EA201990261A1 - 2,5-DUB-SUBSTITUTED 3-METHYL-PYRASINES and 2,5,6-triple-substituted 3-METHYL-PYRASINES AS SHP2 ALLOSTERIC INHIBITORS - Google Patents
2,5-DUB-SUBSTITUTED 3-METHYL-PYRASINES and 2,5,6-triple-substituted 3-METHYL-PYRASINES AS SHP2 ALLOSTERIC INHIBITORSInfo
- Publication number
- EA201990261A1 EA201990261A1 EA201990261A EA201990261A EA201990261A1 EA 201990261 A1 EA201990261 A1 EA 201990261A1 EA 201990261 A EA201990261 A EA 201990261A EA 201990261 A EA201990261 A EA 201990261A EA 201990261 A1 EA201990261 A1 EA 201990261A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrasines
- substituted
- methyl
- dub
- triple
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение направлено на ингибиторы SHP2 и их применение в лечении заболевания. Также раскрыты фармацевтические композиции, содержащие таковые.The present invention is directed to SHP2 inhibitors and their use in the treatment of disease. Also disclosed are pharmaceutical compositions containing them.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762449523P | 2017-01-23 | 2017-01-23 | |
PCT/US2017/041577 WO2018013597A1 (en) | 2016-07-12 | 2017-07-11 | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201990261A1 true EA201990261A1 (en) | 2019-06-28 |
Family
ID=66998651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201990261A EA201990261A1 (en) | 2017-01-23 | 2017-07-11 | 2,5-DUB-SUBSTITUTED 3-METHYL-PYRASINES and 2,5,6-triple-substituted 3-METHYL-PYRASINES AS SHP2 ALLOSTERIC INHIBITORS |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA201990261A1 (en) |
-
2017
- 2017-07-11 EA EA201990261A patent/EA201990261A1/en unknown
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