US20080255612A1 - Self-retaining systems for surgical procedures - Google Patents

Self-retaining systems for surgical procedures Download PDF

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Publication number
US20080255612A1
US20080255612A1 US12/062,256 US6225608A US2008255612A1 US 20080255612 A1 US20080255612 A1 US 20080255612A1 US 6225608 A US6225608 A US 6225608A US 2008255612 A1 US2008255612 A1 US 2008255612A1
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suture
escarpment
helical
retainers
tissue
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William L. Hunter
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Cilag GmbH International
NEC Corp
Ethicon Inc
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Angiotech Pharmaceuticals Inc
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Priority to US12/062,256 priority Critical patent/US20080255612A1/en
Priority to EP18181513.5A priority patent/EP3409214A3/de
Priority to PCT/US2008/060127 priority patent/WO2008128113A1/en
Priority to EP08745687.7A priority patent/EP2146646B1/de
Priority to JP2010503254A priority patent/JP5562829B2/ja
Priority to CA2683819A priority patent/CA2683819C/en
Priority to KR1020097023593A priority patent/KR101485327B1/ko
Assigned to ANGIOTECH PHARMACEUTICALS, INC. reassignment ANGIOTECH PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HUNTER, WILLIAM L.
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Assigned to ANGIOTECH PHARMACEUTICALS, INC., MEDICAL DEVICE TECHNOLOGIES, INC., QUILL MEDICAL, INC., MANAN MEDICAL PRODUCTS, INC., SURGICAL SPECIALTIES CORPORATION, ANGIOTECH BIOCOATINGS CORP., ANGIOTECH PHARMACEUTICALS (US), INC., AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC., ANGIOTECH AMERICA, INC., B.G. SULZLE, INC., ANGIOTECH INTERNATIONAL HOLDINGS CORP. reassignment ANGIOTECH PHARMACEUTICALS, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: WELLS FARGO CAPITAL FINANCE, LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B2017/06057—Double-armed sutures, i.e. sutures having a needle attached to each end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A61B2017/06176—Sutures with protrusions, e.g. barbs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49995—Shaping one-piece blank by removing material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/02—Other than completely through work thickness

Definitions

  • the present invention relates generally to self-retaining systems for surgical procedures, methods of manufacturing self-retaining systems for surgical procedures, and their uses.
  • Wound closure devices such as sutures and staples have been widely used in superficial and deep surgical procedures in humans and animals for closing wounds, repairing traumatic injuries or defects, joining tissues together [bringing severed tissues into approximation, closing an anatomical space, affixing single or multiple tissue layers together, creating anastomoses between two hollow (luminal) structures, adjoining tissues, attaching or reattaching tissues to their proper anatomical location], attaching foreign elements to tissues (affixing medical implants, devices, prostheses and other functional or supportive devices), and for repositioning tissues to new anatomical locations (repairs, tissue elevations, tissue grafting and related procedures) to name but a few examples.
  • Sutures typically consist of a filamentous suture thread attached to a needle with a sharp point (attachment of sutures and surgical needles is described in U.S. Pat. Nos. 3,981,307, 5,084,063, 5,102,418, 5,123,911, 5,500,991, 5,722,991, 6,012,216, and 6,163,948, and U.S. Patent Application Publication No. U.S. 2004/0088003).
  • the needle is advanced through the desired tissue on one side of the wound and then through the adjacent side of the wound to form a “loop” which is then completed by tying a knot in the suture.
  • Sutures materials are broadly classified as being bioabsorbable (i.e., they break down completely in the body over time), such as those composed of catgut, glycolic acid polymers and copolymers, lactic acid polymers and copolymers; or as being non-absorbable (permanent; nondegradable), such as those made of polyamide, polytetrafluoroethylene, polyether-ester, polyurethane, metal alloys, metal (e.g., stainless steel wire), polypropylene, polyethelene, silk, and cotton.
  • bioabsorbable i.e., they break down completely in the body over time
  • non-absorbable permanent; nondegradable
  • Nondegradable (non-absorbable) sutures are used in wounds where healing may be expected to be protracted or where the suture material is needed to provide physical support to the wound for long periods of time; as in, for example, deep tissue repairs, high tension wounds, many orthopedic repairs and some types of surgical anastomoses.
  • the present invention provides for polymeric formulations, surface properties, configurations and diameters designed to increase the holding power, durability and strength of self-retaining closure systems composed of both bioabsorbable and non-absorbable polymers.
  • a new type of suture has been designed with barbs, or with frusto-conical retainers, for engaging tissue when the suture is pulled in a direction other than that in which it was originally deployed in the tissue.
  • Knotless tissue-approximating devices having barbs have been previously described in, for example, U.S. Pat. No. 5,374,268, disclosing armed anchors having barb-like projections, while suture assemblies having barbed lateral members have been described in U.S. Pat. Nos. 5,584,859 and 6,264,675.
  • novel tissue retainer configurations, secondary retainer structures and expanded segment suture configurations are described that increase the ability of the self-retaining sutures to anchor into their surrounding tissue, strengthen their hold, increase the amount of tension they can withstand (without breakage or slippage) and increase their clinical performance.
  • Sutures may be configured to more effectively distribute or resist tensions upon them when deployed in tissue.
  • a suture may include an expanded section disposed away from either end of the suture.
  • a suture may include one or more tissue retainers having an uneven or roughened surface.
  • a suture may include a continuous helical tissue retainer that is unidirectional.
  • a suture may include a continuous helical tissue retainer that is bidirectional.
  • the helix In the bidirectional configuration, the helix is oriented in one direction projecting “away” from the needle until the midpoint (or transition point) of the suture is reached; at this point the configuration of the helix reverses itself 180° along the remaining length of the suture thread before attaching to a second needle at the opposite end.
  • a method of manufacturing a helical self-retaining suture may include cutting a continuous helical tissue retainer in one chiral direction angled away from the suture deployment end, and a second continuous helical tissue retainer cut in the opposite chiral direction also angled away from the deployment end.
  • a method of manufacturing a bidirectional helical self-retaining suture may include cutting a continuous helical tissue retainer in one chiral direction angled away from a first suture deployment end and a second continuous helical tissue retainer cut in the opposite chiral direction also angled away from the first suture deployment end, both at a first portion of the suture that is proximal to the first suture deployment end.
  • the method may further include cutting a continuous helical tissue retainer in one chiral direction angled away from a second suture deployment end and a second continuous helical tissue retainer cut in the opposite chiral direction also angled away from the second suture deployment end, both at a second portion of the suture that is proximal to the second suture deployment end and that is disposed away from the first portion
  • a suture may include tissue retainer “scales” that increase the percentage of the surface area covered by retaining elements as compared to intermittent “barb” configurations.
  • tissue retainer scales may include pointed or rounded tissue penetrating edges.
  • a method of manufacturing a “scaled” self-retaining suture may include cutting a continuous helical tissue retainer in one chiral direction angled away from the suture deployment end, while a second continuous helical tissue retainer is cut in the opposite chiral direction and (also angled away from the suture deployment end).
  • a suture may include one or more primary tissue retainers, with at least one such primary tissue retainer that further includes one or more secondary tissue retainers.
  • Such secondary tissue retainers may include flanges, barbs, and filaments.
  • the surface of the portion of the suture material that is not composed of primary tissue retainers are modified such that they further include one or more secondary tissue retainers.
  • secondary tissue retainers may include flanges, barbs, and filaments.
  • the surface of the portion of the suture material that is not composed of primary tissue retainers (i.e., the “non-barbed” areas of the thread) and the primary tissue retainers themselves are both modified to further include one or more secondary tissue retainers.
  • secondary tissue retainers may include flanges, barbs, and filaments.
  • a method of making a self-retaining suture includes the step of cutting intersecting helical escarpments into the circumferential periphery of a suture body. Such helical escarpments may intersect due to differing pitches or opposing chirality of the helices.
  • a method of making a Self-retaining suture includes an expanded section of the thread such that the diameter of the expanded portion of the thread is greater than the diameter the end of the suture, or, if the suture is adapted for deployment with a needle, than the diameter of the needle.
  • a method of making a bidirectional Self-retaining suture includes an expanded section of the tread such that the diameter of the thread at a specified distance from either needle attachment site (this distance will vary depending upon the clinical indication) is greater than the diameter of the needles that are attached to it; from the point where the barbed suture thread diameter is greatest, the diameter of the thread then tapers down (the rate and length of the tapering segment will vary depending upon the clinical indication) as it approaches the needle attachment sites until the thread diameter is equal to, or smaller than, the diameter of the needles it is attached to.
  • FIGS. 1 a , 1 b , and 1 c are perspective views of an embodiment according to the present invention of a self-retaining suture having uneven-surfaced retainers.
  • FIG. 1 d is a perspective view of a further embodiment according to the present invention of a self-retaining suture having uneven-surfaced retainers.
  • FIGS. 2 a and 2 b are perspective views of an embodiment according to the present invention of a self-retaining suture having an expanded transition segment.
  • FIGS. 3 a , 3 b , 3 c , and 3 d are perspective views of a use of an embodiment according to the present invention of a self-retaining suture having an expanded transition segment.
  • FIG. 3 e is a perspective view of a use of an embodiment according to the present invention of a self-retaining suture having an expanded transition segment.
  • FIGS. 4 a and 4 b are perspective views of embodiments according to the present invention of single helix self-retaining sutures.
  • FIG. 4 c is perspective view of an embodiment according to the present invention of a double helix self-retaining suture in an unexpanded position.
  • FIG. 4 d is perspective view of an embodiment according to the present invention of a double helix self-retaining suture in an expanded position.
  • FIG. 5 is a perspective view of an embodiment according to the present invention of a bidirectional double helix self-retaining suture in an expanded position.
  • FIG. 6 is a perspective view of a further embodiment according to the present invention of a scaled self-retaining suture having rounded retainers.
  • FIG. 7 is a perspective view of a further embodiment according to the present invention of a bidirectional scaled self-retaining suture having rounded retainers in an expanded position.
  • FIGS. 8 a and 8 b are perspective views of an embodiment according to the present invention of a bidirectional double helix self-retaining suture having an expanded transition segment.
  • FIGS. 9 a and 9 b are perspective views of a further embodiment according to the present invention of a bidirectional scaled self-retaining suture having rounded retainers and an expanded transition segment.
  • FIG. 10 is a perspective view of an embodiment according to the present invention of a self-retaining suture having a secondary retainer on a primary retainer.
  • FIG. 11 is a perspective view of a further embodiment according to the present invention of a self-retaining suture having a plurality of secondary retainers on a primary retainer.
  • FIG. 12 is a perspective view of a further embodiment according to the present invention of a self-retaining suture having a plurality of secondary retainers on a primary retainer and secondary retainers on the body of the suture.
  • FIG. 13 is a perspective view of a further embodiment according to the present invention of a self-retaining suture having primary retainers and filamentary secondary retainers.
  • Self-retaining system refers to a self-retaining suture together with means for deploying the suture into tissue.
  • deployment means include, without limitation, suture needles and other deployment devices as well as sufficiently rigid and sharp ends on the suture itself to penetrate tissue.
  • Self-retaining suture refers to a suture that does not require a knot or a suture anchor at its end in order to maintain its position into which it is deployed during a surgical procedure. These may be monofilament sutures or braided sutures, and are positioned in tissue in two stages, namely deployment and affixation, and include at least one tissue retainer.
  • tissue retainer (or simply “retainer”) or “barb” refers to a suture element having a retainer body projecting from the suture body and a retainer end adapted to penetrate tissue.
  • Each retainer is adapted to resist movement of the suture in a direction other than the direction in which the suture is deployed into the tissue by the surgeon, by being oriented to substantially face the deployment direction (i.e. they lie flat when pulled in the deployment direction; and open or “fan out” when pulled in a direction contrary to the deployment direction).
  • the tissue retainers should not catch or grab tissue during this phase.
  • a force exerted in another direction causes the retainers to be displaced from their deployment positions (i.e. resting substantially along the suture body), forces the retainer ends to open (or “fan out”) from the suture body in a manner that catches and penetrates into the surrounding tissue, and results in tissue being caught between the retainer and the suture body; thereby “anchoring” or affixing the Self-retaining suture in place.
  • Retainer configurations refers to configurations of tissue retainers and can include features such as size, shape, surface characteristics, and so forth. These are sometimes also referred to as “barb configurations”.
  • Bidirectional suture refers to a self-retaining suture having retainers oriented in one direction at one end and retainers oriented in the other direction at the other end.
  • a bidirectional suture is typically armed with a needle at each end of the suture thread.
  • Many bidirectional sutures have a transitional segment located between the two barb orientations.
  • Transport segment refers to a retainer-free (barb-free) portion of a bidirectional suture located between a first set of retainers (barbs) oriented in one direction and a second set of retainers (barbs) oriented in another direction.
  • Suture thread refers to the filamentary body component of the suture, and, for sutures requiring needle deployment, does not include the suture needle.
  • the suture thread may be monofilamentary, or, multifilamentary.
  • “Monofilament suture” refers to a suture comprising a monofilamentary suture thread.
  • Braided suture refers to a suture comprising a multifilamentary suture thread.
  • the filaments in such suture threads are typically braided, twisted, or woven together.
  • “Degradable (also referred to as “biodegradable” or “bioabsorbable”) suture” refers to a suture which, after introduction into a tissue is broken down and absorbed by the body. Typically, the degradation process is at least partially mediated by, or performed in, a biological system. “Degradation” refers to a chain scission process by which a polymer chain is cleaved into oligomers and monomers. Chain scission may occur through various mechanisms, including, for example, by chemical reaction (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination or these) or by a thermal or photolytic process.
  • chemical reaction e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination or these
  • Degradable suture material may include polymers such as polyglycolic acid, copolymers of glycolide and lactide, copolymers of trimethylene carbonate and glycolide with diethylene glycol (e.g., MAXONTM, Tyco Healthcare Group), terpolymer composed of glycolide, trimethylene carbonate, and dioxanone (e.g., BIOSYNTM [glycolide (60%), trimethylene carbonate (26%), and dioxanone (14%)], Tyco Healthcare Group), copolymers of glycolide, caprolactone, trimethylene carbonate, and lactide (e.g., CAPROSYNTM, Tyco Healthcare Group).
  • polymers such as polyglycolic acid, copolymers of glycolide and lactide, copolymers of trimethylene carbonate and glycolide with diethylene glycol (e.g., MAXONTM, Tyco Healthcare Group), terpolymer composed of glycolide, trimethylene carbonate, and dioxanone (e
  • sutures can be in either a braided multifilament form or a monofilament form.
  • the polymers used in the present invention can be linear polymers, branched polymers or multi-axial polymers. Examples of multi-axial polymers used in sutures are described in U.S. Patent Application Publication Nos. 20020161168, 20040024169, and 20040116620. Sutures made from degradable suture material lose tensile strength as the material degrades.
  • Non-degradable (also referred to as “non-absorbable”) suture” refers to a suture comprising material that is not degraded by chain scission such as chemical reaction processes (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination or these) or by a thermal or photolytic process.
