|
GB9514465D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
US6143746A
(en)
*
|
1994-01-21 |
2000-11-07 |
Icos Corporation |
Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
|
|
GB9511220D0
(en)
*
|
1995-06-02 |
1995-07-26 |
Glaxo Group Ltd |
Solid dispersions
|
|
US6046216A
(en)
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
|
|
US6232312B1
(en)
|
1995-06-07 |
2001-05-15 |
Cell Pathways, Inc. |
Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
|
|
US6262059B1
(en)
|
1995-06-07 |
2001-07-17 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with quinazoline derivatives
|
|
US6200980B1
(en)
|
1995-06-07 |
2001-03-13 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl purinone derivatives
|
|
US5874440A
(en)
|
1995-06-07 |
1999-02-23 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives
|
|
US6060477A
(en)
|
1995-06-07 |
2000-05-09 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
|
|
GB9514464D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
|
GB9514473D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
SK154498A3
(en)
*
|
1996-05-10 |
2000-01-18 |
Icos Corp |
Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs
|
|
US6331543B1
(en)
*
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
|
US5958926A
(en)
*
|
1996-11-01 |
1999-09-28 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
|
|
US6071934A
(en)
|
1997-03-25 |
2000-06-06 |
Cell Pathways, Inc. |
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions
|
|
ATE315931T1
(de)
|
1997-06-23 |
2006-02-15 |
Cellegy Pharma Inc |
Microdosistherapie von gefässbedingten erscheinungen durch no-donoren
|
|
US6403597B1
(en)
*
|
1997-10-28 |
2002-06-11 |
Vivus, Inc. |
Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
|
|
US6410584B1
(en)
|
1998-01-14 |
2002-06-25 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells with indole derivatives
|
|
US6046199A
(en)
*
|
1998-01-14 |
2000-04-04 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
|
|
US6268372B1
(en)
|
1998-09-11 |
2001-07-31 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
|
|
US6326379B1
(en)
|
1998-09-16 |
2001-12-04 |
Bristol-Myers Squibb Co. |
Fused pyridine inhibitors of cGMP phosphodiesterase
|
|
IL132406A0
(en)
*
|
1998-10-21 |
2001-03-19 |
Pfizer Prod Inc |
Treatment of bph with cgmp elevators
|
|
US6133271A
(en)
|
1998-11-19 |
2000-10-17 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
|
|
US6187779B1
(en)
|
1998-11-20 |
2001-02-13 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
|
|
US6211220B1
(en)
|
1998-11-23 |
2001-04-03 |
Cell Pathways, Inc. |
Method for treating neoplasia with amino or pyridylamino cyclobutene derivatives
|
|
US6348032B1
(en)
|
1998-11-23 |
2002-02-19 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with benzimidazole derivatives
|
|
US6486155B1
(en)
|
1998-11-24 |
2002-11-26 |
Cell Pathways Inc |
Method of inhibiting neoplastic cells with isoquinoline derivatives
|
|
US6420410B1
(en)
|
1998-11-24 |
2002-07-16 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to N,N′-substituted benzimidazol-2-ones
|
|
US6211177B1
(en)
|
1998-11-24 |
2001-04-03 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives
|
|
US6358992B1
(en)
|
1998-11-25 |
2002-03-19 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with indole derivatives
|
|
US6387916B1
(en)
|
1999-03-24 |
2002-05-14 |
Harbor Branch Oceanographic Institution, Inc. |
Anti-inflammatory uses of manzamines
|
|
US6943166B1
(en)
*
|
1999-04-30 |
2005-09-13 |
Lilly Icos Llc. |
Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
|
|
MXPA00003997A
(es)
*
|
1999-04-30 |
2002-03-08 |
Lilly Icos Llc |
Articulos de fabricacion.
