|
AU550148B2
(en)
*
|
1980-02-29 |
1986-03-06 |
University Patents Inc. |
Supports for use in preparation of polynucleotides
|
|
US7101981B1
(en)
|
1980-08-26 |
2006-09-05 |
Regents Of The University Of California |
Bovine growth hormone recombinantly produced in E. coli
|
|
US6692941B1
(en)
*
|
1980-08-26 |
2004-02-17 |
The Regents Of The University Of California |
Bovine growth hormone
|
|
US4973679A
(en)
*
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
JPS58109498A
(ja)
*
|
1981-08-24 |
1983-06-29 |
Agency Of Ind Science & Technol |
オリゴリボヌクレオチド
|
|
EP0090789A1
(en)
*
|
1982-03-26 |
1983-10-05 |
Monsanto Company |
Chemical DNA synthesis
|
|
CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
|
WO1984001394A1
(fr)
*
|
1982-09-30 |
1984-04-12 |
Iro Ab |
Dispositif de stockage, debitage et mesure de fil
|
|
DE3239887A1
(de)
*
|
1982-10-28 |
1984-05-03 |
Hubert Prof. Dr. 2000 Hamburg Köster |
Verfahren zur herstellung von oligonucleotiden
|
|
US5198540A
(en)
*
|
1982-10-28 |
1993-03-30 |
Hubert Koster |
Process for the preparation of oligonucleotides in solution
|
|
FR2544720B1
(fr)
*
|
1983-04-19 |
1987-11-27 |
California Inst Of Techn |
Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
|
|
WO1984004749A1
(en)
*
|
1983-06-01 |
1984-12-06 |
Beckman Instruments Inc |
Novel preparation of nucleoside phosphoramidite intermediates
|
|
USRE34069E
(en)
*
|
1983-08-18 |
1992-09-15 |
Biosyntech Gmbh |
Process for the preparation of oligonucleotides
|
|
DE3329892A1
(de)
*
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
US5166330A
(en)
*
|
1983-09-06 |
1992-11-24 |
Hoechst Aktiengesellschaft |
Process for the preparation of nucleoside alkyl-aralkyl- and aryl-phosphonites and -phosphonates
|
|
DE3332068A1
(de)
*
|
1983-09-06 |
1985-03-21 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
|
|
SE466208B
(sv)
*
|
1983-12-20 |
1992-01-13 |
California Inst Of Techn |
Enkelstraengad aminoderivat av oligonukleotider och foerfarande foer framstaellning daerav
|
|
US5118802A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
|
|
US5118800A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
US5015733A
(en)
*
|
1983-12-20 |
1991-05-14 |
California Institute Of Technology |
Nucleosides possessing blocked aliphatic amino groups
|
|
USRE43096E1
(en)
|
1984-01-16 |
2012-01-10 |
California Institute Of Technology |
Tagged extendable primers and extension products
|
|
US5821058A
(en)
|
1984-01-16 |
1998-10-13 |
California Institute Of Technology |
Automated DNA sequencing technique
|
|
US5367066A
(en)
*
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
JPS61112093A
(ja)
*
|
1984-11-05 |
1986-05-30 |
Wakunaga Seiyaku Kk |
ヌクレオチド誘導体
|
|
FR2575751B1
(fr)
*
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
DE3507881A1
(de)
*
|
1985-03-06 |
1986-09-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren und mittel zur phosphorylierung
|
|
US5332845A
(en)
*
|
1985-03-28 |
1994-07-26 |
Chiron Corporation |
Phosphorylating reagents
|
|
US5252760A
(en)
*
|
1985-03-28 |
1993-10-12 |
Chiron Corporation |
Method of using colored phosphorylating reagents
|
|
DE3689223T2
(de)
*
|
1985-05-15 |
1994-03-03 |
Amoco Corp |
Cytidinanaloga.
|
|
US4751177A
(en)
*
|
1985-06-13 |
1988-06-14 |
Amgen |
Methods and kits for performing nucleic acid hybridization assays
|
|
US4739044A
(en)
*
|
1985-06-13 |
1988-04-19 |
Amgen |
Method for derivitization of polynucleotides
|
|
US4797355A
(en)
*
|
1985-06-13 |
1989-01-10 |
Amgen Inc. |
Methods for attaching polynucleotides to supports
|
|
EP0229053A1
(en)
*
|
1985-06-14 |
1987-07-22 |
University Patents, Inc. |
Method for synthesizing deoxyoligonucleotides
|
|
US4757141A
(en)
*
|
1985-08-26 |
1988-07-12 |
Applied Biosystems, Incorporated |
Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
|
|
EP0216357A3
(en)
*
|
1985-09-25 |
1988-08-31 |
Nippon Zeon Co., Ltd. |
Phosphoramidite compounds and process for production thereof
|
|
US4808708A
(en)
*
|
1985-11-02 |
1989-02-28 |
Toagosei Chemical Industry Co., Ltd. |
Phosphorsulfide derivatives of deoxynucleosides or deoxynucleotides and their uses
|
|
US4855225A
(en)
*
|
1986-02-07 |
1989-08-08 |
Applied Biosystems, Inc. |
Method of detecting electrophoretically separated oligonucleotides
|
|
US5242823A
(en)
*
|
1986-03-07 |
1993-09-07 |
International Genetic Engineering, Inc. |
Cloning of the 38kd Mycoplasma hyorhinis regression-associated antigen
|
|
EP0260032B1
(en)
*
|
1986-09-08 |
1994-01-26 |
Ajinomoto Co., Inc. |
Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
|
|
US4950745A
(en)
*
|
1986-10-30 |
1990-08-21 |
Daicel Chemical Industries, Ltd. |
Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
|
|
US5071974A
(en)
*
|
1986-10-31 |
1991-12-10 |
Amoco Corporation |
Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
|
|
US4923901A
(en)
*
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
|
US6031091A
(en)
*
|
1987-09-21 |
2000-02-29 |
Gen-Probe Incorporated |
Non-nucleotide linking reagents for nucleotide probes
|
|
US5585481A
(en)
*
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US4965349A
(en)
*
|
1987-12-24 |
1990-10-23 |
Applied Biosystems, Inc. |
Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
|
|
WO1989009780A1
(en)
*
|
1988-04-15 |
1989-10-19 |
Chemical Industry Institute Of Toxicology |
Site-specific tritium-labeled oligodeoxynucleotides
|
|
US5602244A
(en)
*
|
1988-05-26 |
1997-02-11 |
Competitive Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5218103A
(en)
*
|
1988-05-26 |
1993-06-08 |
University Patents, Inc. |
Nucleoside thiophosphoramidites
|
|
US5278302A
(en)
*
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
|
IL90359A0
(en)
*
|
1988-05-26 |
1989-12-15 |
University Patents Inc |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production
|
|
US5750666A
(en)
*
|
1988-05-26 |
1998-05-12 |
Competitve Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5216141A
(en)
*
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
|
JPH0291088A
(ja)
*
|
1988-09-29 |
1990-03-30 |
Central Glass Co Ltd |
ホスファイトおよびヌクレオシド‐3’‐ホスファイト誘導体およびこれを用いるオリゴヌクレオチドの合成法
|
|
US5262530A
(en)
*
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
WO1990009786A1
(en)
*
|
1989-02-24 |
1990-09-07 |
City Of Hope |
Heterologous block oligomers
|
|
WO1990012022A1
(en)
*
|
1989-03-31 |
1990-10-18 |
University Patents, Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
|
US6254861B1
(en)
|
1989-05-23 |
2001-07-03 |
Chandra Choudhury |
Hematopoietic growth factor derived from T lymphocytes
|
|
DE3916871A1
(de)
*
|
1989-05-24 |
1990-11-29 |
Boehringer Mannheim Gmbh |
Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
|
|
GR890100349A
(el)
*
|
1989-05-26 |
1994-03-31 |
University Patents Inc |
Ενώσεις νουκλεοσιδίων & πολυνουκλεοτιδίων, θειοφωσφοραμιδίων & φωσφοροδιθειικών εστέρων & μέθοδοι.
|
|
US5256775A
(en)
*
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
WO1990015065A1
(en)
*
|
1989-06-05 |
1990-12-13 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides and methods for preparing the same
|
|
US5164491A
(en)
*
|
1989-06-15 |
1992-11-17 |
Gilead Sciences |
Large scale synthesis of oligonucleotides and their associated analogs
|
|
US6300486B1
(en)
|
1989-06-15 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Large scale synthesis of oligonucleotides and their associated analogs
|
|
US5204455A
(en)
*
|
1989-06-15 |
1993-04-20 |
Froehler Brian C |
Monomethoxytrityl protected oligonucleotides bound to a solid support
|
|
US5545522A
(en)
|
1989-09-22 |
1996-08-13 |
Van Gelder; Russell N. |
Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
|
|
US7049102B1
(en)
|
1989-09-22 |
2006-05-23 |
Board Of Trustees Of Leland Stanford University |
Multi-gene expression profile
|
|
US5003097A
(en)
*
|
1989-10-02 |
1991-03-26 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for the sulfurization of phosphorous groups in compounds
|
|
AU6603690A
(en)
*
|
1989-10-05 |
1991-04-28 |
University Patents Inc. |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes
|
|
US5914396A
(en)
*
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
EP0463712A3
(en)
|
1990-06-27 |
1992-04-08 |
University Patents, Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
|
US5316908A
(en)
*
|
1990-07-13 |
1994-05-31 |
Life Technologies, Inc. |
Size markers for electrophoretic analysis of DNA
|
|
ES2124231T3
(es)
*
|
1990-10-26 |
1999-02-01 |
Genta Inc |
Procedimiento mejorado para sintesis de oligomeros.
|
|
US6605712B1
(en)
*
|
1990-12-20 |
2003-08-12 |
Arch Development Corporation |
Gene transcription and ionizing radiation: methods and compositions
|
|
US5594121A
(en)
*
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US5556961A
(en)
*
|
1991-11-15 |
1996-09-17 |
Foote; Robert S. |
Nucleosides with 5'-O-photolabile protecting groups
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
EP0637965B1
(en)
*
|
1991-11-26 |
2002-10-16 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
TW393513B
(en)
*
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
US6235887B1
(en)
*
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
WO1993012135A1
(en)
|
1991-12-12 |
1993-06-24 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
|
US5644048A
(en)
*
|
1992-01-10 |
1997-07-01 |
Isis Pharmaceuticals, Inc. |
Process for preparing phosphorothioate oligonucleotides
|
|
ATE244259T1
(de)
*
|
1992-02-12 |
2003-07-15 |
Chromagen Inc |
Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
|
|
US5652099A
(en)
*
|
1992-02-12 |
1997-07-29 |
Conrad; Michael J. |
Probes comprising fluorescent nucleosides and uses thereof
|
|
US5428148A
(en)
*
|
1992-04-24 |
1995-06-27 |
Beckman Instruments, Inc. |
N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
|
|
US5616700A
(en)
*
|
1992-04-24 |
1997-04-01 |
Beckman Instruments, Inc. |
Processes for synthesizing nucleotides and modified nucleotides using N.sub.
|
|
US5348868A
(en)
*
|
1992-04-24 |
1994-09-20 |
Beckman Instruments, Inc. |
Methods and reagents for cleaving and deprotecting oligonucleotides
|
|
US5583211A
(en)
*
|
1992-10-29 |
1996-12-10 |
Beckman Instruments, Inc. |
Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
|
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
|
US5428149A
(en)
*
|
1993-06-14 |
1995-06-27 |
Washington State University Research Foundation |
Method for palladium catalyzed carbon-carbon coulping and products
|
|
CA2165821C
(en)
*
|
1993-06-23 |
2002-01-08 |
Albert D. Friesen |
Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection
|
|
US5623068A
(en)
*
|
1994-03-07 |
1997-04-22 |
Beckman Instruments, Inc. |
Synthesis of DNA using substituted phenylacetyl-protected nucleotides
|
|
US6639061B1
(en)
|
1999-07-07 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate oligomers and related compounds
|
|
US5510476A
(en)
*
|
1994-07-07 |
1996-04-23 |
Isis Pharmaceuticals, Inc. |
Carbocation scavenging during oligonucleotide synthesis
|
|
US5552471A
(en)
*
|
1994-08-17 |
1996-09-03 |
The Perkin-Elmer Corporation |
Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
|
|
US5703223A
(en)
*
|
1994-09-02 |
1997-12-30 |
Thomas Jefferson University |
Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
|
|
US6558633B1
(en)
*
|
1994-09-21 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Chemical reaction apparatus and methods
|
|
US5604097A
(en)
|
1994-10-13 |
1997-02-18 |
Spectragen, Inc. |
Methods for sorting polynucleotides using oligonucleotide tags
|
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
|
US5717085A
(en)
*
|
1994-11-23 |
1998-02-10 |
Terrapin Technologies, Inc. |
Process for preparing codon amidites
|
|
US5908926A
(en)
*
|
1995-03-16 |
1999-06-01 |
Duke University |
5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
|
|
US5750341A
(en)
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
|
US5614622A
(en)
*
|
1995-06-01 |
1997-03-25 |
Hybridon, Inc. |
5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
|
|
US6531589B1
(en)
*
|
1995-06-01 |
2003-03-11 |
Hybridon, Inc. |
Base protecting groups and synthons for oligonucleotide synthesis
|
|
CZ392697A3
(cs)
|
1995-06-07 |
1998-06-17 |
Lynx Therapeutics, Inc. |
Oligonukleotidové značky pro stanovení druhu a identifikaci
|
|
US5856464A
(en)
*
|
1995-06-07 |
1999-01-05 |
Lajolla Pharmaceutical Company |
Selective capping solution phase oligonucleotide synthesis
|
|
US6111095A
(en)
*
|
1995-06-07 |
2000-08-29 |
Merck & Co., Inc. |
Capped synthetic RNA, analogs, and aptamers
|
|
US5889136A
(en)
*
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
WO1997014706A1
(en)
|
1995-10-19 |
1997-04-24 |
Nexstar Pharmaceuticals, Inc. |
Method for solution phase synthesis of oligonucleotides
|
|
US5734041A
(en)
*
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US6160109A
(en)
*
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
|
US6476216B1
(en)
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
|
US5705621A
(en)
*
|
1995-11-17 |
1998-01-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
|
|
US20030119724A1
(en)
*
|
1995-11-22 |
2003-06-26 |
Ts`O Paul O.P. |
Ligands to enhance cellular uptake of biomolecules
|
|
US5808035A
(en)
*
|
1995-12-08 |
1998-09-15 |
Usher; David A. |
Protected nucleoside and method for its synthesis
|
|
US5736626A
(en)
|
1996-01-29 |
1998-04-07 |
The Perkin-Elmer Corporation |
Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
|
|
CA2250923A1
(en)
*
|
1996-03-26 |
1997-10-02 |
Gabriella Zupi |
Oligonucleotide treatments and compositions for human melanoma
|
|
US5959100A
(en)
*
|
1996-03-27 |
1999-09-28 |
Nexstar Pharmaceuticals, Inc. |
Pyrimidine nucleosides as therapeutic and diagnostic agents
|
|
US6020481A
(en)
|
1996-04-01 |
2000-02-01 |
The Perkin-Elmer Corporation |
Asymmetric benzoxanthene dyes
|
|
US5852168A
(en)
*
|
1996-04-30 |
1998-12-22 |
Regents Of The University Of Minesota |
Sulfurization of phosphorus-containing compounds
|
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US6060240A
(en)
*
|
1996-12-13 |
2000-05-09 |
Arcaris, Inc. |
Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
|
|
US6103891A
(en)
*
|
1996-12-27 |
2000-08-15 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
|
US6172217B1
(en)
|
1996-12-27 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Method of synthesizing phosphorothioate oligonucleotides
|
|
US5955600A
(en)
*
|
1996-12-27 |
1999-09-21 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
|
US5760209A
(en)
*
|
1997-03-03 |
1998-06-02 |
Isis Pharmaceuticals, Inc. |
Protecting group for synthesizing oligonucleotide analogs
|
|
US5902881A
(en)
|
1997-03-03 |
1999-05-11 |
Isis Pharmaceuticals, Inc. |
Reagent useful for synthesizing sulfurized oligonucleotide analogs
|
|
JP3435416B2
(ja)
|
1997-03-12 |
2003-08-11 |
ピーイー コーポレイション(エヌワイ) |
改善された標識ヌクレオチド取込み特性を有するdnaポリメラーゼ
|
|
WO1998044156A1
(en)
*
|
1997-03-27 |
1998-10-08 |
Life Technologies, Inc. |
Nucleic acid ladders
|
|
EP1001963B1
(en)
|
1997-07-15 |
2011-01-05 |
Life Technologies, Inc. |
Nucleic acid ladders
|
|
US6008379A
(en)
|
1997-10-01 |
1999-12-28 |
The Perkin-Elmer Corporation |
Aromatic-substituted xanthene dyes
|
|
US6583168B1
(en)
|
1997-11-25 |
2003-06-24 |
Applera Corporation |
Sulfonated diarylrhodamine dyes
|
|
US5936087A
(en)
|
1997-11-25 |
1999-08-10 |
The Perkin-Elmer Corporation |
Dibenzorhodamine dyes
|
|
US6441150B1
(en)
|
1997-12-16 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites
|
|
US7427678B2
(en)
*
|
1998-01-08 |
2008-09-23 |
Sigma-Aldrich Co. |
Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
|
|
WO1999034920A1
(en)
*
|
1998-01-12 |
1999-07-15 |
Massachusetts Institute Of Technology |
Method and apparatus for performing microassays
|
|
US6893877B2
(en)
|
1998-01-12 |
2005-05-17 |
Massachusetts Institute Of Technology |
Methods for screening substances in a microwell array
|
|
US6426185B1
(en)
|
1998-01-16 |
2002-07-30 |
Large Scale Biology Corporation |
Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
|
|
US20030027173A1
(en)
*
|
1998-01-16 |
2003-02-06 |
Della-Cioppa Guy |
Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
|
|
US20020164585A1
(en)
*
|
1998-01-16 |
2002-11-07 |
Sean Chapman |
Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
|
|
US6303848B1
(en)
|
1998-01-16 |
2001-10-16 |
Large Scale Biology Corporation |
Method for conferring herbicide, pest, or disease resistance in plant hosts
|
|
US6080868A
(en)
|
1998-01-23 |
2000-06-27 |
The Perkin-Elmer Corporation |
Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
|
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
|
US6020475A
(en)
*
|
1998-02-10 |
2000-02-01 |
Isis Pharmeuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US7273933B1
(en)
|
1998-02-26 |
2007-09-25 |
Isis Pharmaceuticals, Inc. |
Methods for synthesis of oligonucleotides
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
US6531590B1
(en)
*
|
1998-04-24 |
2003-03-11 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligonucleotide compounds
|
|
US6590092B1
(en)
*
|
1998-05-19 |
2003-07-08 |
Nam Q. Ngo |
Process for preparing a “universal support” and the reagents used for generating such support
|
|
US6274725B1
(en)
|
1998-06-02 |
2001-08-14 |
Isis Pharmaceuticals, Inc. |
Activators for oligonucleotide synthesis
|
|
US6335439B1
(en)
|
1998-06-11 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Method of preparing phosphoramidites
|
|
AU4434299A
(en)
|
1998-06-11 |
1999-12-30 |
Isis Pharmaceuticals, Inc. |
Synthetic methods and intermediates for triester oligonucleotides
|
|
US6270730B1
(en)
*
|
1998-06-16 |
2001-08-07 |
Northwest Engineering Inc. |
Multi-well rotary synthesizer
|
|
US7087148B1
(en)
|
1998-06-23 |
2006-08-08 |
Clinical Micro Sensors, Inc. |
Binding acceleration techniques for the detection of analytes
|
|
US6326478B1
(en)
|
1998-07-08 |
2001-12-04 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US6124484A
(en)
|
1998-07-17 |
2000-09-26 |
Isis Pharmaceuticals, Inc. |
Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
|
|
US6271042B1
(en)
|
1998-08-26 |
2001-08-07 |
Alpha Innotech Corporation |
Biochip detection system
|
|
US6335437B1
(en)
|
1998-09-07 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Methods for the preparation of conjugated oligomers
|
|
US6069243A
(en)
*
|
1998-10-06 |
2000-05-30 |
Isis Pharmaceuticals, Inc. |
Process for oligonucleotide synthesis
|
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
|
US6153411A
(en)
*
|
1998-10-30 |
2000-11-28 |
American Water Works Company, Inc. |
Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
|
|
US6169177B1
(en)
|
1998-11-06 |
2001-01-02 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomeric compounds
|
|
WO2000036152A1
(en)
|
1998-12-14 |
2000-06-22 |
Li-Cor, Inc. |
A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
|
|
US6380378B1
(en)
|
1998-12-24 |
2002-04-30 |
Toagosei Company, Ltd. |
Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
|
|
US6432642B1
(en)
*
|
1999-01-15 |
2002-08-13 |
Pe Corporation (Ny) |
Binary probe and clamp composition and methods for a target hybridization detection
|
|
US6465628B1
(en)
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US20040082774A1
(en)
*
|
1999-03-16 |
2004-04-29 |
Guzaev Andrei P. |
Novel phosphate and thiophosphate protecting groups
|
|
US6399765B1
(en)
|
1999-03-17 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Methods for removing dimethoxytrityl groups from oligonucleotides
|
|
US6306578B1
(en)
*
|
1999-03-19 |
2001-10-23 |
Genencor International, Inc. |
Multi-through hole testing plate for high throughput screening
|
|
EP1163251A1
(en)
|
1999-03-24 |
2001-12-19 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
N-acylphosphoramidites and their use in oligonucleotide synthesis
|
|
US20020177135A1
(en)
*
|
1999-07-27 |
2002-11-28 |
Doung Hau H. |
Devices and methods for biochip multiplexing
|
|
US6221635B1
(en)
|
1999-05-06 |
2001-04-24 |
The Wistar Institute |
Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
|
|
US6610842B1
(en)
*
|
1999-05-06 |
2003-08-26 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomers using phosphoramidite compositions
|
|
WO2000071559A1
(en)
*
|
1999-05-24 |
2000-11-30 |
Invitrogen Corporation |
Method for deblocking of labeled oligonucleotides
|
|
US20070059752A1
(en)
*
|
1999-06-09 |
2007-03-15 |
Biosearch Technologies, Inc. |
Fluorescence energy transfer probes with stabilized conformations
|
|
US7183405B2
(en)
|
1999-06-25 |
2007-02-27 |
Syn Gen, Inc. |
Compositions and methods for labeling oligonucleotides
|
|
US6750357B1
(en)
|
1999-06-25 |
2004-06-15 |
Syngen, Inc. |
Rhodamine-based fluorophores useful as labeling reagents
|
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
|
US6306599B1
(en)
|
1999-07-16 |
2001-10-23 |
Agilent Technologies Inc. |
Biopolymer arrays and their fabrication
|
|
US6346423B1
(en)
|
1999-07-16 |
2002-02-12 |
Agilent Technologies, Inc. |
Methods and compositions for producing biopolymeric arrays
|
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US6114518A
(en)
*
|
1999-09-30 |
2000-09-05 |
Becton, Dickinson And Company |
Synthesis and use of labelled phosphoramidite compositions
|
|
US6503713B1
(en)
|
1999-10-04 |
2003-01-07 |
University Of Medicine And Dentistry Of New Jersey |
Methods for identifying RNA binding compounds
|
|
US6451998B1
(en)
|
1999-10-18 |
2002-09-17 |
Agilent Technologies, Inc. |
Capping and de-capping during oligonucleotide synthesis
|
|
WO2001032935A2
(en)
*
|
1999-11-02 |
2001-05-10 |
Celine Hu |
Molecular microarrays and methods for production and use thereof
|
|
US6875619B2
(en)
|
1999-11-12 |
2005-04-05 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
|
US6361958B1
(en)
|
1999-11-12 |
2002-03-26 |
Motorola, Inc. |
Biochannel assay for hybridization with biomaterial
|
|
CA2392218A1
(en)
*
|
1999-11-17 |
2001-05-25 |
Jiuping Ji |
Simultaneous detection of hbv, hcv and hiv in plasma samples using a multiplex capture assay
|
|
US6716994B1
(en)
*
|
2000-01-04 |
2004-04-06 |
Applera Corporation |
Mobility-Modifying Cyanine Dyes
|
|
US7332271B2
(en)
*
|
2000-02-18 |
2008-02-19 |
Board Of Trustees Of The Leland Stanford Junior University |
Apparatus and methods for parallel processing of micro-volume liquid reactions
|
|
US20020151040A1
(en)
|
2000-02-18 |
2002-10-17 |
Matthew O' Keefe |
Apparatus and methods for parallel processing of microvolume liquid reactions
|
|
US7019129B1
(en)
|
2000-05-09 |
2006-03-28 |
Biosearch Technologies, Inc. |
Dark quenchers for donor-acceptor energy transfer
|
|
WO2001092579A2
(en)
*
|
2000-05-30 |
2001-12-06 |
Pe Corporation (Ny) |
Methods for detecting target nucleic acids using coupled ligation and amplification
|
|
US6887664B2
(en)
|
2000-06-06 |
2005-05-03 |
Applera Corporation |
Asynchronous primed PCR
|
|
US6936702B2
(en)
*
|
2000-06-07 |
2005-08-30 |
Li-Cor, Inc. |
Charge-switch nucleotides
|
|
US6869764B2
(en)
|
2000-06-07 |
2005-03-22 |
L--Cor, Inc. |
Nucleic acid sequencing using charge-switch nucleotides
|
|
EP1287154A4
(en)
|
2000-06-07 |
2010-12-15 |
Pacific Biosciences California |
NUCLEOTIDES WITH CHARGE SWITCHING
|
|
EP1176151B1
(en)
|
2000-07-28 |
2014-08-20 |
Agilent Technologies, Inc. |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry
|
|
EP1349958B1
(en)
|
2000-09-26 |
2009-06-03 |
Boston Probes, Inc. |
Probes, probe sets, methods and kits pertaining to the detection, identification and/or enumeration of bacteria
|
|
AU1312502A
(en)
*
|
2000-10-11 |
2002-04-22 |
Pe Corp Ny |
Fluorescent nucleobase conjugates having anionic linkers
|
|
US6693187B1
(en)
*
|
2000-10-17 |
2004-02-17 |
Lievre Cornu Llc |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
|
|
EP1337542A2
(en)
*
|
2000-11-09 |
2003-08-27 |
Invitrogen Corporation |
Method for removing a universal linker from an oligonucleotide
|
|
CN100406065C
(zh)
|
2000-12-01 |
2008-07-30 |
细胞工厂治疗公司 |
糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
|
|
US6794141B2
(en)
|
2000-12-22 |
2004-09-21 |
Arcturus Bioscience, Inc. |
Nucleic acid amplification
|
|
US6825338B2
(en)
|
2001-03-30 |
2004-11-30 |
Isis Pharmaceuticals, Inc. |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
|
|
US8034791B2
(en)
|
2001-04-06 |
2011-10-11 |
The University Of Chicago |
Activation of Egr-1 promoter by DNA damaging chemotherapeutics
|
|
ATE541937T1
(de)
*
|
2001-04-06 |
2012-02-15 |
Univ Chicago |
Chemotherapeutische einleitung der egr-1-promoter-aktivität in gentherapie
|
|
US20040242523A1
(en)
*
|
2003-03-06 |
2004-12-02 |
Ana-Farber Cancer Institue And The Univiersity Of Chicago |
Chemo-inducible cancer gene therapy
|
|
US20030170675A1
(en)
*
|
2001-04-11 |
2003-09-11 |
The Gov't Of The U.S Of America As Represented By The Secretary Of The Dept. Of Health & Human Serv. |
Methods of manipulating nucleic acids
|
|
CA2443894A1
(en)
*
|
2001-04-11 |
2002-10-24 |
Charlie Xiang |
Modified random primers for probe labeling
|
|
CA2381367A1
(en)
|
2001-04-12 |
2002-10-12 |
Hironori Komatsu |
Method for purifying 5'-protected 2'-deoxypurine nucleosides
|
|
US6867050B2
(en)
*
|
2001-05-16 |
2005-03-15 |
Academia Sinica |
Apparatus and methods for chemical synthesis
|
|
US20050009101A1
(en)
*
|
2001-05-17 |
2005-01-13 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
|
CZ20033143A3
(en)
*
|
2001-05-21 |
2004-04-14 |
Aclara Biosciences, Inc. |
Methods and compositions for analyzing proteins
|
|
PT2070939E
(pt)
|
2001-05-25 |
2014-06-09 |
Univ Duke |
Moduladores de agentes farmacológicos
|
|
ATE291925T1
(de)
*
|
2001-06-05 |
2005-04-15 |
Curevac Gmbh |
Stabilisierte mrna mit erhöhtem g/c-gehalt und optimierter codon usage für die gentherapie
|
|
US7118907B2
(en)
*
|
2001-06-06 |
2006-10-10 |
Li-Cor, Inc. |
Single molecule detection systems and methods
|
|
AU2002322351A1
(en)
*
|
2001-06-28 |
2003-03-03 |
Ia, Inc. |
Fiber-optic sensor array
|
|
US7153954B2
(en)
|
2001-07-12 |
2006-12-26 |
Santaris Pharma A/S |
Method for preparation of LNA phosphoramidites
|
|
JP3935487B2
(ja)
|
2001-07-16 |
2007-06-20 |
フーベルト・ケスター |
捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法
|
|
US6822088B2
(en)
|
2001-07-17 |
2004-11-23 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides on solid support
|
|
US20050042629A1
(en)
|
2002-09-13 |
2005-02-24 |
Applera Corporation |
Thermus scotoductus nucleic acid polymerases
|
|
AU2002346498A1
(en)
|
2001-11-30 |
2003-06-17 |
Applera Corporation |
Thermus brockianus nucleic acid polymerases
|
|
AU2002353001A1
(en)
*
|
2001-12-03 |
2003-06-17 |
The Government Of The United States Of America, Represented By The Secretary Of The Department Of He |
Thermolabile hydroxyl protecting groups and methods of use
|
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
|
US7255874B1
(en)
|
2001-12-21 |
2007-08-14 |
Closure Medical Corporation |
Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
|
|
GB0200526D0
(en)
*
|
2002-01-11 |
2002-02-27 |
Science And Technology The |
Methods
|
|
WO2003062452A2
(en)
*
|
2002-01-23 |
2003-07-31 |
Proligo, Llc |
Methods for the integrated synthesis and purification of oligonucleotides
|
|
US20030166282A1
(en)
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
EP1478656B1
(en)
|
2002-02-01 |
2009-09-16 |
Life Technologies Corporation |
Oligonucleotide compositions with enhanced efficiency
|
|
ES2319634T3
(es)
*
|
2002-03-11 |
2009-05-11 |
Caprotec Bioanalytics Gmbh |
Compuestos y metodos para analizar el proteoma.
|
|
CA2477670A1
(en)
*
|
2002-03-15 |
2003-09-25 |
Arcturus Bioscience, Inc. |
Improved nucleic acid amplification
|
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
|
WO2003096015A1
(en)
|
2002-05-08 |
2003-11-20 |
Matsushita Electric Industrial Co., Ltd. |
Biomolecular substrate, method of testing or diagnosis with use thereof and apparatus therefor
|
|
US7291460B2
(en)
*
|
2002-05-31 |
2007-11-06 |
Verenium Corporation |
Multiplexed systems for nucleic acid sequencing
|
|
CN100424091C
(zh)
|
2002-06-05 |
2008-10-08 |
三井化学株式会社 |
保护化2’-脱氧胞苷类的精制法
|
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
|
US7504215B2
(en)
|
2002-07-12 |
2009-03-17 |
Affymetrix, Inc. |
Nucleic acid labeling methods
|
|
EP1386925A1
(en)
*
|
2002-07-31 |
2004-02-04 |
Girindus AG |
Method for preparing oligonucleotides
|
|
US8277753B2
(en)
|
2002-08-23 |
2012-10-02 |
Life Technologies Corporation |
Microfluidic transfer pin
|
|
ATE449103T1
(de)
*
|
2002-09-08 |
2009-12-15 |
Applera Corp |
Festphasengebundene pna-dimere und deren synthese
|
|
US20040235005A1
(en)
*
|
2002-10-23 |
2004-11-25 |
Ernest Friedlander |
Methods and composition for detecting targets
|
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
CN1723216A
(zh)
*
|
2002-12-09 |
2006-01-18 |
三井化学株式会社 |
亚磷酰胺的制造方法
|
|
GB0229423D0
(en)
*
|
2002-12-18 |
2003-01-22 |
Avecia Ltd |
Process
|
|
EP1608952B1
(en)
|
2002-12-20 |
2016-08-10 |
Life Technologies Corporation |
Assay apparatus and method using microfluidic arrays
|
|
EP1585755B1
(en)
*
|
2002-12-31 |
2015-08-05 |
Sigma-Aldrich Co. LLC |
Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
|
|
EP1583972B1
(en)
*
|
2003-01-16 |
2010-11-24 |
caprotec bioanalytics GmbH |
Methods for identifying drug non-target proteins
|
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
|
JP3936300B2
(ja)
*
|
2003-02-28 |
2007-06-27 |
独立行政法人科学技術振興機構 |
新規なグアノシン誘導体及びその用途
|
|
JP2006521116A
(ja)
|
2003-03-27 |
2006-09-21 |
ピーティーシー セラピューティクス,インコーポレーテッド |
抗真菌性および/または抗増殖性分子を同定するためのtRNAスプライシング経路の酵素の標的化
|
|
WO2004087069A2
(en)
|
2003-03-27 |
2004-10-14 |
Ptc Therapeutics, Inc. |
METHODS OF IDENTIFYING COMPOUNDS THAT TARGET tRNA SPLICING ENDONUCLEASE AND USES OF SAID COMPOUNDS AS ANTI-PROLIFERATIVE AGENTS
|
|
US7745116B2
(en)
*
|
2003-04-08 |
2010-06-29 |
Pacific Biosciences Of California, Inc. |
Composition and method for nucleic acid sequencing
|
|
US20070179100A1
(en)
*
|
2003-04-09 |
2007-08-02 |
Muthiah Manoharan |
Protected monomers
|
|
US7612197B2
(en)
*
|
2003-05-09 |
2009-11-03 |
The United States of America as repesented by the Secretary of the Department of Health and Human Services |
Thermolabile hydroxyl protecting groups and methods of use
|
|
EP1660512A4
(en)
|
2003-06-02 |
2009-12-23 |
Isis Pharmaceuticals Inc |
SYNTHESIS OF OLIGONUCLEOTIDES USING ALTERNATIVE SOLVENTS
|
|
WO2005001129A2
(en)
*
|
2003-06-06 |
2005-01-06 |
Applera Corporation |
Mobility cassettes
|
|
DE10335833A1
(de)
|
2003-08-05 |
2005-03-03 |
Curevac Gmbh |
Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
|
|
US7304203B2
(en)
*
|
2003-09-18 |
2007-12-04 |
Mayo Foundation For Medical Education And Research |
Transgenic TIEG non-human animals
|
|
WO2005027962A1
(en)
|
2003-09-18 |
2005-03-31 |
Isis Pharmaceuticals, Inc. |
4’-thionucleosides and oligomeric compounds
|
|
DK2708541T3
(en)
|
2003-11-13 |
2015-02-23 |
Isis Pharmaceuticals Inc |
5,6-dihydroxy-isoindole derivatives as linkers for oligomeric solid phase synthesis
|
|
CA2551094A1
(en)
|
2003-12-22 |
2005-07-14 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for identifying rna-binding proteins
|
|
JP2007520481A
(ja)
*
|
2004-01-15 |
2007-07-26 |
アルザ・コーポレーシヨン |
治療薬を送達するためのリポソーム組成物
|
|
US7691316B2
(en)
*
|
2004-02-12 |
2010-04-06 |
Chemistry & Technology For Genes, Inc. |
Devices and methods for the synthesis of nucleic acids
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
WO2005089945A1
(en)
|
2004-03-12 |
2005-09-29 |
Biotrove, Inc. |
Nanoliter array loading
|
|
CN1980947B
(zh)
|
2004-04-22 |
2013-01-30 |
雷加多生物科学公司 |
改良的凝血因子调节物
|
|
JP4592060B2
(ja)
*
|
2004-04-26 |
2010-12-01 |
キヤノン株式会社 |
Pcr増幅反応装置、ならびに、該装置を利用するpcr増幅反応方法
|
|
IL162276A0
(en)
*
|
2004-06-01 |
2005-11-20 |
Hadasit Med Res Service |
Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US12070731B2
(en)
|
2004-08-04 |
2024-08-27 |
Life Technologies Corporation |
Methods and systems for aligning dispensing arrays with microfluidic sample arrays
|
|
US20060105453A1
(en)
|
2004-09-09 |
2006-05-18 |
Brenan Colin J |