  • chain scission such as chemical reaction processes (e.g., hydrolysis, oxidation/reduction, enzymatic mechanisms or a combination or these) or by a thermal or photolytic process.
  • Non-degradable suture material includes polyamide (also known as nylon, such as nylon 6 and nylon 6.6), polyester (e.g., polyethylene terephthlate), polytetrafluoroethylene (e.g., expanded polytetrafluoroethylene), polyether-ester such as polybutester (block copolymer of butylene terephthalate and polytetra methylene ether glycol), polyurethane, metal alloys, metal (e.g., stainless steel wire), polypropylene, polyethelene, silk, and cotton.
  • Sutures made of non-degradable suture material are suitable for applications in which the suture is meant to remain permanently or is meant to be physically removed from the body.
  • Suture diameter refers to the diameter of the body of the suture. It is to be understood that a variety of suture lengths may be used with the sutures described herein and that while the term “diameter” is often associated with a circular periphery, it is to be understood herein to indicate a cross-sectional dimension associated with a periphery of any shape. Suture sizing is based upon diameter. United States Pharmacopeia (“USP”) designation of suture size runs from 0 to 7 in the larger range and 1-0 to 11-0 in the smaller range; in the smaller range, the higher the value preceding the hyphenated zero, the smaller the suture diameter.
  • USP United States Pharmacopeia
  • the actual diameter of a suture will depend on the suture material, so that, by way of example, a suture of size 5-0 and made of collagen will have a diameter of 0.15 mm, while sutures having the same USP size designation but made of a synthetic absorbable material or a non-absorbable material will each have a diameter of 0.1 mm.
  • the selection of suture size for a particular purpose depends upon factors such as the nature of the tissue to be sutured and the importance of cosmetic concerns; while smaller sutures may be more easily manipulated through tight surgical sites and are associated with less scarring, the tensile strength of a suture manufactured from a given material tends to decrease with decreasing size.
  • sutures and methods of manufacturing sutures disclosed herein are suited to a variety of diameters, including without limitation 7, 6, 5, 4, 3, 2, 1, 0, 1-0, 2-0, 3-0, 4-0, 5-0, 6-0, 7-0, 8-0, 9-0, 10-0 and 11-0.
  • Suture deployment end refers to an end of the suture to be deployed into tissue; one or both ends of the suture may be suture deployment ends.
  • the suture deployment end may be attached to deployment means such as a suture needle, or may be sufficiently sharp and rigid to penetrate tissue on its own.
  • Armed suture refers to a suture having a suture needle on at least one suture deployment end.
  • Needle attachment refers to the attachment of a needle to a suture requiring same for deployment into tissue, and can include methods such as crimping, swaging, using adhesives, and so forth. The point of attachment of the suture to the needle is known as the swage.
  • “Suture needle” refers to needles used to deploy sutures into tissue, which come in many different shapes, forms and compositions. There are two main types of needles, traumatic needles and atraumatic needles. Traumatic needles have channels or drilled ends (that is, holes or eyes) and are supplied separate from the suture thread and are threaded on site. Atraumatic needles are eyeless and are attached to the suture at the factory by swaging whereby the suture material is inserted into a channel at the blunt end of the needle which is then deformed to a final shape to hold the suture and needle together. As such, atraumatic needles do not require extra time on site for threading and the suture end at the needle attachment site is smaller than the needle body.
  • Atraumatic needle In the traumatic needle the thread comes out of the needle's hole on both sides and often the suture rips the tissues to a certain extent as it passes through.
  • Most modern sutures are swaged atraumatic needles.
  • Atraumatic needles may be permanently swaged to the suture or may be designed to come off the suture with a sharp straight tug. These “pop-offs” are commonly used for interrupted sutures, where each suture is only passed once and then tied. For barbed sutures that are uninterrupted, these atraumatic needles would be ideal.
  • Suture needles may also be classified according to their point geometry.
  • needles may be (i) “tapered” whereby the needle body is round and tapers smoothly to a point; (ii) “cutting” whereby the needle body is triangular and has sharpened cutting edge on the inside; (iii) “reverse cutting” whereby the cutting edge is on the outside; (iv) “trocar point” or “tapercut” whereby the needle body is round and tapered, but ends in a small triangular cutting point; (v) “blunt” points for sewing friable tissues; (vi) “side cutting” or “spatula points” whereby the needle is flat on top and bottom with a cutting edge along the front to one side (these are typically used for eye surgery).
  • Suture needles may also be of several shapes including, (i) straight, (ii) half curved or ski, (iii) 1 ⁇ 4 circle, (iv) 3 ⁇ 8 circle, (v) 1 ⁇ 2 circle, (vi) 5 ⁇ 8 circle, (v) and compound curve.
  • Suturing needles are described, for example, in U.S. Pat. Nos. 6,322,581 and 6,214,030 (Mani, Inc., Japan); and 5,464,422 (W. L. Gore, Newark, Del.); and 5,941,899; 5,425,746; 5,306,288 and 5,156,615 (US Surgical Corp., Norwalk, Conn.); and 5,312,422 (Linvatec Corp., Largo, Fla.); and 7,063,716 (Tyco Healthcare, North Haven, Conn.).
  • Other suturing needles are described, for example, in U.S. Pat. Nos. 6,129,741; 5,897,572; 5,676,675; and 5,693,072.
  • the sutures described herein may be deployed with a variety of needle types (including without limitation curved, straight, long, short, micro, and so forth), needle cutting surfaces (including without limitation, cutting, tapered, and so forth), and needle attachment techniques (including without limitation, drilled end, crimped, and so forth). Moreover, the sutures described herein may themselves include sufficiently rigid and sharp ends so as to dispense with the requirement for deployment needles altogether.
  • Needle diameter refers to the diameter of a suture deployment needle at the widest point of that needle. While the term “diameter” is often associated with a circular periphery, it is to be understood herein to indicate a cross-sectional dimension associated with a periphery of any shape.
  • wound closure refers to a surgical procedure for closing of a wound.
  • An injury especially one in which the skin or another external or internal surface is cut, torn, pierced, or otherwise broken is known as a wound.
  • a wound commonly occurs when the integrity of any tissue is compromised (e.g., skin breaks or burns, muscle tears, or bone fractures).
  • a wound may be caused by an act, such as a gunshot, fall, or surgical procedure; by an infectious disease; or by an underlying medical condition.
  • Surgical wound closure facilitates the biological event of healing by joining, or closely approximating, the edges of those wounds where the tissue has been torn, cut, or otherwise separated.
  • Surgical wound closure directly apposes or approximates the tissue layers, which serves to minimize the volume new tissue formation required to bridge the gap between the two edges of the wound. Closure can serve both functional and aesthetic purposes. These purposes include elimination of dead space by approximating the subcutaneous tissues, minimization of scar formation by careful epidermal alignment, and avoidance of a depressed scar by precise eversion of skin edges.
  • tissue elevation procedure refers to a surgical procedure for repositioning tissue from a lower elevation to a higher elevation (i.e. moving the tissue in a direction opposite to the direction of gravity).
  • the retaining ligaments of the face support facial soft tissue in the normal anatomic position.
  • Face-lift procedures are designed to lift these sagging tissues, and are one example of a more general class of medical procedure known as a tissue elevation procedure.
  • tissue elevation procedure reverses the appearance change that results from gravitation effects over time, and other temporal effects that cause tissue to sag, such as genetic effects. It should be noted that tissue can also be repositioned without elevation; in some procedures tissues are repositioned laterally (away from the midline), medially (towards the midline) or inferiorly (lowered) in order to restore symmetry (i.e. repositioned such that the left and right sides of the body “match”).
  • Medical device refers to any object placed in the body for the purpose of restoring physiological function, reducing/alleviating symptoms associated with disease, and/or repairing/replacing damaged or diseased organs and tissues. While normally composed of biologically compatible synthetic materials (e.g., medical-grade stainless steel, titanium and other metals: polymers such as polyurethane, silicon, PLA, PLGA and other materials) that are exogenous, some medical devices and implants include materials derived from animals (e.g., “xenografts” such as whole animal organs; animal tissues such as heart valves; naturally occurring or chemically-modified molecules such as collagen, hyaluronic acid, proteins, carbohydrates and others), human donors (e.g., “allografts” such as whole organs; tissues such as bone grafts, skin grafts and others), or from the patients themselves (e.g., “autografts” such as saphenous vein grafts, skin grafts, tendon/ligament/
  • autografts such
  • Medical devices that can be used in procedures in conjunction with the present invention include, but are not restricted to, orthopaedic implants (artificial joints, ligaments and tendons; screws, plates, and other implantable hardware), dental implants, intravascular implants (arterial and venous vascular bypass grafts, hemodialysis access grafts; both autologous and synthetic), skin grafts (autologous, synthetic), tubes, drains, implantable tissue bulking agents, pumps, shunts, sealants, surgical meshes (e.g., hernia repair meshes, tissue scaffolds), fistula treatments, spinal implants (e.g., artificial intervertebral discs, spinal fusion devices, etc.) and the like.
  • orthopaedic implants artificial joints, ligaments and tendons; screws, plates, and other implantable hardware
  • dental implants include, but are not restricted to, orthopaedic implants (artificial joints, ligaments and tendons; screws, plates, and other implantable hardware), dental implants, intravascular implants (
  • the present invention provides compositions, configurations, methods of manufacturing and methods of using self-retaining systems in surgical procedures which greatly increase their ability to anchor into the surrounding tissue to provide superior holding strength and improve clinical performance.
  • Self-retaining sutures differ from conventional sutures in that they possess numerous tiny tissue retainers (such as barbs) which anchor into the tissue following deployment and resist movement of the suture in a direction opposite to that in which the retainers face, thereby eliminating the need to tie knots to affix adjacent tissues together (a “knotless” closure).
  • knot tying By eliminating knot tying, associated complications are eliminated, including, but not limited to (i) spitting (a condition where the suture, usually a knot) pushes through the skin after a subcutaneous closure), (ii) infection (bacteria are often able to attach and grow in the spaces created by a knot), (iii) bulk/mass (a significant amount of suture material left in a wound is the portion that comprises the knot), (iv) slippage (knots can slip or come untied), and (v) irritation (knots serve as a bulk “foreign body” in a wound).
  • Knot tying may lead to ischemia (they create tension points that can strangulate tissue and limit blood flow to the region) and increased risk of dehiscence or rupture at the surgical wound.
  • Knot tying is also labor intensive and can comprise a significant percentage of the time spent closing a surgical wound. Additional operative procedure time is not only bad for the patient (complication rates rise with time spent under anesthesia), but it also adds to the overall cost of the operation (many surgical procedures are estimated to cost between $15 and $30 per minute of operating time).
  • knotless sutures not only allow patients to experience an improved clinical outcome, but they also save time and costs associated with extended surgeries and follow-up treatments.
  • Self-retaining systems for wound closure also result in better approximation of the wound edges, evenly distribute the tension along the length of the wound (reducing areas of tension that can break or lead to ischemia), decrease the bulk of suture material remaining in the wound (by eliminating knots) and reduce spitting (the extrusion of suture material—typically knots—through the surface of the skin. All of these features are thought to reduce scarring, improve cosmesis, and increase wound strength relative to wound closures effected with plain sutures or staples.
  • Self-retaining sutures provide easier handling in anatomically tight or deep places (such as the pelvis, abdomen and thorax) and make it easier to approximate tissues in laparoscopic and minimally invasive procedures; all without having to secure the closure via a knot. Greater accuracy allows self-retaining sutures to be used for more complex closures (such as those with diameter mismatches, larger defects or purse string suturing) than can be accomplished with plain sutures.
  • Self-retaining sutures also lend themselves to a variety of specialized indications; for example, they are suitable for tissue elevation procedures where tissue is moved from its previous location and repositioned into a new anatomical location (this is typically performed in cosmetic procedures where “drooping” tissue is elevated and fixed in a more “youthful” position; or where “out-of-position” tissue is moved back to its correct anatomical location).
  • tissue elevation procedures where tissue is moved from its previous location and repositioned into a new anatomical location (this is typically performed in cosmetic procedures where “drooping” tissue is elevated and fixed in a more “youthful” position; or where “out-of-position” tissue is moved back to its correct anatomical location).
  • Such procedures include facelifts, brow lifts, breast lifts, buttocks lifts, and so forth.
  • a self-retaining suture may be unidirectional, having one or more retainers oriented in one direction along the length of the suture thread; or bidirectional, typically having one or more retainers oriented in one direction along a portion of the thread, followed by one or more retainers oriented in another (often opposite) direction over the remainder of the thread (as described with barbed retainers in U.S. Pat. Nos. 5,931,855 and. 6,241,747).
  • a common form involves a needle at one end, followed by barbs projecting “away” from the needle until the transition point (often the midpoint) of the suture is reached; at the transition point the configuration of barbs reverses itself about 180° (such that the barbs are now facing in the opposite direction) along the remaining length of the suture thread before attaching to a second needle at the opposite end (with the result that the barbs on this portion of the suture also face away from the nearest needle).
  • the barbs on both “halves” of a bidirectional self-retaining suture point towards the middle with a transition segment (lacking retainers) interspersed between them, and with a needle attached to either end.
  • suture 100 includes retainer 104 projecting from suture body 102 , where retainer 104 includes retainer body 106 , tissue-penetrating end 108 , and tissue engagement surface 110 . As shown in FIG.
  • the tissue engagement surface 110 of retainer 104 can be provided with an uneven configuration thereby increasing the surface area in contact with tissue and enhancing the resistance of the suture 100 to movement in a direction other than the deployment direction.
  • the term “uneven” as used herein indicates any surface configuration that is not flat and therefore comprises a greater surface area than would a comparably-sized flat surface.
  • the term may encompass, without limitation, surfaces that are rippled, corrugated, rough, dimpled, serrated, knobby, ridged, filamented, concave, convex, and so forth.
  • the increased surface area not only increases the interaction between the suture material and the tissue, it also provides a supportive matrix for cellular attachment and ingrowth that can facilitate healing.
  • the tissue engagement surface can be provided with an uneven configuration either during or after the manufacture of the self-retaining suture.
  • a method of forming retainers on a suture can include: providing a suture having a longitudinal axis and a circumferential periphery, a cutter, a displacer for pivoting the cutter, the suture, or both about the longitudinal axis; engaging the cutter with the suture; and, cutting an uneven-surfaced escarpment into the periphery of the suture.
  • the cutter may be a grinding wheel, a burr grinder, have an abrasive surface, etc., while other uneven surface configurations may be achieved with cutters such as, without limitation, arcuate or corrugated blades.
  • providing the surface 162 of the body 152 of suture 150 that faces the inner surface 160 of retainer 154 with an uneven configuration can further enhance surface area, increase the interaction between the suture material and the tissue, increase tissue retention and increase resistance to movement in a direction other than the deployment direction.
  • uneven tissue engagement surfaces on both retainer and suture body in sutures such as the one in FIG. 1 d may similarly be formed during or after the manufacture of the self-retaining suture.
  • the cutter may be a grinding wheel (roughened on both sides), a burr grinder, have an double-sided abrasive surface, etc., while other uneven surface configurations may be achieved with cutters such as, without limitation, arcuate or corrugated blades.