|
|
US6451807B1
(en)
|
1999-04-30 |
2002-09-17 |
Lilly Icos, Llc. |
Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
|
|
US7235625B2
(en)
|
1999-06-29 |
2007-06-26 |
Palatin Technologies, Inc. |
Multiple agent therapy for sexual dysfunction
|
|
AU4491200A
(en)
|
1999-08-03 |
2001-02-19 |
Lilly Icos Llc |
Beta-carboline pharmaceutical compositions
|
|
US6821975B1
(en)
|
1999-08-03 |
2004-11-23 |
Lilly Icos Llc |
Beta-carboline drug products
|
|
SK4562002A3
(en)
|
1999-10-11 |
2003-04-01 |
Pfizer |
5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)- dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors
|
|
TWI224966B
(en)
*
|
1999-11-02 |
2004-12-11 |
Pfizer |
Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient
|
|
US6562830B1
(en)
|
1999-11-09 |
2003-05-13 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives
|
|
US6376489B1
(en)
*
|
1999-12-23 |
2002-04-23 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US20020013327A1
(en)
*
|
2000-04-18 |
2002-01-31 |
Lee Andrew G. |
Compositions and methods for treating female sexual dysfunction
|
|
DE60124085D1
(de)
|
2000-04-19 |
2006-12-07 |
Lilly Icos Llc |
Pde-v hemmer zur behandlung von morbus parkinson
|
|
UA74826C2
(en)
|
2000-05-17 |
2006-02-15 |
Ortho Mcneil Pharm Inc |
?-carboline derivatives as phosphodiesterase inhibitors
|
|
UA72611C2
(uk)
*
|
2000-05-17 |
2005-03-15 |
Орто-Макнейл Фармацевтикал, Інк. |
Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
|
|
WO2001094345A2
(en)
|
2000-06-07 |
2001-12-13 |
Lilly Icos Llc |
Derivatives of 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
|
|
WO2002000658A1
(en)
*
|
2000-06-23 |
2002-01-03 |
Lilly Icos Llc |
Cyclic gmp-specific phosphodiesterase inhibitors
|
|
AU2001261707A1
(en)
*
|
2000-06-23 |
2002-01-08 |
Lilly Icos Llc |
Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives
|
|
MXPA02012659A
(es)
|
2000-06-26 |
2003-09-22 |
Lilly Icos Llc |
Derivados de pirazindiona condensados.
|
|
HUP0301661A3
(en)
*
|
2000-07-24 |
2003-11-28 |
Bayer Cropscience Ag |
Biphenyl carboxamides
|
|
JP4220775B2
(ja)
|
2000-08-02 |
2009-02-04 |
リリー アイコス リミテッド ライアビリティ カンパニー |
ホスホジエステラーゼ阻害剤としての融合複素環式誘導体
|
|
US20040092494A9
(en)
*
|
2000-08-30 |
2004-05-13 |
Dudley Robert E. |
Method of increasing testosterone and related steroid concentrations in women
|
|
US6503894B1
(en)
|
2000-08-30 |
2003-01-07 |
Unimed Pharmaceuticals, Inc. |
Pharmaceutical composition and method for treating hypogonadism
|
|
US6821978B2
(en)
|
2000-09-19 |
2004-11-23 |
Schering Corporation |
Xanthine phosphodiesterase V inhibitors
|
|
WO2002028859A2
(en)
|
2000-10-02 |
2002-04-11 |
Lilly Icos Llc |
Condensed pyridoindole derivatives
|
|
ATE297926T1
(de)
*
|
2000-10-02 |
2005-07-15 |
Lilly Icos Llc |
Hexahydropyrazino(1'2':1,6)-pyrido(3,4-b)indole 1,4-dion-derivate zur behandlung von cardiovaskulären erkrankungen und erektionsstörungen
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
US6828473B2
(en)
|
2000-11-01 |
2004-12-07 |
Pfizer Inc. |
Modulation of PDE11A activity
|
|
EP1211313A3
(en)
*
|
2000-11-01 |
2003-04-23 |
Pfizer Limited |
Modulation of PDE11A activity
|
|
EP1332144B1
(en)
*
|
2000-11-06 |
2006-08-23 |
Lilly Icos LLC |
Indole derivatives as pde5-inhibitors
|
|
JP4216606B2
(ja)
*
|
2001-04-25 |
2009-01-28 |
リリー アイコス リミテッド ライアビリティ カンパニー |
化学化合物
|
|
FR2824829B1
(fr)
*
|
2001-05-16 |
2005-06-03 |
Macef |
Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament
|
|
ES2307758T3
(es)
|
2001-06-05 |
2008-12-01 |
Lilly Icos Llc |
Derivados de pirazino (1',2':1,6)pirido(3,4-b)indol 1,4-diona.