Coating process for microfluidic sample arrays
|
|
WO2006023880A2
(en)
|
2004-08-23 |
2006-03-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
|
DE102004042546A1
(de)
*
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
CA2581174A1
(en)
|
2004-09-16 |
2006-03-30 |
Applera Corporation |
Fluorescent dye compounds, conjugates and uses thereof
|
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
WO2006065751A2
(en)
*
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
|
US20060142228A1
(en)
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
WO2006076650A2
(en)
*
|
2005-01-12 |
2006-07-20 |
Applera Corporation |
Compositions, methods, and kits for selective amplification of nucleic acids
|
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
|
WO2006086777A2
(en)
|
2005-02-11 |
2006-08-17 |
Memorial Sloan Kettering Cancer Center |
Methods and compositions for detecting a drug resistant egfr mutant
|
|
DE102005023170A1
(de)
|
2005-05-19 |
2006-11-23 |
Curevac Gmbh |
Optimierte Formulierung für mRNA
|
|
EP1899361B1
(en)
|
2005-05-26 |
2013-12-11 |
Luminex Corporation |
Reagent for the improved synthesis of isoguanosine-containing oligonucleotides
|
|
WO2007008252A1
(en)
*
|
2005-07-12 |
2007-01-18 |
Temple University - Of The Commonwealth Systems Of Higher Education |
Genetic and epigenetic alterations in the diagnosis and treatment of cancer
|
|
US7892795B2
(en)
|
2005-08-02 |
2011-02-22 |
Focus Diagnostics, Inc. |
Methods and compositions for detecting BK virus
|
|
WO2007047408A2
(en)
*
|
2005-10-12 |
2007-04-26 |
Pathologica, Llc. |
Promac signature application
|
|
WO2007059423A2
(en)
*
|
2005-11-14 |
2007-05-24 |
Siemens Healthcare Diagnostics Inc. |
Planar waveguide detection chips and chambers for performing multiplex pcr assays
|
|
US7579459B2
(en)
*
|
2005-12-12 |
2009-08-25 |
Ngo Nam Q |
Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
|
|
DE602007009487D1
(de)
|
2006-01-27 |
2010-11-11 |
Isis Pharmaceutical Inc |
6-modifizierte bicyclische nukleinsäureanaloga
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
SG10201806098QA
(en)
|
2006-02-13 |
2018-08-30 |
Us Gov Health & Human Services |
Primers and probes for detection and discrimination of types and subtypes of influenza viruses
|
|
EP2012810A2
(en)
*
|
2006-03-24 |
2009-01-14 |
Archemix Corp. |
Solid support reagents for synthesis
|
|
EP2505646A1
(en)
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of CRP
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
CA2651453C
(en)
|
2006-05-11 |
2014-10-14 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
|
AU2007260707A1
(en)
*
|
2006-06-16 |
2007-12-21 |
Pacific Biosciences Of California, Inc. |
Controlled initiation of primer extension
|
|
EP3796002B1
(en)
|
2006-07-14 |
2023-11-22 |
The Regents of The University of California |
Cancer biomarkers and methods of use thereof
|
|
DE102006035618A1
(de)
|
2006-07-31 |
2008-02-07 |
Curevac Gmbh |
Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz
|
|
JP2010507361A
(ja)
|
2006-07-31 |
2010-03-11 |
キュアバック ゲーエムベーハー |
具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸
|
|
US8138330B2
(en)
*
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
US7947447B2
(en)
|
2007-01-16 |
2011-05-24 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
PL2476689T3
(pl)
|
2007-05-10 |
2016-04-29 |
Agilent Technologies Inc |
Tiowęglowe grupy zabezpieczające do syntezy RNA
|
|
EP2152890A1
(en)
*
|
2007-05-23 |
2010-02-17 |
MannKind Corporation |
Multicistronic vectors and methods for their design
|
|
DK2170917T3
(da)
|
2007-05-30 |
2012-10-08 |
Isis Pharmaceuticals Inc |
N-Substituerede bicycliske nukleinsyreanaloge med aminomethylenbro
|
|
WO2008154401A2
(en)
|
2007-06-08 |
2008-12-18 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
JP5745842B2
(ja)
|
2007-06-19 |
2015-07-08 |
ストラトス ゲノミクス インコーポレイテッド |
拡張によるハイスループット核酸配列決定
|
|
AU2008272918B2
(en)
|
2007-07-05 |
2012-09-13 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
US8404830B2
(en)
*
|
2007-07-17 |
2013-03-26 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
EP2188298B1
(en)
|
2007-08-15 |
2013-09-18 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
JP5723154B2
(ja)
|
2007-09-19 |
2015-05-27 |
アプライド バイオシステムズ リミテッド ライアビリティー カンパニー |
RNAiにおけるオフターゲット表現型の影響を減少させるためのSiRNA配列非依存性修飾フォーマットおよびその安定化型
|
|
EP2195015B1
(en)
|
2007-10-09 |
2017-04-12 |
CureVac AG |
COMPOSITION FOR TREATING PROSTATE CANCER (PCa)
|
|
WO2009046738A1
(en)
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating lung cancer, particularly of non-small lung cancers (nsclc)
|
|
US7829735B2
(en)
*
|
2007-10-26 |
2010-11-09 |
Northwestern University |
Universal phosphoramidite for preparation of modified biomolecules and surfaces
|
|
KR20100102107A
(ko)
*
|
2007-11-06 |
2010-09-20 |
파마이센시아 코퍼레이션 |
β-뉴클레오시드의 새로운 합성 방법
|
|
JP5721441B2
(ja)
|
2008-01-31 |
2015-05-20 |
キュアバック ゲーエムベーハーCurevac Gmbh |
免疫賦活剤/アジュバントとしての式(I)(NuGlXmGnNv)aで表される核酸分子及びその誘導体
|
|
EP2265627A2
(en)
|
2008-02-07 |
2010-12-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
EP3643782A1
(en)
|
2008-02-11 |
2020-04-29 |
Phio Pharmaceuticals Corp. |
Modified rnai polynucleotides and uses thereof
|
|
US8426378B2
(en)
|
2008-03-21 |
2013-04-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
|
|
US9290534B2
(en)
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
|
NZ589143A
(en)
|
2008-05-14 |
2012-02-24 |
Genomic Health Inc |
Colorectal cancer response prediction based on AREG EREG DUSP6 and SLC26A3 expression levels
|
|
WO2010005693A1
(en)
*
|
2008-06-23 |
2010-01-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Cyclized ngr peptide compounds, compositions, and methods of their use
|
|
JP5438922B2
(ja)
*
|
2008-06-25 |
2014-03-12 |
日東電工株式会社 |
核酸の製造方法
|
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
|
EP2342340A1
(en)
|
2008-09-22 |
2011-07-13 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
|
WO2010039543A2
(en)
|
2008-09-23 |
2010-04-08 |
Traversa Therapeutics, Inc. |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference
|
|
WO2010036696A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acid analogs
|
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
CA2740785C
(en)
|
2008-10-15 |
2017-06-20 |
Isis Pharmaceuticals, Inc. |
Modulation of factor 11 expression
|
|
EP2358397B1
(en)
|
2008-10-24 |
2020-01-01 |
Ionis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
EP2447274B1
(en)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
US9074211B2
(en)
|
2008-11-19 |
2015-07-07 |
Rxi Pharmaceuticals Corporation |
Inhibition of MAP4K4 through RNAI
|
|
BRPI0923225A2
(pt)
|
2008-12-02 |
2016-10-04 |
Chiralgen Ltd |
metodo para sintese de acidos nucleicos modificados no atomo de fosforo
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
EP2389452A2
(en)
|
2009-01-21 |
2011-11-30 |
Vertex Pharmaceuticals Incorporated |
Methods for amplifying hepatitis c virus nucleic acids
|
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
WO2010138926A1
(en)
|
2009-05-29 |
2010-12-02 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Nucleic acids for detection and discrimination of genotypes of chlamydophila psittaci
|
|
EP2451461A4
(en)
|
2009-07-06 |
2013-05-29 |
Ontorii Inc |
NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
|
|
EP2278334A1
(en)
|
2009-07-22 |
2011-01-26 |
Etablissement Francais du Sang |
A membrane based microarray device for high-throughput multianalyte detection
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US20110053829A1
(en)
|
2009-09-03 |
2011-03-03 |
Curevac Gmbh |
Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
|
|
CA2781682A1
(en)
|
2009-12-04 |
2011-06-09 |
Genentech, Inc. |
Multispecific antibodies, antibody analogs, compositions, and methods
|
|
WO2011069528A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Lyophilization of nucleic acids in lactate-containing solutions
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
|
US10113206B2
(en)
|
2010-02-24 |
2018-10-30 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining human immunodeficiency virus (HIV)
|
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CA2794189C
(en)
|
2010-03-24 |
2022-01-11 |
Rxi Pharmaceuticals Corporation |
Rna interference in dermal and fibrotic indications
|
|
WO2011119852A1
(en)
|
2010-03-24 |
2011-09-29 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering rnai compounds
|
|
US9095504B2
(en)
|
2010-03-24 |
2015-08-04 |
Rxi Pharmaceuticals Corporation |
RNA interference in ocular indications
|
|
NZ602618A
(en)
|
2010-04-12 |
2013-12-20 |
Somalogic Inc |
Aptamers to beta-ngf and their use in treating beta-ngf mediated diseases and disorders
|
|
EP2564200B8
(en)
|
2010-04-27 |
2019-10-02 |
The Regents of The University of California |
Cancer biomarkers and methods of use thereof
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139702A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CA3220104A1
(en)
|
2010-06-08 |
2011-12-15 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
EP2449113B8
(en)
|
2010-07-30 |
2015-11-25 |
CureVac AG |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
DK2620428T3
(da)
|
2010-09-24 |
2019-07-01 |
Wave Life Sciences Ltd |
Asymmetrisk hjælpegruppe
|
|
EP2857499A1
(en)
|
2010-10-01 |
2015-04-08 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP3521451A1
(en)
|
2010-11-17 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
AR084358A1
(es)
|
2010-12-27 |
2013-05-08 |
Lilly Co Eli |
Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
|
|
PT2658570T
(pt)
|
2010-12-27 |
2019-02-08 |
Elanco Us Inc |
Composições e métodos vacinais contra o vírus da diarreia viral bovina tipo 1b
|
|
KR20130130806A
(ko)
|
2010-12-30 |
2013-12-02 |
다우 아그로사이언시즈 엘엘씨 |
딱정벌레목 해충에 대한 저항성을 부여하는 핵산 분자
|
|
AU2011351969A1
(en)
|
2010-12-30 |
2013-07-25 |
Dow Agrosciences Llc |
Nucleic acid molecules that target the RHO1 small GTP-binding protein and confer resistance to coleopteran pests
|
|
BRPI1107329A2
(pt)
|
2010-12-30 |
2019-11-19 |
Dow Agrosciences Llc |
moléculas de ácido nucléico que direcionadas à subunidade h de atpase vacuolar que conferem resistência a pragas de coleópteros, vetor de transformação de planta, célula transformada, bem como métodos para controlar uma população de praga de coleóptero, controlar uma infestação pela dita praga, melhorar o rendimento de uma safra e para produzir uma célula transgênica
|
|
WO2012092573A2
(en)
|
2010-12-30 |
2012-07-05 |
Dow Agrosciences Llc |
Nucleic acid molecules that target the vacuolar atpase c subunit and confer resistance to coleopteran pests
|
|
CA2831613A1
(en)
|
2011-03-31 |
2012-10-04 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
EP2714939B1
(en)
|
2011-05-24 |
2015-04-15 |
Elitech Holding B.V. |
Detection of methicillin-resistant staphylococcus aureus
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
MX340053B
(es)
|
2011-06-15 |
2016-06-22 |
Grifols Therapeutics Inc * |
Metodos, composiciones y kits para determinar el virus de la inmunodeficiencia humana (vih).
|
|
CN107365339A
(zh)
|
2011-07-19 |
2017-11-21 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
|
WO2013016321A1
(en)
|
2011-07-26 |
2013-01-31 |
Elitech Holding B.V. |
Minor groove binder phosphoramidites and methods of use
|
|
CN103764829B
(zh)
|
2011-09-07 |
2016-06-01 |
基立福疗法公司 |
用于测定甲肝病毒的方法、组合物和试剂盒
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
PT3682905T
(pt)
|
2011-10-03 |
2022-04-07 |
Modernatx Inc |
Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
|
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
|
ES2923757T3
(es)
|
2011-12-16 |
2022-09-30 |
Modernatx Inc |
Composiciones de ARNm modificado
|
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
|
WO2013151664A1
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins
|
|
WO2013148147A1
(en)
|
2012-03-26 |
2013-10-03 |
The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services |
Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
WO2013166304A1
(en)
|
2012-05-02 |
2013-11-07 |
Ibis Biosciences, Inc. |
Dna sequencing
|
|
WO2013166303A1
(en)
|
2012-05-02 |
2013-11-07 |
Ibis Biosciences, Inc. |
Dna sequencing
|
|
WO2013173844A1
(en)
|
2012-05-18 |
2013-11-21 |
Pacific Biosciences Of California, Inc. |
Heteroarylcyanine dyes
|
|
EA201492055A1
(ru)
|
2012-06-08 |
2015-11-30 |
Шир Хьюман Дженетик Терапис, Инк. |
ИНГАЛЯЦИОННАЯ ДОСТАВКА мРНК В НЕЛЕГОЧНЫЕ КЛЕТКИ-МИШЕНИ
|
|
SG11201500243WA
(en)
|
2012-07-13 |
2015-04-29 |
Shin Nippon Biomedical Lab Ltd |
Chiral nucleic acid adjuvant
|
|
WO2014010250A1
(en)
|
2012-07-13 |
2014-01-16 |
Chiralgen, Ltd. |
Asymmetric auxiliary group
|
|
DK2872147T3
(da)
|
2012-07-13 |
2023-02-20 |
Wave Life Sciences Ltd |
Fremgangsmåde til fremstilling af kirale oligonukleotider
|
|
WO2014028739A1
(en)
|
2012-08-15 |
2014-02-20 |
Isis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified capping protocols
|
|
JP2015529073A
(ja)
|
2012-08-20 |
2015-10-05 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
生物可逆性基を有するポリヌクレオチド
|
|
WO2014030066A2
(en)
|
2012-08-22 |
2014-02-27 |
Bernitz Mats Nilsson |
Methods for identifying nucleic acid sequences
|
|
US10294261B2
(en)
*
|
2012-09-04 |
2019-05-21 |
Kabushiki Kaisha Dnaform |
Compound, nucleic acid, labeling substance, and detection method
|
|
MX2015004191A
(es)
|
2012-10-04 |
2016-04-04 |
Univ Leland Stanford Junior |
Metodos y reactivos para la deteccion, cuantificacion y serotipado de virus del dengue.
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP3415638B1
(en)
|
2012-10-18 |
2025-10-08 |
IDEXX Laboratories, Inc. |
Nucleic acid amplification controls and kits and methods of use thereof
|
|
WO2014072832A2
(en)
|
2012-10-18 |
2014-05-15 |
Oslo Universitetstssykehus Hf |
Biomarkers for cervical cancer
|
|
PT2922554T
(pt)
|
2012-11-26 |
2022-06-28 |
Modernatx Inc |
Arn modificado nas porções terminais
|
|
DK2951191T3
(en)
|
2013-01-31 |
2019-01-14 |
Ionis Pharmaceuticals Inc |
PROCEDURE FOR MANUFACTURING OLIGOMERIC COMPOUNDS USING MODIFIED CLUTCH PROTOCOLS
|
|
EA201591229A1
(ru)
|
2013-03-14 |
2016-01-29 |
Шир Хьюман Дженетик Терапис, Инк. |
Способы очистки матричной рнк
|
|
EP3932947A1
(en)
|
2013-03-14 |
2022-01-05 |
Translate Bio MA, Inc. |
Methods and compositions for delivering mrna coded antibodies
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
PL2992098T3
(pl)
|
2013-05-01 |
2019-09-30 |
Ionis Pharmaceuticals, Inc. |
Kompozycje i sposoby modulowania ekspresji hbv i ttr
|
|
WO2014197714A1
(en)
|
2013-06-05 |
2014-12-11 |
Am Chemicals Llc |
Phosphoramidite building blocks for sugar-conjugated oligonucleotides
|
|
US9069358B2
(en)
|
2013-06-24 |
2015-06-30 |
Biolytic Lab Performance, Inc. |
System for controlling and optimizing reactions in solid phase synthesis of small molecules
|
|
KR102160389B1
(ko)
|
2013-08-05 |
2020-09-28 |
트위스트 바이오사이언스 코포레이션 |
드 노보 합성된 유전자 라이브러리
|
|
PL3035955T3
(pl)
|
2013-08-21 |
2020-03-31 |
Curevac Ag |
Kompozycja i szczepionka do leczenia raka płuca
|
|
BR112016003361A2
(pt)
|
2013-08-21 |
2017-11-21 |
Curevac Ag |
vacina do vírus sincicial respiratório (rsv)
|
|
KR20160067219A
(ko)
|
2013-10-03 |
2016-06-13 |
모더나 세라퓨틱스, 인코포레이티드 |
저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
US9758546B2
(en)
|
2013-10-21 |
2017-09-12 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
EP3574923A1
(en)
|
2013-10-22 |
2019-12-04 |
Translate Bio, Inc. |
Mrna therapy for phenylketonuria
|
|
ES2707966T3
(es)
|
2013-10-22 |
2019-04-08 |
Translate Bio Inc |
Terapia de ARNm para la deficiencia en síntesis de argininosuccinato
|
|
ES3032935T3
(en)
|
2013-10-22 |
2025-07-29 |
Translate Bio Inc |
Lipid formulations for delivery of messenger rna
|
|
AU2014340149B2
(en)
|
2013-10-22 |
2020-12-24 |
Shire Human Genetic Therapies, Inc. |
CNS delivery of mRNA and uses thereof
|
|
WO2015062738A1
(en)
|
2013-11-01 |
2015-05-07 |
Curevac Gmbh |
Modified rna with decreased immunostimulatory properties
|
|
WO2015073707A1
(en)
|
2013-11-15 |
2015-05-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of treating heart failure with agonists of hypocretin receptor 2
|
|
CA2928207C
(en)
|
2013-11-21 |
2020-09-15 |
Somalogic, Inc. |
Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
|
|
JP6772062B2
(ja)
|
2013-12-02 |
2020-10-21 |
フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. |
癌の免疫療法
|
|
BR102014031844A2
(pt)
|
2013-12-20 |
2015-10-06 |
Dow Agrosciences Llc |
ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros
|
|
MX2016008263A
(es)
|
2013-12-20 |
2017-05-09 |
Dow Agrosciences Llc |
Moleculas de acido nucleico rnapii 140 que confieren resistencia a plagas de coleopteros.
|
|
CA2927254C
(en)
|
2013-12-30 |
2023-10-24 |
Curevac Ag |
Artificial nucleic acid molecules
|
|
EP3090053B1
(en)
|
2013-12-30 |
2018-11-21 |
CureVac AG |
Artificial nucleic acid molecules
|
|
AU2014375402B2
(en)
|
2013-12-30 |
2020-10-01 |
CureVac SE |
Artificial nucleic acid molecules
|
|
WO2015108046A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
EP3095461A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3095459A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
EP3094728B1
(en)
|
2014-01-16 |
2022-03-09 |
Wave Life Sciences Ltd. |
Chiral design
|
|
EP3119789B1
(en)
|
2014-03-17 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
SI3119888T1
(sl)
|
2014-03-19 |
2021-11-30 |
Ionis Pharmaceuticals, Inc. |
Sestavki za moduliranje izražanja ataksina 2
|
|
PL3122878T3
(pl)
|
2014-03-24 |
2019-06-28 |
Translate Bio, Inc. |
TERAPIA mRNA DO LECZENIA CHORÓB OCZU
|
|
HUE050704T2
(hu)
|
2014-04-01 |
2020-12-28 |
Biogen Ma Inc |
Összetételek a SOD-1 expressziójának modulálására
|
|
WO2015149944A2
(en)
|
2014-04-01 |
2015-10-08 |
Curevac Gmbh |
Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
|
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
EP4729528A3
(en)
|
2014-04-25 |
2026-06-24 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
CA2947270A1
(en)
|
2014-04-28 |
2015-11-05 |
Rxi Pharmaceuticals Corporation |
Methods for treating cancer using nucleic acids targeting mdm2 or mycn
|
|
US9926556B2
(en)
|
2014-04-28 |
2018-03-27 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
CN106255697B
(zh)
|
2014-04-30 |
2020-04-28 |
安捷伦科技有限公司 |
磷保护基团及其制备方法和用途
|
|
EP3137115B1
(en)
|
2014-05-01 |
2020-10-14 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
|
CR20160554A
(es)
|
2014-05-01 |
2017-03-07 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para modular la expresión del factor b del complemento
|
|
AU2015255995B2
(en)
|
2014-05-07 |
2018-05-10 |
Dow Agrosciences Llc |
Dre4 nucleic acid molecules that confer resistance to coleopteran pests
|
|
WO2015175870A1
(en)
|
2014-05-16 |
2015-11-19 |
Life Technologies Corporation |
Carbopyronone compounds useful as diagnostic adjuvants
|
|
WO2015184256A2
(en)
|
2014-05-30 |
2015-12-03 |
Shire Human Genetic Therapies, Inc. |
Biodegradable lipids for delivery of nucleic acids
|
|
EP3154996B1
(en)
|
2014-06-10 |
2020-03-11 |
Agilent Technologies, Inc. |
Protecting groups for "z nucleotide" and methods thereof
|
|
KR102559979B1
(ko)
|
2014-06-24 |
2023-07-25 |
샤이어 휴먼 지네틱 테라피즈 인크. |
핵산의 전달용 입체화학적으로 풍부한 조성물
|
|
WO2016004318A1
(en)
|
2014-07-02 |
2016-01-07 |
Shire Human Genetic Therapies, Inc. |
Encapsulation of messenger rna
|
|
US10093967B2
(en)
|
2014-08-12 |
2018-10-09 |
The Regents Of The University Of Michigan |
Detection of nucleic acids
|
|
EP3188799B1
(en)
|
2014-09-05 |
2022-07-06 |
Phio Pharmaceuticals Corp. |
Methods for treating aging and skin disorders using nucleic acids targeting tyr or mmp1
|
|
WO2016040748A1
(en)
|
2014-09-12 |
2016-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for detection of smn protein in a subject and treatment of a subject
|
|
JP2017531620A
(ja)
|
2014-09-12 |
2017-10-26 |
ジェネンテック, インコーポレイテッド |
システイン操作抗体及びコンジュゲート
|
|
BR112017007923B1
(pt)
|
2014-10-17 |
2023-12-12 |
The Penn State Research Foundation |
Método para produzir manipulação genética mediada por reações multiplex com rna em uma célula receptora, construção de ácido nucleico,cassete de expressão, vetor, célula receptora e célula geneticamente modificada
|
|
AU2015357562B2
(en)
|
2014-12-05 |
2021-10-21 |
Translate Bio, Inc. |
Messenger RNA therapy for treatment of articular disease
|
|
WO2016090323A1
(en)
|
2014-12-05 |
2016-06-09 |
Prelude, Inc. |
Dcis recurrence and invasive breast cancer
|
|
EP4023755B1
(en)
|
2014-12-12 |
2023-04-26 |
CureVac SE |
Artificial nucleic acid molecules for improved protein expression
|
|
EP3230468B1
(en)
|
2014-12-12 |
2020-09-16 |
ELITechGroup, Inc. |
Methods and kits for detecting antibiotic resistant bacteria
|
|
EP3230467A1
(en)
|
2014-12-12 |
2017-10-18 |
ELITechGroup B.V. |
Methods and compositions for detecting antibiotic resistant bacteria
|
|
EP3037432B1
(en)
|
2014-12-22 |
2020-06-17 |
Dow AgroSciences LLC |
Nucampholin nucleic acid molecules to control coleopteran insect pests
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
BR112017009835A2
(pt)
|
2014-12-30 |
2017-12-26 |
Curevac Ag |
moléculas de ácido nucleico artificiais
|
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
CA2975852A1
(en)
|
2015-02-04 |
2016-08-11 |
Twist Bioscience Corporation |
Methods and devices for de novo oligonucleic acid assembly
|
|
CA2975855C
(en)
|
2015-02-04 |
2025-09-23 |
Twist Bioscience Corporation |
SYNTHETIC GENE COMPOSITIONS AND ASSEMBLY METHODS
|
|
US10450342B2
(en)
|
2015-02-23 |
2019-10-22 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
US20160264991A1
(en)
|
2015-03-13 |
2016-09-15 |
Dow Agrosciences Llc |
Rna polymerase i1 nucleic acid molecules to control insect pests
|
|
EP3270894B1
(en)
|
2015-03-19 |
2021-02-24 |
Translate Bio, Inc. |
Mrna therapy for pompe disease
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
WO2016172377A1
(en)
|
2015-04-21 |
2016-10-27 |
Twist Bioscience Corporation |
Devices and methods for oligonucleic acid library synthesis
|
|
BR102016012010A2
(pt)
|
2015-05-29 |
2020-03-24 |
Dow Agrosciences Llc |
Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica
|
|
GB201511470D0
(en)
|
2015-06-30 |
2015-08-12 |
Cellcall Kft |
HPV detection method
|
|
US10808247B2
(en)
|
2015-07-06 |
2020-10-20 |
Phio Pharmaceuticals Corp. |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
US11001845B2
(en)
|
2015-07-06 |
2021-05-11 |