  • cutters creating uneven tissue engagement surfaces on both suture body and retainer may be employed during suture manufacture and, if desired, selected tissue engagement surfaces having the resultant uneven configurations may subsequently be scraped or polished to provide a smoother surface.
  • This embodiment can be expected to further increase the immediate holding power of the Self-retaining suture acutely due to the increased area of contact between the suture and the tissue and provide greater holding strength as healing tissue attaches and grows onto both surfaces.
  • a method of forming retainers on a suture can include: providing a suture having a longitudinal axis and a circumferential periphery, a cutter, and a displacer for pivoting the cutter, the suture, or both about the longitudinal axis; engaging the cutter with the suture; cutting an escarpment into the periphery of the suture; and rendering uneven at least a portion of at least one (or both) cut surface(s) of the escarpment.
  • the last step may include, without limitation, treating that portion with an abrasive agent, a polymerising agent, an acid etchant, or a base etchant.
  • Both unidirectional and bidirectional Self-retaining sutures can be provided with an expanded thread section between the two ends.
  • a suture may include an expanded section of the thread such that the diameter of the expanded portion of the thread is greater than the diameter of the end of the suture, or, if the suture is adapted for deployment with a needle that has a greater diameter than the end of the suture, than the diameter of the needle.
  • the diameter of the thread at a specified distance from the needle attachment site is greater than the diameter of the needle that is attached to it.
  • the diameter of the thread then tapers down as it approaches the needle attachment site until the thread diameter is equal to, or smaller than, the diameter of the needle to be used to deploy the suture (at the needle's widest point).
  • the rate, distance, degree and length of the tapering of the thread can be adjusted depending upon the clinical indication.
  • a bidirectional barbed suture may include an expanded segment of the thread which is located at the transition point where the barb configurations change orientation (typically, but not always, located at or near the middle of the thread).
  • the maximum diameter of the suture thread occurs somewhere along the transition segment and is greater than the diameter of either end of the suture, or, in the case of armed sutures, the deployment needle attached to the suture end.
  • the diameter of the thread is greatest at the transition point (typically in the middle) and then tapers down from this segment in both directions towards the needle attachment point until the thread diameter is equal to, or smaller than, the diameter of the ends of the suture or, in the case of armed sutures, the diameter of the needle (at the needle's widest point) attached to it.
  • the rate, distance, degree and length of the tapering of the thread can be adjusted depending upon the clinical indication.
  • one end of the suture is deployed into the tissue at a substantially central first point of the suture path and then the other end is deployed from a second point near the first point but in the opposite direction, in order to avoid engaging the retainers in tissue prior to completing the full deployment of the suture along the desired path.
  • a transitional segment of the suture may be the portion of the suture upon which the greatest tension is exerted and therefore most likely to fail (break and/or pull through), both during deployment and/or after affixation, as the suture is effectively pulled from substantially opposing directions during both deployment and affixation.
  • the portion of the suture upon which the magnitude of the longitudinal forces is greatest can be enhanced to resist those forces by increasing the diameter of the suture thread at that portion; thus reducing the likelihood that it will break.
  • the larger diameter suture thread will be forced into a smaller diameter “hole” created by the needle (or the smaller diameter suture end); this has the effect of “sinking” the expanded suture thread into the needle track, increasing the likelihood that the retainers will contact and embed in the surrounding tissue, and reducing the probability that the Self-retaining suture will pull through the tissue when tension is applied to it (something that is more prevalent when the needle track is larger than the thread diameter, as is the case with previously described barbed sutures).
  • This embodiment is not only useful for wound closure applications, but is particularly helpful for tissue retention applications, an example of which is described below in relation to FIG. 3 e.
  • the expanded thread segment can be created during manufacture of the suture thread (by, for example, extruding a larger amount of suture material for a particular length of a suture thread during an extrusion manufacturing process, cutting or stamping a suture thread with an expanded diameter portion, and so forth), or after the manufacture of the suture thread (by, for example, cutting material away from the ends of a suture thread, adding material to the desired portion of the thread, and so forth).
  • bidirectional suture 200 includes first plurality of retainers 210 facing substantially toward and pointing substantially away from first suture end 204 and second plurality of retainers 212 facing substantially toward and pointing substantially away from second suture end 206 (which may or may not correspond to the actual mid-point of the suture, depending on the arrangement of retainers).
  • first plurality of retainers 210 facing substantially toward and pointing substantially away from first suture end 204
  • second plurality of retainers 212 facing substantially toward and pointing substantially away from second suture end 206 (which may or may not correspond to the actual mid-point of the suture, depending on the arrangement of retainers).
  • transition segment 208 can be expanded such that the diameter at transition segment 208 of suture 200 is greater than the diameter of suture 200 at either end 204 or 206 . Further, as shown in FIG.
  • such expansion can be incremental, with the diameter increasing from each end 204 and 206 of suture 200 and reaching a maximum at transition segment 208 ; the incremental expansion may commence at a point outside the transitional segment, such that some part of the retainer-bearing portions of the suture thread may also have a greater diameter than that of a suture end.
  • the actual proportion of the diameter increase will depend on several factors, including without limitation the initial diameter at the ends of the suture, the nature of the tissue being sutured, the strength and flexibility of the suture material, the degree of tissue “anchorage” required, the amount of tension across the wound, etc.
  • the ratio of the suture diameter at ends 204 and 206 to increasingly central suture diameter at positions x and x′, y and y′, and z and z′, where z and z′ define the boundaries of transition segment 208 rise respectively from 1:1, 1:1.5, and 1:2.
  • the precise values and ratios suitable for any particular self-retaining suture having an expanded diameter at least some portion of the transition segment will vary depending on the purpose of the suture, the tissues for which it is intended, the suture material, and so forth. It should also be noted that for many indications the transition segment may be quite short; it is exaggerated in these figures for illustrative purposes.
  • FIG. 3 e A use of a bidirectional self-retaining suture 300 having an expanded transition segment 368 is depicted in FIG. 3 e .
  • suture 300 attached to needle 314 at suture end 304 is deployed in a subcuticular stitch through wound edges at about the central portion of the wound.
  • First plurality of retainers 310 disposed proximal to and facing suture end 304 , are pulled through tissue at the wound edges in the deployment direction.
  • FIG. 3 b upon subcuticularly connecting wound edges with two stitches 318 running from the center to the end of the wound, suture 300 is pulled in the deployment direction to approximate the wound edges together.
  • suture 300 is pulled in the deployment direction to progressively approximate wound edges until the last stitch in that deployment direction is at an end of the wound and the portion of the wound stitched together is closed, as shown in FIG. 3 c , with the retainer-free segment (the part of the thread where one barb orientation transitions into the opposite barb orientation) remaining at the central portion of the wound.
  • the process is repeated for the rest of the wound with a second set of subcuticular stitches 319 deployed with needle 316 at suture end 306 and second plurality of retainers 312 , resulting in a closed wound.
  • the suture 300 renders the suture 300 more resistant to failure (breakage) caused by the resultant opposing longitudinal tissue engagement forces and the expanded segment also anchors better into the subcuticular tissue, lessening the chances that the retainers will “pull through” or disengage if the wound is under tension.
  • the transition segment is the last portion of the suture 300 to be deployed into the tissue and as the diameter of the tissue perforation made by the needle (or sharpened end of the suture or other deployment element, whatever the case may be) is smaller than the diameter of the expansion portion of the suture, the engagement of the expansion portion of the suture in the tissue entails the exertion of an outwardly radial force from the expansion portion of the suture on the surrounding tissue.
  • the tissue is elastic and so in return exerts a force back upon the expansion portion of the suture, the positioning of the expansion portion of the suture in the tissue is better secured and thus the suture 300 can better resist movement in the tissue due to the longitudinal forces acting on the deployed suture.
  • Expanded diameter self-retaining sutures are also useful for tissue approximation procedures, that is, those used to bring wounds under high tension closer together to hold them in place while a definitive surface closure is performed; this is illustrated by way of example in FIG. 3 e .
  • tissue approximation procedures that is, those used to bring wounds under high tension closer together to hold them in place while a definitive surface closure is performed; this is illustrated by way of example in FIG. 3 e .
  • a bidirectional self-retaining suture 350 is deployed to bring the tissues into closer approximation.
  • needle 364 at suture end 354 (and proximal to first plurality of retainers 360 , which are oriented or pointing away from needle 364 ) is inserted through the wound edge, passed radially outwards from wound, and withdrawn at a distance from the wound edge; the distance is selected to suit the nature of the wound and surrounding tissues, while bearing in mind that the farther the distance, the greater the holding strength).
  • the procedure is then repeated on the other side of the wound with the opposite needle 366 at suture end 356 and the second plurality of retainers 362 oriented or pointing in the opposite direction opposite to the first plurality of retainers 360 .
  • several self-retaining sutures may be required.
  • the tissue can then be progressively “ratcheted” together over the retainers until it is as close together as is required (or as is prudent). Having an expanded diameter at the transition segment 368 that tapers down towards a needle (on either end of suture 350 ) not only provides additional strength where it is needed most (at the center), but also increases the anchorage of the retainers 360 and 362 into the tissue on either side of the wound; thereby increasing the amount of tension the suture can withstand without pulling through the tissue.
  • a self-retaining suture can include improved retainer configurations, such as helical retainers (along the continuous length of which tension is distributed substantially evenly) and scaled retainers (which provide maximal tissue engagement surface area, thereby optimising the tension distribution). For example, with reference to FIG.
  • a self-retaining suture 400 can include a helical retainer 404 disposed along at least part of the suture body 402 , the helical retainer 404 including a retainer body 408 and a tissue penetrating edge 410 , the retainer 404 facing in a direction and being adapted for resisting movement of the suture, when in tissue, in an opposite direction from the direction in which it faces.
  • Such helical self-retaining suture may be unidirectional or bidirectional, wherein the latter can have the helical retainer disposed at least in part proximal to and with the penetrating edge 410 facing away from one end of the suture and can include a second helical retainer disposed at least in part proximal to and with the penetrating edge 410 facing away from the other end of the suture, the suture including a retainer-free mid-section.
  • FIG. 4 b also discloses a helical self-retaining suture in the deployment position (that is, the unexpanded position), the suture 401 including a helical retainer 405 disposed along at least part of the suture body 403 , the helical retainer 405 including a retainer body 409 and a tissue penetrating edge 411 .
  • the retainer 405 also faces in a direction and is adapted for resisting movement of the suture, when in tissue, in an opposite direction from the direction in which it faces.
  • helical retainer 404 of suture 400 is chirally opposite to helical retainer 405 of suture 401 .
  • the helical self-retaining sutures of FIGS. 4 a and 4 b can be produced by a method including (i) providing a suture having a longitudinal axis and a circumference; a cutter; and, a displacer for longitudinally displacing and pivoting about the longitudinal axis at least one of the cutter and suture relative to one another; (ii) placing the cutter and suture into cutting engagement at a transverse cut angle; and, (iii) cutting a first helical circumferential escarpment about the suture.
  • the pivoting displacement of the cutter and/or suture relative to each other can be effected in one of several ways.
  • one of the cutter or suture may be moved: the cutter may revolve in a path about the circumference of the suture or the suture may be rotated on its longitudinal axis.
  • both suture and cutter may be pivotally displaced about the longitudinal axis of the suture, the suture being rotated while the cutter revolves.
  • suture and cutter may be pivoted either in the same direction or in opposing directions about the longitudinal axis. If both cutter and suture are pivoted in the same direction, the angular velocity at which each is pivoted about the longitudinal axis must differ in order to effect a circumferential escarpment on the suture. Where only one of the two is moved, or both are moved in opposing directions, the pivot velocity does not affect the cutting of the circumferential escarpment, although there may be operational limitations on the pivot velocity.
  • the longitudinal displacement of the suture and cutter relative to one another may be achieved in several ways. If it is desired to only move one of the two, then either the suture can be moved while the cutter remains longitudinally stationary (for example, without limitation, by pulling the suture past the location of the cutter) or the cutter can be moved along the length of the suture. Alternatively, both the cutter and suture can be moved longitudinally, either in opposing directions or in the same direction at differing longitudinal speeds.
  • the “net” velocity of longitudinal displacement that is, the velocity at which the cutter and suture move longitudinally relative to one another) affects the pitch of the helical circumferential escarpment, and so may be varied to achieve the desired pitch: the greater the net longitudinal displacement velocity, the longer the helical pitch. It is to be understood that the displacer of this method can be either a single component effecting both longitudinal displacement and pivoting displacement or a combination of components to effect both types of displacement.
  • the transverse cut angle can be an angle selected in the range between 90° and 180° relative to the longitudinal axis of the suture away from the suture deployment end that the retainer is to face; the transverse cut angle can typically be selected to be greater that 135° and less than 180° from the suture end that the retainer is to face, and can often be in the range of about 160° to about 170° from the suture deployment end. The greater the transverse cut angle, the deeper the cut creating the circumferential escarpment may be without eroding the integrity of the suture.
  • the selection of the transverse cut angle may depend on the strength and/or resilience and/or rigidity of the suture material, the tissues for which the suture is intended, and so forth.
  • the selection of the depth of the circumferential cut may depend on factors including without limitation the aforementioned transverse cut angle, the diameter of the suture, and the tissues for which the suture is intended; exemplary parameters such as transverse cut angles, ratios of cut depth to suture diameter and cut distance to suture diameter and so forth are described in U.S. patent application Ser. No. 10/065,279, incorporated by reference. Where smaller retainer configurations are desired or larger suture diameters are present, a series of parallel helical cuts may be provided, as opposed to a single cut.
  • a step of cutting a second helical circumferential escarpment can be added to this method; such second helical escarpment may or may not intersect the first helical escarpment.
  • the first and second helical escarpments may have the same or differing pitches (which depend on the rate of longitudinal displacement during the cutting of the escarpment) and cut depths, and/or the same or opposing chiralities. Depending upon the length of the escarpments and the respective transverse cut angles, a difference in pitch or chirality can result in intersection of the escarpments to create an escarpment point.
  • the cutter can be, without limitation, a laser, a blade, a grinding wheel, or a cutting disc; the cutting surface can be abraded or “roughened” on one or both sides (as described in Section B above) to increase the surface area of one or both sides of the retainer.
  • the cutter may be selected to cause the cut surfaces to disengage from one another, in order to facilitate engagement of the retainer with the tissue during affixation of the suture.
  • a grinding wheel is selected as the cutter, the grinding action of the wheel removes some of the suture material in forming the escarpment and thereby increases the likelihood that the cut surfaces of the escarpment would disengage from one another during affixation.
  • the cutter is a blade or cutting wheel, for example, it may be selected to have slightly thicker or wedge-shaped configuration to achieve this separation of cut surfaces.
  • FIG. 4 c discloses a scaled self-retaining suture 450 in an unexpanded position, produced by the foregoing method, wherein two intersecting helical escarpments are cut having substantially similar transverse cut angles, pitches, and cut depths, but opposing chiralities (i.e. the effect of combining 4 a and 4 b together).
