ATE502940T1 - Ä2,6-ünaphthyridine als proteinkinasehemmer - Google Patents
Ä2,6-ünaphthyridine als proteinkinasehemmerInfo
- Publication number
- ATE502940T1 ATE502940T1 AT08735845T AT08735845T ATE502940T1 AT E502940 T1 ATE502940 T1 AT E502940T1 AT 08735845 T AT08735845 T AT 08735845T AT 08735845 T AT08735845 T AT 08735845T AT E502940 T1 ATE502940 T1 AT E502940T1
- Authority
- AT
- Austria
- Prior art keywords
- unaphthyridine
- protein kinase
- kinase inhibitor
- inhibitors
- provides
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 3
- 102000003964 Histone deacetylase Human genes 0.000 abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 101100383153 Caenorhabditis elegans cdk-9 gene Proteins 0.000 abstract 1
- 101100029886 Caenorhabditis elegans lov-1 gene Proteins 0.000 abstract 1
- 102000004657 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Human genes 0.000 abstract 1
- 108010003721 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Proteins 0.000 abstract 1
- 108010026870 Calcium-Calmodulin-Dependent Protein Kinases Proteins 0.000 abstract 1
- 102000019025 Calcium-Calmodulin-Dependent Protein Kinases Human genes 0.000 abstract 1
- 101001059443 Homo sapiens Serine/threonine-protein kinase MARK1 Proteins 0.000 abstract 1
- 102100039313 Rho-associated protein kinase 1 Human genes 0.000 abstract 1
- 101710088411 Rho-associated protein kinase 1 Proteins 0.000 abstract 1
- 102100039314 Rho-associated protein kinase 2 Human genes 0.000 abstract 1
- 101710088493 Rho-associated protein kinase 2 Proteins 0.000 abstract 1
- 102100028921 Serine/threonine-protein kinase MARK1 Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91051907P | 2007-04-06 | 2007-04-06 | |
| PCT/EP2008/054105 WO2008122615A1 (en) | 2007-04-06 | 2008-04-04 | [2, 6] naphthyridines useful as protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502940T1 true ATE502940T1 (de) | 2011-04-15 |
Family
ID=39590973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08735845T ATE502940T1 (de) | 2007-04-06 | 2008-04-04 | Ä2,6-ünaphthyridine als proteinkinasehemmer |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120142685A1 (de) |
| EP (1) | EP2144909B1 (de) |
| JP (1) | JP2010523530A (de) |
| KR (1) | KR20100016291A (de) |
| CN (1) | CN101679418A (de) |
| AT (1) | ATE502940T1 (de) |
| AU (1) | AU2008235456B2 (de) |
| BR (1) | BRPI0810661A2 (de) |
| CA (1) | CA2682340A1 (de) |
| DE (1) | DE602008005729D1 (de) |
| EA (1) | EA016108B1 (de) |
| ES (1) | ES2363831T3 (de) |
| MX (1) | MX2009010697A (de) |
| PL (1) | PL2144909T3 (de) |
| PT (1) | PT2144909E (de) |
| WO (1) | WO2008122615A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110031318A (ko) * | 2008-06-13 | 2011-03-25 | 노파르티스 아게 | Ｉａ 심부전 및 암 치료에 유용한 단백질 키나제 ｄ 억제제로서의 2,4'-비피리디닐 화합물 |
| PH12012501556A1 (en) * | 2009-12-30 | 2012-10-22 | Arqule Inc | Substituted naphthalenyl-pyrimidine compounds |
| EP2495244A1 (de) * | 2011-03-02 | 2012-09-05 | NovaSaid AB | Piperidinyl-Benzoimidazol-Derivate als mPGEs-1 Inhibitoren |
| EP3030902B1 (de) | 2013-08-07 | 2019-09-25 | Friedrich Miescher Institute for Biomedical Research | Neues screening-verfahren zur behandlung von friedreich-ataxie |
| KR102598895B1 (ko) | 2016-07-12 | 2023-11-07 | 레볼루션 메디슨즈, 인크. | 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진 |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| KR20190110588A (ko) | 2017-01-23 | 2019-09-30 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘 화합물 |
| WO2019051084A1 (en) | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | SHP2 INHIBITOR COMPOSITIONS AND METHODS OF TREATING CANCER |
| MX2020003579A (es) | 2017-10-12 | 2020-07-22 | Revolution Medicines Inc | Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. |
| TW201927791A (zh) | 2017-12-15 | 2019-07-16 | 美商銳新醫藥公司 | 作為變構shp2抑制劑的多環化合物 |
| EP4172144A2 (de) | 2020-06-30 | 2023-05-03 | Genentech, Inc. | Verfahren zur herstellung tricyclischer serd-verbindungen mit einem substituierten phenyl- oder pyridinyl-teil |
| TW202313608A (zh) * | 2021-06-04 | 2023-04-01 | 美商建南德克公司 | ２，８—二氮雜螺［４．５］癸烷化合物 |
| IL313513A (en) * | 2021-12-16 | 2024-08-01 | Teijin Pharma Ltd | Cdk9 inhibitor and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928367A (en) * | 1969-04-14 | 1975-12-23 | Schering Corp | 1-Amino naphthyridines |
