inhibitors
|
|
HK1211208A1
(zh)
|
2012-08-22 |
2016-05-20 |
Immunogen, Inc. |
細胞毒性苯並二氮呯衍生物
|
|
WO2014036022A1
(en)
|
2012-08-29 |
2014-03-06 |
Amgen Inc. |
Quinazolinone compounds and derivatives thereof
|
|
US9682934B2
(en)
|
2012-08-31 |
2017-06-20 |
Sutro Biopharma, Inc. |
Modified amino acids
|
|
WO2014041349A1
(en)
|
2012-09-12 |
2014-03-20 |
Cancer Therapeutics Crc Pty Ltd |
Tetrahydropyran-4-ylethylamino- or tetrahydropyranyl-4-ethyloxy-pyrimidines or -pyridazines as isoprenylcysteincarboxymethyl transferase inhibitors
|
|
WO2014045101A1
(en)
|
2012-09-21 |
2014-03-27 |
Cellzome Gmbh |
Tetrazolo quinoxaline derivatives as tankyrase inhibitors
|
|
WO2014074517A1
(en)
|
2012-11-08 |
2014-05-15 |
Emory University |
Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto
|
|
HK1211235A1
(en)
|
2013-02-22 |
2016-05-20 |
霍夫曼-拉罗奇有限公司 |
Methods of treating cancer and preventing drug resistance
|
|
HK1219423A1
(zh)
|
2013-02-28 |
2017-04-07 |
Immunogen, Inc. |
包含细胞结合剂及细胞毒素剂的轭合物
|
|
EP3566750A3
(en)
|
2013-02-28 |
2020-04-08 |
ImmunoGen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
JP2016510751A
(ja)
|
2013-03-06 |
2016-04-11 |
ジェネンテック, インコーポレイテッド |
抗がん剤耐性を治療及び予防する方法
|
|
HK1220916A1
(zh)
|
2013-03-14 |
2017-05-19 |
基因泰克公司 |
治疗癌症和预防癌症药物抗性的方法
|
|
EP2968537A1
(en)
|
2013-03-15 |
2016-01-20 |
Genentech, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
AR095443A1
(es)
|
2013-03-15 |
2015-10-14 |
Fundación Centro Nac De Investig Oncológicas Carlos Iii |
Heterociclos condensados con acción sobre atr
|
|
WO2014194030A2
(en)
|
2013-05-31 |
2014-12-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
ES2813877T3
(es)
|
2013-08-28 |
2021-03-25 |
Crown Bioscience Inc Taicang |
Distintivos de expresión génica predictivos de la respuesta de un sujeto a un inhibidor multicinasa y métodos de uso de los mismos
|
|
CN103483276B
(zh)
*
|
2013-09-22 |
2018-04-17 |
南京恒道医药科技有限公司 |
一种凡德他尼杂质的制备方法
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
AU2014358773A1
(en)
|
2013-12-06 |
2016-06-02 |
Novartis Ag |
Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor
|
|
CA2943329A1
(en)
|
2014-03-24 |
2015-10-01 |
Genentech, Inc. |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
HK1247955A1
(zh)
|
2015-01-08 |
2018-10-05 |
小利兰.斯坦福大学托管委员会 |
提供骨、骨髓及软骨的诱导的因子和细胞
|
|
GB201510019D0
(en)
|
2015-06-09 |
2015-07-22 |
Cancer Therapeutics Crc Pty Ltd |
Compounds
|
|
CN106317022A
(zh)
*
|
2015-06-25 |
2017-01-11 |
中美华世通生物医药科技(武汉)有限公司 |
化合物的制备方法和用途
|
|
HK1252411A1
(zh)
|
2015-11-02 |
2019-05-24 |
Novartis Ag |
磷脂酰肌醇3-激酶抑制剂的给药方案
|
|
CN105254614B
(zh)
*
|
2015-11-16 |
2017-08-15 |
山东罗欣药业集团股份有限公司 |
一种凡德他尼化合物的合成方法
|
|
WO2017132617A1
(en)
|
2016-01-27 |
2017-08-03 |
Sutro Biopharma, Inc. |
Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates
|
|
WO2017139417A1
(en)
|
2016-02-08 |
2017-08-17 |
Vitrisa Therapeutics, Inc. |
Compositions with improved intravitreal half-life and uses thereof
|
|
CN106317040A
(zh)
*
|
2016-08-09 |
2017-01-11 |
浙江医药高等专科学校 |
含噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途
|
|
CN106349230A
(zh)
*
|
2016-08-09 |
2017-01-25 |
浙江医药高等专科学校 |
一种含硝基噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂及用途
|
|
CN106349231A
(zh)
*
|
2016-08-09 |
2017-01-25 |
浙江医药高等专科学校 |
一类含卤代噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂
|
|
CN106317039A
(zh)
*
|
2016-08-09 |
2017-01-11 |
浙江医药高等专科学校 |
一种含噻吩磺酰胺结构的乙氧苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途