|
|
EP1401449B1
(en)
*
|
2001-06-05 |
2007-04-25 |
Lilly Icos LLC |
Tetracyclic compounds as pde5-inhibitors
|
|
WO2002098875A1
(en)
*
|
2001-06-05 |
2002-12-12 |
Lilly Icos Llc |
Carboline derivatives as pde-5 inhibitors
|
|
US6984641B2
(en)
|
2001-06-21 |
2006-01-10 |
Lilly Icos Llc. |
Carboline derivatives as PDE5 inhibitors
|
|
US10675280B2
(en)
|
2001-10-20 |
2020-06-09 |
Sprout Pharmaceuticals, Inc. |
Treating sexual desire disorders with flibanserin
|
|
UA78974C2
(en)
|
2001-10-20 |
2007-05-10 |
Boehringer Ingelheim Pharma |
Use of flibanserin for treating disorders of sexual desire
|
|
MXPA04004370A
(es)
*
|
2001-11-09 |
2004-08-11 |
Schering Corp |
Derivados policiclicos de guanina inhibidores de fosfodiesterasa v.
|
|
EP1448562B1
(en)
|
2001-11-14 |
2007-07-25 |
Ortho-Mcneil Pharmaceutical Corp. |
Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
|
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
DE10220570A1
(de)
|
2002-05-08 |
2003-11-20 |
Bayer Ag |
Carbamat-substituierte Pyrazolopyridine
|
|
KR20050004195A
(ko)
*
|
2002-05-23 |
2005-01-12 |
화이자 인코포레이티드 |
신규 조합 제제
|
|
EP1719772A1
(en)
|
2002-05-31 |
2006-11-08 |
Schering Corporation |
Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
|
|
GB0214784D0
(en)
*
|
2002-06-26 |
2002-08-07 |
Pfizer Ltd |
Novel combination
|
|
ES2318175T3
(es)
*
|
2002-07-31 |
2009-05-01 |
Lilly Icos Llc |
Reaccion pictet-splenger modificada y productos preparados a partir de la misma.
|
|
GB0219961D0
(en)
|
2002-08-28 |
2002-10-02 |
Pfizer Ltd |
Oxytocin inhibitors
|
|
US7323462B2
(en)
|
2002-12-10 |
2008-01-29 |
Pfizer Inc. |
Morpholine dopamine agonists
|
|
NZ567457A
(en)
|
2002-12-13 |
2009-08-28 |
Warner Lambert Co |
Alpha-2-delta ligand to treat lower urinary tract symptoms
|
|
JP2006522151A
(ja)
|
2003-04-01 |
2006-09-28 |
アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ |
不妊症におけるホスホジエステラーゼ阻害剤
|
|
EP1620437B1
(en)
|
2003-04-29 |
2009-06-17 |
Pfizer Limited |
5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension
|
|
RS52730B
(sr)
*
|
2003-05-22 |
2013-08-30 |
Takeda Gmbh |
Kompozicija koja sadrži pde4 inhibitor i pde5 inhibitor
|
|
ES2391974T3
(es)
*
|
2003-06-13 |
2012-12-03 |
Ironwood Pharmaceuticals, Inc. |
Procedimientos y composiciones para el tratamiento de trastornos gastrointestinales
|
|
JP4671123B2
(ja)
|
2003-06-23 |
2011-04-13 |
小野薬品工業株式会社 |
新規三環性複素環化合物
|
|
US7291640B2
(en)
|
2003-09-22 |
2007-11-06 |
Pfizer Inc. |
Substituted triazole derivatives as oxytocin antagonists
|
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
|
US20060018970A1
(en)
*
|
2003-12-12 |
2006-01-26 |
Myogen, Inc. |
Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
|
|
WO2005068464A2
(en)
*
|
2003-12-15 |
2005-07-28 |
Cadila Healthcare Limited |
Process for preparing tadalafil and its intermediates
|
|
EP1708718A1
(en)
|
2004-01-22 |
2006-10-11 |
Pfizer Limited |
Triazole derivatives which inhibit vasopressin antagonistic activity
|
|
US7649002B2
(en)
|
2004-02-04 |
2010-01-19 |
Pfizer Inc |
(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