  • the resultant overlap of escarpment points 452 of suture 450 produces a pattern of scale-like retainers 454 having tissue-penetrating edges 456 and tissue-engaging surfaces 458 ; as the retainers 454 created by this method cover the entire circumferential suture surface on which they are cut, the tension on the suture 450 is optimally distributed and the risk of suture failure minimized.
  • retainers 454 of suture 450 engage tissue, retainers 454 flare away from the suture body, as shown in the expanded position in FIG. 4 d.
  • a transition segment at some point between the ends of the suture is left retainer-free; the length of the transitional segment may be selected depending on the purpose of the suture, and the transitional segment may be located at or near the middle of the suture.
  • the first pair of helical escarpments is cut along one end of the suture to a selected point some distance from the other suture end while the second pair of helical escarpments is cut to a selected point away from the first pair, so as to avoid having the first and second pair of escarpments from overlapping with one another and thereby providing a retainer-free transitional segment.
  • the orientation of one pair of helical escarpments at one end is about 180° in orientation from the other pair of helical escarpments at the other end, thus creating an identical “mirrored” pattern of helical escarpments.
  • bidirectional scaled self-retaining suture 500 includes a first plurality of scale-like retainers 504 having retainer bodies 508 and tissue-penetrating edges 510 and a second plurality 514 of retainers 516 having retainer bodies 518 and tissue-penetrating edges 520 .
  • First retainer plurality 504 is disposed proximally to first suture deployment end 502 , thus retainers 508 are oriented or pointed substantially away from end 502 .
  • second retainer plurality 514 is disposed proximally to second suture deployment end 512 , being accordingly oriented or pointed substantially away from end 512 .
  • First and second retainer pluralities 504 and 514 are separated by transition segment 522 , that portion of a self-retaining bidirectional suture that is retainer-free.
  • a scaled self-retaining suture may be modified by rounding off or blunting the escarpment points.
  • FIG. 6 there is disclosed a scaled self-retaining suture 600 including on the suture body scale-like retainers 604 having retainer bodies 606 and tissue-penetrating edges 608 .
  • the tissue-penetrating edges 608 are rounded, producing a fish-scale effect, and are less likely bend or break without penetrating through and engaging the tissue.
  • a bidirectional self-retaining suture may be provided with rounded “scales”, as shown in FIG. 7 .
  • bidirectional scaled self-retaining suture 700 (shown in the expanded position) includes a first plurality of scale-like retainers 704 having retainer bodies 708 and rounded tissue-penetrating edges 710 and a second plurality of retainers 714 having retainer bodies 718 and rounded tissue-penetrating edges 720 .
  • First retainer plurality 704 is disposed proximally to first suture deployment end 702 , thus retainers 708 are oriented substantially away from end 702 .
  • second retainer plurality 714 is disposed proximally to second suture deployment end 712 , being separated from first retainer plurality 704 by transition segment 722 , with retainers 718 being accordingly oriented substantially away from end 712 .
  • bidirectional scaled self-retaining suture 800 (shown in the expanded position) includes a first plurality 804 of scale-like retainers 806 having retainer bodies 808 and tissue-penetrating edges 810 and a second plurality 814 of retainers 816 having retainer bodies 818 and tissue-penetrating edges 821 .
  • First retainer plurality 804 is disposed proximally to first suture deployment end 802 , thus retainers 808 are oriented or pointed substantially away from end 802 .
  • second retainer plurality 814 is disposed proximally to second suture deployment end 812 , being separated from first retainer plurality 804 by transition segment 820 , with retainers 818 being accordingly oriented or pointed substantially away from end 812 .
  • suture 800 has a greater diameter than at either end 802 or 812 .
  • such expansion can be incremental, with the diameter increasing from each end 802 and 812 of suture 800 and reaching a maximum at transition segment 820 ; the incremental expansion may commence at a point outside the transitional segment, such that some part of the retainer-bearing portions of the suture thread may also have a greater diameter than that of a suture end.
  • the bidirectional scaled self-retaining suture 900 in FIGS. 9 a and 9 b (shown in the expanded position) includes a first plurality 904 of scale-like retainers 906 having retainer bodies 908 and rounded tissue-penetrating edges 910 and a second plurality 914 of retainers 916 having retainer bodies 918 and rounded tissue-penetrating edges 921 .
  • First retainer plurality 904 is disposed proximally to first suture deployment end 902 , and the retainers 906 are oriented or pointed substantially away from end 902 .
  • second retainer plurality 914 is disposed proximally to second suture deployment end 912 , being separated from first retainer plurality 904 by transition segment 920 .
  • Retainers 918 are oriented or pointed substantially away from end 912 .
  • Suture 900 has a greater diameter at transition segment 920 than at either end 902 or 912 .
  • the expansion is shown in this example to be incremental, with the diameter increasing from each end 902 and 912 of suture 900 and reaching a maximum at transition segment 920 ; the incremental expansion may commence at a point outside the transitional segment, such that some part of the retainer-bearing portions of the suture thread may also have a greater diameter than that of a suture end.
  • Bidirectional scaled self-retaining sutures may further be provided with expanded diameter transitional segments as described in Section C herein, increased surface area provided by the tissue engagement surface configurations described in Section B, and secondary retainer structure configurations as described in Section E.
  • self-retaining sutures may be provided with a secondary retainer structure, that is, secondary retainers upon the primary retainers.
  • Secondary retainers further increase the surface area of the suture and thereby increase the amount of interaction between the suture and tissue.
  • providing secondary retainers on the primary retainers increases the total number of retainers on the suture (and thus the total number of points of tissue penetration) without a reduction in suture tensile strength that may occur by cutting additional primary retainers into the suture body.
  • the increase in the number of retainers and the increase in the suture's tissue engagement surface area results in better distribution of tension on the suture and increased tissue hold.
  • a self-retaining suture can include at least one primary retainer having a primary retainer body projecting from the suture body and a tissue penetrating end, and an inner surface substantially facing the suture body and an outer surface facing substantially away from the suture body, the primary retainer facing and deployed in a direction and being adapted for resisting movement of the suture when in tissue, in an opposite direction from the direction in which the primary retainer faces and is deployed.
  • the primary retainer can further include at least one secondary retainer projecting from the primary retainer body.
  • Such secondary retainers can be oriented in a direction at least about 90° away from the direction in which the primary retainer faces and is deployed, thus facilitating “double-hooking” of tissue, and may be located on any surface of the primary retainer.
  • the primary retainer can be a barb, it can be frusto-conical, helical, and so forth.
  • the secondary retainer can also be a barb, frusto-conical, helical, as well as filamentary.
  • a self-retaining suture 1000 is shown, the suture 1000 including a suture body 1002 and a plurality of primary retainers 1004 with face 1005 extending from suture body 1002 and having primary retainer bodies 1006 and primary retainer edges 1008 and primary retainer tissue engagement surfaces 1016 .
  • the primary retainers 1004 further include a secondary retainer 1010 disposed on the tissue engagement surface 1016 at the primary retainer edge 1008 with face 1009 and with the primary retainer 1004 facing the deployment direction and with the second retainer 1010 facing substantially away from the deployment direction.
  • the secondary retainers 1010 include a secondary retainer body 1012 and a secondary retainer edge 1014 .
  • Both primary and secondary retainers 1004 and 1010 are configured as barbs, such that the combination of the two have a “fishhook” appearance and function much the same way. That is, during suture deployment, primary retainers 1004 rest along suture body 1002 and secondary retainers 1010 in turn rest between primary retainers 1004 and suture body 1002 . During affixation, primary retainers 1004 are displaced away from suture body 1002 thereby exposing secondary retainers 1010 and allowing them to further engage tissue being engaged between primary retainers 1004 and suture body 1002 .
  • Such a “fishhook” combination of primary and secondary retainers may be produced by forming a primary retainer on the suture thread by a single transverse cut and then removing some suture material from the tissue engagement surface of the retainer (such as by hand-cutting or laser-cutting) to form the secondary retainer.
  • this combination may be made by making a first transverse cut on the suture thread to form the primary retainer, followed by back-cutting a second transverse cut onto the primary retainer to form the secondary retainer; these cuts may be made in a single continuous motion or may be made in separate motions.
  • the combination of primary retainers with “breakback” secondary retainers disposed on the tissue engagement surfaces of the primary retainers may be provided with frusto-conical and helical primary retainers; the secondary retainers may be cut onto the tissue engagement surfaces of such primary retainers to provide a secondary retainer lip along at least part of the length of the tissue penetrating edge of the primary retainer.
  • FIG. 11 discloses a primary/secondary retainer combination as well, but with a plurality of secondary retainers 1110 with face 1111 on primary retainer 1104 with face 1105 .
  • self-retaining suture 1100 includes suture body 1102 and primary retainers 1104 having a plurality of secondary retainers 1110 projecting from primary retainer body 1106 and with the secondary retainer 1110 located between the primary retainer 1104 and the suture body 1102 facing away from the direction of deployment
  • Both primary and secondary retainers 1104 and 1110 are configured as barbs, such that the combination of the two resemble the microstructure of a porcupine's quill and function in much the same way.
  • primary retainers 1104 rest along suture body 1102 and secondary retainers 1110 disposed on inner surface 1116 in turn rest between primary retainers 1104 and suture body 1102 .
  • tissue resistance during deployment may increase slightly.
  • the secondary retainers 1110 can enhance the hold or positioning of the primary retainers 1104 .
  • the uneven primary retainer surface resulting from these secondary retainers 1110 may increase local tissue disruption and increase surface area, both of which can promote healing and fixation. It is to be understood that such pluralities of secondary retainers may be provided on frusto-conical and helical primary retainers as well.
  • Self-retaining sutures having secondary retainers associated with primary retainers may further be provided with secondary retainers along the suture body, as disclosed in FIG. 12 .
  • Suture 1200 in FIG. 12 includes suture body 1202 and primary retainers 1204 having a plurality of secondary retainers 1210 (that project from primary retainer body 1206 ) and with the secondary retainer 1210 located between the primary retainer 1204 and the suture body 1202 facing away from the direction of deployment
  • Suture body 1202 further includes secondary retainers 1212 , which point away from the direction of deployment and face the directly of deployment; given their orientation, secondary retainers 1212 rest along body 1202 during deployment of suture 1200 and so do not increase tissue resistance as suture 1200 is deployed through it.
  • secondary retainers 1212 fan away from suture body 1202 and engage tissue during affixation of the suture 1200 . Provision of secondary retainers 1212 along suture body 1202 further increases surface area and therefore the holding strength of the suture. While retainers 1212 are configured as barbs, it is to be understood that other retainer configurations may be used.
  • FIG. 13 shows a self-retaining suture 1300 including a suture body 1302 and primary retainers 1304 having a plurality of secondary retainers 1310 extending from primary retainer bodies 1306 , which secondary retainers 1310 are filamentary.
  • These filamentary retainers 1310 may be created on the primary retainers 1304 by polymer grafting or growing techniques, by which polymer chains grown off of the surface of the primary retainers 1304 increase the microscopic surface area of the primary retainers 1304 thereby improving tissue engagement.
  • Suture threads described herein may be produced by any suitable method, including without limitation injection moulding, stamping, cutting, laser, extrusion, and so forth.
  • polymeric thread or filaments may be manufactured or purchased for the suture body, and the retainers can be subsequently cut onto the suture body; they may be hand-cut, laser-cut, or mechanically machine-cut using blades, cutting wheels, grinding wheels, and so forth.
  • the sutures may be made of any suitable biocompatible material, and may be further treated with any suitable biocompatible material, whether to enhance the sutures' strength, resilience, longevity, or other qualities, or to equip the sutures to fulfill additional functions besides joining tissues together, repositioning tissues, or attaching foreign elements to tissues.
  • Self-retaining sutures described herein may also incorporate materials that further promote tissue engagement.
  • tissue engagement-promoting materials in at least part of the suture bodies (whether or not such materials also make up all or part of the retainers) can enhance the ability of the sutures to stay in place.
  • tissue engagement-promoting materials are porous polymers that can be extruded to form suture bodies, including both microporous polymers and polymers that can be extruded with bubbles (whether bioabsorbable or nonbioabsorbable).
  • a suture synthesized with such materials can have a three-dimensional lattice structure that increases tissue engagement surface area and permits tissue infiltration into the suture body itself, thus having a primary structure that promotes successful suture use.
  • fibroblast ingrowth can be encouraged, further facilitating the suture to be anchored in the tissue.
  • ePTFE expanded polytetra-fluoroethylene
  • Self-retaining incorporating ePTFE are well-suited to uses requiring a strong and permanent lift (such as breast lifts, face lifts, and other tissue repositioning procedures), as tissue infiltration of the suture results in improved fixation and engraftment of the suture and the surrounding tissue thus providing superior hold and greater longevity of the lift.
  • self-retaining sutures described herein may be provided with compositions to promote healing and prevent undesirable effects such as scar formation, infection, pain, and so forth.
  • This can be accomplished in a variety of manners, including for example: (a) by directly affixing to the suture a formulation (e.g., by either spraying the suture with a polymer/drug film, or by dipping the suture into a polymer/drug solution), (b) by coating the suture with a substance such as a hydrogel which will in turn absorb the composition, (c) by interweaving formulation-coated thread (or the polymer itself formed into a thread) into the suture structure in the case of multi-filamentary sutures, (d) by inserting the suture into a sleeve or mesh which is comprised of, or coated with, a formulation, or (e) constructing the suture itself with a composition.
  • compositions may include without limitation anti-proliferative agents, anti-angiogenic agents, anti-infective agents, fibrosis-inducing agents, anti-scarring agents, lubricious agents, echogenic agents, anti-inflammatory agents, cell cycle inhibitors, analgesics, and anti-microtubule agents.
  • a composition can be applied to the suture before the retainers are formed, so that when the retainers engage, the engaging surface is substantially free of the coating. In this way, tissue being sutured contacts a coated surface of the suture as the suture is introduced, but when the retainer engages, a non-coated surface of the retainer contacts the tissue.
  • the suture may be coated after or during formation of retainers on the suture if, for example, a fully-coated rather than selectively-coated suture is desired.
  • a suture may be selectively coated either during or after formation of retainers by exposing only selected portions of the suture to the coating.
  • the particular purpose to which the suture is to be put or the composition may determine whether a fully-coated or selectively-coated suture is appropriate; for example, with lubricious coatings, it may be desirable to selectively coat the suture, leaving, for instance, the tissue-engaging surfaces of the sutures uncoated in order to prevent the tissue engagement function of those surfaces from being impaired.
  • coatings such as those comprising such compounds as anti-infective agents may suitably be applied to the entire suture, while coatings such as those comprising fibrosing agents may suitably be applied to all or part of the suture (such as the tissue-engaging surfaces).
  • the purpose of the suture may also determine the sort of coating that is applied to the suture; for example, self-retaining sutures having anti-proliferative coatings may be used in closing tumour excision sites, while self-retaining sutures with fibrosing coatings may be used in tissue repositioning procedures and those having anti-scarring coatings may be used for wound closure on the skin.
  • sutures having an expanded segment may include a fibrosis-inducing composition on the expanded segment to further secure the segment in position in the tissue.
  • Coatings may also include a plurality of compositions either together or on different portions of the suture, where the multiple compositions can be selected either for different purposes (such as combinations of analgesics, anti-infective and anti-scarring agents) or for their synergistic effects.