|
|
CN106279135A
(zh)
*
|
2016-08-09 |
2017-01-04 |
浙江医药高等专科学校 |
一种噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂
|
|
CN106478598B
(zh)
*
|
2016-08-30 |
2018-11-13 |
山东罗欣药业集团股份有限公司 |
一种凡德他尼水合物晶体及其制备方法
|
|
CN106397401B
(zh)
*
|
2016-08-30 |
2018-11-13 |
山东罗欣药业集团股份有限公司 |
一种抗癌药物的晶体化合物及其制备方法
|
|
AU2017321973B2
(en)
|
2016-09-02 |
2024-09-05 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of treating B cell disorders
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
AU2017372722B2
(en)
|
2016-12-05 |
2021-09-09 |
Apros Therapeutics, Inc. |
Pyrimidine compounds containing acidic groups
|
|
US10786502B2
(en)
|
2016-12-05 |
2020-09-29 |
Apros Therapeutics, Inc. |
Substituted pyrimidines containing acidic groups as TLR7 modulators
|
|
US10532042B2
(en)
|
2016-12-22 |
2020-01-14 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
|
US20200207859A1
(en)
|
2017-07-26 |
2020-07-02 |
Sutro Biopharma, Inc. |
Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma
|
|
EP4403175A3
(en)
|
2017-09-08 |
2024-10-02 |
Amgen Inc. |
Inhibitors of kras g12c and methods of using the same
|
|
KR20200051802A
(ko)
|
2017-09-18 |
2020-05-13 |
서트로 바이오파마, 인크. |
항-엽산 수용체 알파 항체 접합체 및 이의 용도
|
|
NL2019801B1
(en)
|
2017-10-25 |
2019-05-02 |
Univ Leiden |
Delivery vectors
|
|
MA52501A
(fr)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
|
JP7361722B2
(ja)
|
2018-05-04 |
2023-10-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤及び同一物の使用方法
|
|
EP3790886B1
(en)
|
2018-05-10 |
2024-06-26 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JP7351859B2
(ja)
|
2018-06-04 |
2023-09-27 |
アプロス セラピューティクス, インコーポレイテッド |
Tlr7の調節に関係する疾患を処置するのに有用な酸性基を含むピリミジン化合物
|
|
JP7357644B2
(ja)
|
2018-06-11 |
2023-10-06 |
アムジエン・インコーポレーテツド |
がんを処置するためのkras g12c阻害剤
|
|
EP3807276B1
(en)
|
2018-06-12 |
2025-12-10 |
Amgen Inc. |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
|
GB201810092D0
(en)
|
2018-06-20 |
2018-08-08 |
Ctxt Pty Ltd |
Compounds
|
|
GB201810581D0
(en)
|
2018-06-28 |
2018-08-15 |
Ctxt Pty Ltd |
Compounds
|
|
US20220047716A1
(en)
|
2018-09-17 |
2022-02-17 |
Sutro Biopharma, Inc. |
Combination therapies with anti-folate receptor antibody conjugates
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
EP3883565A1
(en)
|
2018-11-19 |
2021-09-29 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
MA54547A
(fr)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
|
|
ES2996960T3
(en)
|
2018-12-20 |
2025-02-13 |
Amgen Inc |
Heteroaryl amides useful as kif18a inhibitors
|
|
US12459932B2
(en)
|
2018-12-20 |
2025-11-04 |
Amgen Inc. |
KIF18A inhibitors
|
|
IL283639B2
(en)
|
2018-12-20 |
2024-06-01 |
Amgen Inc |
Kif18a inhibitors
|
|
JPWO2020130125A1
(ja)
|
2018-12-21 |
2021-11-04 |
第一三共株式会社 |
抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ
|
|
MX2021010323A
(es)
|
2019-03-01 |
2021-12-10 |
Revolution Medicines Inc |
Compuestos bicíclicos de heterociclilo y usos de este.
|
|
WO2020180768A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
CN113646303A
(zh)
|
2019-03-28 |
2021-11-12 |
安普利亚治疗有限公司 |
Fak抑制剂的盐和晶型
|
|
WO2020227105A1
(en)
|
2019-05-03 |
2020-11-12 |
Sutro Biopharma, Inc. |
Anti-bcma antibody conjugates
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
WO2020236947A1
(en)
|
2019-05-21 |
2020-11-26 |
Amgen Inc. |
Solid state forms
|
|
MX2022001296A
(es)
|
2019-08-02 |
2022-02-22 |
Amgen Inc |
Inhibidores de kif18a.