|
|
US20060030611A1
(en)
*
|
2004-03-22 |
2006-02-09 |
Myogen, Inc. |
Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
|
|
US20060025463A1
(en)
*
|
2004-03-22 |
2006-02-02 |
Michael Bristow |
Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
|
|
ATE417849T1
(de)
|
2004-04-07 |
2009-01-15 |
Pfizer |
Pyrazoloä4,3-düpyrimidine
|
|
WO2005116030A1
(en)
*
|
2004-05-31 |
2005-12-08 |
Matrix Laboratories Ltd |
A process for the preparation of tadalafil
|
|
CA2572179A1
(en)
*
|
2004-06-23 |
2006-01-19 |
Myogen, Inc. |
Enoximone formulations and their use in the treatment of pde-iii mediated diseases
|
|
CN101106997A
(zh)
|
2004-08-17 |
2008-01-16 |
约翰·霍普金斯大学 |
Pde5抑制剂组合物及治疗心脏病征候的方法
|
|
EP2216329A1
(en)
*
|
2004-10-28 |
2010-08-11 |
Dr. Reddy's Laboratories Ltd. |
Processes for the preparation of tadalafi
|
|
CA2582092A1
(en)
*
|
2004-11-02 |
2006-05-11 |
Teva Pharmaceutical Industries Ltd. |
Tadalafil crystal forms and processes for preparing them
|
|
AR051780A1
(es)
*
|
2004-11-29 |
2007-02-07 |
Japan Tobacco Inc |
Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
|
|
DK1829874T3
(da)
|
2004-12-22 |
2014-05-12 |
Ono Pharmaceutical Co |
Tricyklisk forbindelse og anvendelse deraf
|
|
MX2007009707A
(es)
*
|
2005-02-25 |
2007-09-12 |
Teva Pharma |
Proceso para sintetizar tadalafil.
|
|
EP1851223A1
(en)
*
|
2005-02-25 |
2007-11-07 |
Teva Pharmaceutical Industries Ltd |
Process of purifying tadalafil
|
|
EP1851221A1
(en)
|
2005-02-25 |
2007-11-07 |
Teva Pharmaceutical Industries Ltd |
Tadalafil having a large particle size and a process for preparation thereof
|
|
US20070088012A1
(en)
*
|
2005-04-08 |
2007-04-19 |
Woun Seo |
Method of treating or preventing type-2 diabetes
|
|
US20060276652A1
(en)
*
|
2005-04-12 |
2006-12-07 |
Ben-Zion Dolitzky |
Preparation of tadalafil intermediates
|
|
RS52944B
(sr)
|
2005-04-19 |
2014-02-28 |
Takeda Gmbh |
Roflumilast za lečenje pulmonarne hipertenzije
|
|
US8506934B2
(en)
|
2005-04-29 |
2013-08-13 |
Robert I. Henkin |
Methods for detection of biological substances
|
|
EP1881985B1
(en)
|
2005-05-12 |
2010-12-29 |
Pfizer, Inc. |
Anhydrous crystalline forms of n-ý1-(2-ethoxyethyl)-5-(n-ethyl-n-methylamino)-7-(4-methylpyridin-2-yl-amino)-1h-pyrazolo[4,3-d]pyrimidine-3-carbonyl¨methanesulfonamide
|
|
US20070010525A1
(en)
*
|
2005-06-27 |
2007-01-11 |
Meyer Jackson |
Method and compositions for modulating neuropeptide hormone secretion
|
|
KR20080047375A
(ko)
*
|
2005-07-29 |
2008-05-28 |
콘서트 파마슈티컬즈, 인크. |
약제 화합물
|
|
US7863274B2
(en)
*
|
2005-07-29 |
2011-01-04 |
Concert Pharmaceuticals Inc. |
Deuterium enriched analogues of tadalafil as PDE5 inhibitors
|
|
EP1912650B8
(en)
|
2005-08-03 |
2017-10-18 |
Sprout Pharmaceuticals, Inc. |
Use of flibanserin in the treatment of obesity
|
|
US7678363B2
(en)
|
2005-08-26 |
2010-03-16 |
Braincells Inc |
Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
|
|
EP2258358A3
(en)
|
2005-08-26 |
2011-09-07 |
Braincells, Inc. |
Neurogenesis with acetylcholinesterase inhibitor
|
|
US20070104792A1
(en)
*
|
2005-09-13 |
2007-05-10 |
