WO2018013597A1 - 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors - Google Patents

2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors Download PDF

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Publication number
WO2018013597A1
WO2018013597A1 PCT/US2017/041577 US2017041577W WO2018013597A1 WO 2018013597 A1 WO2018013597 A1 WO 2018013597A1 US 2017041577 W US2017041577 W US 2017041577W WO 2018013597 A1 WO2018013597 A1 WO 2018013597A1
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Prior art keywords
alkyl
cycloalkyl
heterocycle
heteroaryl
optionally substituted
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PCT/US2017/041577
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English (en)
French (fr)
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WO2018013597A4 (en
Inventor
Ash JOGALEKAR
Walter Won
Elena S. Koltun
Adrian Gill
Kevin MELLEM
Naing Aay
Andreas BUCKL
Christopher Semko
Gert KISS
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Revolution Medicines Inc
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Revolution Medicines Inc
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Priority to PH1/2019/500056A priority Critical patent/PH12019500056B1/en
Priority to SG11201900157RA priority patent/SG11201900157RA/en
Priority to AU2017296289A priority patent/AU2017296289A1/en
Priority to CN201780050842.XA priority patent/CN109983001B/zh
Priority to MX2019000548A priority patent/MX395351B/es
Priority to JP2019522611A priority patent/JP6916279B2/ja
Priority to IL264186A priority patent/IL264186B2/en
Priority to CA3030167A priority patent/CA3030167A1/en
Priority to CN202310285469.3A priority patent/CN116478132A/zh
Priority to CR20190063A priority patent/CR20190063A/es
Priority to KR1020197004088A priority patent/KR102598895B1/ko
Priority to BR112019000494-7A priority patent/BR112019000494B1/pt
Priority to MYPI2018003070A priority patent/MY199046A/en
Priority to NZ749959A priority patent/NZ749959B2/en
Priority to EA201990261A priority patent/EA201990261A1/ru
Priority to TNP/2019/000010A priority patent/TN2019000010A1/en
Priority to KR1020237037794A priority patent/KR20230156174A/ko
Priority to CN202310268752.5A priority patent/CN116478131A/zh
Application filed by Revolution Medicines Inc filed Critical Revolution Medicines Inc
Priority to EP17742609.5A priority patent/EP3484856B1/en
Priority to EP23209237.9A priority patent/EP4302834A3/en
Publication of WO2018013597A1 publication Critical patent/WO2018013597A1/en
Publication of WO2018013597A4 publication Critical patent/WO2018013597A4/en
Priority to US16/228,324 priority patent/US10590090B2/en
Anticipated expiration legal-status Critical
Priority to CONC2019/0000613A priority patent/CO2019000613A2/es
Priority to US16/905,884 priority patent/US11661401B2/en
Priority to AU2021277664A priority patent/AU2021277664B2/en
Priority to US18/124,352 priority patent/US20240116878A1/en
Priority to AU2023266357A priority patent/AU2023266357A1/en
Priority to IL311645A priority patent/IL311645B2/en
Priority to IL321811A priority patent/IL321811A/en
Ceased legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D477/26—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 4
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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Definitions

  • the present disclosure relates to inhibitors of protein tyrosine phosphatase SHP2 useful in the treatment of diseases or disorders. Specifically, this disclosure is concerned with compounds and compositions inhibiting SHP2, methods of treating diseases associated with SHP2, and methods of synthesizing these compounds.
  • SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) is a non-receptor protein tyrosine phosphatase encoded by the PTPN1 1 gene that contributes to multiple cellular functions including proliferation, differentiation, cell cycle maintenance and migration. SHP2 is involved in signaling through the Ras-mitogen-activated protein kinase, the JAK-STAT or the phosphoinositol 3- kinase-AKT pathways.
  • SHP2 has two N-terminal Src homology 2 domains (N-SH2 and C-SH2), a catalytic domain (PTP), and a C-terminal tail.
  • the two SH2 domains control the subcellular localization and functional regulation of SHP2.
  • the molecule exists in an inactive, self-inhibited conformation stabilized by a binding network involving residues from both the N-SH2 and PTP domains. Stimulation by, for example, cytokines or growth factors leads to exposure of the catalytic site resulting in enzymatic activation of SHP2.
  • the present disclosure relates to compounds capable of inhibiting the activity of SHP2.
  • the disclosure further provides a process for the preparation of compounds disclosed herein, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y is -S- or a direct bond
  • Y 2 is -NR a -, -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-,-N(R a )C(S)N(R a )-, -C(0)0- -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0- -C(0)N(R a )0-,-N(R a )C(S)-, -C(S)N(R a )-, or
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 - C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or -NH 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or poly cyclic 3- to 12- membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or poly cyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 2 is - R a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 H-, -(CR a 2 ) m O-, -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 , -NR 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C3-C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R
  • R a is independently, at each occurrence, -H, -D, -OH, -C3-C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C3-C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or -NH 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo; or R a and R 4 , together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C 3 -Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C2-C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 2 is - R a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0- -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0- -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side of Y 2
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycl
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or -NH 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo; or R a and R 4 , together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C 3 -Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are 5- to 12-membered monocyclic or 5- to 12-membered polycyclic;
  • Y 2 is - R a - wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R a and R 4 together with the atom or atoms to which they are attached, are combined to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, -OR 6 , halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0) R 5 R 6 , -C(0)R 5 ,-C0 2 R 5 , -C(0)NR 5 R 6 , -C(0)NR 5 R 6 , - R 5 C(0)R 6 , monocyclic or polycyclic heterocycly
  • R 2 is independently -NH 2 , -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -
  • R b is independently, at each occurrence, -H, -D, -OH, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, -(CH 2 ) n -aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, heterocycle, heteroaryl, or -(CH 2 )n-aryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0)
  • R 3 is independently -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, a 5- to 12-membered spiroheterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, spiroheterocycle, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-Cealkyl, -OH, - H 2 , -OR b , - HR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C3-C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , -CF 3 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OR b , or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN; and
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • I-V2 and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, and isomers thereof, wherein:
  • A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are 5- to 12-membered monocyclic or 5- to 12-membered polycyclic;
  • Y 2 is -NR a -, wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -
  • R 2 is independently -NH 2 , -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -
  • R b is independently, at each occurrence, -H, -D, -OH, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, -(CH 2 ) n -aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, heterocycle, heteroaryl, or -(CH 2 ) n -aryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxy alkyl, -CF 2 OH, -CHFOH, -NH-NHR 5 , -NH-OR 5 , -0-NR 5 R 6 , -NHR 5 , -OR 5 , -NHC(0)R 5 , -NHC(0)NHR 5 , -NHS(0) 2 R 5 , -NHS(0) 2 NHR 5 , -S(0) 2 OH, -C(0)OR 5 , -NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n R b , -C(0)R b , -NH 2 , -OH, -CN, -C(0)NR 5 R 6 , -S(0) 2 NR 5 R 6 , C 3 -C 8
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or poly cyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , -CF 3 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OR b , or a monocyclic or poly cyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN; and
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are 5- to 12-membered monocyclic or 5- to 12-membered polycyclic;
  • Y 2 is -NR a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0- -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0- -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side of Y 2
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 ,
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, -Ci-C 6 alkyl, 3- to 12-membered heterocyclyl, or -(CH 2 ) n -aryl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , or wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8-membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -OH, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, -(CH 2 ) n -aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, heterocycle, heteroaryl, or -(CH 2 ) n -aryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxy alkyl -CF 2 OH, -CHFOH - H- HR 5 , - H-OR 5 , -0- R 5 R 6 , - HR 5 , -OR 5 , -NHC(0)R 5 , - HC(0) HR 5 , - HS(0) 2 R 5 , -NHS(0) 2 HR 5 , -S(0) 2 HR 5 , -S(0) 2 OH, -C(0)OR 5 , - H(CH 2 ) n OH, -C(0) H(CH 2 ) n OH, -C(0) H(CH 2 ) n R b , -C(0)R b , - H 2 , -OH, -CN, -C(0) R 5 R 6 , -S(0) 2 R 5 R 6 , C 3 -
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , -CF 3 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OR b , or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y is -S- or a direct bond
  • Y 2 is -NR a -, -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O-, -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0- -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more - H 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 - C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 R 5 R 6 , - R 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , -NR 5 S(0) R 5 R 6 , - R 5 S(0) 2 R 6 , -
  • R 3 is independently -H, -Ci-C 6 alkyl, or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or - H 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, - H- HR 5 , - H-OR 5 , -0- R 5 R 6 , - HR 5 , -OR 5 , - HC(0)R 5 , - HC (0) HR 5 , - HS(0) 2 R 5 , - HS(0) 2 HR 5 , -S(0) 2 OH, -C(0)OR 5 , -C(0) R 5 R 6 , -S(0) 2 R 5 R 6 , C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, cycloalkyl, or heterocyclyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 1 is -S- or a direct bond
  • Y 2 is - R a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0- -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side of Y
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 , -NR 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C3-C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R
  • R a is independently, at each occurrence, -H, -D, -OH, -C3-C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C3-C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , -OR b , -NHR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , heteroaryl, heterocyclyl, -(CH 2 ) n NH 2 , -COOR b , -CONHR b , -CONH(CH 2 ) n COOR b , -NHCOOR b , -CF 3 , -CHF 2 , or -CH 2 F;
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, - H- HR 5 , - H-OR 5 , -0- R 5 R 6 , - HR 5 , -OR 5 , - HC(0)R 5 , - HC (0) HR 5
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C 3 -Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 2 is - R a -, -(CR a 2 ) m - -C(R a ) 2 H-, -(CR a 2 ) m O-, -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -OC(0)N(R a )-, -N(R a )C(0)0- -C(0)N(R a )0-, -N(R a )C(S)-, or -C(S)N(R a )-; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -NH 2 , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -
  • R a is independently, at each occurrence -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8-membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 R 5 R 6 , - R 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)R 6 , heterocycle,
  • R 3 is independently -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , -OR b , - HR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F;
  • R 4 is independently -Ci-C 6 alkyl, - H- HR 5 , - H-OR 5 , -0- R 5 R 6 , - HR 5 , -OR 5 , - HC(0)R 5 , - HC (0) HR 5 , - HS(0) 2 R 5 , - HS(0) 2 HR 5 , -S(0) 2 OH, -C(0)OR 5 , - H(CH 2 ) n OH, -C(0) H(CH 2 ) n OH, -C(0) H(CH 2 ) n R b , -C(0)R b , - H 2 , -OH, -C(0) R 5 R 6 , -S(0) 2 R 5 R 6 , C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of
  • R a and R 4 together with the atom or atoms to which they are attached, are combined to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Another aspect of the disclosure relates to methods of treating a disease associated with SHP2 modulation in a subject in need thereof, comprising administering to the subject an effective amount of one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof).
  • compounds disclosed herein e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof.
  • Another aspect of the disclosure relates to methods of inhibiting SHP2.
  • the method comprises administering to a patient in need thereof, an effective amount of one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof).
  • compounds disclosed herein e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof.
  • compositions comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), and a pharmaceutically acceptable carrier.
  • the pharmaceutically acceptable carrier can further comprise an excipient, diluent, or surfactant.
  • the pharmaceutical composition can be effective for treating a disease associated with SHP2 modulation in a subject in need thereof.
  • Another aspect of the disclosure relates to methods of treating a disease associated with SHP2 modulation in a subject in need thereof, comprising administering to the subject an effective amount of a pharmaceutical composition comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof).
  • a pharmaceutical composition comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof).
  • Another aspect of the disclosure relates to methods of inhibiting SHP2 comprising administering to a patient in need thereof, an effective amount of a pharmaceutical composition comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof).
  • a pharmaceutical composition comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof).
  • Another aspect of the disclosure relates to one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), for use in treating or preventing a disease associated with SHP2 modulation.
  • compounds disclosed herein e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof
  • compositions comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), and a pharmaceutically acceptable carrier, for use in treating of preventing a disease associated with SHP2 modulation.
  • compounds disclosed herein e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof
  • a pharmaceutically acceptable carrier for use in treating of preventing a disease associated with SHP2 modulation.
  • Another aspect of the disclosure relates to the use of one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), in the manufacture of a medicament for treating or preventing a disease associated with SHP2 modulation.
  • compounds disclosed herein e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof
  • compositions comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), and a pharmaceutically acceptable carrier, in the manufacture of a medicament for treating or preventing a disease associated with SHP2 modulation.
  • compounds disclosed herein e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof
  • a pharmaceutically acceptable carrier in the manufacture of a medicament for treating or preventing a disease associated with SHP2 modulation.
  • Another aspect of the disclosure relates to one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), for use as a medicament.
  • compounds disclosed herein e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof
  • compositions comprising one or more compounds disclosed herein (e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), for use as a medicament.
  • the medicament is used for treating or preventing a disease associated with SHP2 modulation.
  • the present disclosure also provides compounds and pharmaceutical compositions that are useful in inhibiting SHP2. Detailed Description of the Disclosure
  • One aspect of the disclosure relates to compounds of Formula I-Vl :
  • an alkyl group that is optionally substituted can be a fully saturated alkyl chain (i.e. a pure hydrocarbon).
  • the same optionally substituted alkyl group can have substituents different from hydrogen. For instance, it can, at any point along the chain be bonded to a halogen atom, a hydroxyl group, or any other substituent described herein.
  • optionally substituted means that a given chemical moiety has the potential to contain other functional groups, but does not necessarily have any further functional groups.
  • aryl refers to cyclic, aromatic hydrocarbon groups that have 1 to 2 aromatic rings, including monocyclic or bicyclic groups such as phenyl, biphenyl or naphthyl. Where containing two aromatic rings (bicyclic, etc.), the aromatic rings of the aryl group may be joined at a single point (e.g., biphenyl), or fused (e.g., naphthyl).