  • Self-retaining sutures can be used in a variety of other inidcations.
  • Self-retaining sutures described herein may be used in various dental procedures, i.e., oral and maxillofacial surgical procedures and thus may be referred to as “self-retaining dental sutures.”
  • the above-mentioned procedures include, but are not limited to, oral surgery (e.g., removal of impacted or broken teeth), surgery to provide bone augmentation, surgery to repair dentofacial deformities, repair following trauma (e.g., facial bone fractures and injuries), surgical treatment of odontogenic and non-odontogenic tumors, reconstructive surgeries, repair of cleft lip or cleft palate, congenital craniofacial deformities, and esthetic facial surgery.
  • Self-retaining dental sutures may be degradable or non-degradable, and may typically range in size from USP 2-0 to USP 6-0.
  • Self-retaining sutures described herein may also be used in tissue repositioning surgical procedures and thus may be referred to as “self-retaining tissue repositioning sutures”. Such surgical procedures include, without limitation, face lifts, neck lifts, brow lifts, thigh lifts, and breast lifts. Self-retaining sutures used in tissue repositioning procedures may vary depending on the tissue being repositioned; for example, sutures with larger and further spaced-apart retainers may be suitably employed with relatively soft tissues such as fatty tissues.
  • Self-retaining sutures described herein may also be used in microsurgical procedures that are performed under a surgical microscope (and thus may be referred to as “self-retaining microsutures”). Such surgical procedures include, but are not limited to, reattachment and repair of peripheral nerves, spinal microsurgery, microsurgery of the hand, various plastic microsurgical procedures (e.g., facial reconstruction), microsurgery of the male or female reproductive systems, and various types of reconstructive microsurgery. Microsurgical reconstruction is used for complex reconstructive surgery problems when other options such as primary closure, healing by secondary intention, skin grafting, local flap transfer, and distant flap transfer are not adequate. Self-retaining microsutures have a very small caliber, often as small as USP 9-0 or USP10-0, and may have an attached needle of corresponding size. They may be degradable or non-degradable.
  • Self-retaining sutures as described herein may be used in similarly small caliber ranges for ophthalmic surgical procedures and thus may be referred to as “ophthalmic self-retaining sutures”. Such procedures include but are not limited to keratoplasty, cataract, and vitreous retinal microsurgical procedures. Ophthalmic self-retaining sutures may be degradable or non-degradable, and have an attached needle of correspondingly-small caliber.
  • Self-retaining sutures can be used in a variety of veterinary applications for a wide number of surgical and traumatic purposes in animal health.

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US12/062,256 US20080255612A1 (en) 2007-04-13 2008-04-03 Self-retaining systems for surgical procedures
CA2683819A CA2683819C (en) 2007-04-13 2008-04-11 Self-retaining systems for surgical procedures
PCT/US2008/060127 WO2008128113A1 (en) 2007-04-13 2008-04-11 Self retaining systems for surgical procedures
EP08745687.7A EP2146646B1 (de) 2007-04-13 2008-04-11 Selbsthaltende chirurgisches nähte für chirurgische verfahren
JP2010503254A JP5562829B2 (ja) 2007-04-13 2008-04-11 外科的手技用自己保持システム
EP18181513.5A EP3409214A3 (de) 2007-04-13 2008-04-11 Selbsthaltende chirurgisches nähte für chirurgische verfahren
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008057218A1 (de) * 2008-11-06 2010-05-12 Aesculap Ag Chirurgisches Nahtmaterial mit im unverstreckten Zustand eingeschnittenen Widerhaken
US20100256676A1 (en) * 2009-04-06 2010-10-07 Hay Alan R Suture clips for securing sutures
US20110022085A1 (en) * 2009-07-22 2011-01-27 Wisconsin Alumni Research Foundation Biologically active sutures for regenerative medicine
US20130172931A1 (en) * 2011-06-06 2013-07-04 Jeffrey M. Gross Methods and devices for soft palate tissue elevation procedures
US8793863B2 (en) 2007-04-13 2014-08-05 Ethicon, Inc. Method and apparatus for forming retainers on a suture
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US9044225B1 (en) 2007-12-20 2015-06-02 Ethicon, Inc. Composite self-retaining sutures and method
US9125647B2 (en) 2008-02-21 2015-09-08 Ethicon, Inc. Method and apparatus for elevating retainers on self-retaining sutures
US9675341B2 (en) 2010-11-09 2017-06-13 Ethicon Inc. Emergency self-retaining sutures and packaging
US9955962B2 (en) 2010-06-11 2018-05-01 Ethicon, Inc. Suture delivery tools for endoscopic and robot-assisted surgery and methods
US10420546B2 (en) 2010-05-04 2019-09-24 Ethicon, Inc. Self-retaining systems having laser-cut retainers
US10492780B2 (en) 2011-03-23 2019-12-03 Ethicon, Inc. Self-retaining variable loop sutures
US10548592B2 (en) 2004-05-14 2020-02-04 Ethicon, Inc. Suture methods and devices
US11007296B2 (en) 2010-11-03 2021-05-18 Ethicon, Inc. Drug-eluting self-retaining sutures and methods relating thereto

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6241747B1 (en) * 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
US5931855A (en) 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
US7056331B2 (en) * 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
US6848152B2 (en) * 2001-08-31 2005-02-01 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
US6773450B2 (en) 2002-08-09 2004-08-10 Quill Medical, Inc. Suture anchor and method
US8100940B2 (en) 2002-09-30 2012-01-24 Quill Medical, Inc. Barb configurations for barbed sutures
US20040088003A1 (en) 2002-09-30 2004-05-06 Leung Jeffrey C. Barbed suture in combination with surgical needle
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
US9393013B2 (en) * 2007-05-08 2016-07-19 Heeyoung Lee Lee Tools for fiber reinforced anti-compressive adherent suture method
US8747436B2 (en) * 2007-06-13 2014-06-10 Ethicon, Inc. Bi-directional barbed suture
ES2488406T3 (es) 2007-09-27 2014-08-27 Ethicon Llc Suturas de auto-retención que incluyen elementos de retención a tejido con resistencia mejorada
WO2009086172A2 (en) 2007-12-19 2009-07-09 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with heat-contact mediated retainers
EP2242430B1 (de) 2008-01-30 2016-08-17 Ethicon, LLC Vorrichtung und verfahren zur bildung von selbstfixierenden nähten
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8641732B1 (en) 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
US20090228021A1 (en) * 2008-03-06 2009-09-10 Leung Jeffrey C Matrix material
CA2720847C (en) * 2008-04-15 2016-06-28 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with bi-directional retainers or uni-directional retainers
SG196767A1 (en) * 2008-11-03 2014-02-13 Ethicon Llc Length of self-retaining suture and method and device for using the same
DE102008057213A1 (de) * 2008-11-06 2010-05-12 Aesculap Ag Medizintechnisches Produkt, ein chirurgisches Kit sowie ein Herstellungsverfahren für das medizintechnische Produkt
US8402621B2 (en) 2009-04-29 2013-03-26 Covidien Lp System and method for forming barbs on a suture
ES2600359T3 (es) * 2009-06-29 2017-02-08 Aesculap Ag Hilo quirúrgico que comprende células y método de fabricación del hilo
US9011487B2 (en) * 2009-08-27 2015-04-21 Ethicon, Inc. Barbed sutures having pledget stoppers and methods therefor
EP2501300B1 (de) * 2009-11-16 2018-07-11 Ethicon LLC Selbsthaltende geflochtene nahten und verfahren dafür
WO2011090628A2 (en) * 2009-12-29 2011-07-28 Angiotech Pharmaceuticals, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
US9980708B2 (en) 2010-01-20 2018-05-29 Micro Interventional Devices, Inc. Tissue closure device and method
US10743854B2 (en) 2010-01-20 2020-08-18 Micro Interventional Devices, Inc. Tissue closure device and method
US10959840B2 (en) 2010-01-20 2021-03-30 Micro Interventional Devices, Inc. Systems and methods for affixing a prosthesis to tissue
JP5828147B2 (ja) 2010-01-20 2015-12-02 マイクロ インターベンショナル デバイシズ，インコーポレイティド 組織修復用インプラントと送達装置と送達方法
US10058314B2 (en) 2010-01-20 2018-08-28 Micro Interventional Devices, Inc. Tissue closure device and method
EP2549933A4 (de) * 2010-03-25 2015-10-14 Covidien Lp Chemische knoten für nähte
US9044224B2 (en) 2010-04-12 2015-06-02 Covidien Lp Barbed medical device and method
AU2011248466B2 (en) * 2010-04-29 2015-03-19 Angiotech Pharmaceuticals, Inc. High-density self-retaining sutures, manufacturing equipment and methods
US20130204295A1 (en) * 2010-05-05 2013-08-08 William L. Hunter Surface texture configuration for self-retaining sutures and methods for forming same
US8945156B2 (en) 2010-05-19 2015-02-03 University Of Utah Research Foundation Tissue fixation
US8858577B2 (en) 2010-05-19 2014-10-14 University Of Utah Research Foundation Tissue stabilization system
US8852214B2 (en) 2011-02-04 2014-10-07 University Of Utah Research Foundation System for tissue fixation to bone
US9687227B2 (en) 2011-04-29 2017-06-27 Covidien Lp Apparatus and method of forming barbs on a suture
EP2720623A4 (de) * 2011-06-17 2015-04-22 Curaseal Inc Verfahren und vorrichtungen zur behandlung von fisteln
US8911466B2 (en) * 2011-12-02 2014-12-16 Ethicon, Inc. Medical insertion device and method of use
US10278694B2 (en) 2012-02-23 2019-05-07 Northwestern University Indirect attachment of a needle to a mesh suture
BR112014020564B1 (pt) 2012-02-23 2021-05-11 Northwestern University dispositivo médico e método de reposicionamento do tecido macio
US9585654B2 (en) 2012-05-01 2017-03-07 Dean & Webb, LLC Segmentally rigid suture and suturing technique
US10835241B2 (en) 2012-07-30 2020-11-17 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10219804B2 (en) 2012-07-30 2019-03-05 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11253252B2 (en) 2012-07-30 2022-02-22 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10390935B2 (en) 2012-07-30 2019-08-27 Conextions, Inc. Soft tissue to bone repair devices, systems, and methods
US11957334B2 (en) 2012-07-30 2024-04-16 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9427309B2 (en) 2012-07-30 2016-08-30 Conextions, Inc. Soft tissue repair devices, systems, and methods
US11944531B2 (en) 2012-07-30 2024-04-02 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
CN103571804B (zh) * 2012-08-10 2015-08-12 中国科学院生物物理研究所 3-吡唑基酪氨酸翻译系统及其应用
NL2009404C2 (nl) * 2012-09-03 2014-03-04 Medishield B V Seton voor de behandeling van een fistel, werkwijze voor het vormen van een gesloten lus uit een seton, alsmede smeltklem daarvoor.
WO2014116780A1 (en) * 2013-01-25 2014-07-31 Genesee Biomedical, Inc. Dual diameter, dual density eptfe suture
JP6313450B2 (ja) 2013-08-29 2018-04-18 テレフレックス メディカル インコーポレイテッド 高強度マルチコンポーネント縫合糸
KR101432497B1 (ko) * 2013-09-27 2014-08-25 유원석 고착형 미늘 봉합사
US11583384B2 (en) 2014-03-12 2023-02-21 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
WO2015138760A1 (en) 2014-03-12 2015-09-17 Conextions, Inc. Soft tissue repair devices, systems, and methods
DE102014004772A1 (de) * 2014-04-01 2015-10-01 Ruprecht-Karls-Universität Heidelberg Chirurgische Vorrichtung, Verfahren zum Verwenden der chirurgischen Vorrichtung und Nahtmaterial
WO2016154609A1 (en) * 2015-03-26 2016-09-29 Central Park Diagnostics, Inc. Suture delivery device, and suture, for facilitating fibrosis and healing
US11684358B2 (en) 2015-04-20 2023-06-27 Boston Scientific Scimed, Inc. Fusible biodegradable sutures utilizing tissue soldering technology
KR101692693B1 (ko) * 2015-05-13 2017-01-04 김대중 성형 수술용 실 제조장치
DE202016100026U1 (de) 2016-01-05 2016-01-25 Torsten Kern Schneidevorrichtung zum Einschneiden von fadenförmigen Werkstoffen
US11696822B2 (en) 2016-09-28 2023-07-11 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
CN107049388B (zh) * 2016-11-25 2019-03-05 温州科技职业学院 一种外科手术线切线装置
CN111432749B (zh) 2017-10-19 2023-04-04 C.R.巴德公司 自抓握式疝假体
US11547397B2 (en) 2017-12-20 2023-01-10 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
JP2021514288A (ja) 2018-02-20 2021-06-10 コネクションズ, インク.Conextions, Inc. 軟質組織を修復し、軟質組織を骨に取り付けるための装置、システム、および方法
US11272924B2 (en) 2018-07-18 2022-03-15 Arthrex, Inc. Knotless closure sutures and methods of tissue fixation
CN111419297A (zh) * 2019-01-09 2020-07-17 张国正 具有螺旋状凸出物的缝线及其制造方法
CN110151240A (zh) * 2019-05-07 2019-08-23 张为 椎间盘纤维环裂纹缝合工具
US11576666B2 (en) 2019-10-04 2023-02-14 Arthrex, Inc Surgical constructs for tissue fixation and methods of tissue repairs
KR102307404B1 (ko) * 2020-04-10 2021-09-30 21세기메디칼 주식회사 수술용 및 안면 거상술용 봉합사
JP2023524918A (ja) 2020-05-15 2023-06-14 エル． モリバー、クレイトン 一体化された閉鎖部を含む無結節縫合
KR102516369B1 (ko) * 2021-03-03 2023-03-30 장미경 미늘을 포함하는 필라멘트사 제조 방법 및 장치
GR1010233B (el) * 2021-07-26 2022-05-17 Αγγελος Νικολαου Γιαλαμας Χειρουργικο ραμμα αυτοασφαλιζομενο
KR102390262B1 (ko) * 2021-08-18 2022-04-25 주식회사 필코리아 리프팅용 코그실

Citations (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US879758A (en) * 1907-06-14 1908-02-18 Frank Brooks Foster Needle.