Elan Pharma International, Limited |
Nanoparticulate tadalafil formulations
|
|
ES2399763T3
(es)
|
2005-10-12 |
2013-04-03 |
Unimed Pharmaceuticals, Llc |
Gel de testosterona mejorado y método de utilización
|
|
EP2377530A3
(en)
|
2005-10-21 |
2012-06-20 |
Braincells, Inc. |
Modulation of neurogenesis by PDE inhibition
|
|
JP2009513604A
(ja)
|
2005-10-29 |
2009-04-02 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
月経前障害及び他の女性の性的障害治療用のベンゾイミダゾロン誘導体
|
|
EP1942879A1
(en)
|
2005-10-31 |
2008-07-16 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
WO2007100387A2
(en)
*
|
2005-11-03 |
2007-09-07 |
Dr. Reddy's Laboratories Ltd. |
Process for preparing tadalafil
|
|
EP1956906A4
(en)
|
2005-11-09 |
2009-12-30 |
Combinatorx Inc |
METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
|
|
US7202229B1
(en)
*
|
2005-12-30 |
2007-04-10 |
Alan James Group, Llc. |
Aspirin formulation for cardiovascular health
|
|
US7201929B1
(en)
*
|
2005-12-30 |
2007-04-10 |
Alan James Group, Llc. |
Aspirin formulation for cardiovascular health
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
AU2007223036A1
(en)
*
|
2006-03-08 |
2007-09-13 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
EP2004644A1
(en)
*
|
2006-03-24 |
2008-12-24 |
Glenmark Pharmaceuticals Limited |
Process for the preparation of tadalafil
|
|
WO2007124045A2
(en)
*
|
2006-04-20 |
2007-11-01 |
Ampla Pharmaceuticals, Inc. |
Piperidine and piperazine compounds for use in the treatment of obesity, eating disorders and sexual dysfunction by potentiation of mc4 receptor activity
|
|
US20100009983A1
(en)
*
|
2006-05-09 |
2010-01-14 |
Braincells, Inc. |
5 ht receptor mediated neurogenesis
|
|
US7678808B2
(en)
|
2006-05-09 |
2010-03-16 |
Braincells, Inc. |
5 HT receptor mediated neurogenesis
|
|
WO2007134136A2
(en)
|
2006-05-09 |
2007-11-22 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
|
US20090291958A1
(en)
*
|
2006-06-08 |
2009-11-26 |
Auspex Pharmaceuticals, Inc. |
Substituted PDE5 inhibitors
|
|
ATE456369T1
(de)
|
2006-06-30 |
2010-02-15 |
Boehringer Ingelheim Int |
Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen
|
|
BRPI0621852A2
(pt)
*
|
2006-07-07 |
2011-12-20 |
Teva Pharma |
compostos sólidos consistindo de tadalafil e pelo menos um veìculo
|
|
RU2452469C2
(ru)
|
2006-07-21 |
2012-06-10 |
Новартис Аг |
Составы бензимидазолилпиридилэфиров
|
|
EA200900264A1
(ru)
|
2006-08-14 |
2009-08-28 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Композиции флибансерина и способ их приготовления
|
|
JP5220746B2
(ja)
|
2006-08-25 |
2013-06-26 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
制御放出システム及びその製造方法
|
|
AR062501A1
(es)
*
|
2006-08-29 |
2008-11-12 |
Actelion Pharmaceuticals Ltd |
Composiciones terapeuticas
|
|
AU2007292848A1
(en)
*
|
2006-09-08 |
2008-03-13 |
Braincells, Inc. |
Combinations containing a 4-acylaminopyridine derivative
|
|
US20080103165A1
(en)
*
|
2006-09-19 |
2008-05-01 |
Braincells, Inc. |
Ppar mediated modulation of neurogenesis
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
US20080139593A1
(en)