  • the aryl group may be optionally substituted by one or more substituents, e.g., 1 to 5 substituents, at any point of attachment.
  • substituents include, but are not limited to, -H, halogen, -0-Ci-C 6 alkyl, -Ci-Cealkyl, -OC 2 -C 6 alkenyl, -OC 2 -C 6 alkynyl, -C 2 -C 6 alkenyl, -C 2 -C 6 alkynyl, -OH, -OP(0)(OH) 2 , -OC(0)Ci-C 6 alkyl, -C(0)Ci-C 6 alkyl, -OC(0)OCi-C 6 alkyl, -NH 3 ⁇ 4 -NH(Ci- Cealkyl), -N(Ci-C 6 alkyl) 2 , -S(0) 2 -Ci-C 6 alkyl, -S(0) HCi-C 6 alkyl, and -S(0)N(Ci-C 6 alkyl) 2 .
  • the substituents can themselves be optionally substituted.
  • heteroaryl means a monovalent or multivalent monocyclic aromatic radical or a polycyclic aromatic radical of 5 to 24 ring atoms, containing one or more ring heteroatoms selected from N, S, P, and O, the remaining ring atoms being C.
  • Heteroaryl as herein defined also means a bicyclic heteroaromatic group wherein the heteroatom is selected from N, S, P, and O.
  • the aromatic radical is optionally substituted independently with one or more substituents described herein.
  • Examples include, but are not limited to, furyl, thienyl, pyrrolyl, pyridyl, pyrazolyl, pyrimidinyl, imidazolyl, isoxazolyl, oxazolyl, oxadiazolyl, pyrazinyl, indolyl, thiophen-2-yl, quinolyl, benzopyranyl, isothiazolyl, thiazolyl, thiadiazolyl, benzo[ ⁇ i]imidazolyl, thieno[3,2-£]thiophene, triazolyl, triazinyl, imidazo[l,2-£]pyrazolyl, furo[2,3-c]pyridinyl, imidazo[l,2-a]pyridinyl, indazolyl, 1 -methyl- 1H- indazolyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[3,2-c]pyridiny
  • Alkyl refers to a straight or branched chain saturated hydrocarbon. Ci-C 6 alkyl groups contain 1 to 6 carbon atoms. Examples of a Ci-C 6 alkyl group include, but are not limited to, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, sec-butyl and tert-butyl, isopentyl and neopentyl.
  • alkenyl means an aliphatic hydrocarbon group containing a carbon— carbon double bond and which may be straight or branched having about 2 to about 6 carbon atoms in the chain. Certain alkenyl groups have 2 to about 4 carbon atoms in the chain. Branched means that one or more lower alkyl groups such as methyl, ethyl, or propyl are attached to a linear alkenyl chain. Exemplary alkenyl groups include ethenyl, propenyl, n- butenyl, and z-butenyl.
  • a C 2 -C 6 alkenyl group is an alkenyl group containing between 2 and 6 carbon atoms.
  • alkynyl means an aliphatic hydrocarbon group containing a carbon— carbon triple bond and which may be straight or branched having about 2 to about 6 carbon atoms in the chain. Certain alkynyl groups have 2 to about 4 carbon atoms in the chain. Branched means that one or more lower alkyl groups such as methyl, ethyl, or propyl are attached to a linear alkynyl chain. Exemplary alkynyl groups include ethynyl, propynyl, «-butynyl, 2-butynyl, 3-methylbutynyl, and «-pentynyl.
  • a C 2 -C 6 alkynyl group is an alkynyl group containing between 2 and 6 carbon atoms.
  • cycloalkyl means monocyclic or polycyclic saturated carbon rings containing 3-18 carbon atoms.
  • cycloalkyl groups include, without limitations, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptanyl, cyclooctanyl, norboranyl, norborenyl, bicyclo[2.2.2]octanyl, or bicyclo[2.2.2]octenyl.
  • a C3-C8 cycloalkyl is a cycloalkyl group containing between 3 and 8 carbon atoms.
  • a cycloalkyl group can be fused (e.g., decalin) or bridged (e.g., norbornane).
  • cycloalkenyl means monocyclic, non-aromatic unsaturated carbon rings containing 4-18 carbon atoms.
  • examples of cycloalkenyl groups include, without limitation, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, and norborenyl.
  • a C 4 -C 8 cycloalkenyl is a cycloalkenyl group containing between 4 and 8 carbon atoms.
  • heterocyclyl or “heterocycloalkyl” or “heterocycle” refer to monocyclic or polycyclic 3 to 24-membered rings containing carbon and heteroatoms selected from oxygen, phosphorus, nitrogen, and sulfur and wherein there are no delocalized ⁇ electrons (aromaticity) shared among the ring carbon or heteroatoms.
  • Heterocyclyl rings include, but are not limited to, oxetanyl, azetidinyl, tetrahydrofuranyl, pyrrolidinyl, oxazolinyl, oxazolidinyl, thiazolinyl, thiazolidinyl, pyranyl, thiopyranyl, tetrahydropyranyl, dioxalinyl, piperidinyl, morpholinyl, thiomorpholinyl, thiomorpholinyl S-oxide, thiomorpholinyl S-di oxide, piperazinyl, azepinyl, oxepinyl, diazepinyl, tropanyl, and homotropanyl.
  • a heteroycyclyl or heterocycloalkyl ring can also be fused or bridged, e.g., can be a bicyclic ring.
  • heterocyclyl or “heterocycloalkyl” or “heterocycle” is a saturated, partially saturated or unsaturated, mono or bicyclic ring containing 3-24 atoms of which at least one atom is chosen from nitrogen, sulfur or oxygen, which may, unless otherwise specified, be carbon or nitrogen linked, wherein a -CH 2 - group can optionally be replaced by a -C(O)- or a ring sulfur atom may be optionally oxidised to form the S-oxides.
  • Heterocyclyl can be a saturated, partially saturated or unsaturated, mono or bicyclic ring containing 5 or 6 atoms of which at least one atom is chosen from nitrogen, sulfur or oxygen, which may, unless otherwise specified, be carbon or nitrogen linked, wherein a -CH 2 - group can optionally be replaced by a -C(O)- or a ring sulfur atom may be optionally oxidised to form S-oxide(s).
  • Non- limiting examples and suitable values of the term "heterocyclyl” are thiazolidinyl, pyrrolidinyl, pyrrolinyl, 2-pyrrolidonyl, 2,5-dioxopyrrolidinyl, 2-benzoxazolinonyl, 1, 1-dioxotetrahydro thienyl, 2,4-dioxoimidazolidinyl, 2-oxo-l,3,4-(4-triazolinyl), 2-oxazolidinonyl, 5,6-dihydro uracilyl, 1,3-benzodioxolyl, 1,2,4-oxadiazolyl, 2-azabicyclo[2.2.1]heptyl, 4-thiazolidonyl, morpholino, 2-oxotetrahydrofuranyl, tetrahydrofuranyl, 2,3-dihydrobenzofuranyl, benzothienyl, tetrahydro
  • halo or halogen means a fluoro, chloro, bromo, or iodo group.
  • “Spirocycle” or “spirocyclic” means carbogenic bicyclic ring systems with both rings connected through a single atom. The ring can be different in size and nature, or identical in size and nature. Examples include spiropentane, spirohexane, spiroheptane, spirooctane, spirononane, or spirodecane.
  • One or both of the rings in a spirocycle can be fused to another carbocyclic, heterocyclic, aromatic, or heteroaromatic ring.
  • One or more of the carbon atoms in the spirocycle can be substituted with a heteroatom (e.g., O, N, S, or P).
  • a C5-C 12 spirocycle is a spirocycle containing between 5 and 12 carbon atoms.
  • One or more of the carbon atoms can be substituted with a heteroatom.
  • spirocyclic heterocycle is understood to mean a spirocycle wherein at least one of the rings is a heterocycle (e.g., at least one of the rings is furanyl, morpholinyl, or piperadinyl).
  • a spirocyclic heterocycle can contain between 5 and 12 atoms, at least one of which is a heteroatom selected from N, O, S and P.
  • compositions comprising an effective amount of one or more disclosed compounds and a pharmaceutically acceptable carrier.
  • pharmaceutically acceptable carrier includes without limitation any adjuvant, carrier, excipient, glidant, sweetening agent, diluent, preservative, dye/colorant, flavor enhancer, surfactant, wetting agent, dispersing agent, suspending agent, stabilizer, isotonic agent, solvent, surfactant, or emulsifier that has been approved by the United States Food and Drug Administration as being acceptable for use in humans or domestic animals.
  • the disclosure includes pharmaceutically acceptable salts of the compounds described herein.
  • pharmaceutically acceptable salts include, but are not limited to, e.g., water-soluble and water-insoluble salts, such as the acetate, amsonate (4,4- diaminostilbene-2,2-disulfonate), benzenesulfonate, benzonate, bicarbonate, bisulfate, bitartrate, borate, bromide, butyrate, calcium, calcium edetate, camsylate, carbonate, chloride, citrate, clavulariate, dihydrochloride, edetate, edisylate, estolate, esylate, fiunarate, gluceptate, gluconate, glutamate, glycollylarsanilate, hexafluorophosphate, hexylresorcinate, hydrabamine, hydrobromide, hydrochloride, hydroxynaphthoate, io
  • “Pharmaceutically acceptable salt” also includes both acid and base addition salts.
  • “Pharmaceutically acceptable acid addition salt” refers to those salts which retain the biological effectiveness and properties of the free bases, which are not biologically or otherwise undesirable, and which are formed with inorganic acids such as, but are not limited to, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as, but not limited to, acetic acid, 2,2-dichloroacetic acid, adipic acid, alginic acid, ascorbic acid, aspartic acid, benzenesulfonic acid, benzoic acid, 4-acetamidobenzoic acid, camphoric acid, camphor- 10-sulfonic acid, capric acid, caproic acid, caprylic acid, carbonic acid, cinnamic acid, citric acid, cyclamic acid, dodecylsulfuric acid, ethane- 1,2-disulf
  • “Pharmaceutically acceptable base addition salt” refers to those salts which retain the biological effectiveness and properties of the free acids, which are not biologically or otherwise undesirable. These salts are prepared from addition of an inorganic base or an organic base to the free acid. Salts derived from inorganic bases include, but are not limited to, the sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. For example, inorganic salts include, but are not limited to, ammonium, sodium, potassium, calcium, and magnesium salts.
  • Salts derived from organic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as ammonia, isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, diethanolamine, ethanolamine, deanol, 2-dimethylaminoethanol, 2-diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, benethamine, benzathine, ethylenediamine, glucosamine, methylglucamine, theobromine, triethanolamine, tromethamine, purines, piperazine, piperidine, N-ethylpiperidine, polyamine resins and the like.
  • basic ion exchange resins such as
  • tautomers refers to a set of compounds that have the same number and type of atoms, but differ in bond connectivity and are in equilibrium with one another.
  • a "tautomer” is a single member of this set of compounds. Typically a single tautomer is drawn but it is understood that this single structure is meant to represent all possible tautomers that might exist. Examples include enol-ketone tautomerism. When a ketone is drawn it is understood that both the enol and ketone forms are part of the disclosure.
  • compounds of the present disclosure can exist in tautomeric form.
  • R 2 can be oxygen and tautomers of the compounds can exist in equilibrium:
  • prodrugs of the compounds described herein include prodrugs of the compounds described herein.
  • prodrug means a compound which is convertible in vivo by metabolic means (e.g., by hydrolysis) to a disclosed compound.
  • a prodrug is a drug which is inactive in the body, but is transformed in the body typically either during absorption or after absorption from the gastrointestinal tract into the active compound.
  • the conversion of the prodrug into the active compound in the body may be done chemically or biologically (i.e., using an enzyme).
  • the disclosure includes solvates of the compounds described herein.
  • solvate refers to a complex of variable stoichiometry formed by a solute and solvent.
  • solvents for the purpose of the disclosure may not interfere with the biological activity of the solute.
  • suitable solvents include, but are not limited to, water, MeOH, EtOH, and AcOH.
  • Solvates wherein water is the solvent molecule are typically referred to as hydrates. Hydrates include compositions containing stoichiometric amounts of water, as well as compositions containing variable amounts of water.
  • the disclosure includes isomers of the compounds described herein.
  • the term "isomer” refers to compounds that have the same composition and molecular weight but differ in physical and/or chemical properties. The structural difference may be in constitution (geometric isomers) or in the ability to rotate the plane of polarized light (stereoisomers). With regard to stereoisomers, the compounds of the present disclosure may have one or more asymmetric carbon atom and may occur as racemates, racemic mixtures and as individual enantiomers or diastereomers.
  • stereoisomers refers to the set of compounds which have the same number and type of atoms and share the same bond connectivity between those atoms, but differ in three dimensional structure.
  • stereoisomer refers to any member of this set of compounds. For instance, a stereoisomer may be an enantiomer or a diastereomer.
  • the disclosure includes stereoisomers of the compounds described herein.
  • the present disclosure embraces all geometric and positional isomers.
  • a compound of the present disclosure incorporates a double bond or a fused ring, both the cis- and trans-forms, as well as mixtures, are embraced within the scope of the disclosure.
  • the substituent may be in the E or Z configuration.
  • the cycloalkyl substituent may have a cis or trans configuration.
  • enantiomers refers to a pair of stereoisomers which are non- superimposable mirror images of one another.
  • the term “enantiomer” refers to a single member of this pair of stereoisomers.
  • the term “racemic” refers to a 1 : 1 mixture of a pair of enantiomers.
  • the disclosure includes enantiomers of the compounds described herein. Each compound herein disclosed includes all the enantiomers that conform to the general structure of the compound. The compounds may be in a racemic or enantiomerically pure form, or any other form in terms of stereochemistry.
  • the compounds are the (,S)-enantiomer.
  • the compounds are the (R)-enantiomer.
  • the compounds are the (+) or (-) enantiomers
  • compounds and compositions of the disclosure may be enriched to provide predominantly one enantiomer of a compound described herein.
  • An enantiomerically enriched mixture may comprise, for example, at least 60 mol percent of one enantiomer, or more preferably at least 75, 80, 85, 90, 95, 96, 97, 98, 99, 99.5 or even 100 mol percent.
  • the compound described herein enriched in one enantiomer is substantially free of the other enantiomer, wherein substantially free means that the substance in question makes up less than 10%, or less than 5%, or less than 4%, or less than 3%, or less than 2%), or less than 1% as compared to the amount of the other enantiomer, e.g., in the composition or compound mixture.
  • substantially free means that the substance in question makes up less than 10%, or less than 5%, or less than 4%, or less than 3%, or less than 2%), or less than 1% as compared to the amount of the other enantiomer, e.g., in the composition or compound mixture.
  • a composition or compound mixture contains 98 grams of a first enantiomer and 2 grams of a second enantiomer, it would be said to contain 98 mol percent of the first enantiomer and only 2 mol percent of the second enantiomer.
  • diastereomers refers to the set of stereoisomers which cannot be made superimposable by rotation around single bonds. For example, cis- and trans- double bonds, endo- and exo- substitution on bicyclic ring systems, and compounds containing multiple stereogenic centers with different relative configurations are considered to be diastereomers.
  • diastereomer refers to any member of this set of compounds.
  • the synthetic route may produce a single diastereomer or a mixture of diastereomers.
  • the disclosure includes diastereomers of the compounds described herein.
  • the compounds and compositions of the disclosure may be enriched to provide predominantly one diastereomer of a compound disclosed herein.
  • a diastereomerically enriched mixture may comprise, for example, at least 60 mol percent of one diastereomer, or more preferably at least 75, 99, 95, 96, 97, 98, 99, or even 100 mol percent.
  • the compounds described herein further include all pharmaceutically acceptable isotopically labeled compounds.
  • An “isotopically” or “radio-labeled” compound is a compound where one or more atoms are replaced or substituted by an atom having an atomic mass or mass number different from the atomic mass or mass number typically found in nature (i.e., naturally occurring).
  • hydrogen atoms are replaced or substituted by one or more deuterium or tritium.
  • radioactive isotopes tritium, i.e., 3 H, and carbon 14, i.e., 14 C are particularly useful for this purpose in view of their ease of incorporation and ready means of detection. Substitution with heavier isotopes such as deuterium, i.e., 2 H, may afford certain therapeutic advantages resulting from greater metabolic stability, for example, increased in vivo half-life or reduced dosage requirements, and hence may be preferred in some circumstances.
  • Suitable isotopes that may be incorporated in compounds described herein include but are not limited to 2 H (also written as D for deuterium), 3 H (also written as T for tritium), U C, 13 C, 14 C, 13 N, 15 N, 15 0, 17 0, 18 0, 18 F, 35 S, 36 C1 , 82 Br, 75 Br, 76 Br, 77 Br, 123 I, 124 I, 125 I, and 131 I.
  • Substitution with positron emitting isotopes, such as U C, 18 F, 15 0, and 13 N can be useful in Positron Emission Topography (PET) studies.
  • PET Positron Emission Topography
  • an "effective amount" when used in connection with a compound is an amount effective for treating or preventing a disease in a subject as described herein.
  • carrier encompasses carriers, excipients, and diluents and means a material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material, involved in carrying or transporting a pharmaceutical agent from one organ, or portion of the body, to another organ, or portion of the body of a subject.
  • treating refers to improving at least one symptom of the subject's disorder. Treating includes curing, improving, or at least partially ameliorating the disorder.
  • preventing refers to keeping a disease or disorder from afflicting the subject. Preventing includes prophylactic treatment. For instance, preventing can include administering to the subject one or more compounds disclosed herein before a subject is afflicted with a disease and the administration will keep the subject from being afflicted with the disease.
  • disorder is used in this disclosure to mean, and is used interchangeably with, the terms disease, condition, or illness, unless otherwise indicated.
  • administer refers to either directly administering one or more disclosed compounds or a pharmaceutically acceptable salt of one or more disclosed compounds or a composition comprising one or more disclosed compounds to a subject, or administering a prodrug derivative or analog of the compound or a pharmaceutically acceptable salt of the compound or composition to the subject, which can form an equivalent amount of active compound within the subject's body.
  • a "patient” or “subject” is a mammal, e.g., a human, mouse, rat, guinea pig, dog, cat, horse, cow, pig, or non-human primate, such as a monkey, chimpanzee, baboon or rhesus.
  • the compound is of the Formula I- A:
  • A is aryl
  • Y 1 is -S- or a direct bond
  • Y 2 is - R a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 H- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0- -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0- -C(0)N(R a )0- -N(R a )C(S)-, -C(S)N(R a )-, or
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C3-C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R
  • R a is independently, at each occurrence, -H, -D, -OH, -C3-C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C3-C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo; or R a and R 4 , together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C 3 -Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C4-C 8 cycloalkenyl, -C2-C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • the compound is of the
  • A is heteroaryl
  • Y 1 is -S- or a direct bond
  • Y 2 is - R a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 H- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0- -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0- -C(0)N(R a )0- -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side of Y 2 ,
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci-Cealkyl, -OH, or -NH 2 ; or R can combine with R a to form a 3- to 12-membered monocyclic or poly cyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C3-Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • the compound is of the Formula I-Wl :
  • A is heterocycloalkyl, aryl, or heteroaryl, wherein heterocycloalkyl, aryl, and heteroaryl are 5- to 12-membered monocyclic or 5- to 12-membered polycyclic;
  • Y 1 is -S- or a direct bond
  • Y 2 is -NR a -, -(CR a 2 )m-, -C(O)-, -C(R a ) 2 H-, or -(CR a 2 ) m O-; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, or aryl; wherein each alkyl, cycloalkyl, or aryl is optionally substituted with one or more -OH, halogen, -OR 5 , or -NR 5 R 6 ;
  • R a is independently, at each occurrence, -H or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -NH 2 , or wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8-membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -(CH 2 )n-aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, -(CH 2 ) n -aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more -OH, halogen, -R 5 , -OR 5 , -NR 5 R 6 , -NR 5 C(0)R 6 , heterocycle, aryl, heteroaryl, -(CH 2 ) n OH, -CF 3 , -CHF 2 , or -CH 2 F;
  • R 3 is independently -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, a 5-to 12-membered spiroheterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, spiroheterocycle, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-Cealkyl, -OH, -NH 2 , -OR b , -NHR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl; or
  • R 4 is independently -H, -Ci-C 6 alkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxyalkyl -CF 2 OH, -CHFOH -NHR 5 , -OR 5 , -NHC(0)R 5 , -NHC(0)NHR 5 , -C(0)OR 5 , -NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n R b , -C(0)R b , NH 2 , -OH, -CN, -C(0)NR 5 R 6 , -S(0) 2 R 5 R 6 , C 3 -C8cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C 3 -Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, a monocyclic or poly cyclic 3- to 12-membered heterocycle, -OR 7 , halogen, - R 7 R 8 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -OR b , or a monocyclic or poly cyclic 3- to 12-membered heterocycle, wherein each alkyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, - H 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Y 2 is -(CR a 2 ) m - In one or more embodiments of the compounds of Formula I-Wl, Y 2 is -NR a -
  • the compound is of the Formula I-W2:
  • A is heterocycloalkyl. In one or more embodiments of Formula I-W2, A is aryl. In one or more embodiments of Formula I-W2, A is heteroaryl. In one or more embodiments of Formula I-W2, A is pyridinyl. [0082] In one or more embodiments of Formula I-W2, n is independently, at each occurrence, 0, 1, 2, or 3.
  • R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, or -NR 5 R 6 . In certain such embodiments, R 5 and R 6 are both -H. In one or more embodiments of Formula I-W2, R 1 is independently, at each occurrence, methyl, fluoro, chloro, or - H 2 .
  • R 2 is OR b .
  • R b is H or optionally substituted -Ci-Cealkyl.
  • R 2 is -CN.
  • R 2 is optionally substituted -Ci-C 6 alkyl. In certain such embodiments, R 2 is methyl.
  • R 4 is -Ci-C 6 alkyl, which is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo. In one or more embodiments of Formula I-W2, R 4 is -Ci-C 6 alkyl, which is substituted with one or more -OH. In certain such embodiments, R 4 is -CH 2 -OH. In one or more embodiments of Formula I-W2, R 4 is -H. In one or more embodiments of Formula I-W2, R 4 is -CN.
  • R 4 is -Ci-Cehaloalkyl or -Ci-C 6 hydrox alkyl. In one or more embodiments of Formula I- W2, R 4 is -CF 2 OH or -CHFOH.
  • R 3 is -Ci-C 6 alkyl, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , -OR b , -NHR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl.
  • R 3 is -Ci-C 6 alkyl, which is optionally substituted with one or more -Ci-Cealkyl, -OH, -NH 2 , -OR b , -NHR b , or -(CH 2 ) n OH.
  • R 3 is an optionally substituted 3- to 12-membered monocyclic or polycyclic heterocycle. In certain such embodiments, R a is -H. In one or more embodiments of Formula I-W2, R 3 is an optionally substituted 3- to 12-membered monocyclic heterocycle. In certain such embodiments, R a is -H. In one or more embodiments of Formula I-W2, R 3 is an optionally substituted 3- to 12-membered polycyclic heterocycle. In certain such embodiments, R a is -H. In one or more embodiments of Formula I-W2, R 3 is an optionally substituted 5-to 12-membered polycyclic spiroheterocycle.
  • R a is -H.
  • R and R a together with the atom to which they are attached combine to form a 3- to 12-membered monocyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R 3 and R a together with the atoms to which they are attached combine to form a 3- to 12-membered polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R 3 and R a together with the atoms to which they are attached combine to form a 5- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R 3 and R a together with the atoms to which they are attached combine to form a 10- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R a and R 4 together with the atom to which they are attached combine to form an optionally substituted monocyclic or polycyclic 3- to 12-membered cycloalkyl.
  • the cycloalkyl is substituted with oxo.
  • R a and R 4 together with the atom to which they are attached combine to form an optionally substituted monocyclic or polycyclic 3- to 12-membered heterocycle.
  • the heterocycle is substituted with oxo.
  • the compound is of the Formula I-W3 :
  • the heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, halogen, -OH, -OR b , -CO HR b , heteroaryl, -CF 3 , -CHF 2 , -CH 2 F, or - H 2 .
  • A is heterocycloalkyl. In one or more embodiments of Formula I-W3, A is aryl. In one or more embodiments of Formula I-W3, A is heteroaryl. In one or more embodiments of Formula I-W3, A is pyridinyl.
  • n is independently, at each occurrence, 0, 1, 2, or 3.
  • R 1 is independently, at each occurrence, -Ci-C 6 alkyl, halogen, or -NR 5 R 6 . In certain such embodiments, R 5 and R 6 are both -H. In one or more embodiments of Formula I-W3, R 1 is independently, at each occurrence, methyl, fluoro, chloro, or - H 2 .
  • R 2 is OR b .
  • R b is H or optionally substituted -Ci-C 6 alkyl.
  • R 2 is -CN.
  • R 2 is optionally substituted -Ci-C 6 alkyl.
  • R 2 is methyl.
  • R 4 is -Ci-C 6 alkyl, which is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo. In one or more embodiments of Formula I-W3, R 4 is optionally substituted -Ci-C 6 alkyl, which is substituted with one or more -OH. In certain such embodiments, R 4 is -CH 2 -OH. In one or more embodiments of Formula I- W3, R 4 is -H. In one or more embodiments of Formula I-W3, R 4 is -CN.
  • R 4 is -Ci-C 6 haloalkyl or -Ci-C 6 hydroxyalkyl. In one or more embodiments of Formula I-W3, R 4 is -CF 2 OH or -CHFOH.
  • the compound is of the Formula I-W4:
  • A is heterocycloalkyl. In one or more embodiments of Formula I-W4, A is aryl. In one or more embodiments of Formula I-W4, A is heteroaryl. In one or more embodiments of Formula I-W4, A is pyridinyl.
  • n is independently, at each occurrence, 0, 1, 2, or 3.
  • R 1 is independently, at each occurrence, -Ci-C 6 alkyl, halogen, or -NR 5 R 6 . In certain such embodiments, R 5 and R 6 are both -H. In one or more embodiments of Formula I-W4, R 1 is independently, at each occurrence, methyl, fluoro, chloro, or - H 2 .
  • R 2 is OR b .
  • R b is H or optionally substituted -Ci-C 6 alkyl.
  • R 2 is -CN.
  • R 2 is optionally substituted -Ci-C 6 alkyl. In certain such embodiments, R 2 is methyl.
  • R 4 is -Ci-C 6 alkyl, which is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo. In one or more embodiments of Formula I-W4, R 4 is -Ci-C 6 alkyl, which is substituted with one or more -OH. In certain such embodiments, R 4 is -CH 2 -OH. In one or more embodiments of Formula I-W4, R 4 is -H. In one or more embodiments of Formula I-W4, R 4 is -CN.
  • R 4 is -Ci-Cehaloalkyl or -Ci-C 6 hydrox alkyl. In one or more embodiments of Formula I- W4, R 4 is -CF 2 OH or -CHFOH.
  • R 3 is -Ci-C 6 alkyl, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , -OR b , - HR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl.
  • R 3 is -Ci-C 6 alkyl, which is optionally substituted with one or more -Ci-Cealkyl, -OH, - H 2 , -OR b , - HR b , or -(CH 2 ) n OH.