US2232142A (en) * 1940-09-27 1941-02-18 Schumann Seymour Wound clip
US2779083A (en) * 1955-02-09 1957-01-29 Edward N Eaton Lip and mouth adjuster
US3123077A (en) * 1964-03-03 Surgical suture
US3166072A (en) * 1962-10-22 1965-01-19 Jr John T Sullivan Barbed clips
US3234636A (en) * 1962-03-19 1966-02-15 Ernest C Wood Clip applicator
US3494006A (en) * 1968-01-12 1970-02-10 George C Brumlik Self-gripping fastening device
US3557795A (en) * 1968-06-19 1971-01-26 Weck & Co Inc Edward Suture provided with wound healing coating
US3716058A (en) * 1970-07-17 1973-02-13 Atlanta Res Inst Barbed suture
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4008303A (en) * 1971-08-30 1977-02-15 American Cyanamid Company Process for extruding green polyglycolic acid sutures and surgical elements
USD246911S (en) * 1976-02-27 1978-01-10 Bess Jr Kenneth B Automatic blind suturing machine
US4069825A (en) * 1976-01-28 1978-01-24 Taichiro Akiyama Surgical thread and cutting apparatus for the same
US4073298A (en) * 1976-08-03 1978-02-14 New Research & Development Lab., Inc. Wound clip
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4182340A (en) * 1972-05-12 1980-01-08 Spencer Dudley W C Hoof repair
US4311002A (en) * 1977-09-22 1982-01-19 Kabel Metallwerke Ghh Forming stranded stock
US4313448A (en) * 1980-01-28 1982-02-02 Medtronic, Inc. Myocardial sutureless lead
US4316469A (en) * 1976-09-07 1982-02-23 Kapitanov Nikolai N Surgical apparatus for suturing soft tissues with lengths of suturing material with spicules
US4372293A (en) * 1980-12-24 1983-02-08 Vijil Rosales Cesar A Apparatus and method for surgical correction of ptotic breasts
US4428376A (en) * 1980-05-02 1984-01-31 Ethicon Inc. Plastic surgical staple
US4430998A (en) * 1982-06-01 1984-02-14 Thoratec Laboratories Corporation Wound closing device
US4492075A (en) * 1982-01-26 1985-01-08 Asa S.A. Method for producing fiber spun yarns and the fiber spun yarns obtained with said method
US4493323A (en) * 1982-12-13 1985-01-15 University Of Iowa Research Foundation Suturing device and method for using same
US4635637A (en) * 1984-03-29 1987-01-13 Schreiber Saul N Surgical suture
US4637380A (en) * 1985-06-24 1987-01-20 Orejola Wilmo C Surgical wound closures
US4719917A (en) * 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
US4895148A (en) * 1986-05-20 1990-01-23 Concept, Inc. Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member
US4898156A (en) * 1987-05-18 1990-02-06 Mitek Surgical Products, Inc. Suture anchor
US4900605A (en) * 1988-09-16 1990-02-13 Harold Thorgersen Bristle pile textile for garment applications
US4899743A (en) * 1987-12-15 1990-02-13 Mitek Surgical Products, Inc. Suture anchor installation tool
US4981149A (en) * 1989-05-16 1991-01-01 Inbae Yoon Method for suturing with a bioabsorbable needle
US4994073A (en) * 1989-02-22 1991-02-19 United States Surgical Corp. Skin fastener
US4994084A (en) * 1989-06-23 1991-02-19 Brennan H George Reconstructive surgery method and implant
US5084063A (en) * 1989-09-27 1992-01-28 United States Surgical Corporation Surgical needle-suture attachment
US5089010A (en) * 1989-09-27 1992-02-18 United States Surgical Corporation Surgical needle-suture attachment possessing weakened suture segment for controlled suture release
US5176692A (en) * 1991-12-09 1993-01-05 Wilk Peter J Method and surgical instrument for repairing hernia
US5179964A (en) * 1991-08-30 1993-01-19 Cook Melvin S Surgical stapling method
US5282832A (en) * 1992-10-09 1994-02-01 United States Surgical Corporation Suture clip
US5380334A (en) * 1993-02-17 1995-01-10 Smith & Nephew Dyonics, Inc. Soft tissue anchors and systems for implantation
US5391173A (en) * 1994-02-10 1995-02-21 Wilk; Peter J. Laparoscopic suturing technique and associated device
US5480403A (en) * 1991-03-22 1996-01-02 United States Surgical Corporation Suture anchoring device and method
US5480411A (en) * 1992-03-03 1996-01-02 United States Surgical Corporation Method of suturing using a polyetherimide ester suture
US5484451A (en) * 1992-05-08 1996-01-16 Ethicon, Inc. Endoscopic surgical instrument and staples for applying purse string sutures
US5486197A (en) * 1994-03-24 1996-01-23 Ethicon, Inc. Two-piece suture anchor with barbs
US5494154A (en) * 1994-07-12 1996-02-27 Look Incorporated Surgical suture package
US5601557A (en) * 1982-05-20 1997-02-11 Hayhurst; John O. Anchoring and manipulating tissue
US5709692A (en) * 1994-09-16 1998-01-20 General Surgical Innovations Surgical instrument for placing suture or fasteners
US5716376A (en) * 1996-06-28 1998-02-10 United States Surgical Corporation Absorbable mixture and coatings for surgical articles fabricated therefrom
US5716358A (en) * 1994-12-02 1998-02-10 Johnson & Johnson Professional, Inc. Directional bone fixation device
US5863360A (en) * 1994-03-05 1999-01-26 The University Of Dundee Surface treatment of shape memory alloys
US6012216A (en) * 1997-04-30 2000-01-11 Ethicon, Inc. Stand alone swage apparatus
US6015410A (en) * 1997-12-23 2000-01-18 Bionx Implants Oy Bioabsorbable surgical implants for endoscopic soft tissue suspension procedure
US6024757A (en) * 1998-04-14 2000-02-15 Ethicon, Inc. Method for cutting a surgical suture tip
US6027523A (en) * 1997-10-06 2000-02-22 Arthrex, Inc. Suture anchor with attached disk
US6168633B1 (en) * 1998-08-10 2001-01-02 Itzhak Shoher Composite surface composition for an implant structure
US6174324B1 (en) * 1998-07-13 2001-01-16 Axya Medical, Inc. Suture guide and fastener
US6183499B1 (en) * 1998-09-11 2001-02-06 Ethicon, Inc. Surgical filament construction
US6187095B1 (en) * 1996-10-31 2001-02-13 Samsel K. Labrecque Process and apparatus for coating surgical sutures
US6334865B1 (en) * 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US20020007218A1 (en) * 1999-10-20 2002-01-17 Cauthen Joseph C. Spinal disc annulus reconstruction method and spinal disc annulus stent
US20020022861A1 (en) * 2000-05-19 2002-02-21 Daniel Jacobs Multi-point tissue tension distribution device, a combined orbital rim repair and suspension variation, and a method of tissue approximation using the device
USRE37963E1 (en) * 1995-06-06 2003-01-07 Raymond Thal Knotless suture anchor assembly
US6506190B1 (en) * 1998-05-21 2003-01-14 Christopher J. Walshe Tissue anchor system
US20030014077A1 (en) * 2001-06-29 2003-01-16 Leung Jeffrey C. Suture method
US6511488B1 (en) * 1998-06-23 2003-01-28 Orthopaedic Biosystems Ltd., Inc. Surgical knot manipulator
US6514265B2 (en) * 1999-03-01 2003-02-04 Coalescent Surgical, Inc. Tissue connector apparatus with cable release
US20030040795A1 (en) * 2001-05-31 2003-02-27 Elson Robert J. Anterior cruciate ligament reconstruction system
US20040010275A1 (en) * 2000-05-19 2004-01-15 Daniel Jacobs Multi-point tissue tension distribution device and method, a custom-fittable variation
US20040010276A1 (en) * 2000-05-19 2004-01-15 Daniel Jacobs Multi-point tissue tension distribution device and method, a chin lift variation
US20040015187A1 (en) * 2002-04-18 2004-01-22 Mnemoscience Corporation Biodegradable shape memory polymeric sutures
US20040024169A1 (en) * 2000-10-27 2004-02-05 Shalaby Shalaby W. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US20040024420A1 (en) * 1996-09-13 2004-02-05 Tendon Technology, Ltd. Apparatus and methods for securing tendons or ligaments to bone
US20040028655A1 (en) * 1999-08-06 2004-02-12 Nelson Kevin D. Drug releasing biodegradable fiber for delivery of therapeutics
US20040060409A1 (en) * 2002-09-30 2004-04-01 Leung Jeffrey C. Barb configurations for barbed sutures
US20040088003A1 (en) * 2002-09-30 2004-05-06 Leung Jeffrey C. Barbed suture in combination with surgical needle
US6838493B2 (en) * 1999-03-25 2005-01-04 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US20050004602A1 (en) * 2003-07-02 2005-01-06 Applied Medical Resources Corporation Interlocking suture clinch
US20050004601A1 (en) * 2003-04-29 2005-01-06 Kong James Kam Fu Coded surgical aids
US6981983B1 (en) * 1999-03-31 2006-01-03 Rosenblatt Peter L System and methods for soft tissue reconstruction
US6986780B2 (en) * 2002-03-26 2006-01-17 Ethicon, Inc. Surgical element delivery system and method
US20060020272A1 (en) * 2004-06-24 2006-01-26 Gildenberg Philip L Semi-robotic suturing device
US6991643B2 (en) * 2000-12-20 2006-01-31 Usgi Medical Inc. Multi-barbed device for retaining tissue in apposition and methods of use
US7156862B2 (en) * 2000-05-19 2007-01-02 Coapt Systems, Inc. Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US7156858B2 (en) * 2000-04-20 2007-01-02 Ethicon G.M.B.H. Implant
US20070005109A1 (en) * 2005-06-29 2007-01-04 Popadiuk Nicholas M Barbed suture
US20070005110A1 (en) * 2005-06-29 2007-01-04 Collier John P Braided barbed suture
US7160312B2 (en) * 1999-06-25 2007-01-09 Usgi Medical, Inc. Implantable artificial partition and methods of use
US7166570B2 (en) * 2003-11-10 2007-01-23 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20070021779A1 (en) * 2003-06-27 2007-01-25 Garvin Dennis D Device for surgical repair, closure, and reconstruction
US20070213770A1 (en) * 2006-03-07 2007-09-13 Dreyfuss Peter J Tapered Suture
US20080004603A1 (en) * 2006-06-29 2008-01-03 Intuitive Surgical Inc. Tool position and identification indicator displayed in a boundary area of a computer display screen
US20080009888A1 (en) * 2006-07-07 2008-01-10 Usgi Medical, Inc. Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US20080009902A1 (en) * 2006-01-30 2008-01-10 Angiotech Pharmaceuticals, Inc. Sutures and fibrosing agents
US20080009838A1 (en) * 2006-06-30 2008-01-10 Intuitive Surgical Inc. Compact capstan
US7322105B2 (en) * 2005-11-18 2008-01-29 Ultradent Products, Inc. Methods for manufacturing endodontic instruments by milling
US20080027486A1 (en) * 2006-07-28 2008-01-31 Angiotech Pharmaceuticals, Inc. Minimally-invasive nipple-lift procedure and apparatus
US20080027273A1 (en) * 2006-07-27 2008-01-31 Gutterman Lee R Nonaugmentive mastopexy
US20090012560A1 (en) * 2007-04-13 2009-01-08 Angiotech Pharmaceuticals, Inc. Self-retaining systems for surgical procedures
US20090018577A1 (en) * 1993-05-03 2009-01-15 Quill Medical, Inc. Barbed sutures
US20100023055A1 (en) * 2008-07-23 2010-01-28 Ethicon, Inc. Collapsible barbed sutures having reduced drag and methods therefor
US20110009902A1 (en) * 2002-08-09 2011-01-13 Quill Medical, Inc. Multiple suture thread configuration with an intermediate connector

Family Cites Families (721)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1321011A (en) 1919-11-04 Surgical
US709392A (en) 1902-05-06 1902-09-16 Haydn Brown Suture-clamp.
US733723A (en) 1903-02-16 1903-07-14 Clarence D Lukens Serrefin.
US789401A (en) * 1904-07-15 1905-05-09 Ernest V Acheson Umbilical forceps and metal sealing-band.
US816026A (en) * 1905-03-09 1906-03-27 Albert J Meier Surgical clip.
US1142510A (en) 1914-11-04 1915-06-08 Lillian K Engle Fastening device.
US1248825A (en) 1915-04-08 1917-12-04 Carleton Dederer Surgical needle.