|
2006-12-12 |
2008-06-12 |
Gerber Michael J |
Method for treating a pulmonary hypertension condition
|
|
WO2008095136A2
(en)
|
2007-01-31 |
2008-08-07 |
Henkin Robert I |
Methods for detection of biological substances
|
|
SG174079A1
(en)
*
|
2007-02-12 |
2011-09-29 |
Dmi Biosciences Inc |
Treatment of comorbid premature ejaculation and erectile dysfunction
|
|
KR20130122023A
(ko)
|
2007-02-12 |
2013-11-06 |
디엠아이 바이오사이언시스 인코포레이티드 |
트라마돌의 부작용을 감소시키는 방법
|
|
WO2008103470A2
(en)
*
|
2007-02-21 |
2008-08-28 |
Trustees Of Columbia University In The City Of New York |
Oncogenic-ras-signal dependent lethal compounds
|
|
KR20100012867A
(ko)
*
|
2007-04-25 |
2010-02-08 |
테바 파마슈티컬 인더스트리즈 리미티드 |
타다라필을 포함하는 고체 제형
|
|
FR2916200A1
(fr)
*
|
2007-05-18 |
2008-11-21 |
Fourtillan Snc |
Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique
|
|
DE102007028869A1
(de)
*
|
2007-06-22 |
2008-12-24 |
Ratiopharm Gmbh |
Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil
|
|
SI2170880T1
(sl)
*
|
2007-06-29 |
2012-10-30 |
Ranbaxy Lab Ltd |
Postopek za pripravo intermediatov tetracikličnih spojin
|
|
EP2033962A1
(en)
*
|
2007-08-22 |
2009-03-11 |
4Sc Ag |
Tetracyclic indolopyridines as EG5 inhibitors
|
|
CL2008002693A1
(es)
|
2007-09-12 |
2009-10-16 |
Boehringer Ingelheim Int |
Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad
|
|
US20090181975A1
(en)
*
|
2008-01-15 |
2009-07-16 |
Forest Laboratories Holdings Limited |
Nebivolol in the treatment of sexual dysfunction
|
|
ITMI20080285A1
(it)
*
|
2008-02-22 |
2009-08-23 |
Endura Spa |
Procedimento per la preparazione di esteri di acidi tetraidro-1h-betacarbolin-3-carbossilici
|
|
EP2107059A1
(en)
|
2008-03-31 |
2009-10-07 |
LEK Pharmaceuticals D.D. |
Conversion of tryptophan into ß-carboline derivatives
|
|
PL385356A1
(pl)
|
2008-06-03 |
2009-12-07 |
Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna |
Sposób wytwarzania tadalafilu
|
|
US8580801B2
(en)
|
2008-07-23 |
2013-11-12 |
Robert I. Henkin |
Phosphodiesterase inhibitor treatment
|
|
EP2181997A1
(en)
|
2008-10-30 |
2010-05-05 |
Chemo Ibérica, S.A. |
A process for the preparation of tadalafil
|
|
DE102008063992A1
(de)
|
2008-12-19 |
2010-09-02 |
Lerner, Zinoviy, Dipl.-Ing. |
Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
|
|
JP2012513464A
(ja)
|
2008-12-23 |
2012-06-14 |
ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク |
ホスホジエステラーゼ阻害剤及びその使用
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
JP6074142B2
(ja)
|
2009-02-26 |
2017-02-01 |
タール ファーマシューティカルズ，インコーポレイテッド |
医薬化合物の結晶化
|
|
GB0903493D0
(en)
|
2009-02-27 |
2009-04-08 |
Vantia Ltd |
New compounds
|
|
DE102009033396A1
(de)
|
2009-07-16 |
2011-01-20 |
Ratiopharm Gmbh |
Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung
|
|
UY33041A
(es)
|
2009-11-27 |
2011-06-30 |
Bayer Schering Pharma Aktienegesellschaft |
Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
|
|
US10610528B2
(en)
|
2009-12-08 |
2020-04-07 |
Intelgenx Corp. |
Solid oral film dosage forms and methods for making same
|
|
US20110136815A1
(en)
*
|
2009-12-08 |
2011-06-09 |