  • R 3 is an optionally substituted 3- to 12-membered monocyclic or polycyclic heterocycle. In certain such embodiments, R a is -H. In one or more embodiments of Formula I-W4, R 3 is an optionally substituted 3- to 12-membered monocyclic heterocycle. In certain such embodiments, R a is -H. In one or more embodiments of Formula I-W4, R 3 is an optionally substituted 3- to 12-membered polycyclic heterocycle. In certain such embodiments, R a is -H. In one or more embodiments of Formula I-W4, R 3 is an optionally substituted 5-to 12-membered polycyclic spiroheterocycle. In certain such embodiments, R a is -H.
  • R 3 and R a together with the atom to which they are attached combine to form a 3- to 12-membered monocyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R 3 and R a together with the atoms to which they are attached combine to form a 3- to 12-membered polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R 3 and R a together with the atoms to which they are attached combine to form a 5- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R 3 and R a together with the atoms to which they are attached combine to form a 10- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , halogen, heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • R a and R 4 together with the atom to which they are attached combine to form an optionally substituted monocyclic or polycyclic 3- to 12-membered cycloalkyl.
  • the cycloalkyl is substituted with oxo.
  • R a and R 4 together with the atom to which they are attached combine to form an optionally substituted monocyclic or polycyclic 3- to 12-membered heterocycle.
  • the heterocycle is substituted with oxo.
  • the compound is of the Formula I-W5:
  • the heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-Cealkyl, halogen, -OH, -OR b , -CO HR b , heteroaryl, -CF 3 , -CHF 2 , -CH 2 F, or - H 2 .
  • A is heterocycloalkyl.
  • A is aryl.
  • A is heteroaryl.
  • A is pyridinyl.
  • n is independently, at each occurrence, 0, 1, 2, or 3.
  • R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, or -NR 5 R 6 . In certain such embodiments, R 5 and R 6 are both -H. In one or more embodiments of Formula I-W5, R 1 is independently, at each occurrence, methyl, fluoro, chloro, or -NH 2 .
  • R 2 is OR b .
  • R b is H or optionally substituted -Ci-C 6 alkyl.
  • R 2 is -CN.
  • R 2 is optionally substituted -Ci-C 6 alkyl.
  • R 2 is methyl.
  • R 4 is -Ci-C 6 alkyl, which is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo. In one or more embodiments of Formula I-W5, R 4 is -Ci-C 6 alkyl, which is substituted with one or more -OH. In certain such embodiments, R 4 is -CH 2 -OH. In one or more embodiments of Formula I-W5, R 4 is -H. In one or more embodiments of Formula I-W5, R 4 is -CN.
  • R 4 is -Ci-Cehaloalkyl or -Ci-C 6 hydrox alkyl. In one or more embodiments of Formula I- W5, R 4 is -CF 2 OH or -CHFOH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features:
  • A is heterocycloalkyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen,
  • R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R and R a together with the atom to which they are attached combine to form a 3- to 12- membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features:
  • A is aryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R 3 and R a together with the atom to which they are attached combine to form a 3- to 12- membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features: a) A is heteroaryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R 3 and R a together with the atom to which they are attached combine to form a 3- to 12- membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features: a) A is pyridinyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R 3 and R a together with the atom to which they are attached combine to form a 3- to 12- membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features: a) A is heterocycloalkyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R 3 and R a together with the atom to which they are attached combine to form a 5- to 12- membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features: a) A is aryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R 3 and R a together with the atom to which they are attached combine to form a 5- to 12- membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features: a) A is heteroaryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R 3 and R a together with the atom to which they are attached combine to form a 5- to 12- membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W2 or I-W4 having one, two, three, four, or more of the following features: a) A is pyridinyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) R and R a together with the atom to which they are attached combine to form a 5- to 12- membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is heterocycloalkyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 3- to 12-membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is aryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 3- to 12-membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is heteroaryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen,
  • R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 3- to 12-membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is pyridinyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 3- to 12-membered monocyclic or polycyclic heterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is heterocycloalkyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 5- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is aryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen,
  • R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 5- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is heteroaryl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen, -OCH 3 or - H 2 ; d) R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 5- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the present disclosure provides a compound of Formula I-W3 or I-W5 having one, two, three, four, or more of the following features: a) A is pyridinyl; b) n is independently, at each occurrence, 1 or 2; c) R 1 is independently, at each occurrence, optionally substituted -Ci-C 6 alkyl, halogen,
  • R 2 is optionally substituted -Ci-C 6 alkyl, such as methyl; e) B is a 5- to 12-membered spiroheterocycle, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , or halogen; and f) R 4 is -CH 2 -OH.
  • the compound is of Formula I-W6:
  • A is a 5- to 12-membered monocyclic or polycyclic heteroaryl
  • Y 2 is - R a -; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R 3 is combined with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or
  • spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , - -CHF 2 , or -CH 2 F;
  • R 1 is independently, at each occurrence, -H, -Ci-C 6 alkyl, -OH, halogen, -N0 2 ,
  • R 2 is -Ci-Cealkyl
  • R b is independently, at each occurrence, -H or -Ci-C 6 alkyl;
  • R 4 is -H, -Ci-Cealkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxyalkyl, -CF 2 OH, -CHFOH, -C(0) H(CH 2 ) n OH, -C(0) H(CH 2 ) n R b , -C(0)R b ,-C(0) R 5 R 6 , -OH, or -CN, wherein alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R 5 and R 6 are each independently, at each occurrence, -H or -Ci-C 6 alkyl
  • n is independently, at each occurrence, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • the compound is of Formula I-W7:
  • A is a 5- to 12-membered monocyclic or polycyclic heteroaryl
  • Y 1 is a direct bond
  • Y 2 is - R a -; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R 3 is combined with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or
  • spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F;
  • R 1 is independently, at each occurrence, -H, -Ci-C 6 alkyl, -OH, halogen, -N0 2 , -CN, -NR 5 R 6 , -SR 5 , -C(0)R 5 , or -C0 2 R 5 ;
  • R 2 is -Ci-Cealkyl
  • R b is independently, at each occurrence, -H or -Ci-C 6 alkyl
  • R 4 is-H, -Ci-Cealkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxyalkyl, -CF 2 OH, -CHFOH, -C(0)NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n R b , -C(0)R b ,-C(0)NR 5 R 6 , -OH, or -CN, wherein alkyl is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo; or R 5 and R 6 are each independently, at each occurrence, -H or -Ci-C 6 alkyl; and n is independently, at each occurrence, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • the compound is of the Formula II-A1 :
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12- membered spiroheterocycle along with the nitrogen atom to which it is attached, wherein the heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 .
  • the compound is of the Formula II- A2:
  • the compound is of the Formula II- A3 :
  • the compound is of the Formula II-B:
  • the compound is of the Formula II-B 1 :
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12- membered spiroheterocycle along with the carbon atom to which it is attached, wherein the heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 .
  • the compound is of the Formula II-B2:
  • the compound is of the Formula II-B 3 :
  • the compound is of the Formula II-B 4:
  • the compound is of the Formula II-B 5:
  • the compound is of the Formula II-B 6:
  • the compound is of the II-C:
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein the heterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or - H 2 .
  • the compound is of the Formula II-C 1 :
  • the compound is of the Formula II-D:
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein the heterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or - H 2
  • the compound is of the Formula II-D 1 :
  • the compound is of the Formula II-E: R 4 HIM .
  • the compound is of the Formula II-F:
  • the compound is of the II-G:
  • R 2 is an aryl or heteroaryl.
  • the compound is of the Formula III-A:
  • the compound is of the Formula III-Al :
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12- membered spiroheterocycle along with the nitrogen atom to which it is attached, wherein the heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or -NH 2 .
  • the compound is of the Formula III- A2:
  • the compound is of the Formula III- A3 :
  • a compound of the present disclosure e.g., a compound of Formula I, II, III, I-Vl, I-V2, 1-W, I-X, I-Y, or I-Z
  • a compound of the present disclosure e.g., a compound of Formula I, II, III, I-Vl, I-V2, 1-W, I-X, I-Y, or I-Z
  • a compound of the present disclosure e.g., a compound of Formula I, II, III, I-Vl, I-V2, 1-W, I-X, I-Y, or I-Z
  • a compound of the present disclosure can be selected from:
  • a compound of the present disclosure e.g., a compound of Formula I, II, III, I-Vl, I-V2, 1-W, I-X, I-Y, or I-Z
  • a compound of the present disclosure can be selected from:
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl.
  • A is heterocycloalkyl.
  • A is aryl.
  • A is heteroaryl. In one or more embodiments of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, A is pyridinyl.
  • Y 1 is -S(0 2 )-. In one or more embodiments of Formula I-Vl, I-V2, I-W, or I-Z, Y 1 is -S(0 2 )- H-.
  • Y 2 is - R a - In one or more embodiments of Formula I, II, III, I-W, I-X, I-Y, or I-Z, Y 2 is -(CR a 2 ) m - In one or more embodiments of Formula I, II, III, I-W, I-X, I-Y, or I-Z, Y 2 is -C(O)-.
  • Y 2 is -C(R a ) 2 H- or -(CR a 2 ) m O-. In one or more embodiments of Formula I, II, III, I-W, I-X, I-Y, or I-Z, Y 2 is -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(S)-, or -C(S)N(R a )-.
  • Y 2 is -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -OC(0)N(R a )-, -N(R a )C(0)0- or -C(0)N(R a )0-.
  • Y 2 is -C(0)0- -OC(O)-, or -OC(0)0-.
  • R 1 is independently, at each occurrence, selected from -H, optionally substituted -Ci-C 6 alkyl, halogen, -OH, -CN, and - R 5 R 6 .
  • R 1 is independently, at each occurrence, selected from -H, optionally substituted -Ci-C 6 alkyl, halogen, -OH, and - R 5 R 6 .
  • R 1 is independently, at each occurrence, selected from -H, optionally substituted -Ci-C 6 alkyl, halogen, and -NR 5 R 6 . In one or more embodiments of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, R 1 is independently, at each occurrence, selected from -H, methyl, fluoro, chloro, bromo, and - H 2 .
  • R 1 is independently, at each occurrence, selected from -H, methyl, fluoro, chloro, and - H 2 .
  • R 1 is -H.
  • the alkyl is substituted with halogen.
  • the halogen is fluoro.
  • R 1 is oxo
  • R 1 is -S(0) 2 R 5 .
  • R 5 is -Ci-C 6 alkyl.
  • R 1 is heteroaryl.
  • the heteroaryl is substituted with R 5 .
  • R 5 is -Ci-C 6 alkyl.
  • R 1 is -C(0) R 5 R 6 .
  • R 5 and R 6 are both -H.
  • R 1 is optionally substituted heterocyclyl. In one or more embodiments of Formula I-Vl, I-V2, or I-W, R 1 is optionally substituted spiroheterocyclyl.
  • R 1 is - R 5 R 6 .
  • R 5 is independently, at each occurrence, -H or -Ci-C 6 alkyl and R 6 is independently, at each occurrence, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, or monocyclic or polycyclic 3- to 12-membered heterocycle.
  • R 1 is -OR 6 .
  • R 6 is independently, at each occurrence, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, or monocyclic or polycyclic 3- to 12-membered heterocycle. In certain such embodiments, R 6 is -CH 3 .
  • R 2 is -OR b .
  • R b is -H.
  • R b is optionally substituted -Ci-C 6 alkyl.
  • R 2 is optionally substituted -Ci-C 6 alkyl. In one or more embodiments of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, R 2 is -CN. In one or more embodiments of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, R 2 is optionally substituted -C 2 -C 6 alkenyl.
  • R 2 is optionally substituted -C4-C 8 Cycloalkenyl. In one or more embodiments of Formula I, II, III, I-W, I-Vl, I-V2, I-X, I- Y, or I-Z, R 2 is optionally substituted -C 2 -C 6 alkynyl. In one or more embodiments of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, R 2 is optionally substituted -C 3 -C 8 cycloalkyl.
  • R 2 is optionally substituted aryl. In one or more embodiments of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, R 2 is optionally substituted heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O.
  • R 2 is optionally substituted heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O.
  • R 2 is methyl.
  • R 2 is halogen.
  • R 2 is - H 2 .
  • R 2 is -C(0)OR b .
  • R b is optionally substituted -Ci-C 6 alkyl.
  • R a is -H. In one or more embodiments of Formula I, II, III, I-W, I-X, or I-Y, R a is -OH. In one or more embodiments of Formula I, II, III, I-W, I-X, or I-Y, R a is optionally substituted -C 3 -C 8 cycloalkyl. In one or more embodiments of Formula I, II, III, I-W, I-X, or I-Y, R a is optionally substituted -Ci-C 6 alkyl.
  • R b is -H. In one or more embodiments of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, R b is optionally substituted -Ci-C 6 alkyl. In one or more embodiments of Formula I, II, III, I-Vl, I- V2, I-W, I-X, I-Y, or I-Z, R b is optionally substituted -C 3 -C 8 cycloalkyl.
  • R b is optionally substituted -C 2 -C 6 alkenyl.
  • R b is optionally substituted heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O.
  • R b is optionally substituted heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O.
  • R b is optionally substituted -(CH 2 ) n -aryl.
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , - R 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , -S(0)R 5 ,
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 , -NR 5
  • R 3 is optionally substituted -Ci-C 6 alkyl. In one or more embodiments of Formula I, II, III, I-Vl, I-W, I-X, I-Y, or I-Z, R 3 is an optionally substituted 3- to 12-membered monocyclic or polycyclic heterocycle. In one or more embodiments of Formula I, II, III, I-Vl, I-W, I-X, I-Y, or I-Z, R 3 is an optionally substituted 3- to 12-membered monocyclic heterocycle.