US1558037A (en) 1925-06-17 1925-10-20 Harry D Morton Surgical needle and suture assembly and method of making the same
GB267007A (en) 1926-09-04 1927-03-10 Mayr Alfred Improvements in containers for surgical suture material
US1728316A (en) 1927-07-02 1929-09-17 Kirurgiska Instr Fabriks Aktie Wound clasp
US1886721A (en) 1928-08-10 1932-11-08 Rubber Products Corp Road marker
US2094578A (en) 1932-09-13 1937-10-05 Blumenthal Bernhard Material for surgical ligatures and sutures
US2201610A (en) * 1938-05-20 1940-05-21 Jr James C Dawson Wound clip
US2254620A (en) 1939-11-14 1941-09-02 George I Miller Clip
US2347956A (en) 1943-02-06 1944-05-02 Earl P Lansing Cable sheath cutting and stripping tool
US2421193A (en) * 1943-08-02 1947-05-27 Cleveland Clinic Foundation Surgical dressing
US2355907A (en) 1943-11-12 1944-08-15 Johnson & Johnson Method and apparatus for grinding and polishing ligatures
US2480271A (en) 1945-02-27 1949-08-30 Sumner Thomas Soap dispenser with reciprocating cutter blade
US2472009A (en) * 1945-08-01 1949-05-31 Cleveland Clinic Foundation Surgical dressing
US2452734A (en) 1945-10-26 1948-11-02 John F Costelow Insulation cutter
US2572936A (en) 1947-02-27 1951-10-30 American Viscose Corp Process for making crimped artificial filaments
US2591063A (en) * 1949-05-14 1952-04-01 Goldberg Harry Surgical suture
US2910067A (en) 1952-10-13 1959-10-27 Technical Oil Tool Corp Wound clip and extractor therefor
US2684070A (en) 1953-03-23 1954-07-20 Walter L Kelsey Surgical clip
US2817339A (en) 1953-08-10 1957-12-24 Norman M Sullivan Rigid fascial suture
US2814296A (en) 1954-04-15 1957-11-26 S & R J Everett & Co Ltd Surgical needles
US2736964A (en) * 1954-05-18 1956-03-06 Lieberman Frank Chiropodist's knife
US2830366A (en) * 1955-08-11 1958-04-15 Ernest F Chisena Cutting implements for electric cables
US2866256A (en) 1956-04-05 1958-12-30 Rohm & Haas Wool-like artificial fibers
US3003155A (en) 1956-07-06 1961-10-10 Felix C Mielzynski Hair darts for implanting in live or artificial media
US2988028A (en) 1956-08-13 1961-06-13 John H Alcamo Surgeon's suturing device
US2928395A (en) 1957-06-20 1960-03-15 Ethicon Inc Sutures
US3066673A (en) * 1959-04-23 1962-12-04 American Cyanamid Co Surgical sutures
US3066452A (en) 1959-04-23 1962-12-04 American Cyanamid Co Precision grinding of surgical sutures
US3068869A (en) 1959-10-01 1962-12-18 Sheiden Charles Hunter Tissue suture clamp
US3273562A (en) 1960-02-24 1966-09-20 Rene G Le Vaux Skin and surgical clips
US3068870A (en) 1960-03-18 1962-12-18 Levin Abraham Wound clip
US3209652A (en) 1961-03-30 1965-10-05 Burgsmueller Karl Thread whirling method
US3209754A (en) 1961-08-10 1965-10-05 Ernest C Wood Surgical clip
US3082523A (en) * 1961-09-26 1963-03-26 Imp Eastman Corp Stripping tool
US3187752A (en) 1962-04-27 1965-06-08 American Cyanamid Co Non-absorbable silicone coated sutures and method of making
US3221746A (en) 1963-01-25 1965-12-07 Noble John William Surgical connecting device
US3212187A (en) 1963-03-27 1965-10-19 Bard Parker Company Inc Suture cutting and removing instrument
US3214810A (en) 1963-05-23 1965-11-02 Robert V Mathison Fastener devices
GB1091282A (en) 1963-07-09 1967-11-15 Nat Res Dev Sutures
US3206018A (en) 1963-07-10 1965-09-14 Ethicon Inc Wire suturing device
US3352191A (en) 1965-04-23 1967-11-14 Allan H Crawford Dowel
US3378010A (en) * 1965-07-28 1968-04-16 Coldling Surgical clip with means for releasing the clamping pressure
US3394704A (en) 1965-10-20 1968-07-30 Torrington Co Surgical needle with bonded suture
US3385299A (en) * 1965-10-23 1968-05-28 New Res And Dev Lab Inc Wound clip
US3527223A (en) 1967-09-01 1970-09-08 Melvin Shein Ear stud and hollow piercer for insertion thereof
US3525340A (en) 1967-10-31 1970-08-25 Joseph G Gilbert Surgical dressing with skin clips thereon
US3586002A (en) 1968-01-08 1971-06-22 Ernest C Wood Surgical skin clip
US3522637A (en) * 1968-03-06 1970-08-04 George C Brumlik Self-gripping fastening filament
US3545608A (en) 1968-06-28 1970-12-08 Ethicon Inc Suture package
AT326803B (de) 1968-08-26 1975-12-29 Binder Fa G Maschenware sowie verfahren zur herstellung derselben
US3608539A (en) 1968-11-06 1971-09-28 Daniel G Miller Method for the biopsy of subcutaneous masses
US3570497A (en) * 1969-01-16 1971-03-16 Gerald M Lemole Suture apparatus and methods
US3833972A (en) 1969-09-11 1974-09-10 G Brumlik Self-adhering fastening filament
US3618447A (en) 1969-09-15 1971-11-09 Phillips Petroleum Co Deterioration fasteners
US3646615A (en) * 1970-01-26 1972-03-07 Richard A Ness Reinforcing element for muscles
US3608095A (en) 1970-03-05 1971-09-28 Federal Tool Eng Co Method of fixing hair pieces to scalps
FR2084475A5 (de) 1970-03-16 1971-12-17 Brumlik George
CH521459A (fr) 1970-03-20 1972-04-15 Sobico Inc Fil textile et procédé pour sa fabrication
CH515699A (fr) 1970-04-29 1971-11-30 Velcro Sa Soulie Article en forme de nappe à éléments d'accrochage multiples
US3683926A (en) 1970-07-09 1972-08-15 Dainippon Pharmaceutical Co Tube for connecting blood vessels
US3700433A (en) 1971-07-12 1972-10-24 United Aircraft Corp Enhancement of transverse properties of directionally solidified superalloys
US3889322A (en) 1971-10-22 1975-06-17 Ingrip Fasteners Multi-element self-gripping device
US4198734A (en) * 1972-04-04 1980-04-22 Brumlik George C Self-gripping devices with flexible self-gripping means and method
US3762418A (en) 1972-05-17 1973-10-02 W Wasson Surgical suture
US3922455A (en) 1972-05-23 1975-11-25 Ingrip Fasteners Linear element with grafted nibs and method therefor
US3847156A (en) 1972-07-17 1974-11-12 Sherwood Medical Ind Inc Suture
AU476672B2 (en) 1972-07-24 1976-09-30 Ethicon Inc. Braided suture dimension control
US3985138A (en) 1972-08-25 1976-10-12 Jarvik Robert K Preformed ligatures for bleeders and methods of applying such ligatures
US3825010A (en) 1973-04-23 1974-07-23 Donald B Mc Surgical apparatus for closing wounds
US3977937A (en) 1973-10-10 1976-08-31 Candor James T System for making a non-woven sheet by creating an electrostatic field action
US3980177A (en) 1973-10-26 1976-09-14 Johnson & Johnson Controlled release suture
US3987797A (en) 1974-02-25 1976-10-26 Ethicon, Inc. Antimicrobial sutures
US3918455A (en) 1974-04-29 1975-11-11 Albany Int Corp Combined surgical suture and needle
US3981307A (en) 1974-07-01 1976-09-21 Ethicon, Inc. Thermal attachment of surgical sutures to needles
US3951261A (en) * 1974-08-28 1976-04-20 Ethicon, Inc. Needled suture mounting and dispensing device and package
US3963031A (en) 1974-12-11 1976-06-15 Ethicon, Inc. Juncture-lubricated needle-suture combination
US3941164A (en) * 1975-02-13 1976-03-02 Musgrave Daniel D Process for making barbed material
US3990144A (en) 1975-06-30 1976-11-09 Boris Schwartz Suture cutter and removal means
US3985227A (en) 1975-11-05 1976-10-12 Ethicon, Inc. Package for armed sutures
JPS5315191Y2 (de) 1975-11-17 1978-04-21
GB1508627A (en) 1975-11-26 1978-04-26 Ethicon Inc Rapid closure suture
US4052988A (en) 1976-01-12 1977-10-11 Ethicon, Inc. Synthetic absorbable surgical devices of poly-dioxanone
US4027608A (en) 1976-02-20 1977-06-07 Raymond Kelder Suturing device
US4043344A (en) 1976-09-20 1977-08-23 American Cyanamid Company Non-absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4186239A (en) * 1976-12-06 1980-01-29 Berkley & Company, Inc. Monofilament weed cutters
SU715082A1 (ru) * 1977-01-24 1980-02-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Хирургический сшивающий аппарат
US4098210A (en) 1977-02-18 1978-07-04 Wright V Gene Canvasworking method and article
US4075962A (en) * 1977-03-02 1978-02-28 Mabry Patricia D Needlework technique using ribbon
US4300424A (en) 1977-03-14 1981-11-17 American Greetings Corporation Candle manufacturing system including wick cutting means
US4204542A (en) 1977-08-03 1980-05-27 Carbomedics, Inc. Multistrand carbon coated sutures
CA1107989A (en) 1978-05-16 1981-09-01 Alexandre Wolosianski Apparatus for screw-threading
US5147382A (en) 1978-12-08 1992-09-15 Ethicon, Inc. Elastomeric surgical sutures comprising segmented copolyether/esters
US4259959A (en) * 1978-12-20 1981-04-07 Walker Wesley W Suturing element
FR2457583A1 (fr) 1979-05-21 1980-12-19 Matra Perfectionnements aux procedes et appareils de denudage de fils electriques
US4317451A (en) * 1980-02-19 1982-03-02 Ethicon, Inc. Plastic surgical staple
US4505274A (en) * 1980-10-17 1985-03-19 Propper Manufacturing Co., Inc. Suture clip
SU982676A1 (ru) * 1981-04-07 1982-12-23 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Хирургическа скобка
DE3214479C2 (de) * 1981-07-22 1986-05-15 Siemens AG, 1000 Berlin und 8000 München Handgerät zum Abschälen der äußeren Mantelschicht elektrischer Leitungen und elektrischer Kabel
US4490326A (en) 1981-07-30 1984-12-25 Ethicon, Inc. Molding process for polydioxanone polymers
US4454875A (en) 1982-04-15 1984-06-19 Techmedica, Inc. Osteal medical staple
US6656182B1 (en) 1982-05-20 2003-12-02 John O. Hayhurst Tissue manipulation
US4741330A (en) 1983-05-19 1988-05-03 Hayhurst John O Method and apparatus for anchoring and manipulating cartilage
US5417691A (en) 1982-05-20 1995-05-23 Hayhurst; John O. Apparatus and method for manipulating and anchoring tissue
US4467805A (en) 1982-08-25 1984-08-28 Mamoru Fukuda Skin closure stapling device for surgical procedures
US4553544A (en) 1982-09-20 1985-11-19 Janome Sewing Machine Co. Ltd. Suturing instrument for surgical operation
US4676245A (en) 1983-02-09 1987-06-30 Mamoru Fukuda Interlocking surgical staple assembly
US4535772A (en) 1983-03-10 1985-08-20 Kells Medical, Incorporated Skin closure device
US4595007A (en) 1983-03-14 1986-06-17 Ethicon, Inc. Split ring type tissue fastener
US4510934A (en) 1983-05-13 1985-04-16 Batra Subhash K Suture
US4548202A (en) 1983-06-20 1985-10-22 Ethicon, Inc. Mesh tissue fasteners
US4531522A (en) 1983-06-20 1985-07-30 Ethicon, Inc. Two-piece tissue fastener with locking top and method for applying same
US4532926A (en) 1983-06-20 1985-08-06 Ethicon, Inc. Two-piece tissue fastener with ratchet leg staple and sealable latching receiver
IL74460A (en) 1983-09-02 1990-01-18 Istec Ind & Technologies Ltd Surgical implement particularly useful for suturing prosthetic valves
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US7166125B1 (en) 1988-03-09 2007-01-23 Endovascular Technologies, Inc. Intraluminal grafting system
US4873976A (en) 1984-02-28 1989-10-17 Schreiber Saul N Surgical fasteners and method
US4653486A (en) 1984-04-12 1987-03-31 Coker Tom P Fastener, particularly suited for orthopedic use
WO1986000020A1 (en) 1984-06-14 1986-01-03 Bioresearch Inc. Composite surgical sutures
US4689882A (en) 1984-10-22 1987-09-01 United Technologies Automotive, Inc. Hand tool and method for removing insulation from wire-wound ignition cable
US4610251A (en) 1985-04-19 1986-09-09 Kumar Sarbjeet S Surgical staple
US4712553A (en) 1985-05-30 1987-12-15 Cordis Corporation Sutures having a porous surface
US4669473A (en) 1985-09-06 1987-06-02 Acufex Microsurgical, Inc. Surgical fastener
US4610250A (en) 1985-10-08 1986-09-09 United States Surgical Corporation Two-part surgical fastener for fascia wound approximation
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4750910A (en) 1986-01-22 1988-06-14 Mitsui Toatsu Chemicals, Incorporated Indigo blue-colored bioabsorbable surgical fibers and production process thereof
US4924865A (en) 1986-05-20 1990-05-15 Concept, Inc. Repair tack for bodily tissue
US4751621A (en) 1986-08-28 1988-06-14 Jenkins Edward L Light knife
US4841960A (en) 1987-02-10 1989-06-27 Garner Eric T Method and apparatus for interosseous bone fixation
US4865026A (en) 1987-04-23 1989-09-12 Barrett David M Sealing wound closure device
US5437680A (en) 1987-05-14 1995-08-01 Yoon; Inbae Suturing method, apparatus and system for use in endoscopic procedures
US5478353A (en) 1987-05-14 1995-12-26 Yoon; Inbae Suture tie device system and method for suturing anatomical tissue proximate an opening
JPS63288146A (ja) 1987-05-20 1988-11-25 Nippon Medical Supply Corp 縫合糸包装用台紙
US4832025A (en) 1987-07-30 1989-05-23 American Cyanamid Company Thermoplastic surgical suture with a melt fused length
FR2619129B1 (fr) 1987-08-07 1990-02-09 Mas Richard Aiguillee de fil a coudre
US5103073A (en) 1987-08-28 1992-04-07 Danilov Viktor A Device for laser treatment of an object
FR2620633B1 (fr) 1987-09-23 1991-09-20 Lyonnaise Eaux Procede et dispositif pour la realisation d'un faisceau de filaments, notamment de fibres creuses semi-permeables
EP0314412B1 (de) 1987-10-30 1993-10-06 Howmedica Inc. Vorrichtung zum Wiederherstellen einer Sehne oder eines Bandes
US4887601A (en) 1987-11-06 1989-12-19 Ophthalmic Ventures Limited Partnership Adjustable surgical staple and method of using the same
US4968315A (en) 1987-12-15 1990-11-06 Mitek Surgical Products, Inc. Suture anchor and suture anchor installation tool
JP2561853B2 (ja) 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス 形状記憶性を有する成形体及びその使用方法
US4930945A (en) 1988-05-20 1990-06-05 Mitsubishi Metal Corporation Insert rotary cutter
US5002562A (en) 1988-06-03 1991-03-26 Oberlander Michael A Surgical clip
DE68921762T2 (de) 1988-10-04 1995-08-03 Peter Emmanuel Petros Chirurgisches instrument, prothese.
US5047047A (en) 1988-10-26 1991-09-10 Inbae Yoon Wound closing device
US4905367A (en) 1988-11-08 1990-03-06 Corvita Corporation Manufacture of stretchable porous sutures
US5217494A (en) 1989-01-12 1993-06-08 Coggins Peter R Tissue supporting prosthesis
US4997439A (en) 1989-01-26 1991-03-05 Chen Fusen H Surgical closure or anastomotic device
US4932962A (en) 1989-05-16 1990-06-12 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US5053047A (en) 1989-05-16 1991-10-01 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US5222976A (en) 1989-05-16 1993-06-29 Inbae Yoon Suture devices particularly useful in endoscopic surgery
US5002550A (en) 1989-06-06 1991-03-26 Mitek Surgical Products, Inc. Suture anchor installation tool
US4946468A (en) 1989-06-06 1990-08-07 Mitek Surgical Products, Inc. Suture anchor and suture anchor installation tool
DE3928677C2 (de) * 1989-08-30 1998-05-14 Kimberly Clark Gmbh Tampon für medizinische oder hygienische Zwecke sowie Verfahren zu seiner Herstellung
US5451461A (en) 1989-09-01 1995-09-19 Ethicon, Inc. Thermal treatment of thermoplastic filaments for the preparation of surgical sutures
US5129906A (en) 1989-09-08 1992-07-14 Linvatec Corporation Bioabsorbable tack for joining bodily tissue and in vivo method and apparatus for deploying same
US5102418A (en) 1989-09-27 1992-04-07 United States Surgical Corporation Method for attaching a surgical needle to a suture
US5123911A (en) 1989-09-27 1992-06-23 United States Surgical Corporation Method for attaching a surgical needle to a suture
US5156615A (en) 1989-09-27 1992-10-20 United States Surgical Corporation Surgical needle-suture attachment for controlled suture release
CA2026200A1 (en) 1989-09-27 1991-03-28 Herbert W. Korthoff Combined surgical needle-suture device and method for its manufacture
US5133738A (en) 1989-09-27 1992-07-28 United States Surgical Corporation Combined surgical needle-spiroid braided suture device
US5026390A (en) 1989-10-26 1991-06-25 Brown Alan W Surgical staple
US5007921A (en) 1989-10-26 1991-04-16 Brown Alan W Surgical staple
US5007922A (en) 1989-11-13 1991-04-16 Ethicon, Inc. Method of making a surgical suture
US5156788A (en) 1989-11-14 1992-10-20 United States Surgical Corporation Method and apparatus for heat tipping sutures
US4950285A (en) 1989-11-27 1990-08-21 Wilk Peter J Suture device
US5123913A (en) 1989-11-27 1992-06-23 Wilk Peter J Suture device
EP0609212A4 (de) 1989-12-04 1995-04-19 Kensey Nash Corp Stöpselvorrichtung zum abdichten von öffnungen sowie verfahren zur anwendung.