|
|
WO2021026101A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
US20220289724A1
(en)
|
2019-08-02 |
2022-09-15 |
Amgen Inc. |
Kif18a inhibitors
|
|
CA3147276A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
WO2021037219A1
(zh)
|
2019-08-31 |
2021-03-04 |
上海奕拓医药科技有限责任公司 |
用于fgfr抑制剂的吡唑类衍生物及其制备方法
|
|
AU2020369569A1
(en)
|
2019-10-24 |
2022-04-14 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as KRAS G12C and KRAS G12D inhibitors in the treatment of cancer
|
|
WO2021091982A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
CN115873020B
(zh)
|
2019-11-04 |
2025-06-13 |
锐新医药公司 |
Ras抑制剂
|
|
CA3160142A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
PE20230249A1
(es)
|
2019-11-08 |
2023-02-07 |
Revolution Medicines Inc |
Compuestos de heteroarilo biciclicos y usos de estos
|
|
IL292315A
(en)
|
2019-11-14 |
2022-06-01 |
Amgen Inc |
Improved synthesis of kras g12c inhibitor compound
|
|
WO2021097207A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
|
EP4065231A1
(en)
|
2019-11-27 |
2022-10-05 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
WO2021142026A1
(en)
|
2020-01-07 |
2021-07-15 |
Revolution Medicines, Inc. |
Shp2 inhibitor dosing and methods of treating cancer
|
|
WO2021178597A1
(en)
|
2020-03-03 |
2021-09-10 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use
|
|
TW202214253A
(zh)
|
2020-06-18 |
2022-04-16 |
美商銳新醫藥公司 |
延遲、預防及治療對ras抑制劑之後天抗性之方法
|
|
WO2022053130A1
(en)
|
2020-09-09 |
2022-03-17 |
Sid Alex Group, S.R.O. |
Antago-mir-155 for treatment of v-src, c-src-tyrosine kinase-induced cancers
|
|
JP7832184B2
(ja)
|
2020-09-15 |
2026-03-17 |
レヴォリューション・メディスンズ,インコーポレイテッド |
がんの治療における、ras阻害剤としてのインドール誘導体
|
|
AR124449A1
(es)
|
2020-12-22 |
2023-03-29 |
Qilu Regor Therapeutics Inc |
Inhibidores de sos1 y usos de los mismos
|
|
CN117500811A
(zh)
|
2021-05-05 |
2024-02-02 |
锐新医药公司 |
共价ras抑制剂及其用途
|
|
PE20240088A1
(es)
|
2021-05-05 |
2024-01-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
AR125787A1
(es)
|
2021-05-05 |
2023-08-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
US20250188147A1
(en)
|
2022-03-04 |
2025-06-12 |
Panalos Bioscience, Inc. |
Composition for combi-therapy comprising vegf-grab and pd-1 or pd-l1 antagonist
|
|
US20250188036A1
(en)
|
2022-03-07 |
2025-06-12 |
Amgen Inc. |
A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
|
|
EP4489755A1
(en)
|
2022-03-08 |
2025-01-15 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
|
EP4531927A1
(en)
|
2022-05-24 |
2025-04-09 |
Daiichi Sankyo Company, Limited |
Dosage regimen of an anti-cdh6 antibody-drug conjugate
|
|
IL317476A
(en)
|
2022-06-10 |
2025-02-01 |
Revolution Medicines Inc |
Macrocyclic RAS inhibitors
|
|
JP2025525445A
(ja)
|
2022-06-30 |
2025-08-05 |
ストロ バイオファーマ インコーポレーテッド |
抗ror1抗体及び抗体コンジュゲート、抗ror1抗体又は抗体コンジュゲートを含む組成物、並びに抗ror1抗体及び抗体コンジュゲートを作製及び使用する方法
|
|
CR20250141A
(es)
|
2022-10-14 |
2025-05-26 |
Black Diamond Therapeutics Inc |
Métodos de tratamiento del cáncer usando derivados de isoquinolina o 6-aza-quinolina
|
|
WO2024206858A1
(en)
|
2023-03-30 |
2024-10-03 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
PE20260039A1
(es)
|
2023-04-07 |
2026-01-09 |
Revolution Medicines Inc |
Inhibidores macrociclicos de ras
|
|
PE20252777A1
(es)
|
2023-04-07 |
2025-12-22 |
Revolution Medicines Inc |
Inhibidores macrociclicos de ras
|
|
KR20250169290A
(ko)
|
2023-04-14 |
2025-12-02 |
레볼루션 메디슨즈, 인크. |
Ras 억제제의 결정형, 이를 함유하는 조성물 및 이의 사용 방법
|
|
WO2024216016A1
(en)
|
2023-04-14 |
2024-10-17 |
Revolution Medicines, Inc. |
Crystalline forms of a ras inhibitor
|
|
EP4704850A1
(en)
|
2023-05-04 |
2026-03-11 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
US20250154171A1
(en)
|
2023-10-12 |
2025-05-15 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US12540197B2
(en)
|
2023-10-13 |
2026-02-03 |
Sutro Biopharma, Inc. |
Anti-tissue factor antibodies and antibody conjugates, compositions comprising anti-tissue factor antibodies or antibody conjugates, and methods of making and using anti-tissue factor antibodies and antibody conjugates
|
|
WO2025137507A1
(en)
|
2023-12-22 |
2025-06-26 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025250825A1
(en)
|
2024-05-30 |
2025-12-04 |
Sutro Biopharma, Inc. |
Anti-trop2 antibodies, compositions comprising anti-trop2 antibodies and methods of making and using anti-trop2 antibodies
|
|
WO2025253311A1
(en)
|
2024-06-04 |
2025-12-11 |
Hetero Labs Limited |
1,2-dicarboxamide compounds as kinase inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|
|
WO2026050446A1
(en)
|
2024-08-29 |
2026-03-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|