| JP2008518883A (ja) * | 2004-09-21 | 2008-06-05 | エフ．ホフマン−ラ ロシュ アーゲー | タンパク質キナーゼ阻害剤として有用な６−（２−アルキル−フェニル）−ピリド［２，３−ｄ］ピリミジン |
| JP2010523529A (ja) * | 2007-04-06 | 2010-07-15 | ノバルティス アーゲー | プロテインキナーゼ調節剤としての２，６−ナフチリジン誘導体 |
-
2008
- 2008-04-04 PT PT08735845T patent/PT2144909E/pt unknown
- 2008-04-04 BR BRPI0810661-4A patent/BRPI0810661A2/pt not_active IP Right Cessation
- 2008-04-04 CA CA002682340A patent/CA2682340A1/en not_active Abandoned
- 2008-04-04 CN CN200880015131A patent/CN101679418A/zh active Pending
- 2008-04-04 DE DE602008005729T patent/DE602008005729D1/de active Active
- 2008-04-04 MX MX2009010697A patent/MX2009010697A/es active IP Right Grant
- 2008-04-04 KR KR1020097023216A patent/KR20100016291A/ko not_active Withdrawn
- 2008-04-04 PL PL08735845T patent/PL2144909T3/pl unknown
- 2008-04-04 EA EA200901325A patent/EA016108B1/ru not_active IP Right Cessation
- 2008-04-04 US US12/594,728 patent/US20120142685A1/en not_active Abandoned
- 2008-04-04 EP EP08735845A patent/EP2144909B1/de not_active Not-in-force
- 2008-04-04 AT AT08735845T patent/ATE502940T1/de active
- 2008-04-04 WO PCT/EP2008/054105 patent/WO2008122615A1/en not_active Ceased
- 2008-04-04 AU AU2008235456A patent/AU2008235456B2/en not_active Expired - Fee Related
- 2008-04-04 ES ES08735845T patent/ES2363831T3/es active Active
- 2008-04-04 JP JP2010501526A patent/JP2010523530A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2144909A1 (de) | 2010-01-20 |
| PT2144909E (pt) | 2011-06-29 |
| ES2363831T3 (es) | 2011-08-17 |
| CN101679418A (zh) | 2010-03-24 |
| JP2010523530A (ja) | 2010-07-15 |
| BRPI0810661A2 (pt) | 2019-04-30 |
| EP2144909B1 (de) | 2011-03-23 |
| EA016108B1 (ru) | 2012-02-28 |
| DE602008005729D1 (en) | 2011-05-05 |
| AU2008235456A1 (en) | 2008-10-16 |
| PL2144909T3 (pl) | 2011-08-31 |
| AU2008235456B2 (en) | 2011-12-08 |
| EA200901325A1 (ru) | 2010-04-30 |
| WO2008122615A1 (en) | 2008-10-16 |
| MX2009010697A (es) | 2009-12-11 |
| KR20100016291A (ko) | 2010-02-12 |
| CA2682340A1 (en) | 2008-10-16 |
| US20120142685A1 (en) | 2012-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE502940T1 (de) | Ä2,6-ünaphthyridine als proteinkinasehemmer | |
| BRPI0613429A2 (pt) | inibidores de histona desacetilase | |
| EA200701257A1 (ru) | Пирролопиразолы в качестве сильнодействующих ингибиторов киназы | |
| BRPI0720525B8 (pt) | inibidores de mapk/erk quinase | |
| EA200401197A1 (ru) | Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы | |
| EA200970156A1 (ru) | Пиридизиноновые производные | |
| ATE479687T1 (de) | Kinaseinhibitoren | |
| ATE539073T1 (de) | Heterocyclylalkylderivate als neue inhibitoren von histondeacetylase | |
| EA200901488A1 (ru) | Замещенные имидазолопиридазины, как ингибиторы липидкиназы | |
| EA200700138A1 (ru) | Замещённые индолильные алкиламинопроизводные в качестве новых ингибиторов гистондеацетилазы | |
| EA201101341A1 (ru) | Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе | |
| EA200801291A1 (ru) | Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ | |
| DE602007001190D1 (de) | Aminophenylderivate als neue inhibitoren von histondeacetylase | |
| EA200401199A1 (ru) | Ингибиторы гистондеацетилазы | |
| WO2010009139A3 (en) | Imidazolylpyrimidine compounds as hdac and / or cdk inhibitors | |
| ATE549336T1 (de) | Heteroarylverbindungen,zusammensetzungen daraus und ihre verwendung als proteinkinasehemmer | |
| UY30297A1 (es) | Inhibidores de la quinasa c-fms-i | |
| ATE527253T1 (de) | Pyrimidin-substituierte benzimidazolderivate als proteinkinasehemmer | |
| BRPI0809542A8 (pt) | Compostos derivados de indol tendo atividade de inibição de cpla2, composição farmacêutica, e métodos de produção dos referidos compostos | |
| GT200800251A (es) | Nitrilos espirociclicos como inhibidores de proteasa | |
| ATE533759T1 (de) | Imidazolinon- und hydantoinderivate als neue inhibitoren von histondeacetylase | |
| EA200700143A1 (ru) | Производные замещенного пропенилпиперазина в качестве новых ингибиторов гистондеацетилазы | |
| ATE509920T1 (de) | Quadratsäurederivate als inhibitoren von histondeacetylase | |
| ATE482948T1 (de) | Chemische verbindungen | |
| ATE510821T1 (de) | Sulfonylpyrrole als histondeacetylaseinhibitoren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 2144909 Country of ref document: EP |