  • R 3 is an optionally substituted 3- to 12-membered polycyclic heterocycle. In one or more embodiments of Formula I-Vl or I-W, R 3 is an optionally substituted 5- to 12-membered spiroheterocycle.
  • R 3 is -Ci-C 6 alkyl, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , -OR b , -NHR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl.
  • R 4 is -H. In one or more embodiments of Formula I, II, III, I-V2, I-W, I-X, or I-Y, R 4 is optionally substituted -Ci-Cealkyl. In one or more embodiments of Formula or I-V2 or I-W, R 4 is -Ci-C 6 alkyl, substituted with one or more -OH, - H 2 , -OR b , halogen, or oxo.
  • R 4 is -Ci-C 6 alkyl substituted with -OH. In one or more embodiments of Formula I, II, III, I-V2, I-W, I-X, or I-Y, R 4 is -CH 2 -OH. In one or more embodiments of Formula I-V2, I-W, or I-Y, R 4 is -CN. In one or more embodiments of Formula I-V2, I-W, I-X, or I-Y, R 4 is optionally substituted heteroaryl.
  • R 4 is -Ci-C 6 haloalkyl or -Ci-C 6 hydroxyalkyl. In one or more embodiments of Formula I-V2 or I-W, R 4 is -CF 2 OH or -CHFOH.
  • R 4 is -C(0)R b .
  • R b is optionally substituted heterocyclyl.
  • R 4 is -C(0) H(CH 2 ) n R b
  • R b is optionally substituted heterocyclyl and n is 0.
  • R 4 is -C(0) H(CH 2 ) n OH. In certain such embodiments, n is 0.
  • R 4 is - H(CH 2 ) n OH. In certain such embodiments, n is 2.
  • R 4 is - HR 5 .
  • R 5 is -H.
  • R 4 is -OR 5 .
  • R 5 is -H.
  • R 4 is -C(0)OR 5 .
  • R 5 is -Ci-C 6 alkyl.
  • R 4 is -C(0) R 5 R 6 .
  • R 5 and R 6 are both -H.
  • the 5- to 12-membered spiroheterocycle is substituted with -OR b , R b is -H, -Ci-C 6 alkyl, or C 3 -C 8 cycloalkyl.
  • the 10- to 12-membered spiroheterocycle is substituted with -OR b , R b is -H, -Ci-C 6 alkyl, or C 3 -C 8 cycloalkyl.
  • R 3 is an optionally substituted 3- to 12-membered monocyclic or polycyclic heterocycle.
  • R 3 is -Ci-C 6 alkyl optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , -OR b , - HR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl.
  • R 3 is substituted with - H 2; heterocyclyl, or spiroheterocyclyl.
  • R 3 is a 3- to 12-membered monocyclic or polycyclic heterocycle, a 5- to 12-membered spiroheterocycle, or C3-C 8 cycloalkyl, wherein the heterocycle, spiroheterocycle, and C 3 - C 8 cycloalkyl are optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , -OR b , - HR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl.
  • n is independently, at each occurrence, 0, 1, 2, or 3. In one or more embodiments of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, n is 1. In one or more embodiments of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, n is 2. In one or more embodiments of Formula I, II, III, I- VI, I- V2, 1-W, I-X, I-Y, or I-Z, n is 0. In one or more embodiments of Formula I, II, III, I-Vl, I-V2, 1- W, I-X, I-Y, or I-Z, n is 3.
  • R 2 is -Ci-C 6 alkyl and R 4 is -H.
  • R 2 is -Ci-C 6 alkyl and R 4 is -Ci-C6alkyl.
  • R 2 is -Ci-C 6 alkyl and R 4 is -Ci-C 6 alkyl, substituted with one or more -OH, - H 2 , halogen, or oxo.
  • R 2 is -Ci-C 6 alkyl and R 4 is -Ci-C 6 alkyl, substituted with -OH.
  • R 2 is -OR b and R 4 is -H.
  • R 2 is -OR b and R 4 is -Ci-C 6 alkyl.
  • R 4 is -Ci-C 6 alkyl, substituted with one or more -OH, - H 2 , halogen, or oxo.
  • R 2 is -OR b and R 4 is -Ci-C 6 alkyl, substituted with -OH.
  • Y 1 is -S- and A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl.
  • Y 1 is -S- and A is heterocycloalkyl.
  • Y 1 is -S- and A is aryl.
  • Y 1 is -S- and A is heteroaryl.
  • Y 1 is a direct bond and A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl.
  • Y 1 is a direct bond and A is heterocycloalkyl.
  • Y 1 is a direct bond and A is aryl.
  • Y 1 is a direct bond and A is heteroaryl.
  • the compounds of the present disclosure may be made by a variety of methods, including standard chemistry. Suitable synthetic routes are depicted in the schemes given below.
  • the compounds of any of the formulae described herein may be prepared by methods known in the art of organic synthesis as set forth in part by the following synthetic schemes and examples. In the schemes described below, it is well understood that protecting groups for sensitive or reactive groups are employed where necessary in accordance with general principles or chemistry. Protecting groups are manipulated according to standard methods of organic synthesis (T. W. Greene and P. G. M. Wuts, "Protective Groups in Organic Synthesis," Third edition, Wiley, New York 1999). These groups are removed at a convenient stage of the compound synthesis using methods that are readily apparent to those skilled in the art. The selection processes, as well as the reaction conditions and order of their execution, shall be consistent with the preparation of compounds of the present disclosure.
  • the present disclosure includes both possible stereoisomers (unless specified in the synthesis) and includes not only racemic compounds but the individual enantiomers and/or diastereomers as well.
  • a compound When a compound is desired as a single enantiomer or diastereomer, it may be obtained by stereospecific synthesis or by resolution of the final product or any convenient intermediate. Resolution of the final product, an intermediate, or a starting material may be affected by any suitable method known in the art. See, for example, "Stereochemistry of Organic Compounds" by E. L. Eliel, S. H. Wilen, and L. N. Mander (Wiley- lnterscience, 1994).
  • the compounds described herein may be made from commercially available starting materials or synthesized using known organic, inorganic, and/or enzymatic processes.
  • the compounds of the present disclosure can be prepared in a number of ways well known to those skilled in the art of organic synthesis.
  • compounds of the present disclosure can be synthesized using the methods described below, together with synthetic methods known in the art of synthetic organic chemistry, or variations thereon as appreciated by those skilled in the art. These methods include but are not limited to those methods described below.
  • Scheme 1 General synthesis of 2-amino-5-thioaryl-(or thioheteroaryl)-6-methylpyrazines
  • a general synthesis of 3-amino-6-aryl-5-methylpyrazinyl-2-methanol and 3-amino-5- methyl-6-arylsulfanylpyrazinyl-2-methanol is outlined in Scheme 3.
  • Ethyl 6-bromo-3-chloro-5- methylpyrazine-2-carboxylate can be coupled to a substituted primary or secondary amine.
  • the resulting aminopyrazine intermediate can be coupled to a substituted aryl- or heteroaryl boronic acid or a substitures aryl thiol in the presence of a palladium catalyst (e.g., Pd(dppf)Cl 2 ), followed by a reduction step. Additional deprotection and/or functionalization steps can be required to produce the final compound.
  • a palladium catalyst e.g., Pd(dppf)Cl 2
  • aminopirazine intermediate can be prepared from ethyl 3-chloro-5- methylpyrazine-2-carboxylate by coupling to a substituted primary or secondary amine and the subsequent bromination with BS or an alternative bromination agent.
  • Another aspect of the disclosure relates to a method of treating a disease associated with SHP2 modulation in a subject in need thereof.
  • the method involves administering to a patient in need of treatment for diseases or disorders associated with SHP2 modulation an effective amount of one or more compounds of the present disclosure (e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), or of one or more pharmaceutical compositions of the present disclosure.
  • compounds of the present disclosure e.g., compounds of Formula I, II, III, I-Vl, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof.
  • the disease can be, but is not limited to Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon.
  • SHP2 is an important downstream signaling molecule for a variety of receptor tyrosine kinases, including the receptors of platelet-derived growth factor (PDGF-R), fibroblast growth factor (FGF-R) and epidermal growth factor (EGF-R).
  • PDGF-R platelet-derived growth factor
  • FGF-R fibroblast growth factor
  • EGF-R epidermal growth factor
  • SHP2 is also an important downstream signaling molecule for the activation of the mitogen activated protein (MAP) kinase pathway which can lead to cell transformation, a prerequisite for the development of cancer.
  • MAP mitogen activated protein
  • SHP2 significantly inhibited cell growth of lung cancer cell lines with SHP2 mutation or EML4/ALK translocations as well as EGFR amplified breast cancers and esophageal cancers.
  • SHP2 is also activated downstream of oncogenes in gastric carcinoma, anaplastic large-cell lymphoma and glioblastoma.
  • SHP2 plays a role in transducing signals originating from immune checkpoint molecules, including but not limited to programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).
  • PD-1 programmed cell death protein 1
  • CTL-4 cytotoxic T-lymphocyte-associated protein 4
  • modulation of SHP2 function can lead to immune activation, specifically anti-cancer immune responses.
  • Another aspect of the disclosure is directed to a method of inhibiting SHP2.
  • the method involves administering to a patient in need thereof an effective amount of one or more compounds of the present disclosure (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), or of one or more pharmaceutical compositions of the present disclosure.
  • compounds of the present disclosure e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof.
  • the present disclosure relates to compounds or compositions disclosed herein that are capable of modulating the activity of (e.g., inhibiting) SHP2.
  • the present disclosure also relates to the therapeutic use of such compounds and compositions.
  • One or more disclosed compounds or compositions can be administered in effective amounts to treat or prevent a disorder and/or prevent the development thereof in subjects.
  • SHP2 is inhibited after treatment with less than 1000 nM of a compound of the disclosure. In some embodiments, SHP2 is inhibited after treatment with about 10 nM to about 100 nM of a compound of the disclosure. In some embodiments, SHP2 is inhibited after treatment with 10 nM to 100 nM of a compound of the disclosure. In some embodiments, SHP2 is inhibited after treatment with less than 10 nM of a compound of the disclosure.
  • Another aspect of the present disclosure relates to one or more compounds of the present disclosure (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), or one or more compositions of the present disclosure for use in treating or preventing a disease associated with SHP2 modulation.
  • the disease is Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon.
  • SHP2 is an important downstream signaling molecule for a variety of receptor tyrosine kinases, including the receptors of platelet- derived growth factor (PDGF-R), fibroblast growth factor (FGF-R) and epidermal growth factor (EGF-R).
  • SHP2 is also an important downstream signaling molecule for the activation of the mitogen activated protein (MAP) kinase pathway which can lead to cell transformation, a prerequisite for the development of cancer.
  • MAP mitogen activated protein
  • Knock-down of SHP2 significantly inhibited cell growth of lung cancer cell lines with SHP2 mutation or EML4/ALK translocations as well as EGFR amplified breast cancers and esophageal cancers.
  • SHP2 is also activated downstream of oncogenes in gastric carcinoma, anaplastic large-cell lymphoma and glioblastoma.
  • the present disclosure relates to the use of one or more compounds of the present disclosure (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), in the manufacture of a medicament for treating or preventing a disease.
  • the disease is associated with SHP2 modulation.
  • the present disclosure relates to one or more compounds of the present disclosure (e.g., compounds of Formula I, II, III, I- VI, I-V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), for use as a medicament.
  • the medicament is used for treating or preventing a disease associated with SHP2 modulation.
  • the present disclosure relates to one or more compositions comprising one or more compounds of the present disclosure (e.g., compounds of Formula I, II, III, I-Vl, I- V2, I-W, I-X, I-Y, or I-Z, and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers thereof), for use as a medicament.
  • the medicament is used for treating or preventing a disease associated with SHP2 modulation.
  • compositions comprising one or more compounds of the present disclosure and a pharmaceutically acceptable carrier.
  • the pharmaceutically acceptable carrier can further include an excipient, diluent, or surfactant.
  • compositions can be prepared according to conventional mixing, granulating or coating methods, respectively, and the present pharmaceutical compositions can contain from about 0.1% to about 99%, from about 5% to about 90%, or from about 1% to about 20% of the disclosed compound by weight or volume.
  • Administration of the disclosed compounds and pharmaceutical compositions can be accomplished via any mode of administration for therapeutic agents. These modes include systemic or local administration such as oral, nasal, parenteral, intravenous, transdermal, subcutaneous, vaginal, buccal, rectal or topical administration modes.
  • systemic or local administration such as oral, nasal, parenteral, intravenous, transdermal, subcutaneous, vaginal, buccal, rectal or topical administration modes.
  • the disclosed compounds or pharmaceutical compositions can be in solid, semi-solid or liquid dosage form, such as, for example, injectables, tablets, suppositories, pills, time-release capsules, elixirs, tinctures, emulsions, syrups, powders, liquids, suspensions, or the like, sometimes in unit dosages and consistent with conventional pharmaceutical practices.
  • injectables tablets, suppositories, pills, time-release capsules, elixirs, tinctures, emulsions, syrups, powders, liquids, suspensions, or the like, sometimes in unit dosages and consistent with conventional pharmaceutical practices.
  • they can also be administered in intravenous (both bolus and infusion), intraperitoneal, subcutaneous or intramuscular form, and all using forms well known to those skilled in the pharmaceutical arts.
  • Illustrative pharmaceutical compositions are tablets and gelatin capsules comprising one or more compounds of the present disclosure and a pharmaceutically acceptable carrier, such as, but not limited to, a) a diluent, e.g., purified water, triglyceride oils, such as hydrogenated or partially hydrogenated vegetable oil, or mixtures thereof, corn oil, olive oil, sunflower oil, safflower oil, fish oils, such as EPA or DHA, or their esters or triglycerides or mixtures thereof, omega-3 fatty acids or derivatives thereof, lactose, dextrose, sucrose, mannitol, sorbitol, cellulose, sodium, saccharin, glucose and/or glycine; b) a lubricant, e.g., silica, talcum, stearic acid, its magnesium or calcium salt, sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride and/or
  • Liquid, particularly injectable, compositions can, for example, be prepared by dissolution, dispersion, etc.
