EA201892539A1 - Пиридинильные производные, фармацевтические композиции и их применение в качестве ингибиторов аос3 - Google Patents

Пиридинильные производные, фармацевтические композиции и их применение в качестве ингибиторов аос3

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Publication number
EA201892539A1
EA201892539A1 EA201892539A EA201892539A EA201892539A1 EA 201892539 A1 EA201892539 A1 EA 201892539A1 EA 201892539 A EA201892539 A EA 201892539A EA 201892539 A EA201892539 A EA 201892539A EA 201892539 A1 EA201892539 A1 EA 201892539A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
aos3
inhibitors
application
pyridinyl derivatives
Prior art date
Application number
EA201892539A
Other languages
English (en)
Other versions
EA037188B1 (ru
Inventor
Андреас Блюм
Седрикс Годбу
Йёрг П. Хен
Штефан Петерс
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201892539A1 publication Critical patent/EA201892539A1/ru
Publication of EA037188B1 publication Critical patent/EA037188B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новым пиридинильным производным формулыгде Rи A являются такими, как определено в описании и формуле изобретения, к их применению в качестве лекарственных средств, к способам их терапевтического применения и к фармацевтическим композициям, содержащим их.
EA201892539A 2016-05-12 2017-05-08 Пиридинильные производные, фармацевтические композиции и их применение в качестве ингибиторов аос3 EA037188B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16169356 2016-05-12
PCT/EP2017/060890 WO2017194453A1 (en) 2016-05-12 2017-05-08 Pyridinyl derivatives, pharmaceutical compositions and uses thereof as aoc3 inhibitors

Publications (2)

Publication Number Publication Date
EA201892539A1 true EA201892539A1 (ru) 2019-06-28
EA037188B1 EA037188B1 (ru) 2021-02-17

Family

ID=55967162

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892539A EA037188B1 (ru) 2016-05-12 2017-05-08 Пиридинильные производные, фармацевтические композиции и их применение в качестве ингибиторов аос3

Country Status (32)

Country Link
US (1) US9926292B2 (ru)
EP (1) EP3455216B1 (ru)
JP (1) JP6639702B2 (ru)
KR (1) KR20190003995A (ru)
CN (1) CN109153664B (ru)
AR (1) AR108462A1 (ru)
AU (1) AU2017262707B2 (ru)
CA (1) CA3023805A1 (ru)
CL (1) CL2018003158A1 (ru)
CO (1) CO2018012020A2 (ru)
CY (1) CY1123744T1 (ru)
DK (1) DK3455216T3 (ru)
EA (1) EA037188B1 (ru)
ES (1) ES2844926T3 (ru)
HR (1) HRP20202078T1 (ru)
HU (1) HUE053312T2 (ru)
IL (1) IL262662B (ru)
JO (1) JOP20170115B1 (ru)
LT (1) LT3455216T (ru)
MA (1) MA44965B1 (ru)
MX (1) MX2018013701A (ru)
PE (1) PE20190151A1 (ru)
PH (1) PH12018502376A1 (ru)
PL (1) PL3455216T3 (ru)
PT (1) PT3455216T (ru)
RS (1) RS61256B1 (ru)
SA (1) SA518400393B1 (ru)
SG (1) SG11201809687TA (ru)
SI (1) SI3455216T1 (ru)
TW (1) TWI746551B (ru)
UA (1) UA121930C2 (ru)
WO (1) WO2017194453A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019201752A1 (en) 2018-04-17 2019-10-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2020083264A1 (zh) * 2018-10-22 2020-04-30 广东东阳光药业有限公司 胍类衍生物及其用途
DK3873600T5 (da) * 2018-10-29 2024-03-18 Boehringer Ingelheim Int Pyridinylsulfonamidderivater, farmaceutiske sammensætninger og anvendelser deraf
EP4051669A4 (en) 2019-10-29 2023-12-13 Eccogene (Shanghai) Co., Ltd. SSAO INHIBITORS AND THEIR USE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19518073A1 (de) * 1995-05-17 1996-11-21 Hoechst Ag Substituierte Benzyloxycarbonylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
JP5010917B2 (ja) * 2003-08-29 2012-08-29 エグゼリクシス， インコーポレイテッド ｃ−Ｋｉｔ調節因子および使用方法
US20070254931A1 (en) * 2004-07-27 2007-11-01 Astellas Pharma Inc. Thiazole Derivatives Having Vap-1 Inhibitory Activity
PT2479165T (pt) * 2009-09-16 2017-12-19 Astellas Pharma Inc Composto de glicina
RS56136B1 (sr) 2011-03-15 2017-10-31 Astellas Pharma Inc Jedinjenje guanidina
AU2016301745B2 (en) 2015-08-06 2020-07-16 Ube Industries, Ltd. Substituted guanidine derivative

Also Published As

Publication number Publication date
CN109153664B (zh) 2021-07-16
CN109153664A (zh) 2019-01-04
TWI746551B (zh) 2021-11-21
IL262662B (en) 2021-07-29
PH12018502376B1 (en) 2019-04-08
ES2844926T3 (es) 2021-07-23
EA037188B1 (ru) 2021-02-17
UA121930C2 (uk) 2020-08-10
EP3455216B1 (en) 2020-11-04
EP3455216A1 (en) 2019-03-20
AU2017262707A1 (en) 2018-10-11
CL2018003158A1 (es) 2019-01-18
MX2018013701A (es) 2019-05-02
SA518400393B1 (ar) 2021-09-08
HRP20202078T1 (hr) 2021-02-19
LT3455216T (lt) 2021-01-11
US9926292B2 (en) 2018-03-27
PE20190151A1 (es) 2019-01-22
PL3455216T3 (pl) 2021-05-17
AR108462A1 (es) 2018-08-22
NZ746586A (en) 2021-08-27
JP6639702B2 (ja) 2020-02-05
TW201805278A (zh) 2018-02-16
JP2019519495A (ja) 2019-07-11
PH12018502376A1 (en) 2019-04-08
CY1123744T1 (el) 2022-05-27
RS61256B1 (sr) 2021-01-29
MA44965A (fr) 2019-03-20
HUE053312T2 (hu) 2021-07-28
AU2017262707B2 (en) 2020-11-19
CA3023805A1 (en) 2017-11-16
CO2018012020A2 (es) 2018-11-13
WO2017194453A1 (en) 2017-11-16
MA44965B1 (fr) 2021-02-26
PT3455216T (pt) 2021-01-18
IL262662A (en) 2018-12-31
KR20190003995A (ko) 2019-01-10
JOP20170115B1 (ar) 2021-08-17
SI3455216T1 (sl) 2021-02-26
SG11201809687TA (en) 2018-11-29
US20170327483A1 (en) 2017-11-16
DK3455216T3 (da) 2021-01-18

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM