UY30297A1 - Inhibidores de la quinasa c-fms-i - Google Patents

Inhibidores de la quinasa c-fms-i

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Publication number
UY30297A1
UY30297A1 UY30297A UY30297A UY30297A1 UY 30297 A1 UY30297 A1 UY 30297A1 UY 30297 A UY30297 A UY 30297A UY 30297 A UY30297 A UY 30297A UY 30297 A1 UY30297 A1 UY 30297A1
Authority
UY
Uruguay
Prior art keywords
fms
diseases
tautomers
solvates
hydrates
Prior art date
Application number
UY30297A
Other languages
English (en)
Inventor
Kenneth Wilson
Bruce E Tomczuk
Renee Desjarlais
Mark J Wall
Sanath Meegalla
Jinsheng Chen
Shelley K Ballentine
Carl R Illig
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY30297A1 publication Critical patent/UY30297A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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Abstract

La invención se refiere a compuestos de Fórmula I: donde Z, X, J, R2 y W se exponen en la memoria descriptiva, así como también sus solvatos, hidratos, tautómeros y sales aceptables para uso farmacéutico, que inhiben las proteína tirosina quinasas, especialmente la quinasa c-fms. Además se proveen métodos para tratar enfermedades autoinmunes; y enfermedades con un componente inflamatorio. Además el compuesto de Fórmula I, sus solvatos, hidratos, tautómeros y sales aceptables para uso farmacéutica, proveen métodos para enfermedades como se describen en las reivindicaciones y memoria descriptiva.
UY30297A 2006-04-20 2007-04-19 Inhibidores de la quinasa c-fms-i UY30297A1 (es)

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US79366706P 2006-04-20 2006-04-20

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UY30297A1 true UY30297A1 (es) 2007-08-31

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UY30297A UY30297A1 (es) 2006-04-20 2007-04-19 Inhibidores de la quinasa c-fms-i

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US (7) US8722718B2 (es)
EP (3) EP2016070B1 (es)
JP (3) JP5331680B2 (es)
KR (3) KR101367646B1 (es)
CN (1) CN101472914B (es)
AR (3) AR060612A1 (es)
AU (3) AU2007240443B2 (es)
BR (1) BRPI0710548B8 (es)
CA (3) CA2649739C (es)
ES (3) ES2565238T3 (es)
HK (1) HK1133878A1 (es)
IL (1) IL194845A (es)
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RU (1) RU2475483C2 (es)
SG (1) SG171593A1 (es)
TW (3) TWI411612B (es)
UA (1) UA93085C2 (es)
UY (1) UY30297A1 (es)
WO (3) WO2007124319A1 (es)
ZA (1) ZA200809873B (es)

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US20060281788A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
EP2705854A1 (en) * 2006-01-05 2014-03-12 Novartis AG Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
SG171592A1 (en) * 2006-04-20 2011-06-29 Janssen Pharmaceutica Nv Method of inhibiting c-kit kinase
EP2021335B1 (en) 2006-04-20 2011-05-25 Janssen Pharmaceutica N.V. Heterocyclic compounds as inhibitors of c-fms kinase
JP5480619B2 (ja) * 2006-04-20 2014-04-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ｃ−ｆｍｓキナーゼの阻害剤
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
UA93085C2 (en) * 2006-04-20 2011-01-10 Янссен Фармацевтика Н.В. Inhibitors of c-fms kinase
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
US10106798B2 (en) 2010-01-05 2018-10-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) FLT3 receptor antagonists for the treatment or the prevention of pain disorders
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AU2007240440B2 (en) 2012-09-20
JP5331680B2 (ja) 2013-10-30
UA93085C2 (en) 2011-01-10
US8815867B2 (en) 2014-08-26
MX2008013531A (es) 2009-01-20
BRPI0710548A2 (pt) 2012-06-05
KR101406877B1 (ko) 2014-06-13
US8722718B2 (en) 2014-05-13
SG171593A1 (en) 2011-06-29
WO2007124322A1 (en) 2007-11-01
US9403804B2 (en) 2016-08-02
US20140329815A1 (en) 2014-11-06
RU2008145763A (ru) 2010-05-27
TWI411612B (zh) 2013-10-11
EP2016074A1 (en) 2009-01-21
CA2649924A1 (en) 2007-11-01
EP2016074B1 (en) 2016-01-13

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