SG11202005254RA - 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors - Google Patents
1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitorsInfo
- Publication number
- SG11202005254RA SG11202005254RA SG11202005254RA SG11202005254RA SG11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA
- Authority
- SG
- Singapore
- Prior art keywords
- inhibitors
- histone deacetylase
- oxadiazole derivatives
- oxadiazole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382835 | 2017-12-05 | ||
| EP18382562 | 2018-07-26 | ||
| PCT/EP2018/083655 WO2019110663A1 (en) | 2017-12-05 | 2018-12-05 | 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202005254RA true SG11202005254RA (en) | 2020-07-29 |
Family
ID=64556931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202005254RA SG11202005254RA (en) | 2017-12-05 | 2018-12-05 | 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20200339569A1 (en) |
| EP (1) | EP3720851A1 (en) |
| JP (1) | JP7369458B2 (en) |
| KR (1) | KR20200097294A (en) |
| CN (1) | CN111406054B (en) |
| AU (1) | AU2018379321A1 (en) |
| BR (1) | BR112020010534A2 (en) |
| CA (1) | CA3083061A1 (en) |
| IL (1) | IL274973B1 (en) |
| MX (1) | MX2020005841A (en) |
| SG (1) | SG11202005254RA (en) |
| WO (1) | WO2019110663A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| US20220298156A1 (en) * | 2019-06-06 | 2022-09-22 | Oryzon Genomics, S.A. | 3-(2-(heteroaryl)-pyridin-4-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole derivatives as hdac6 inhibitors |
| KR102576148B1 (en) * | 2020-04-13 | 2023-09-07 | 주식회사 종근당 | 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same |
| KR20220030134A (en) * | 2020-09-02 | 2022-03-10 | 주식회사 종근당 | Novel Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same |
| KR20240013098A (en) | 2021-04-23 | 2024-01-30 | 테나야 테라퓨틱스, 인코포레이티드 | HDAC6 inhibitors for use in the treatment of dilated cardiomyopathy |
| TW202308619A (en) | 2021-05-04 | 2023-03-01 | 美商特納亞治療股份有限公司 | Hdac6 inhibitors for treatment of metabolic disease and hfpef |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006109817A1 (en) | 2005-04-06 | 2006-10-19 | Banyu Pharmaceutical Co., Ltd. | 1,4-substituted piperazine derivative |
| WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| CA2856334A1 (en) | 2011-11-28 | 2013-06-06 | Christina Hebach | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| EP3342772A4 (en) | 2015-08-25 | 2019-03-27 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3436445B1 (en) | 2016-03-15 | 2023-09-06 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2017222952A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| EP3558984B1 (en) | 2016-12-20 | 2023-08-02 | FMC Corporation | Fungicidal oxadiazoles |
-
2018
- 2018-12-05 WO PCT/EP2018/083655 patent/WO2019110663A1/en unknown
- 2018-12-05 MX MX2020005841A patent/MX2020005841A/en unknown
- 2018-12-05 JP JP2020550896A patent/JP7369458B2/en active Active
- 2018-12-05 EP EP18811280.9A patent/EP3720851A1/en active Pending
- 2018-12-05 BR BR112020010534-1A patent/BR112020010534A2/en unknown
- 2018-12-05 US US16/768,931 patent/US20200339569A1/en not_active Abandoned
- 2018-12-05 CA CA3083061A patent/CA3083061A1/en active Pending
- 2018-12-05 CN CN201880077326.0A patent/CN111406054B/en active Active
- 2018-12-05 KR KR1020207019402A patent/KR20200097294A/en not_active Application Discontinuation
- 2018-12-05 AU AU2018379321A patent/AU2018379321A1/en active Pending
- 2018-12-05 IL IL274973A patent/IL274973B1/en unknown
- 2018-12-05 SG SG11202005254RA patent/SG11202005254RA/en unknown
-
2022
- 2022-02-10 US US17/650,561 patent/US20230026909A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020010534A2 (en) | 2020-10-20 |
| CA3083061A1 (en) | 2019-06-13 |
| CN111406054B (en) | 2024-01-02 |
| JP2021505684A (en) | 2021-02-18 |
| JP7369458B2 (en) | 2023-10-26 |
| EP3720851A1 (en) | 2020-10-14 |
| US20200339569A1 (en) | 2020-10-29 |
| RU2020121391A (en) | 2022-01-10 |
| US20230026909A1 (en) | 2023-01-26 |
| RU2020121391A3 (en) | 2022-01-20 |
| WO2019110663A1 (en) | 2019-06-13 |
| IL274973B1 (en) | 2024-03-01 |
| IL274973A (en) | 2020-07-30 |
| KR20200097294A (en) | 2020-08-18 |
| AU2018379321A1 (en) | 2020-06-11 |
| CN111406054A (en) | 2020-07-10 |
| MX2020005841A (en) | 2020-09-07 |
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