  • one or more disclosed compounds are dissolved in or mixed with a pharmaceutically acceptable solvent such as, for example, water, saline, aqueous dextrose, glycerol, ethanol, and the like, to thereby form an injectable isotonic solution or suspension.
  • a pharmaceutically acceptable solvent such as, for example, water, saline, aqueous dextrose, glycerol, ethanol, and the like.
  • Proteins such as albumin, chylomicron particles, or serum proteins can be used to solubilize the disclosed compounds.
  • One or more disclosed compounds or compositions can be also formulated as a suppository that can be prepared from fatty emulsions or suspensions; using polyalkylene glycols such as propylene glycol, as the carrier.
  • One or more disclosed compounds or compositions can also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles and multilamellar vesicles.
  • Liposomes can be formed from a variety of phospholipids, containing cholesterol, stearylamine or phosphatidylcholines.
  • a film of lipid components is hydrated with an aqueous solution of drug to a form lipid layer encapsulating the drug, as described for instance in U.S. Pat. No. 5,262,564, the contents of which are hereby incorporated by reference.
  • One or more disclosed compounds or compositions can also be delivered by the use of monoclonal antibodies as individual carriers to which the disclosed compounds are coupled.
  • the disclosed compounds can also be coupled with soluble polymers as targetable drug carriers.
  • Such polymers can include polyvinylpyrrolidone, pyran copolymer, polyhydroxy propylmethacrylamide-phenol, polyhydroxyethylaspanamidephenol, or polyethyleneoxide polylysine substituted with palmitoyl residues.
  • the one or more disclosed compounds can be coupled to a class of biodegradable polymers useful in achieving controlled release of a drug, for example, polylactic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacrylates and cross-linked or amphipathic block copolymers of hydrogels.
  • one or more disclosed compounds are not covalently bound to a polymer, e.g., a polycarboxylic acid polymer, or a polyacrylate.
  • One or more disclosed compounds or compositions can be delivered by parental administration.
  • Parental injectable administration is generally used for subcutaneous, intramuscular or intravenous injections and infusions.
  • Injectables can be prepared in conventional forms, either as liquid solutions or suspensions or solid forms suitable for dissolving in liquid prior to injection.
  • the dosage regimen utilizing the disclosed compound is selected in accordance with a variety of factors including type, species, age, weight, sex and medical condition of the patient; the severity of the condition to be treated; the route of administration; the renal or hepatic function of the patient; and the particular disclosed compound employed.
  • a physician or veterinarian of ordinary skill in the art can readily determine and prescribe the effective amount of the drug required to prevent, counter or arrest the progress of the condition.
  • Effective dosage amounts of the disclosed compounds when used for the indicated effects, range from about 0.5 mg to about 5000 mg of the disclosed compound as needed to treat the condition.
  • Compositions for in vivo or in vitro use can contain about 0.5, 5, 20, 50, 75, 100, 150, 250, 500, 750, 1000, 1250, 2500, 3500, or 5000 mg of the disclosed compound, or, in a range of from one amount to another amount in the list of doses.
  • the compositions are in the form of a tablet that can be scored.
  • the effective daily dose of one or more compounds or compositions of this disclosure may be administered as one, two, three, four, five, six, or more sub-doses administered separately at appropriate intervals throughout the day, optionally, in unit dosage forms.
  • the one or more compounds or compositions of this disclosure, or mixtures thereof may be administered two or three times daily.
  • the one or more compounds or compositions of this disclosure will be administered once daily.
  • one or more compounds or compositions described herein may be used alone or together or conjointly administered, or used in combination, with another type of therapeutic agent.
  • Conjoint administration or used in combination refers to any form of administration of two or more different therapeutic compounds or compositions such that the second compound or composition is administered while the previously administered therapeutic compound or composition is still effective in the body.
  • the different therapeutic compounds or compositions can be administered either in the same formulation or in a separate formulation, either simultaneously, sequentially, or by separate dosing of the individual components of the treatment.
  • the different therapeutic compounds or compositions can be administered within one hour, 12 hours, 24 hours, 36 hours, 48 hours, 72 hours, or a week of one another.
  • an individual who receives such treatment can benefit from a combined effect of different therapeutic compounds or compositions.
  • this disclosure also provides a pharmaceutical package or kit comprising one or more containers filled with at least one compound or composition of this disclosure.
  • a container(s) can be a notice in the form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceuticals or biological products, which notice reflects (a) approval by the agency of manufacture, use or sale for human administration, (b) directions for use, or both.
  • the kit comprises at least two containers, at least one of which contains at least one compound or composition of this disclosure.
  • the kit contains at least two containers, and each of the at least two containers contains at least one compound or composition of this disclosure.
  • the kit includes additional materials to facilitate delivery of the subject compounds and compositions.
  • the kit may include one or more of a catheter, tubing, infusion bag, syringe, and the like.
  • the compounds and compositions are packaged in a lyophilized form, and the kit includes at least two containers: a container comprising the lyophilized compounds or compositions and a container comprising a suitable amount of water, buffer, or other liquid suitable for reconstituting the lyophilized material.
  • Embodiment 1-1 A compound of the Formula I:
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y is -S- or a direct bond
  • Y 2 is - R a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 H- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0- -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0- -C(0)N(R a )0- -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side of Y 2 ,
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalkyl is
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or -NH 2 ; or R can combine with R a to form a 3- to 12-membered monocyclic or poly cyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C3-Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment 1-2 The compound of embodiment I-l, wherein A is a 5- to 12- membered monocyclic or polycyclic cycloalkyl.
  • Embodiment 1-3 The compound of embodiment I-l or 1-2, wherein A is heterocycloalkyl.
  • Embodiment 1-4 The compound of any one of embodiments I-l to 1-3, wherein A is aryl.
  • Embodiment 1-5 The compound of any one of embodiments I-l to 1-4, wherein A is heteroaryl.
  • Embodiment 1-6 The compound of any one of embodiments I-l to 1-5, wherein Y 1 is -S-.
  • Embodiment 1-7 The compound of any one of embodiments I-l to 1-6, wherein Y 1 is a direct bond.
  • Embodiment 1-8 The compound of any one of embodiments I-l to 1-7, wherein Y 2 is - R a -
  • Embodiment 1-9 The compound of any one of embodiments I-l to 1-8, wherein Y 2 is -(CR a 2 ) m -.
  • Embodiment I- 10 The compound of any one of embodiments I-l to 1-9, wherein Y 2 is -C(O)-.
  • Embodiment I-l l The compound of any one of embodiments I-l to 1-10, wherein Y 2 is -C(R a ) 2 H- or -(CR a 2 ) m O-.
  • Embodiment 1-12 The compound of any one of embodiments I-l to I-l l, wherein Y 2 is -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(S)-, or -C(S)N(R a )-.
  • Embodiment 1-13 The compound of any one of embodiments I-l to 1-12, wherein Y 2 is -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -OC(0)N(R a )-, -N(R a )C(0)0- or -C(0)N(R a )0-.
  • Embodiment 1-14 The compound of any one of embodiments I-l to 1-13, wherein Y 2 is -C(0)0- -OC(O)-, or -OC(0)0-.
  • Embodiment 1-15 The compound of any one of embodiments I-l to 1-14, wherein R 2 is -OR b .
  • Embodiment 1-16 The compound of any one of embodiments I-l to 1-15, wherein R 2 is -Ci-Cealkyl.
  • Embodiment 1-17 The compound of any one of embodiments I-l to 1-16, wherein R 2 is -CN.
  • Embodiment 1-18 The compound of any one of embodiments I-l to 1-17, wherein R 2 is -C 2 -C 6 alkenyl.
  • Embodiment 1-19 The compound of any one of embodiments I-l to 1-18, wherein R 2 is -C4-C 8 Cycloalkenyl.
  • Embodiment 1-20 The compound of any one of embodiments I-l to 1-19, wherein R 2 s -C 2 -C 6 alkynyl.
  • Embodiment 1-21 The compound of any one of embodiments I-l to 1-20, wherein R 2 s -C3-C 8 Cycloalkyl.
  • Embodiment 1-22 The compound of any one of embodiments I-l to 1-21, wherein R 2 s aryl.
  • Embodiment 1-2 The compound of any one of embodiments I-l to 1-22, wherein R 2 s heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O.
  • Embodiment 1-24 The compound of any one of embodiments I-l to 1-23, wherein R 2 s or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O.
  • Embodiment 1-25 The compound of any one of embodiments I-l to 1-24, wherein R a s -H.
  • Embodiment 1-26 The compound of any one of embodiments I-l to 1-25, wherein R a s -OH.
  • Embodiment 1-27 The compound of any one of embodiments I-l to 1-26, wherein R a s -C3-C 8 Cycloalkyl.
  • Embodiment 1-28 The compound of any one of embodiments I-l to 1-27, wherein R a s -Ci-C 6 alkyl.
  • Embodiment 1-2 The compound of any one of embodiments I-l to 1-28, wherein R b s -H.
  • Embodiment 1-30 The compound of any one of embodiments I-l to 1-29, wherein R b s -Ci-Cealkyl.
  • Embodiment 1-3 The compound of any one of embodiments I-l to 1-30, wherein R b s -C3-C 8 Cycloalkyl.
  • Embodiment 1-32 The compound of any one of embodiments I-l to 1-31, wherein R b s -C 2 -C 6 alkenyl. [0275] Embodiment 1-33. The compound of any one of embodiments 1-1 to 1-32, wherein R b is heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O.
  • Embodiment 1-34 The compound of any one of embodiments 1-1 to 1-33, wherein R 3 is -Ci-C 6 alkyl.
  • Embodiment 1-35 The compound of any one of embodiments 1-1 to 1-34, wherein R 3 is 3- to 12-membered monocyclic or polycyclic heterocycle.
  • Embodiment 1-36 The compound of any one of embodiments 1-1 to 1-35, wherein R 3 is a 3- to 12-membered monocyclic heterocycle.
  • Embodiment 1-37 The compound of any one of embodiments 1-1 to 1-36, wherein R 3 is a 3- to 12-membered polycyclic heterocycle.
  • Embodiment 1-38 The compound of any one of embodiments 1-1 to 1-37, wherein R 3 and R a together with the atom to which they are attached combine to form a 3- to 12-membered monocyclic heterocycle.
  • Embodiment 1-39 The compound of any one of embodiments 1-1 to 1-38, wherein R 3 and R a together with the atoms to which they are attached combine to form a 3- to 12-membered polycyclic heterocycle.
  • Embodiment 1-40 The compound of any one of embodiments 1-1 to 1-39, wherein R 3 and R a together with the atoms to which they are attached combine to form a 5- to 12-membered spiroheterocycle.
  • Embodiment 1-4 The compound of any one of embodiments 1-1 to 1-40, wherein R a and R 4 together with the atom to which they are attached combine to form a monocyclic or polycyclic 3- to 12-membered cycloalkyl.
  • Embodiment 1-42 The compound of any one of embodiments 1-1 to 1-41, wherein R a and R 4 together with the atom to which they are attached combine to form a monocyclic or polycyclic 3- to 12-membered heterocycle.
  • Embodiment 1-4 A compound of the Formula I-A:
  • A is aryl
  • Y 1 is -S- or a direct bond
  • Y 2 is -NR a -, -(CR a 2 ) m - -C(O)-, -C(R a ) 2 H-, -(CR a 2 ) m O-, -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 R 5 R 6 , - R 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)R 6 , heterocycle,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or - H 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C3-Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is heteroaryl
  • Y 1 is -S- or a direct bond
  • Y 2 is -NR a -, -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side of
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C3-C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more - H 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C3-C 8 cycloalkyl, -C2-C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 R 5 R 6 , - R 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)R 6 , heterocycle, aryl,
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or - H 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C3-Ci 2 cycloalkyl, or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, - C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C3-C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12- membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C3-C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN; m is independently, at each occurrence, 1, 2, 3, 4, 5 or 6; and
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment 1-45 A compound of the Formula II:
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 2 is -NR a -, -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more - H 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 R 5 R 6 , - R 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)R 6 , heterocycle, ary
  • R 3 is independently -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci- C 6 alkyl, -OH, or - H 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment 1-46 The compound of embodiment 1-45, where the compound is of the Formula II- A:
  • Embodiment 1-47 The compound of embodiment 1-46, where the compound is of the Formula II- Al :
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12- membered spiroheterocycle along with the nitrogen atom to which it is attached, wherein the heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 .
  • Embodiment 1-48 The compound of embodiment 1-46, wherein the compound is of the Formula II- A2:
  • Embodiment 1-49 The compound of embodiment 1-46, wherein the compound is of the Formula II- A3 :
  • Embodiment 1-50 The compound of embodiment 1-45, wherein the compound is of the Formula II-B:
  • Embodiment 1-51 The compound of embodiment 1-50, wherein the compound is of the Formula II-B 1 :
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12- membered spiroheterocycle along with the carbon atom to which it is attached, wherein the heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 .
  • Embodiment 1-52 The compound of embodiment 1-50, wherein the compound is of the Formula II-B2:
  • Embodiment 1-53 The compound of embodiment 1-50, wherein the compound is of the Formula II-B3 :
  • Embodiment 1-54 The compound of embodiment 1-50, wherein the compound is of the Formula II-B4:
  • Embodiment 1-55 The compound of embodiment 1-50, wherein the compound is of the Formula II-B5:
  • Embodiment 1-56 The compound of embodiment 1-50, wherein the compound is of the Formula II-B6:
  • Embodiment 1-57 The compound of embodiment 1-45, wherein the compound is of the Formula II-C:
  • B forms a 3- to 12-membered monocyclic or poly cyclic heterocycle, wherein the heterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or -NH 2 .
  • Embodiment 1-58 The compound of embodiment 1-57, wherein the compound is of the Formula II-C 1 :
  • Embodiment 1-59 The compound of embodiment 1-57, wherein the compound is of the Formula II-D:
  • B forms a 3- to 12-membered monocyclic or poly cyclic heterocycle, wherein the heterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2.
  • Embodiment 1-60 The compound of embodiment 1-57, wherein the compound is of the Formula II-D 1 :
  • Embodiment 1-61 The compound of embodiment 1-45, wherein the compound is of the Formula II-E: R 4 HIM .
  • Embodiment 1-62 The compound of embodiment 1-45, wherein the compound is of the Formula II-F:
  • Embodiment 1-63 The compound of embodiment 1-45, wherein the compound is of the Formula II-G:
  • R 2 is aryl or heteroaryl.
  • Embodiment 1-64 A compound of the Formula III:
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 2 is -NR a -, -(CR a 2 ) m -, -C(O)-, -C(R a ) 2 H-, -(CR a 2 ) m O-, -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0- ,-OC(0)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, and -OC(0)0-; wherein the bond on the left side
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 R 5 R 6 , - R 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)R 6 , heterocycle,
  • R 3 is independently, at each occurrence, selected from the group consisting of -Ci-C 6 alkyl or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, or - H 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment 1-65 The compound of embodiment 1-64, wherein the compound is of the Formula III-A:
  • Embodiment 1-66 The compound of embodiment 1-65, wherein the compound is of the Formula III-Al :
  • B forms a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12- membered spiroheterocycle along with the nitrogen atom to which it is attached, wherein the heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 .
  • Embodiment 1-67 The compound of embodiment 1-65, wherein the compound is of the Formula III- A2:
  • Embodiment 1-68 The compound of embodiment 1-65, wherein the compound is of the Formula III- A3 :
  • Embodiment 1-69 A compound selected from the group consisting of Compounds 1- 41, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof.
  • Embodiment 1-70 A pharmaceutical composition comprising one or more compounds of any one of embodiments I-l to 1-69 and a pharmaceutically acceptable carrier.
  • Embodiment 1-71 A method of treating a disease associated with SHP2 modulation in a subject in need thereof, comprising administering to the subject an effective amount of one or more compounds of any one of embodiments I-l to 1-69.
  • Embodiment 1-72 The method of embodiment 1-71, wherein the disease is selected from Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon.
  • the disease is selected from Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon.
  • Embodiment 1-73 One or more compounds of any one of embodiments I-l to 1-69 for use in treating or preventing a disease associated with SHP2 modulation.
  • Embodiment 1-74 Use of one or more compounds of any one of embodiments I-l to 1-69 in the manufacture of a medicament for treating or preventing a disease associated with SHP2 modulation.
  • Embodiment 1-75 A compound of the Formula I-X:
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 1 is -S- or a direct bond
  • Y 2 is -NR a - -(CR a 2 ) m - -C(O)-, -C(R a ) 2 H-, -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0- -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side of
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 ,
  • R 3 is independently -H, -Ci-C 6 alkyl, or a 3- to 12-membered monocyclic or polycyclic heterocycle, wherein each alkyl or heterocycle is optionally substituted with one or more -Ci-Cealkyl, -OH, or - H 2 ; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, - H- HR 5 , - H-OR 5 , -0- R 5 R 6 , - HR 5 , -OR 5 , - HC(0)R 5 , - HC (0) HR 5 , - HS(0) 2 R 5 , - HS(0) 2 HR 5 , -S(0) 2 OH, -C(0)OR 5 , -C(0) R 5 R 6 , -S(0) 2 R 5 R 6 , C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, cycloalkyl, or heterocyclyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo i wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN; m is independently, at each occurrence, 1, 2, 3, 4, 5 or 6; and
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment 1-76 A compound of the Formula I-Y:
  • I-Y or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof, wherein:
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y is -S- or a direct bond
  • Y 2 is -NR a -, -(CR a 2 ) m - -C(O)-, -C(R a ) 2 NH- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left side
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 R 5
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more - H 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , -OR a , -NHR a , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl; or
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, -NH 2 , heteroaryl, heterocyclyl, -(CH 2 ) n NH 2 , -COOR b , -CONHR b , -CONH(CH 2 ) n COOR b , -NHCOOR b , -CF 3 , -CHF 2 , or -CH 2 F;
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, -NH-NHR 5 , -NH-OR 5 , -0-NR 5 R 6 , -NHR 5 , -OR 5 , -NHC(0)R 5 , -NHC (0)NHR 5 , -NHS(0) 2 R 5 , -NHS(0) 2 NHR 5 , -S(0) 2 OH, -C(0)OR 5 , -NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n R b , -C(0)R b , -NH 2 , -OH, -CN, -C(0)NR 5 R 6 , -S(0) 2 NR 5 R 6 , C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • A is a 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 2 is - R a - -(CR a 2 ) m - -C(R a ) 2 H- -(CR a 2 ) m O- -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 - -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0-, -N(R a )C(S)-, or -C(S)N(R a )-; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y
  • R 2 is independently -OR b , -NH 2 , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -
  • R a is independently, at each occurrence, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8-membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 - C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 is independently, at each occurrence, -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , -OR a , -NHR a , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl; or R can combine with R a to form a 3- to 12-membered monocyclic or poly cyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl
  • R 4 is independently -Ci-C 6 alkyl, - H- HR 5 , - H-OR 5 , -0- R 5 R 6 , - HR 5 , -OR 5 , - HC(0)R 5 , - HC (0) HR 5 , - HS(0) 2 R 5 , - HS(0) 2 HR 5 , -S(0) 2 OH, -C(0)OR 5 , - H(CH 2 ) n OH, -C(0) H(CH 2 ) n OH, -C(0) H(CH 2 ) n R b , -C(0)R b , - H 2 , -OH, -C(0) R 5 R 6 , -S(0) 2 R 5 R 6 , C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of
  • R a and R 4 together with the atom or atoms to which they are attached, are combined to form a monocyclic or poly cyclic C 3 -Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment 1-78 A compound selected from the group consisting of Compounds A-l to A-141, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof.
  • Embodiment II- 1 A compound of Formula I-W:
  • A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are 5- to 12-membered monocyclic or 5- to 12-membered polycyclic;
  • Y 2 is -NR a -, -(CR a 2 ) m -, -C(O)-, -C(R a ) 2 H-, -(CR a 2 ) m O-, -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0- -N(R a )C(S)-, -C(S)N(R a )-, or -OC(0)0-; wherein the bond on the left
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, -OR 6 , halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0) R 5 R 6 , -C(0)R 5 ,-C0 2 R 5 , -C(0)NR 5 R 6 , - R 5 C(0)R 6 , monocyclic or polycyclic heterocycl
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , - R 5 R 6 ,
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, -Ci-C 6 alkyl, 3- to 12-membered heterocyclyl, or -(CH 2 ) n -aryl, wherein each alkyl or cycloalkyl is optionally substituted with one or more - H 2 , or wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8-membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -OH, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, -(CH 2 ) n -aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, heterocycle, heteroaryl, or -(CH 2 ) n -aryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5
  • R 3 is independently -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, a 5- to 12-membered spiroheterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, spiroheterocycle, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-C 6 alkyl, -OH, -NH 2 , -OR b , -NHR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl; or
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxy alkyl, -CF 2 OH, -CHFOH, -NH-NHR 5 , -NH-OR 5 , -0-NR 5 R 6 , -NHR 5 , -OR 5 , -NHC(0)R 5 , -NHC(0)NHR 5 , -NHS(0) 2 R 5 , -NHS(0) 2 NHR 5 , -S(0) 2 OH, -C(0)OR 5 , -NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n R b , -C(0)R b , -NH 2 , -OH, -CN, -C(0)NR 5 R 6 , -S(0) 2 NR 5 R 6 , C 3 -C 8
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or poly cyclic C 3 -Ci 2 cycloalkyl or a monocyclic or poly cyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or poly cyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , -CF 3 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OR b , or a monocyclic or poly cyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment II-2 The compound of embodiment II- 1, wherein the compound is Formula I:
  • A is 5- to 12-membered monocyclic or polycyclic cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
  • Y 1 is -S- or a direct bond
  • Y 2 is -NR a -, -(CR a 2 ) m -, -C(O)-, -C(R a ) 2 H-, -(CR a 2 ) m O-, -C(0)N(R a )-, -N(R a )C(0)-, -S(0) 2 N(R a )-, -N(R a )S(0) 2 -, -N(R a )C(0)N(R a )-, -N(R a )C(S)N(R a )-, -C(0)0-, -OC(O)-, -OC(0)N(R a )-, -N(R a )C(0)0-, -C(0)N(R a )0- -N(R a )C(S)-, -C(S)N(R a )-
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0)NR 5 R 6 , - R 5 S(0)R 6 , -C(0)R 5 , or -C0 2 R 5 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, or cycloalky
  • R 2 is independently -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR
  • R a is independently, at each occurrence, -H, -D, -OH, -C 3 -C 8 cycloalkyl, or -Ci-C 6 alkyl, wherein each alkyl or cycloalkyl is optionally substituted with one or more -NH 2 , wherein 2 R a , together with the carbon atom to which they are both attached, can combine to form a 3- to 8- membered cycloalkyl;
  • R b is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, or heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, or heterocycle is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0) 2 NR 5 R 6 , -NR 5 S(0) 2 R 6 , -NR 5 S(0) 2 R 6 , -S(0)NR 5 R 6 , -S(0)R 5 , -NR 5 S(0)NR 5 R 6 ,
  • R 3 can combine with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with -Ci-C 6 alkyl, -OH, or - H 2 ;
  • R 4 is independently -H, -D, or -Ci-C 6 alkyl, wherein each alkyl is optionally substituted with one or more -OH, - H 2 , halogen, or oxo; or
  • R a and R 4 together with the atom or atoms to which they are attached, can combine to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo;
  • R 5 and R 6 are each independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, - H 2 , -N0 2 , or -CN;
  • n is independently, at each occurrence, 1, 2, 3, 4, 5 or 6;
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment II-3 The compound of embodiment II- 1, wherein the compound is Formula I-W6:
  • I-W6 or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof, wherein:
  • A is a 5- to 12-membered monocyclic or polycyclic heteroaryl
  • Y 1 is -S-;
  • Y 2 is - R a -; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R 3 is combined with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F;
  • R 1 is independently, at each occurrence, -H, -Ci-C 6 alkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -C(0)R 5 , or -C0 2 R 5 ;
  • R 2 is -Ci-C 6 alkyl
  • R b is independently, at each occurrence, -H or -Ci-C 6 alkyl
  • R 4 is -H, -Ci-Cealkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxyalkyl, -CF 2 OH, -CHFOH, -C(0) H(CH 2 ) n OH, -C(0) H(CH 2 ) n R b , -C(0)R b ,-C(0) R 5 R 6 , -OH, or -CN, wherein alkyl is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo; or
  • R 5 and R 6 are each independently, at each occurrence, -H or -Ci-C 6 alkyl
  • n is independently, at each occurrence, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment II-4 The compound of embodiment II- 1 , wherein the compound is Formula I-W7:
  • I-W7 or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof, wherein:
  • A is a 5- to 12-membered monocyclic or polycyclic heteroaryl
  • Y 1 is a direct bond
  • Y 2 is -NR a -; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R is combined with R a to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F;
  • R 1 is independently, at each occurrence, -H, -Ci-C 6 alkyl, -OH, halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -C(0)R 5 , or -C0 2 R 5 ;
  • R 2 is -Ci-Cealkyl
  • R b is independently, at each occurrence, -H or -Ci-C 6 alkyl
  • R 4 is -H, -Ci-Cealkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxyalkyl, -CF 2 OH, -CHFOH, -C(0) H(CH 2 ) n OH, -C(0) H(CH 2 ) n R b , -C(0)R b ,-C(0) R 5 R 6 , -OH, or -CN, wherein alkyl is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo; or
  • R 5 and R 6 are each independently, at each occurrence, -H or -Ci-C 6 alkyl
  • n is independently, at each occurrence, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment II-5 A compound of Formula I-Vl :
  • A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are 5- to 12-membered monocyclic or 5- to 12-membered polycyclic;
  • Y 2 is -NR a -, wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R a and R 4 together with the atom or atoms to which they are attached, are combined to form a monocyclic or polycyclic C 3 -Ci 2 cycloalkyl or a monocyclic or polycyclic 3- to 12- membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with oxo; wherein the heterocycle optionally comprises -S(0) 2 - in the heterocycle;
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C2-C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OH, -OR 6 , halogen, -N0 2 , -CN, - R 5 R 6 , -SR 5 , -S(0) 2 R 5 R 6 , -S(0) 2 R 5 , - R 5 S(0) 2 R 5 R 6 , -NR 5 S(0) 2 R 6 , -S(0) R 5 R 6 , -S(0)R 5 , - R 5 S(0) R 5 R 6 , -C(0)R 5 ,-C0 2 R 5 , -C(0)NR 5 R 6 , -C(0)NR 5 R 6 , - R 5 C(0)R 6 , monocyclic or polycyclic heterocycly
  • R 2 is independently -NH 2 , -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -
  • R b is independently, at each occurrence, -H, -D, -OH, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, -(CH 2 ) n -aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, heterocycle, heteroaryl, or -(CH 2 )n-aryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5 S(0)
  • R 3 is independently -H, -Ci-C 6 alkyl, a 3- to 12-membered monocyclic or polycyclic heterocycle, a 5- to 12-membered spiroheterocycle, C 3 -C 8 cycloalkyl, or -(CH 2 ) n -R b , wherein each alkyl, spiroheterocycle, heterocycle, or cycloalkyl is optionally substituted with one or more -Ci-Cealkyl, -OH, - H 2 , -OR b , - HR b , -(CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl;
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C3-C 8 cycloalkyl, a monocyclic or polycyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , -CF 3 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C4-C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OR b , or a monocyclic or polycyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN; and
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • I-V2 or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, and isomer thereof, wherein:
  • A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are 5- to 12-membered monocyclic or 5- to 12-membered polycyclic;
  • Y 2 is -NR a -, wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2 moiety, as drawn, is bound to R 3 ;
  • R 1 is independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -
  • R 2 is independently -NH 2 , -OR b , -CN, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, halogen, -C(0)OR b , -C 3 -C 8 cycloalkyl, aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -
  • R b is independently, at each occurrence, -H, -D, -OH, -Ci-C 6 alkyl, -C 3 -C 8 cycloalkyl, -C 2 -C 6 alkenyl, -(CH 2 ) n -aryl, heterocyclyl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; wherein each alkyl, cycloalkyl, alkenyl, heterocycle, heteroaryl, or -(CH 2 ) n -aryl is optionally substituted with one or more -OH, halogen, -N0 2 , oxo, -CN, -R 5 , -OR 5 , -NR 5 R 6 , -SR 5 , -S(0) 2 NR 5 R 6 , -S(0) 2 R 5 , -NR 5
  • R 4 is independently -H, -D, -Ci-C 6 alkyl, -Ci-C 6 haloalkyl, -Ci-C 6 hydroxy alkyl, -CF 2 OH, -CHFOH, -NH-NHR 5 , -NH-OR 5 , -0-NR 5 R 6 , -NHR 5 , -OR 5 , -NHC(0)R 5 , -NHC(0)NHR 5 , -NHS(0) 2 R 5 , -NHS(0) 2 NHR 5 , -S(0) 2 OH, -C(0)OR 5 , -NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n OH, -C(0)NH(CH 2 ) n R b , -C(0)R b , -NH 2 , -OH, -CN, -C(0)NR 5 R 6 , -S(0) 2 NR 5 R 6 , C 3 -C 8
  • R 5 and R 6 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, a monocyclic or poly cyclic 3- to 12-membered heterocycle, -OR 7 , -SR 7 , halogen, - R 7 R 8 , -N0 2 , -CF 3 , or -CN;
  • R 7 and R 8 are independently, at each occurrence, -H, -D, -Ci-C 6 alkyl, -C 2 -C 6 alkenyl, -C 4 -C 8 cycloalkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -OR b , or a monocyclic or poly cyclic 3- to 12-membered heterocycle, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocycle is optionally substituted with one or more -OH, -SH, -NH 2 , -N0 2 , or -CN; and
  • n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
  • Embodiment II-7 The compound of embodiment II-5 or II-6, wherein R 2 is -NH 2 .
