MX2020005841A - Derivados de 1,2,4-oxadiazol como inhibidores de histona-desacetilasa 6. - Google Patents
Derivados de 1,2,4-oxadiazol como inhibidores de histona-desacetilasa 6.Info
- Publication number
- MX2020005841A MX2020005841A MX2020005841A MX2020005841A MX2020005841A MX 2020005841 A MX2020005841 A MX 2020005841A MX 2020005841 A MX2020005841 A MX 2020005841A MX 2020005841 A MX2020005841 A MX 2020005841A MX 2020005841 A MX2020005841 A MX 2020005841A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- histone deacetylase
- oxadiazole derivatives
- compounds
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La invención se refiere a compuestos de la Fórmula (I) como se describe en la presente, útiles como inhibidores de histona-desacetilasa 6 (HDAC6). La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a su uso en terapia.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17382835 | 2017-12-05 | ||
EP18382562 | 2018-07-26 | ||
PCT/EP2018/083655 WO2019110663A1 (en) | 2017-12-05 | 2018-12-05 | 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020005841A true MX2020005841A (es) | 2020-09-07 |
Family
ID=64556931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020005841A MX2020005841A (es) | 2017-12-05 | 2018-12-05 | Derivados de 1,2,4-oxadiazol como inhibidores de histona-desacetilasa 6. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20200339569A1 (es) |
EP (1) | EP3720851A1 (es) |
JP (1) | JP7369458B2 (es) |
KR (1) | KR20200097294A (es) |
CN (1) | CN111406054B (es) |
AU (1) | AU2018379321A1 (es) |
BR (1) | BR112020010534A2 (es) |
CA (1) | CA3083061A1 (es) |
IL (1) | IL274973B1 (es) |
MX (1) | MX2020005841A (es) |
SG (1) | SG11202005254RA (es) |
WO (1) | WO2019110663A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
WO2020245381A1 (en) * | 2019-06-06 | 2020-12-10 | Oryzon Genomics, S.A. | 3-(2-(heteroaryl)-pyridin-4-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole derivatives as hdac6 inhibitors |
KR102576148B1 (ko) * | 2020-04-13 | 2023-09-07 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
KR20220030134A (ko) * | 2020-09-02 | 2022-03-10 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 새로운 구조의 화합물 및 이를 포함하는 약제학적 조성물 |
CA3215958A1 (en) | 2021-04-23 | 2022-10-27 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for use in the treatment of dilated cardiomyopathy |
TW202308619A (zh) | 2021-05-04 | 2023-03-01 | 美商特納亞治療股份有限公司 | 用於治療代謝疾病和hfpef的hdac6抑制劑 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1870401A4 (en) * | 2005-04-06 | 2011-06-15 | Msd Kk | SUBSTITUTE DERIVATIVE PIPERAZINE IN 1,4 |
WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
BR112014012815A8 (pt) * | 2011-11-28 | 2017-06-20 | Novartis Ag | derivados de trifluormetil-oxadiazol e uso dos mesmos no tratamento de doença |
JPWO2017033946A1 (ja) | 2015-08-25 | 2018-06-07 | 武田薬品工業株式会社 | 複素環化合物 |
EP3436445B1 (en) | 2016-03-15 | 2023-09-06 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
WO2017222952A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
PL3558984T3 (pl) | 2016-12-20 | 2024-01-15 | Fmc Corporation | Oksadiazole grzybobójcze |
-
2018
- 2018-12-05 CA CA3083061A patent/CA3083061A1/en active Pending
- 2018-12-05 JP JP2020550896A patent/JP7369458B2/ja active Active
- 2018-12-05 EP EP18811280.9A patent/EP3720851A1/en active Pending
- 2018-12-05 US US16/768,931 patent/US20200339569A1/en not_active Abandoned
- 2018-12-05 CN CN201880077326.0A patent/CN111406054B/zh active Active
- 2018-12-05 SG SG11202005254RA patent/SG11202005254RA/en unknown
- 2018-12-05 BR BR112020010534-1A patent/BR112020010534A2/pt unknown
- 2018-12-05 AU AU2018379321A patent/AU2018379321A1/en active Pending
- 2018-12-05 MX MX2020005841A patent/MX2020005841A/es unknown
- 2018-12-05 IL IL274973A patent/IL274973B1/en unknown
- 2018-12-05 KR KR1020207019402A patent/KR20200097294A/ko not_active Application Discontinuation
- 2018-12-05 WO PCT/EP2018/083655 patent/WO2019110663A1/en unknown
-
2022
- 2022-02-10 US US17/650,561 patent/US20230026909A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200339569A1 (en) | 2020-10-29 |
JP2021505684A (ja) | 2021-02-18 |
BR112020010534A2 (pt) | 2020-10-20 |
RU2020121391A3 (es) | 2022-01-20 |
KR20200097294A (ko) | 2020-08-18 |
AU2018379321A1 (en) | 2020-06-11 |
WO2019110663A1 (en) | 2019-06-13 |
JP7369458B2 (ja) | 2023-10-26 |
EP3720851A1 (en) | 2020-10-14 |
RU2020121391A (ru) | 2022-01-10 |
US20230026909A1 (en) | 2023-01-26 |
IL274973B1 (en) | 2024-03-01 |
CN111406054A (zh) | 2020-07-10 |
CN111406054B (zh) | 2024-01-02 |
CA3083061A1 (en) | 2019-06-13 |
IL274973A (en) | 2020-07-30 |
SG11202005254RA (en) | 2020-07-29 |
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