Horst Zerbe |
Solid oral film dosage forms and methods for making same
|
|
JP2013523809A
(ja)
|
2010-04-05 |
2013-06-17 |
エスケー ケミカルズ カンパニー リミテッド |
Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物
|
|
DE102010021637A1
(de)
|
2010-05-26 |
2011-12-01 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
|
|
JP5806320B2
(ja)
|
2010-10-15 |
2015-11-10 |
ギリアード サイエンシーズ， インコーポレイテッド |
肺高血圧症を処置するための組成物および方法
|
|
WO2012107092A1
(en)
|
2011-02-10 |
2012-08-16 |
Synthon Bv |
Pharmaceutical composition comprising tadalafil and a cyclodextrin
|
|
EP2672959A1
(en)
|
2011-02-10 |
2013-12-18 |
Synthon BV |
Granulated composition comprising tadalafil and a disintegrant
|
|
JP5816704B2
(ja)
|
2011-02-10 |
2015-11-18 |
インテルキム、ソシエダッド アノニマ |
テトラヒドロ−β−カルボリンから誘導される化合物を得る方法
|
|
WO2012107541A1
(en)
|
2011-02-10 |
2012-08-16 |
Synthon Bv |
Pharmaceutical composition comprising tadalafil and a cyclodextrin
|
|
US20120123124A1
(en)
*
|
2011-04-22 |
2012-05-17 |
Drug Process Licensing Associates, LLC |
Manufacturing process for Tadalafil from racemic or L-tryptophan
|
|
CN102180876B
(zh)
*
|
2011-05-28 |
2016-05-18 |
浙江华海药业股份有限公司 |
一种他达那非晶型i的制备方法
|
|
EP2535049A1
(en)
|
2011-06-17 |
2012-12-19 |
Proyecto de Biomedicina Cima, S.L. |
Tadalafil for the treatment of dementia
|
|
CN102367253B
(zh)
*
|
2011-09-20 |
2016-04-06 |
浙江华海药业股份有限公司 |
一种制备他达拉非晶型a的方法
|
|
WO2013067309A1
(en)
|
2011-11-04 |
2013-05-10 |
Xion Pharmaceutical Corporation |
Methods and compositions for oral administration of melanocortin receptor agonist compounds
|
|
US20150119399A1
(en)
|
2012-01-10 |
2015-04-30 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
WO2013109738A1
(en)
|
2012-01-17 |
2013-07-25 |
The Trustees Of Columbia University In The City Of New York |
Novel phosphodiesterase inhibitors and uses thereof
|
|
WO2013109223A1
(en)
|
2012-01-18 |
2013-07-25 |
Mahmut Bilgic |
Particulate formulations of tadalafil in effervescent form
|
|
WO2014092661A1
(en)
|
2012-01-18 |
2014-06-19 |
Mahmut Bilgic |
Particulate formulations of tadalafil in effervescent form
|
|
WO2013109227A1
(en)
|
2012-01-18 |
2013-07-25 |
Mahmut Bilgic |
Pharmaceutical compositions comprising ceftibuten
|
|
EP2821066B1
(en)
|
2012-02-28 |
2018-04-25 |
Seoul Pharma. Co. Ltd. |
High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient
|
|
EP2903619B1
(en)
|
2012-10-05 |
2019-06-05 |
Robert I. Henkin |
Phosphodiesterase inhibitors for treating taste and smell disorders
|
|
KR102146673B1
(ko)
|
2012-12-04 |
2020-08-21 |
주식회사 아리바이오 |
포스포디에스테라제 타입 ５ 저해제를 포함하는 신경세포의 아폽토시스 억제용 조성물
|
|
KR101953735B1
(ko)
|
2012-12-14 |
2019-03-04 |
한미약품 주식회사 |
포스포다이에스터라제-5 억제제를 포함하는 츄정
|
|
ES2882258T3
(es)
|
2012-12-21 |
2021-12-01 |
Mayo Found Medical Education & Res |
Métodos y materiales para tratar estenosis de la válvula aórtica calcificada
|
|
EP2958914B1
(en)
|
2013-02-21 |
2020-07-15 |
Adverio Pharma GmbH |
Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
|
|
CN103232451A
(zh)
*
|
2013-05-14 |
2013-08-07 |
张家港威胜生物医药有限公司 |
一种他达那非的简易制备工艺
|
|
ES2776353T3
(es)
|
2013-07-17 |
2020-07-30 |