  • Embodiment II-8 The compound of any one of embodiments II- 1 to II-2 and II-5 to II-7, wherein A is cycloalkyl.
  • Embodiment II-9 The compound of any one of embodiments II-l to II-2 and II-5 to II-7, wherein A is heterocycloalkyl.
  • Embodiment 11-10 The compound of any one of embodiments II-l to II-2 and II-5 to II-7, wherein A is aryl.
  • Embodiment II-l 1. The compound of any one of embodiments II-l to II-2 and II-5 to II-7, wherein A is heteroaryl.
  • Embodiment 11-12 The compound of any one of embodiments II-l to II-7, wherein A is pyridinyl.
  • Embodiment 11-13 The compound of any one of embodiments II-l to 11-12, wherein n is 1 or 2.
  • Embodiment 11-14 The compound of any one of embodiments II-l to 11-13, wherein R 1 is independently, at each occurrence, -Ci-Cealkyl, halogen, or -NR 5 R 6 .
  • Embodiment 11-15 The compound of any one of embodiments II-l to 11-13, wherein R 1 is independently selected from methyl, fluoro, chloro, and - H 2 .
  • Embodiment 11-16 The compound of any one of embodiments II-l to II-2 and II-5 to 11-15, wherein Y 1 is -S-.
  • Embodiment 11-17 The compound of any one of embodiments II-l to II-2 and II-5 to 11-15, wherein Y 1 is a direct bond.
  • Embodiment 11-18 The compound of any of one of embodiments II-l to II-6 and II-8 to 11-17, wherein R 2 is -OR b .
  • Embodiment 11-19 The compound of embodiment 18, wherein R b is -H.
  • Embdoment 11-20 The compound of embodiment 18, wherein R b is -Ci-C 6 alkyl.
  • Embodiment 11-21 The compound of any of one of embodiments II-l to II-6 and II-8 to 11-17, wherein R 2 is -CN.
  • Embodiment 11-22 The compound of any of one of embodiments II-l to II-6 and II-8 to 11-17, wherein R 2 is -Ci-C 6 alkyl.
  • Embodiment 11-23 The compound of any of embodiment 11-22, wherein R 2 is methyl.
  • Embodiment 11-24 The compound of any of one of embodiments II-l to II-6 and II-8 to 11-17, wherein R 2 is -C2-C 6 alkenyl.
  • Embodiment 11-25 The compound of any of one of embodiments II-l to II-6 and II-8 to 11-17, wherein R 2 is -C 2 -C 6 alkynyl.
  • Embodiment 11-26 The compound of any one of embodiments II-l to II-4 and II-6 to 11-25, wherein R 4 is -Ci-C 6 alkyl, which is optionally substituted with one or more -OH, -NH 2 , halogen, or oxo.
  • Embodiment 11-27 The compound of embodiment 11-26, wherein R 4 is -Ci-C 6 alkyl, which is substituted with -OH.
  • Embodiment 11-28 The compound of embodiment 11-26, wherein R 4 is -CH 2 -OH.
  • Embodiment 11-29 The compound of any one of embodiments II-l to II-4 and II-6 to 11-25, wherein R 4 is -H.
  • Embodiment 11-30 The compound of any one of embodiments II-l to II-4 and II-6 to 11-25, wherein R 4 is -CN.
  • Embodiment 11-31 The compound of any one of embodiments II-l to II-4 and II-6 to 11-25, wherein R 4 is -CF 2 OH or -CHFOH.
  • Embodiment 11-32 The compound of any one of embodiments II-l to II-2 and II-7 to II-31, wherein Y 2 is -NR a -
  • Embodiment 11-33 The compound of any one of embodiments II-l to II-2 and II-7 to II-31, wherein Y 2 is -(CR a 2 ) m -.
  • Embodiment 11-34 The compound of any one of embodiments II-l to II-2, II-5, and II-7 to 11-33, wherein R 3 is -Ci-C 6 alkyl, which is optionally substituted with one or more -Ci-C 6 alkyl, -OH, - H 2 , -OR b , - HR b , - (CH 2 ) n OH, heterocyclyl, or spiroheterocyclyl.
  • Embodiment 11-35 The compound of any one of embodiments II-l to II-2, II-5, and II-7 to 11-34, wherein R a is -H.
  • Embodiment 11-36 The compound of any one of embodiments II-l to II-2, II-5, II-7 to 11-33, and 11-35, wherein R 3 is 3- to 12-membered monocyclic or polycyclic heterocycle.
  • Embodiment 11-37 The compound of any one of embodiments II-l to II-2, II-5, II-7 to 11-33, and 11-35, wherein R 3 is a 3- to 12-membered monocyclic heterocycle.
  • Embodiment 11-38 The compound of any one of embodiments II-l to II-2, II-5 to II- 33, and 11-35, wherein R 3 is a 3- to 12-membered polycyclic heterocycle.
  • Embodiment 11-39 The compound of any one of embodiments II-l to II-4 and II-7 to 11-33, wherein R 3 and R a together with the atom to which they are attached combine to form a 3- to 12-membered monocyclic heterocycle, which is optionally substituted with -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • Embodiment 11-40 The compound of any one of embodiments II-l to II-4 and II-6 to 11-33, wherein R 3 and R a together with the atoms to which they are attached combine to form a 3- to 12-membered polycyclic heterocycle, which is optionally substituted with -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • Embodiment 11-41 The compound of any one of embodiments II-l to II-4 and II-6 to 11-33, wherein R 3 and R a together with the atoms to which they are attached combine to form a 5- to 12-membered spiroheterocycle, which is optionally substituted with -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • Embodiment 11-42 The compound of embodiment 11-41, wherein R 3 and R a together with the atoms to which they are attached combine to form a 10- to 12-membered spiroheterocycle, which is optionally substituted with -Ci-C 6 alkyl, -OH, - H 2 , heteroaryl, heterocyclyl, -(CH 2 ) n H 2 , -COOR b , -CO HR b , -CO H(CH 2 ) n COOR b , - HCOOR b , -CF 3 , -CHF 2 , or -CH 2 F.
  • Embodiment 11-43 The compound of any of embodiments II- 1 to II-2, II-7 to 11-25, 11-32 to 11-34 and 11-36 to 11-38, wherein R a and R 4 together with the atom to which they are attached combine to form a monocyclic or polycyclic 3- to 12-membered cycloalkyl.
  • Embodiment 11-44 The compound of any of embodiments II-l to II-2, II-7 to 11-25, 11-32 to 11-34 and 11-36 to 11-38, wherein R a and R 4 together with the atom to which they are attached combine to form a monocyclic or polycyclic 3- to 12-membered heterocycle.
  • Embodiment 11-45 A compound selected from the group consisting of Compounds 1-41 and Compounds A-l to A-309, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof.
  • Embodiment 11-46 A pharmaceutical composition comprising a compound of any one of embodiments II-l to 11-45, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof, and a pharmaceutically acceptable carrier.
  • Embodiment 11-47 A method of treating a disease associated with SHP2 modulation in a subject in need thereof, comprising administering to the subject an effective amount of a compound of any one of embodiments II-l to 11-45, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof.
  • Embodiment 11-48 The method of embodiment 11-47, wherein the disease is selected from Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon.
  • Embodiment 11-49 A compound of any one of embodiments II- 1 to 11-45, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof, for use as a medicament.
  • Embodiment 11-50 A compound of any one of embodiments II- 1 to 11-45, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof, for use in treating or preventing a disease associated with SHP2 modulation.
  • Embodiment 11-51 Use of a compound of any one of embodiments II-l to 11-45, or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer thereof, in the manufacture of a medicament for treating or preventing a disease associated with SHP2 modulation.
  • Embodiment 11-52 A method of treating a disease associated with SHP2 modulation in a subject in need thereof, comprising administering to the subject an effective amount of a pharmaceutical composition of embodiment 11-48.
  • Embodiment 11-53 The method of embodiment 11-52, wherein the disease is selected from Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon.
  • Embodiment 11-54 A pharmaceutical composition of embodiment 11-48 for use as a medicament.
  • Embodiment 11-55 A pharmaceutical composition of embodiment 11-48 for use in treating or preventing a disease associated with SHP2 modulation.
  • Embodiment 11-56 Use of a pharmaceutical composition of embodiment 11-48 in the manufacture of a medicament for treating or preventing a disease associated with SHP2 modulation. Examples

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PCT/US2017/041577 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors Ceased WO2018013597A1 (en)

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KR1020237037794A KR20230156174A (ko) 2016-07-12 2017-07-11 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
AU2017296289A AU2017296289A1 (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors
CN201780050842.XA CN109983001B (zh) 2016-07-12 2017-07-11 作为变构shp2抑制剂的2,5-双取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪
MX2019000548A MX395351B (es) 2016-07-12 2017-07-11 3-metil pirazinas 2,5-disustituidas y 3-metil pirazinas 2,5,6-trisustituidas como inhibidores alostericos de shp2.
JP2019522611A JP6916279B2 (ja) 2016-07-12 2017-07-11 アロステリックｓｈｐ２阻害剤としての２，５−二置換３−メチルピラジンおよび２，５，６−三置換３−メチルピラジン
IL264186A IL264186B2 (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
CA3030167A CA3030167A1 (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
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CR20190063A CR20190063A (es) 2016-07-12 2017-07-11 3-metil pirazinas 2,5-disustituídas y 3-metil pirazinas 2,5,6-trisustituídas como inhibidores alostéricos de shp2
KR1020197004088A KR102598895B1 (ko) 2016-07-12 2017-07-11 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
BR112019000494-7A BR112019000494B1 (pt) 2016-07-12 2017-07-11 3-metil pirazinas 2,5-dissubstituídas e 3-metil pirazinas 2,5,6- trissubstituídas, composição farmacêutica e seus usos como inibidores de shp2 alostéricos
MYPI2018003070A MY199046A (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
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EA201990261A EA201990261A1 (ru) 2017-01-23 2017-07-11 2,5-двузамещенные 3-метилпиразины и 2,5,6-тризамещенные 3-метилпиразины в качестве аллостерических ингибиторов shp2
TNP/2019/000010A TN2019000010A1 (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
PH1/2019/500056A PH12019500056B1 (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
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CN202310268752.5A CN116478131A (zh) 2016-07-12 2017-07-11 作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪
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US16/228,324 US10590090B2 (en) 2016-07-12 2018-12-20 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors
CONC2019/0000613A CO2019000613A2 (es) 2016-07-12 2019-01-22 3-metil pirazinas 2,5-disustituidas y 3-metil pirazinas 2,5,6-trisustituidas como inhibidores alostéricos de shp2
US16/905,884 US11661401B2 (en) 2016-07-12 2020-06-18 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors
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US18/124,352 US20240116878A1 (en) 2016-07-12 2023-03-21 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
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