Phio Pharmaceuticals Corp. |
Nucleic acid molecules targeting superoxide dismutase 1 (SOD1)
|
|
CN117965536A
(zh)
|
2015-07-22 |
2024-05-03 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
US11458205B2
(en)
|
2015-08-04 |
2022-10-04 |
Duke University |
Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
|
|
US12258567B2
(en)
|
2015-08-28 |
2025-03-25 |
CureVac SE |
Artificial nucleic acid molecules
|
|
KR20180050411A
(ko)
|
2015-09-18 |
2018-05-14 |
트위스트 바이오사이언스 코포레이션 |
올리고핵산 변이체 라이브러리 및 그의 합성
|
|
WO2017053450A1
(en)
|
2015-09-22 |
2017-03-30 |
Twist Bioscience Corporation |
Flexible substrates for nucleic acid synthesis
|
|
WO2017053781A1
(en)
|
2015-09-25 |
2017-03-30 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
|
US11021707B2
(en)
|
2015-10-19 |
2021-06-01 |
Phio Pharmaceuticals Corp. |
Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
|
|
EP3374504B1
(en)
|
2015-11-09 |
2025-03-19 |
CureVac SE |
Optimized nucleic acid molecules
|
|
EP3384077A4
(en)
|
2015-12-01 |
2019-05-08 |
Twist Bioscience Corporation |
FUNCTIONALIZED SURFACES AND MANUFACTURE THEREOF
|
|
EP3389670A4
(en)
|
2015-12-04 |
2020-01-08 |
Ionis Pharmaceuticals, Inc. |
METHODS OF TREATING BREAST CANCER
|
|
US11752213B2
(en)
|
2015-12-21 |
2023-09-12 |
Duke University |
Surfaces having reduced non-specific binding and antigenicity
|
|
JPWO2017111137A1
(ja)
|
2015-12-22 |
2018-10-18 |
味の素株式会社 |
オリゴヌクレオチドの製造方法
|
|
WO2017117496A1
(en)
|
2015-12-31 |
2017-07-06 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
EP3400300A4
(en)
|
2016-01-05 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
PROCESS FOR REDUCING LRRK2 EXPRESSION
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
CA3013799A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
|
AU2017248189B2
(en)
|
2016-04-08 |
2021-04-29 |
Translate Bio, Inc. |
Multimeric coding nucleic acid and uses thereof
|
|
WO2017180420A1
(en)
|
2016-04-11 |
2017-10-19 |
Board Of Regents, The University Of Texas System |
Methods and compositions for detecting single t cell receptor affinity and sequence
|
|
WO2017210476A1
(en)
|
2016-06-01 |
2017-12-07 |
Duke University |
Nonfouling biosensors
|
|
AU2017283479B2
(en)
|
2016-06-13 |
2023-08-17 |
Translate Bio, Inc. |
Messenger RNA therapy for the treatment of ornithine transcarbamylase deficiency
|
|
AU2017286811A1
(en)
|
2016-06-17 |
2018-11-22 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
|
WO2018013999A1
(en)
|
2016-07-15 |
2018-01-18 |
Am Chemicals Llc |
Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis
|
|
EP3494139B1
(en)
|
2016-08-05 |
2022-01-12 |
F. Hoffmann-La Roche AG |
Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
|
|
WO2018035380A1
(en)
|
2016-08-17 |
2018-02-22 |
Solstice Biologics, Ltd. |
Polynucleotide constructs
|
|
WO2018033454A1
(en)
|
2016-08-19 |
2018-02-22 |
Fundación Para La Investigación Biomédica Del Hospital Universitario Ramón Y Cajal |
Mir-127 agents for use in the treatment of renal fibrosis
|
|
WO2018038772A1
(en)
|
2016-08-22 |
2018-03-01 |
Twist Bioscience Corporation |
De novo synthesized nucleic acid libraries
|
|
EP4664304A3
(en)
|
2016-09-21 |
2026-01-21 |
Atlas Data Storage, Inc. |
Nucleic acid based data storage
|
|
KR20190064600A
(ko)
|
2016-09-23 |
2019-06-10 |
듀크 유니버시티 |
Lcst 거동을 갖는 비구조화된 비-반복적 폴리펩티드
|
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
|
WO2018089237A1
(en)
|
2016-11-10 |
2018-05-17 |
Dow Agrosciences Llc |
Cytochrome b (cytb) nucleic acid molecules that control pathogens
|
|
JP7560946B2
(ja)
|
2016-11-10 |
2024-10-03 |
トランスレイト バイオ, インコーポレイテッド |
メッセンジャーrnaの皮下送達
|
|
US20180153822A1
(en)
|
2016-11-10 |
2018-06-07 |
Translate Bio, Inc. |
Process of Preparing mRNA-Loaded Lipid Nanoparticles
|
|
CN116549671A
(zh)
|
2016-11-10 |
2023-08-08 |
川斯勒佰尔公司 |
用于递送mrna的改进的基于ice的脂质纳米颗粒制剂
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
|
GB2573069A
(en)
|
2016-12-16 |
2019-10-23 |
Twist Bioscience Corp |
Variant libraries of the immunological synapse and synthesis thereof
|
|
EP3342780A1
(en)
|
2016-12-30 |
2018-07-04 |
Dow AgroSciences LLC |
Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests
|
|
US11648200B2
(en)
|
2017-01-12 |
2023-05-16 |
Duke University |
Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
|
|
WO2018156792A1
(en)
|
2017-02-22 |
2018-08-30 |
Twist Bioscience Corporation |
Nucleic acid based data storage
|
|
ES2899323T3
(es)
|
2017-02-27 |
2022-03-10 |
Translate Bio Inc |
Métodos de purificación de ARN mensajero
|
|
IL268856B2
(en)
|
2017-02-27 |
2024-09-01 |
Translate Bio Inc |
Methods for purification of messenger rna
|
|
WO2018165257A1
(en)
|
2017-03-07 |
2018-09-13 |
Translate Bio, Inc. |
Polyanionic delivery of nucleic acids
|
|
EP3592768B1
(en)
|
2017-03-08 |
2024-12-25 |
The Regents of The University of Michigan |
Analyte detection
|
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
|
CA3056388A1
(en)
|
2017-03-15 |
2018-09-20 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
|
JP7167059B2
(ja)
|
2017-04-19 |
2022-11-08 |
フィオ ファーマシューティカルズ コーポレーション |
核酸化合物の局所送達
|
|
WO2018213320A1
(en)
|
2017-05-15 |
2018-11-22 |
Duke University |
Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
|
|
IL270631B2
(en)
|
2017-05-16 |
2024-03-01 |
Translate Bio Inc |
Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
|
|
US11530298B2
(en)
|
2017-06-12 |
2022-12-20 |
Translate Bio, Inc. |
Poly(phosphoesters) for delivery of nucleic acids
|
|
WO2018231864A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
|
IL271205B2
(en)
|
2017-06-12 |
2025-02-01 |
Twist Bioscience Corp |
Methods for assembling continuous nucleic acids
|
|
US10780183B2
(en)
|
2017-06-19 |
2020-09-22 |
Translate Bio, Inc. |
Messenger RNA therapy for the treatment of Friedreich's ataxia
|
|
US11597744B2
(en)
|
2017-06-30 |
2023-03-07 |
Sirius Therapeutics, Inc. |
Chiral phosphoramidite auxiliaries and methods of their use
|
|
EP3658168A4
(en)
|
2017-06-30 |
2021-07-14 |
Duke University |
ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-RESPONDING BIOPOLYMER NETWORKS
|
|
CA3071033A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
|
CN111566125A
(zh)
|
2017-09-11 |
2020-08-21 |
特韦斯特生物科学公司 |
Gpcr结合蛋白及其合成
|
|
CN111344403B
(zh)
|
2017-09-15 |
2025-05-06 |
利兰斯坦福初级大学董事会 |
遗传工程细胞的多元性产生和条形码编制
|
|
CN111565834B
(zh)
|
2017-10-20 |
2022-08-26 |
特韦斯特生物科学公司 |
用于多核苷酸合成的加热的纳米孔
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
MA51306A
(fr)
|
2017-12-20 |
2020-10-28 |
Translate Bio Inc |
Compositions et procédés améliorés pour le traitement du déficit en ornithine transcarbamylase
|
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
IL312616B2
(en)
|
2018-01-04 |
2025-08-01 |
Twist Bioscience Corp |
Dna-based digital information storage
|
|
CA3088522A1
(en)
|
2018-01-15 |
2019-07-18 |
Ionis Pharmaceuticals, Inc. |
Modulators of dnm2 expression
|
|
WO2019147954A1
(en)
|
2018-01-26 |
2019-08-01 |
Duke University |
Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
|
|
US11975110B2
(en)
|
2018-02-02 |
2024-05-07 |
Translate Bio, Inc. |
Cationic polymers
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
WO2019169243A1
(en)
|
2018-03-02 |
2019-09-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-beta precursor protein
|
|
WO2019183440A1
(en)
|
2018-03-22 |
2019-09-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
|
WO2019200172A1
(en)
|
2018-04-11 |
2019-10-17 |
Ionis Pharmaceuticals, Inc. |
Modulators of ezh2 expression
|
|
EP3774824A1
(en)
|
2018-04-13 |
2021-02-17 |
Bristol-Myers Squibb Company |
Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds
|
|
WO2019213150A1
(en)
|
2018-04-30 |
2019-11-07 |
Duke University |
Stimuli-responsive peg-like polymer-based drug delivery platform
|
|
US11866788B2
(en)
|
2018-05-08 |
2024-01-09 |
Sanford Burnham Prebys Medical Discovery Institute |
Role of PVT1 in the diagnosis and treatment of MYC-driven cancer
|
|
JP2021522800A
(ja)
|
2018-05-09 |
2021-09-02 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Atxn3発現を低減するための化合物及び方法
|
|
IL277970B2
(en)
|
2018-05-09 |
2025-03-01 |
Ionis Pharmaceuticals Inc |
Oligomeric compounds comprising modified oligonucleotides and conjugated groups for use in the treatment of end-stage renal disease, chronic kidney disease and coronary artery disease
|
|
EP3793689A1
(en)
|
2018-05-15 |
2021-03-24 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger rna
|
|
AU2019271215B2
(en)
|
2018-05-16 |
2024-09-12 |
Translate Bio, Inc. |
Ribose cationic lipids
|
|
EP3814497A4
(en)
|
2018-05-18 |
2022-03-02 |
Twist Bioscience Corporation |
POLYNUCLEOTIDES, REAGENTS AND METHODS FOR NUCLEIC ACID HYBRIDIZATION
|
|
US12076439B2
(en)
|
2018-05-24 |
2024-09-03 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
AU2019277355A1
(en)
|
2018-05-30 |
2020-12-17 |
Translate Bio, Inc. |
Phosphoester cationic lipids
|
|
CN118436618A
(zh)
|
2018-05-30 |
2024-08-06 |
川斯勒佰尔公司 |
信使rna疫苗及其用途
|
|
EP3802507A1
(en)
|
2018-05-30 |
2021-04-14 |
Translate Bio, Inc. |
Vitamin cationic lipids
|
|
MA52762A
(fr)
|
2018-05-30 |
2021-04-14 |
Translate Bio Inc |
Lipides cationiques comprenant une fraction stéroïdienne
|
|
US11384376B2
(en)
|
2018-05-31 |
2022-07-12 |
Roche Molecular Systems, Inc. |
Reagents and methods for post-synthetic modification of nucleic acids
|
|
CA3103429A1
(en)
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
WO2020001793A1
(en)
|
2018-06-29 |
2020-01-02 |
Eberhard-Karls-Universität Tübingen |
Artificial nucleic acids for rna editing
|
|
WO2020018558A1
(en)
|
2018-07-17 |
2020-01-23 |
Aronora, Inc. |
Methods for safely reducing thrombopoietin
|
|
WO2020023533A1
(en)
|
2018-07-23 |
2020-01-30 |
Translate Bio, Inc. |
Dry power formulations for messenger rna
|
|
AU2019310097A1
(en)
|
2018-07-25 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ATXN2 expression
|
|
EP3829622A4
(en)
|
2018-08-02 |
2022-05-11 |
Duke University |
DOUBLE AGONIST FUSION PROTEINS
|
|
US11174500B2
(en)
|
2018-08-24 |
2021-11-16 |
Translate Bio, Inc. |
Methods for purification of messenger RNA
|
|
EP3843709A1
(en)
|
2018-08-29 |
2021-07-07 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
WO2020051541A1
(en)
|
2018-09-07 |
2020-03-12 |
Duke University |
Nanoparticulate drug delivery systems
|
|
EP3849617A1
(en)
|
2018-09-14 |
2021-07-21 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
|
WO2020056338A1
(en)
|
2018-09-14 |
2020-03-19 |
Prelude Corporation |
Method of selection for treatment of subjects at risk of invasive breast cancer
|
|
CN112888451A
(zh)
|
2018-10-19 |
2021-06-01 |
川斯勒佰尔公司 |
信使rna的无泵包封
|
|
CA3115119A1
(en)
|
2018-11-08 |
2020-05-14 |
Translate Bio, Inc. |
Methods and compositions for messenger rna purification
|
|
KR102860605B1
(ko)
|
2018-11-09 |
2025-09-15 |
트랜슬레이트 바이오 인코포레이티드 |
에스테르, 티오에스테르, 이황화물, 및 무수물 모이어티가 삽입된 2,5-디옥소피페라진
|
|
US20220016265A1
(en)
|
2018-11-09 |
2022-01-20 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
|
WO2020097379A2
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
|
CA3117866A1
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Multi-peg lipid compounds
|
|
EP3880174A2
(en)
|
2018-11-12 |
2021-09-22 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
MX2021005758A
(es)
|
2018-11-15 |
2021-09-21 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresión de irf5.
