EA201990261A1 - 2,5-двузамещенные 3-метилпиразины и 2,5,6-тризамещенные 3-метилпиразины в качестве аллостерических ингибиторов shp2 - Google Patents

2,5-двузамещенные 3-метилпиразины и 2,5,6-тризамещенные 3-метилпиразины в качестве аллостерических ингибиторов shp2

Info

Publication number
EA201990261A1
EA201990261A1 EA201990261A EA201990261A EA201990261A1 EA 201990261 A1 EA201990261 A1 EA 201990261A1 EA 201990261 A EA201990261 A EA 201990261A EA 201990261 A EA201990261 A EA 201990261A EA 201990261 A1 EA201990261 A1 EA 201990261A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrasines
substituted
methyl
dub
triple
Prior art date
Application number
EA201990261A
Other languages
English (en)
Inventor
Ашутош Джогалекар
Уолтер ВОН
Елена С. Колтун
Адриан Джилл
Кевин Меллем
Наинг Аай
Андреас Бакл
Кристофер Семко
Герт Кисс
Original Assignee
Революшн Медсинз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Революшн Медсинз, Инк. filed Critical Революшн Медсинз, Инк.
Priority claimed from PCT/US2017/041577 external-priority patent/WO2018013597A1/en
Publication of EA201990261A1 publication Critical patent/EA201990261A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение направлено на ингибиторы SHP2 и их применение в лечении заболевания. Также раскрыты фармацевтические композиции, содержащие таковые.
EA201990261A 2017-01-23 2017-07-11 2,5-двузамещенные 3-метилпиразины и 2,5,6-тризамещенные 3-метилпиразины в качестве аллостерических ингибиторов shp2 EA201990261A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762449523P 2017-01-23 2017-01-23
PCT/US2017/041577 WO2018013597A1 (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors

Publications (1)

Publication Number Publication Date
EA201990261A1 true EA201990261A1 (ru) 2019-06-28

Family

ID=66998651

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990261A EA201990261A1 (ru) 2017-01-23 2017-07-11 2,5-двузамещенные 3-метилпиразины и 2,5,6-тризамещенные 3-метилпиразины в качестве аллостерических ингибиторов shp2

Country Status (1)

Country Link
EA (1) EA201990261A1 (ru)

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EA201990261A1 (ru) 2,5-двузамещенные 3-метилпиразины и 2,5,6-тризамещенные 3-метилпиразины в качестве аллостерических ингибиторов shp2