Univ Columbia |
Inhibidores de la fosfodiesterasa novedosos y usos de los mismos
|
|
EP3082428A4
(en)
|
2013-12-09 |
2017-08-02 |
Respira Therapeutics, Inc. |
Pde5 inhibitor powder formulations and methods relating thereto
|
|
CN106233141B
(zh)
|
2014-02-18 |
2018-08-21 |
罗伯特·I·汉金 |
用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物
|
|
AR099416A1
(es)
|
2014-02-28 |
2016-07-20 |
Lilly Co Eli |
Terapia combinada para la hipertensión resistente
|
|
JP6687550B2
(ja)
|
2014-06-23 |
2020-04-22 |
セルジーン コーポレイション |
肝疾患又は肝機能異常を治療するためのアプレミラスト
|
|
ES2784251T3
(es)
|
2014-06-30 |
2020-09-23 |
Montero Gida Sanayi Ve Ticaret As |
Formulaciones de disgregación por vía oral de tadalafilo
|
|
EP2962684A1
(en)
|
2014-06-30 |
2016-01-06 |
Sanovel Ilac Sanayi ve Ticaret A.S. |
Orally disintegrating formulations of tadalafil
|
|
CN104086546B
(zh)
*
|
2014-07-14 |
2016-08-17 |
福建广生堂药业股份有限公司 |
他达拉非的药用酸盐及其制备方法
|
|
EA035390B1
(ru)
|
2014-07-23 |
2020-06-05 |
КРКА, д.д., НОВО МЕСТО |
Совместный осадок тадалафила с фармацевтически приемлемыми эксципиентами, содержащая его фармацевтическая композиция и способ их получения
|
|
KR101645652B1
(ko)
|
2014-11-03 |
2016-08-08 |
(주)퓨젠바이오농업회사법인 |
세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물
|
|
KR102457316B1
(ko)
*
|
2015-06-26 |
2022-10-20 |
총킹 디캉 에릴 파마 씨오. 엘티디. |
새로운 5형포스포디에스테라아제 억제제 및 그 용도
|
|
CN105541835B
(zh)
*
|
2015-12-31 |
2017-12-05 |
湖南千金湘江药业股份有限公司 |
顺式四氢咔啉中间体及其合成方法和在制备他达拉非方面的应用
|
|
CN105541840B
(zh)
*
|
2015-12-31 |
2017-12-05 |
湖南千金湘江药业股份有限公司 |
关键中间体及其合成方法和在制备他达拉非方面的应用
|
|
CN110381951A
(zh)
|
2016-12-14 |
2019-10-25 |
瑞必治公司 |
用于治疗肺性高血压和其他肺病症的方法及组合物
|
|
CN106977516B
(zh)
*
|
2017-03-02 |
2019-06-18 |
山东裕欣药业有限公司 |
一种他达拉非的制备方法
|
|
CA3136550A1
(en)
|
2019-04-10 |
2020-10-15 |
Mayo Foundation For Medical Education And Research |
Methods and materials for gender-dependent treatment of cardiovascular dysfunction
|
|
RU2692764C1
(ru)
|
2019-04-26 |
2019-06-27 |
Общество с ограниченной ответственностью "Балтфарма" |
Способ получения тадалафила
|
|
CN111995658B
(zh)
*
|
2019-05-27 |
2022-08-02 |
首都医科大学 |
Ldv修饰的五环哌嗪二酮及其制备和应用
|
|
BR112021024894A2
(pt)
|
2019-07-15 |
2022-01-25 |
Biolab Sanus Farmaceutica Ltda |
Estereoisômeros do composto 3-(benzo[d][1,3]dioxol-5-il)-7-(1-hidroxipropan-2-il)-1-(1h-indol-3-il)-6,7-dihidro-3h-oxazol[3,4-a]pirazina-5,8-diona e seu uso como antitumoral e inibidor da enzima fosfodiesterase
|
|
CN110606847A
(zh)
*
|
2019-07-30 |
2019-12-24 |
中国医药集团总公司四川抗菌素工业研究所 |
一种他达拉非顺式中间体的制备方法及其应用
|
|
US11590209B2
(en)
|
2020-01-21 |
2023-02-28 |
Palatin Technologies, Inc. |
Use of bremelanotide in patients with controlled hypertension
|
|
WO2021245192A1
(en)
|
2020-06-04 |
2021-12-09 |
Topadur Pharma Ag |
Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
|
|
CN120641103A
(zh)
|
2023-01-25 |
2025-09-12 |
阿丽派欧株式会社 |
包含5型磷酸二酯酶抑制剂作为有效成分用于预防或治疗创伤后应激障碍的组合物
|
|
AU2024220563A1
(en)
|
2023-02-16 |
2025-08-14 |
University Of Rochester |
Improving glymphatic-lymphatic efflux
|
|
CN116715667A
(zh)
*
|
2023-06-20 |
2023-09-08 |
常州制药厂有限公司 |
一种他达拉非新晶型b及其制备方法
|