|
|
US12281305B2
(en)
|
2018-11-21 |
2025-04-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing prion expression
|
|
AU2019384557B2
(en)
|
2018-11-21 |
2025-07-17 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR
|
|
US12257305B2
(en)
|
2018-11-21 |
2025-03-25 |
Translate Bio, Inc. |
Cationic lipid compounds
|
|
EP3902816A4
(en)
|
2018-12-26 |
2022-09-14 |
Twist Bioscience Corporation |
HIGH-PRECISION DE NOVO POLYNUCLEOTIDE SYNTHESIS
|
|
WO2020146344A1
(en)
|
2019-01-07 |
2020-07-16 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
TW202214854A
(zh)
|
2019-01-31 |
2022-04-16 |
美商Ionis製藥公司 |
Yap1表現之調節劑
|
|
CA3129265A1
(en)
|
2019-02-08 |
2020-08-13 |
The Board Of Trustees Of The Leland Stanford Junor University |
Production and tracking of engineered cells with combinatorial genetic modifications
|
|
KR20210144698A
(ko)
|
2019-02-26 |
2021-11-30 |
트위스트 바이오사이언스 코포레이션 |
항체 최적화를 위한 변이 핵산 라이브러리
|
|
CA3131689A1
(en)
|
2019-02-26 |
2020-09-03 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for glp1 receptor
|
|
WO2020176771A1
(en)
|
2019-02-27 |
2020-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of malat1 expression
|
|
TW202536179A
(zh)
|
2019-03-29 |
2025-09-16 |
美商Ionis製藥公司 |
用於調節ube3a-ats之化合物及方法
|
|
WO2020214946A1
(en)
|
2019-04-18 |
2020-10-22 |
Translate Bio, Inc. |
Cystine cationic lipids
|
|
EP3959195B1
(en)
|
2019-04-22 |
2023-11-08 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
WO2020227085A1
(en)
|
2019-05-03 |
2020-11-12 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
|
AU2020274758B2
(en)
|
2019-05-14 |
2025-05-01 |
Translate Bio, Inc. |
Improved process of preparing mRNA-loaded lipid nanoparticles
|
|
US11453877B2
(en)
|
2019-05-15 |
2022-09-27 |
Translate Bio, Inc. |
Methods for purification of messenger RNA
|
|
EP3976593A1
(en)
|
2019-05-31 |
2022-04-06 |
Translate Bio, Inc. |
Macrocyclic lipids
|
|
EP3986858A1
(en)
|
2019-06-21 |
2022-04-27 |
Translate Bio, Inc. |
Tricine and citric acid lipids
|
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
|
EP3987019A4
(en)
|
2019-06-21 |
2023-04-19 |
Twist Bioscience Corporation |
Barcode-based nucleic acid sequence assembly
|
|
CA3146369A1
(en)
|
2019-07-08 |
2021-01-14 |
Translate Bio, Inc. |
Improved mrna-loaded lipid nanoparticles and processes of making the same
|
|
US11512314B2
(en)
|
2019-07-12 |
2022-11-29 |
Duke University |
Amphiphilic polynucleotides
|
|
AU2020315962B2
(en)
|
2019-07-23 |
2026-02-12 |
Translate Bio, Inc. |
Stable compositions of mRNA-loaded lipid nanoparticles and processes of making
|
|
PL3956450T3
(pl)
|
2019-07-26 |
2025-12-22 |
Ionis Pharmaceuticals, Inc. |
Związki i sposoby modulowania gfap
|
|
IL290078B2
(en)
|
2019-07-30 |
2025-09-01 |
Translate Bio Inc |
Treatment of cystic fibrosis by administering mRNA encoding CFTR in the form of a fine spray
|
|
KR20220062517A
(ko)
|
2019-08-15 |
2022-05-17 |
아이오니스 파마수티컬즈, 인코포레이티드 |
결합 변형된 올리고머 화합물 및 이의 용도
|
|
WO2021055846A1
(en)
|
2019-09-19 |
2021-03-25 |
Sanford Burnham Prebys Medical Discovery Institute |
Methods and compositions for treating myc-driven cancers
|
|
US12091777B2
(en)
|
2019-09-23 |
2024-09-17 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for CRTH2
|
|
CN115023440B
(zh)
|
2019-09-23 |
2025-09-12 |
特韦斯特生物科学公司 |
结合CD3ε的抗体
|
|
AU2020400030B2
(en)
|
2019-12-09 |
2026-05-21 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for adenosine receptors
|
|
MX2022007756A
(es)
|
2019-12-20 |
2022-09-27 |
Translate Bio Inc |
Suministro rectal de arn mensajero.
|
|
JP2023508881A
(ja)
|
2019-12-20 |
2023-03-06 |
トランスレイト バイオ, インコーポレイテッド |
Mrna担持脂質ナノ粒子を調製する改善されたプロセス
|
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
|
CA3170319A1
(en)
|
2020-02-10 |
2021-08-19 |
Translate Bio, Inc. |
Methods and compositions for messenger rna purification
|
|
CN115427021A
(zh)
|
2020-02-25 |
2022-12-02 |
翻译生物公司 |
制备负载mrna的脂质纳米颗粒的改进方法
|
|
AU2021225957A1
(en)
|
2020-02-28 |
2022-09-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating SMN2
|
|
CN115667207B
(zh)
|
2020-04-01 |
2025-09-16 |
翻译生物公司 |
基于酚酸脂质的阳离子脂质
|
|
CN116096890A
(zh)
|
2020-04-02 |
2023-05-09 |
米雷楚莱股份有限公司 |
使用工程化寡核苷酸的靶向抑制
|
|
TWI901676B
(zh)
|
2020-05-01 |
2025-10-21 |
美商Ionis製藥公司 |
調節atxn1之化合物及方法
|
|
WO2021226463A1
(en)
|
2020-05-07 |
2021-11-11 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
ES3066134T3
(en)
|
2020-05-14 |
2026-05-11 |
Translate Bio Inc |
Peg lipidoid compounds
|
|
JP7873638B2
(ja)
|
2020-05-15 |
2026-06-12 |
トランスレイト バイオ, インコーポレイテッド |
mRNA送達のための脂質ナノ粒子製剤
|
|
CA3178965A1
(en)
|
2020-05-15 |
2021-11-18 |
Christian COBAUGH |
Messenger rna encoding cas9 for use in genome-editing systems
|
|
TW202216996A
(zh)
|
2020-06-29 |
2022-05-01 |
美商Ionis製藥公司 |
調節plp1之化合物及方法
|
|
US20240307556A1
(en)
|
2020-07-02 |
2024-09-19 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
|
MX2023001222A
(es)
|
2020-07-28 |
2023-04-26 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para reducir la expresion de app.
|
|
IL300258A
(en)
|
2020-08-07 |
2023-03-01 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulating SCN2A
|
|
JP7844452B2
(ja)
|
2020-09-23 |
2026-04-13 |
トランスレイト バイオ, インコーポレイテッド |
Tesベースのカチオン性脂質
|
|
WO2022066916A1
(en)
|
2020-09-23 |
2022-03-31 |
Translate Bio, Inc. |
Piperazine-based cationic lipids
|
|
EP4222258A2
(en)
|
2020-10-01 |
2023-08-09 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
CA3194863A1
(en)
|
2020-10-06 |
2022-04-14 |
Shrirang KARVE |
Improved process and formulation of lipid nanoparticles
|
|
WO2022078569A1
(en)
|
2020-10-12 |
2022-04-21 |
Eberhard Karls Universität Tübingen |
Artificial nucleic acids for rna editing
|
|
US12678406B2
(en)
|
2020-10-12 |
2026-07-14 |
Translate Bio Inc. |
Process of preparing ice-based lipid nanoparticles
|
|
CA3198411A1
(en)
|
2020-10-12 |
2022-04-21 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
WO2022099003A1
(en)
|
2020-11-06 |
2022-05-12 |
Sanofi |
Lipid nanoparticles for delivering mrna vaccines
|
|
KR20230108728A
(ko)
|
2020-11-18 |
2023-07-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
앤지오텐시노겐 발현을 조절하기 위한 화합물 및 방법
|
|
AR124408A1
(es)
|
2020-12-18 |
2023-03-22 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular el factor xii
|
|
US20240226307A9
(en)
|
2021-02-22 |
2024-07-11 |
Duke University |
Non-immunogenic poegma-aptamer conjugates
|
|
WO2022183015A1
(en)
|
2021-02-26 |
2022-09-01 |
The Regents Of The University Of California |
Assembled three-dimensional cultures of human neurons and glia and their use
|
|
TW202309002A
(zh)
|
2021-04-15 |
2023-03-01 |
美商轉譯生技公司 |
基於「古德」緩衝液的陽離子脂質
|
|
WO2022240960A1
(en)
|
2021-05-14 |
2022-11-17 |
Crispr Therapeutics Ag |
Mrna large scale synthesis and purification
|
|
EP4347110B1
(en)
|
2021-05-31 |
2026-07-08 |
Genscript USA Inc. |
Electrografted films for dna synthesis
|
|
US20240262878A1
(en)
|
2021-06-07 |
2024-08-08 |
The Board Of Trustees Of The University Of Illinois |
Photoactivatable gasdermin proteins
|
|
US11753644B2
(en)
|
2021-06-18 |
2023-09-12 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing IFNAR1 expression
|
|
AU2022294274A1
(en)
|
2021-06-18 |
2024-02-01 |
Sanofi Pasteur Inc. |
Multivalent influenza vaccines
|
|
CN117677698A
(zh)
|
2021-07-14 |
2024-03-08 |
米雷楚来股份有限公司 |
用于神经肌肉障碍的寡核苷酸及其组合物
|
|
WO2023031856A1
(en)
|
2021-09-02 |
2023-03-09 |
Sanofi |
Compositions and methods for rna affinity purification
|
|
EP4395933A1
(en)
|
2021-09-03 |
2024-07-10 |
Elegen Corporation |
Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
|
|
KR20240065326A
(ko)
|
2021-10-05 |
2024-05-14 |
사노피 |
지질 나노입자(lnp)를 냉동 및 냉동-건조하는 방법 및 이를 사용하여 수득된 lnp
|
|
WO2023059412A1
(en)
|
2021-10-05 |
2023-04-13 |
Microsoft Technology Licensing, Llc |
Regulation of dna synthesis by nucleotides linked to protecting groups
|
|
WO2023077107A1
(en)
|
2021-10-29 |
2023-05-04 |
Sana Biotechnology, Inc. |
Methods and reagents for amplifying viral vector nucleic acid products
|
|
US20230302112A1
(en)
|
2021-11-05 |
2023-09-28 |
Sanofi |
Respiratory synctial virus rna vaccine
|
|
JP2024545572A
(ja)
|
2021-11-10 |
2024-12-10 |
トランスレイト バイオ, インコーポレイテッド |
原発性線毛機能不全の治療のための組成物及び方法
|
|
AR127808A1
(es)
|
2021-11-30 |
2024-02-28 |
Sanofi Pasteur Inc |
Vacunas contra el metapneumovirus humano
|
|
CA3242439A1
(en)
|
2021-12-17 |
2023-06-22 |
Sanofi |
Lyme disease rna vaccine
|
|
JP2025504430A
(ja)
|
2022-01-17 |
2025-02-12 |
サノフイ |
脂質化合物及びその使用
|
|
JP2025506248A
(ja)
|
2022-02-21 |
2025-03-07 |
コンセプト トゥー メディシン バイオテック カンパニー, リミテッド |
抗5t4抗体およびその使用
|
|
EP4493548A1
(en)
|
2022-03-16 |
2025-01-22 |
Translate Bio, Inc. |
Asymmetric piperazine-based cationic lipids
|
|
AU2023242443A1
(en)
|
2022-03-28 |
2024-08-29 |
F. Hoffmann-La Roche Ag |
Synthesis of isomerically pure polyol-based phosphoramidites
|
|
CN121318878A
(zh)
|
2022-04-13 |
2026-01-13 |
赛诺菲 |
基于“古德”缓冲液的阳离子脂质
|
|
WO2023214082A2
(en)
|
2022-05-06 |
2023-11-09 |
Sanofi |
Signal sequences for nucleic acid vaccines
|
|
CN119421716A
(zh)
|
2022-06-17 |
2025-02-11 |
赛诺菲 |
用于环状rna亲和纯化的组合物和方法
|
|
CN119487130A
(zh)
|
2022-06-28 |
2025-02-18 |
豪夫迈·罗氏有限公司 |
具有大斯托克斯位移的荧光染料
|
|
AU2023316794A1
(en)
|
2022-07-29 |
2025-03-13 |
Sanofi Pasteur Inc. |
Methods for ethanol-free mrna purification
|
|
JP2025529906A
(ja)
|
2022-08-22 |
2025-09-09 |
ザ ヘンリー エム ジャクソン ファンデイション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド |
コロナウイルスに対するワクチン
|
|
JP2025532127A
(ja)
|
2022-09-23 |
2025-09-29 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Mecp2発現を低減する化合物及び方法
|
|
EP4360657A1
(en)
|
2022-10-28 |
2024-05-01 |
Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal |
Mir-326 for the treatment of cancer
|
|
JP2025536595A
(ja)
|
2022-11-04 |
2025-11-07 |
サノフィ パスツール インコーポレイテッド |
メッセンジャーrnaテール付加の方法
|
|
KR20250099727A
(ko)
|
2022-11-04 |
2025-07-02 |
사노피 파스퇴르 인크 |
호흡기 세포융합 바이러스 rna 백신접종
|
|
WO2024099575A1
(en)
|
2022-11-11 |
2024-05-16 |
Eberhard Karls Universität Tübingen |
Artificial nucleic acids for site-directed editing of a target rna
|
|
EP4622630A1
(en)
|
2022-11-21 |
2025-10-01 |
Translate Bio, Inc. |
Compositions of dry powder formulations of messenger rna and methods of use thereof
|
|
CN120659802A
(zh)
|
2022-12-15 |
2025-09-16 |
赛诺菲巴斯德有限公司 |
mRNA重组加帽酶
|
|
EP4638415A1
(en)
|
2022-12-22 |
2025-10-29 |
Sanofi Pasteur Inc. |
Bis-ester and amide cationic lipids
|
|
CN120418451A
(zh)
|
2023-01-06 |
2025-08-01 |
Dna斯克瑞普特公司 |
用于获得正确组装核酸的方法
|
|
GB202300915D0
(en)
|
2023-01-20 |
2023-03-08 |
Sisaf Ltd |
mRNA COMPOSITIONS
|
|
AR132053A1
(es)
|
2023-03-02 |
2025-05-21 |
Sanofi Pasteur |
Composiciones para su uso en el tratamiento de clamidia
|
|
EP4666070A2
(en)
|
2023-03-31 |
2025-12-24 |
The Regents of University of California |
Induced pluripotent stem cell model of fibrous dysplasia/mccune-albright syndrome and methods of use
|
|
KR20260021596A
(ko)
|
2023-04-05 |
2026-02-13 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Pln 발현을 감소시키는 화합물 및 방법
|
|
MX2025012337A
(es)
|
2023-04-17 |
2026-02-03 |
Sanofi Pasteur Inc |
Formulaciones de polvo seco reconstituibles y métodos de uso de las mismas
|
|
WO2024228121A1
(en)
|
2023-05-02 |
2024-11-07 |
The University Of Tokyo |
Long interspersed nuclear element r2 for target-specific gene delivery
|
|
IL324411A
(en)
|
2023-05-05 |
2026-01-01 |
Sanofi Pasteur Inc |
Preparations for use in the treatment of acne
|
|
US20250009865A1
(en)
|
2023-05-10 |
2025-01-09 |
Sanofi |
Combination respiratory mrna vaccines
|
|
JP2026524780A
(ja)
|
2023-06-12 |
2026-07-24 |
サノフイ |
芳香族頭部基を有するステロール系カチオン性脂質
|
|
JP2026524781A
(ja)
|
2023-06-12 |
2026-07-24 |
サノフイ |
芳香族頭部基を有するトリシン及びクエン酸系カチオン性脂質
|
|
MX2025015001A
(es)
|
2023-06-12 |
2026-02-03 |
Sanofi Sa |
Lipidos cationicos basados en tricina y acido citrico
|
|
WO2025003760A1
(en)
|
2023-06-28 |
2025-01-02 |
Sanofi |
Sterol analogs in lipid nanoparticle formulations
|
|
JP2026524354A
(ja)
|
2023-06-28 |
2026-07-22 |
サノフィ ワクチンズ ユーエス インコーポレイテッド |
核酸送達のためのジアンヒドロヘキシトール系イオン化可能な脂質
|
|
JP2026524414A
(ja)
|
2023-06-28 |
2026-07-22 |
サノフィ ワクチンズ ユーエス インコーポレイテッド |
核酸送達のためのヘルパー脂質
|
|
IL325951A
(en)
|
2023-07-19 |
2026-03-01 |
Sanofi Sa |
Porphyromonas gingivalis antigenic constructs
|
|
TW202527960A
(zh)
|
2023-09-06 |
2025-07-16 |
美商賽諾菲巴斯德公司 |
經修飾b型流感血球凝集素多肽及核酸及其用途
|
|
WO2025059511A1
(en)
|
2023-09-15 |
2025-03-20 |
Praxis Precision Medicines, Inc. |
Elsunersen / prax-222 for use in the treatment of scn2a-related disorders
|
|
EP4780812A1
(en)
|
2023-09-20 |
2026-07-29 |
Sanofi |
Good" buffer-based cationic lipids for nucleic acid delivery
|
|
AU2024361969A1
(en)
|
2023-10-16 |
2026-04-23 |
The University Of Tokyo |
R2 retrotransposons for gene writing
|
|
AU2024363859A1
(en)
|
2023-10-18 |
2026-04-09 |
Amgen Inc. |
Evaluation of mrna transcript levels using ddpcr for early pool and single-cell clone assessment in cell line development
|
|
EP4553174A1
(en)
|
2023-11-08 |
2025-05-14 |
Consejo Superior De Investigaciones Científicas |
Methods to determine the thymic function by droplet digital pcr system
|
|
WO2025134071A1
(en)
|
2023-12-22 |
2025-06-26 |
Sanofi |
Malic and glutaric acid based ionizable lipids
|
|
WO2025141521A1
(en)
|
2023-12-29 |
2025-07-03 |
Sanofi |
Lipids having dendritic moieties
|
|
WO2025163146A1
(en)
|
2024-01-31 |
2025-08-07 |
Sanofi |
Methods for ethanol-free mrna purification
|
|
WO2025196065A1
(en)
|
2024-03-20 |
2025-09-25 |
Sanofi |
Novel homocysteine based lipids and their use for delivery of nucleic acids
|
|
WO2025210592A1
(en)
|
2024-04-05 |
2025-10-09 |
Sanofi Pasteur Inc. |
Muscle cell lnp-mrna quality control assays
|
|
WO2025217194A1
(en)
|
2024-04-09 |
2025-10-16 |
Typewriter Therapeutics, Inc. |
Repeat dosing of retrotransposons
|
|
WO2025250906A1
(en)
|
2024-05-30 |
2025-12-04 |
Aera Therapeutics, Inc. |
Process for preparation of targeted lipid nanoparticles
|
|
WO2026006524A2
(en)
|
2024-06-26 |
2026-01-02 |
Sanofi Pasteur Inc. |
Bis-ester and amide cationic lipids
|
|
WO2026003373A1
(en)
|
2024-06-28 |
2026-01-02 |
Sanofi |
Phenolic acid lipid based cationic lipids
|
|
WO2026008743A1
(en)
|
2024-07-02 |
2026-01-08 |
Sanofi Pasteur Inc. |
Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid
|
|
WO2026027730A1
(en)
|
2024-07-31 |
2026-02-05 |
Sanofi |
Modified h5 influenza hemagglutinin polypeptides and nucleic acids and uses thereof
|
|
WO2026033123A1
(en)
|
2024-08-08 |
2026-02-12 |
Sanofi Pasteur Inc. |
Lipid nanoparticle formulations for mrna delivery
|
|
WO2026053147A1
(en)
|
2024-09-05 |
2026-03-12 |
Sanofi Pasteur Inc. |
Helper lipids and lnp compositions comprising same
|
|
WO2026052773A1
(en)
|
2024-09-06 |
2026-03-12 |
Sanofi |
Modified influenza a hemagglutinin polypeptides and nucleic acids and uses thereof
|
|
WO2026052826A1
(en)
|
2024-09-09 |
2026-03-12 |
Roche Diagnostics Gmbh |
Methods for producing fluorescent dyes
|
|
WO2026094020A1
(en)
|
2024-11-04 |
2026-05-07 |
Sanofi Pasteur Inc. |
Phthalic acid and vanillic acid based cationic lipids
|
|
WO2026104670A1
(en)
|
2024-11-15 |
2026-05-21 |
Sanofi Pasteur |
Variants of epstein-barr virus glycoprotein b, nucleic acids encoding the same, and uses thereof
|
|
WO2026142992A1
(en)
|
2024-12-23 |
2026-07-02 |
Sanofi Pasteur Inc. |
Lipid nanoparticle formulations
|
|
WO2026143002A2
(en)
|
2024-12-23 |
2026-07-02 |
Sanofi Pasteur Inc. |
Dianhydrohexitol based ionizable lipids for nucleic acid delivery
|
|
WO2026149921A1
(en)
|
2025-01-09 |
2026-07-16 |
Roche Molecular Systems, Inc. |
Methods for producing rna molecules
|
|
WO2026165320A1
(en)
|
2025-01-31 |
2026-08-06 |
Sanofi Vaccines US Inc. |
Morpholino cationic lipids
|