US5037433A (en) 1990-05-17 1991-08-06 Wilk Peter J Endoscopic suturing device and related method and suture
US5197597A (en) 1990-06-05 1993-03-30 United States Surgical Corporation Suture retainer
US5102421A (en) 1990-06-14 1992-04-07 Wm. E. Anpach, III Suture anchor and method of forming
US6203565B1 (en) * 1990-06-28 2001-03-20 Peter M. Bonutti Surgical devices assembled using heat bondable materials
SU1752358A1 (ru) 1990-06-29 1992-08-07 Крымский Медицинский Институт Хирургический шовный материал
US5224946A (en) 1990-07-02 1993-07-06 American Cyanamid Company Bone anchor and method of anchoring a suture to a bone
US5269809A (en) 1990-07-02 1993-12-14 American Cyanamid Company Locking mechanism for use with a slotted suture anchor
US5037422A (en) 1990-07-02 1991-08-06 Acufex Microsurgical, Inc. Bone anchor and method of anchoring a suture to a bone
US5041129A (en) 1990-07-02 1991-08-20 Acufex Microsurgical, Inc. Slotted suture anchor and method of anchoring a suture
SU1745214A1 (ru) 1990-07-04 1992-07-07 Межотраслевой научно-технический комплекс "Микрохирургия глаза" Головка автомата дл наложени хирургического ниточного шва
US5342395A (en) 1990-07-06 1994-08-30 American Cyanamid Co. Absorbable surgical repair devices
US5127413A (en) 1990-08-09 1992-07-07 Ebert Edward A Sinous suture
JP2890063B2 (ja) 1990-08-09 1999-05-10 グンゼ株式会社 手術用縫合糸の製造法
CA2048464A1 (en) 1990-08-17 1992-02-18 Michael P. Chesterfield Apparatus and method for producing braided suture products
US5306288A (en) 1990-09-05 1994-04-26 United States Surgical Corporation Combined surgical needle-suture device
CA2049123C (en) 1990-09-13 2002-01-15 David T. Green Apparatus and method for subcuticular stapling of body tissue
US5372146A (en) 1990-11-06 1994-12-13 Branch; Thomas P. Method and apparatus for re-approximating tissue
US5123910A (en) 1990-11-07 1992-06-23 Mcintosh Charles L Blunt tip surgical needle
CA2704197C (en) 1990-12-13 2011-01-04 United States Surgical Corporation Method and apparatus for tipping sutures
US5258013A (en) 1991-01-07 1993-11-02 United States Surgical Corporation Siliconized surgical needle and method for its manufacture
US5259846A (en) 1991-01-07 1993-11-09 United States Surgical Corporation Loop threaded combined surgical needle-suture device
US5320629B1 (en) 1991-01-07 2000-05-02 Advanced Surgical Inc Device and method for applying suture
US5234006A (en) 1991-01-18 1993-08-10 Eaton Alexander M Adjustable sutures and method of using the same
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
JP3124564B2 (ja) 1991-02-21 2001-01-15 マニー株式会社 医療用縫合針及びその製造方法
US5354298A (en) 1991-03-22 1994-10-11 United States Surgical Corporation Suture anchor installation system
US5101968A (en) 1991-05-07 1992-04-07 Lukens Medical Corporation Retainers for needled surgical sutures
US5192274A (en) 1991-05-08 1993-03-09 Bierman Steven F Anchor pad for catheterization system
US5269783A (en) 1991-05-13 1993-12-14 United States Surgical Corporation Device and method for repairing torn tissue
DE4115836C2 (de) 1991-05-15 1999-11-25 Jordan Reflektoren Gmbh & Co Leuchte mit einer Reflektoranordnung und einem Abblendkörper
SE9101752D0 (sv) 1991-06-10 1991-06-10 Procordia Ortech Ab Method of producing a microstructure in a bioresorbable element
US5263973A (en) 1991-08-30 1993-11-23 Cook Melvin S Surgical stapling method
US5207679A (en) 1991-09-26 1993-05-04 Mitek Surgical Products, Inc. Suture anchor and installation tool
US5141520A (en) 1991-10-29 1992-08-25 Marlowe Goble E Harpoon suture anchor
DE4136266A1 (de) 1991-11-04 1993-05-06 Kabelmetal Electro Gmbh Vorrichtung zum verseilen von strangfoermigem gut insbesondere groesseren querschnittes mit wechselnder schlagrichtung
US5123919A (en) 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5765560A (en) 1991-12-16 1998-06-16 Adeva Medical, Gesellschaft Fur Entwicklung Und Vertrieb Von Medizinischen, Implantat-Artikeln Mbh Trachostoma valve and tissue connector and housing for use as a part thereof
US5249673A (en) 1992-02-07 1993-10-05 United States Surgical Corporation Package and method of loading for resilient surgical sutures
US5217486A (en) 1992-02-18 1993-06-08 Mitek Surgical Products, Inc. Suture anchor and installation tool
US5352515A (en) 1992-03-02 1994-10-04 American Cyanamid Company Coating for tissue drag reduction
CA2090371A1 (en) 1992-03-27 1993-09-28 William Frank Banholzer Water jet mixing tubes used in water jet cutting devices and method of preparation thereof
FR2690840B1 (fr) 1992-05-07 1994-08-19 Patrick Frechet Dispositif d'extension de tissu vivant.
US5242457A (en) 1992-05-08 1993-09-07 Ethicon, Inc. Surgical instrument and staples for applying purse string sutures
US5766246A (en) 1992-05-20 1998-06-16 C. R. Bard, Inc. Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis
FR2693108B3 (fr) 1992-06-10 1994-08-12 Hexabio Matériau chirurgical résorbable en particulier fil de suture résorbable.
US5366756A (en) 1992-06-15 1994-11-22 United States Surgical Corporation Method for treating bioabsorbable implant material
CA2094111C (en) 1992-06-15 1999-02-16 Daniel R. Lee Suture anchoring device and method
US5207694A (en) 1992-06-18 1993-05-04 Surgical Invent Ab Method for performing a surgical occlusion, and kit and applicator for carrying out the method
FR2692774B1 (fr) 1992-06-25 1999-05-21 Bfl Medical Sarl Materiel utilisable pour la reparation du tendon d'achille rompu.
US5312422A (en) 1992-07-16 1994-05-17 Linvatec Corporation Endoscopic suturing needle
US5540704A (en) 1992-09-04 1996-07-30 Laurus Medical Corporation Endoscopic suture system
US5387227A (en) 1992-09-10 1995-02-07 Grice; O. Drew Method for use of a laparo-suture needle
CA2100532C (en) 1992-09-21 2004-04-20 David T. Green Device for applying a meniscal staple
CN1091315A (zh) 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US5222508A (en) 1992-10-09 1993-06-29 Osvaldo Contarini Method for suturing punctures of the human body
DE4304353A1 (de) 1992-10-24 1994-04-28 Helmut Dipl Ing Wurster Endoskopisches Nähgerät
IL103737A (en) 1992-11-13 1997-02-18 Technion Res & Dev Foundation Stapler device particularly useful in medical suturing
US5649939A (en) 1992-12-08 1997-07-22 Reddick; Eddie J. Laparoscopic suture introducer
US20020095164A1 (en) 1997-06-26 2002-07-18 Andreas Bernard H. Device and method for suturing tissue
US5417699A (en) 1992-12-10 1995-05-23 Perclose Incorporated Device and method for the percutaneous suturing of a vascular puncture site
US6387363B1 (en) 1992-12-31 2002-05-14 United States Surgical Corporation Biocompatible medical devices
US5403346A (en) 1992-12-31 1995-04-04 Loeser; Edward A. Self-affixing suture assembly
US5632753A (en) 1992-12-31 1997-05-27 Loeser; Edward A. Surgical procedures
US5336239A (en) 1993-01-15 1994-08-09 Gimpelson Richard J Surgical needle
DE4302895C2 (de) 1993-02-02 1996-03-28 Wiessner Serag Gmbh & Co Kg Chirurgischer Faden
US5306290A (en) 1993-02-12 1994-04-26 Mitek Surgical Products, Inc. Suture button
US5341922A (en) 1993-02-24 1994-08-30 Ethicon, Inc. Peelable foil suture packaging
US5330488A (en) 1993-03-23 1994-07-19 Goldrath Milton H Verres needle suturing kit
US5395126A (en) 1993-04-05 1995-03-07 The Bentley-Harris Manufacturing Company Braided tubular gasket with integral attachment means
US5350385A (en) 1993-04-28 1994-09-27 Christy William J Surgical stab wound closure device and method
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US5342376A (en) 1993-05-03 1994-08-30 Dermagraphics, Inc. Inserting device for a barbed tissue connector
DE69426168T2 (de) 1993-05-13 2001-05-17 American Cyanamid Co Wässrige Siloxan-Beschichtungs-Zusammensetzung
US5464426A (en) 1993-05-14 1995-11-07 Bonutti; Peter M. Method of closing discontinuity in tissue
US5500000A (en) 1993-07-01 1996-03-19 United States Surgical Corporation Soft tissue repair system and method
WO1995001129A1 (en) 1993-07-01 1995-01-12 W.L. Gore & Associates, Inc. A suture needle
US5921982A (en) 1993-07-30 1999-07-13 Lesh; Michael D. Systems and methods for ablating body tissue
US5354271A (en) 1993-08-05 1994-10-11 Voda Jan K Vascular sheath
US5462561A (en) 1993-08-05 1995-10-31 Voda; Jan K. Suture device
US5899911A (en) 1993-08-25 1999-05-04 Inlet Medical, Inc. Method of using needle-point suture passer to retract and reinforce ligaments
US5450860A (en) 1993-08-31 1995-09-19 W. L. Gore & Associates, Inc. Device for tissue repair and method for employing same
US5546957A (en) 1993-09-09 1996-08-20 Norbert Heske Biopsy needle
US5540718A (en) 1993-09-20 1996-07-30 Bartlett; Edwin C. Apparatus and method for anchoring sutures
US5411613A (en) 1993-10-05 1995-05-02 United States Surgical Corporation Method of making heat treated stainless steel needles
US5425747A (en) 1993-10-12 1995-06-20 Brotz; Gregory R. Suture
US5584859A (en) 1993-10-12 1996-12-17 Brotz; Gregory R. Suture assembly
CA2117967A1 (en) 1993-10-27 1995-04-28 Thomas W. Sander Tissue repair device and apparatus and method for fabricating same
US5566822A (en) 1993-12-09 1996-10-22 United States Surgical Corporation Suture retainer
US5545180A (en) 1993-12-13 1996-08-13 Ethicon, Inc. Umbrella-shaped suture anchor device with actuating ring member
US5527342A (en) 1993-12-14 1996-06-18 Pietrzak; William S. Method and apparatus for securing soft tissues, tendons and ligaments to bone
US5487216A (en) 1994-01-13 1996-01-30 Ethicon, Inc. Control system for an automatic needle-suture assembly and packaging machine
US5728122A (en) 1994-01-18 1998-03-17 Datascope Investment Corp. Guide wire with releaseable barb anchor
US5571216A (en) 1994-01-19 1996-11-05 The General Hospital Corporation Methods and apparatus for joining collagen-containing materials
US5662714A (en) 1994-01-21 1997-09-02 M.X.M. Device for extending living tissues
US5626611A (en) * 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
US6315788B1 (en) 1994-02-10 2001-11-13 United States Surgical Corporation Composite materials and surgical articles made therefrom
US5411523A (en) 1994-04-11 1995-05-02 Mitek Surgical Products, Inc. Suture anchor and driver combination
US5950505A (en) 1994-05-24 1999-09-14 Locher; Beat Process for stripping an insulated wire or cable having a cross-section which may be non-circular and stripping device for carrying out the process
CA2192103C (en) * 1994-06-06 2002-02-05 Arnold I. Caplan Biomatrix for tissue regeneration
US5593424A (en) * 1994-08-10 1997-01-14 Segmed, Inc. Apparatus and method for reducing and stabilizing the circumference of a vascular structure
US5549633A (en) 1994-08-24 1996-08-27 Kensey Nash Corporation Apparatus and methods of use for preventing blood seepage at a percutaneous puncture site
US5472452A (en) 1994-08-30 1995-12-05 Linvatec Corporation Rectilinear anchor for soft tissue fixation
US6206908B1 (en) 1994-09-16 2001-03-27 United States Surgical Corporation Absorbable polymer and surgical articles fabricated therefrom
US5522845A (en) 1994-09-27 1996-06-04 Mitek Surgical Products, Inc. Bone anchor and bone anchor installation
US5464427A (en) 1994-10-04 1995-11-07 Synthes (U.S.A.) Expanding suture anchor
ATE175560T1 (de) 1994-10-06 1999-01-15 Theratechnologies Inc Nahtloser wundverschluss mit hilfe einer verschnürung von auf der haut befestigten pflasterelementen
US5938668A (en) 1994-10-07 1999-08-17 United States Surgical Surgical suturing apparatus
US5807406A (en) 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
DE4440095A1 (de) 1994-11-10 1996-05-15 Braun B Surgical Gmbh Chirurgisches Nahtmaterial, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
US5653716A (en) 1994-12-29 1997-08-05 Acufex Microsurgical, Inc. Suture manipulating instrument with grasping members
US5643295A (en) 1994-12-29 1997-07-01 Yoon; Inbae Methods and apparatus for suturing tissue
US5665109A (en) 1994-12-29 1997-09-09 Yoon; Inbae Methods and apparatus for suturing tissue
US5968076A (en) 1995-03-03 1999-10-19 United States Surgical Corporation Channel-bodied surgical needle and method of manufacture
US5531760A (en) 1995-04-14 1996-07-02 Alwafaie; Mohammed G. Skin closure clip
US5571139A (en) 1995-05-19 1996-11-05 Jenkins, Jr.; Joseph R. Bidirectional suture anchor
US5540705A (en) 1995-05-19 1996-07-30 Suturtek, Inc. Suturing instrument with thread management
US5722991A (en) 1995-06-07 1998-03-03 United States Surgical Corporation Apparatus and method for attaching surgical needle suture components
US5571175A (en) 1995-06-07 1996-11-05 St. Jude Medical, Inc. Suture guard for prosthetic heart valve
US6814748B1 (en) 1995-06-07 2004-11-09 Endovascular Technologies, Inc. Intraluminal grafting system
US6129741A (en) 1995-06-10 2000-10-10 Forschungszentrum Karlsruhe Gmbh Surgical suturing needle
JP2000500029A (ja) 1995-06-14 2000-01-11 メドワークス・コーポレーション 腹腔鏡による尿道固定術を施すための外科手術用キット及び手術方法並びに尿道固定術において使用される装置
US5997554A (en) 1995-06-14 1999-12-07 Medworks Corporation Surgical template and surgical method employing same
US5662654A (en) 1995-06-14 1997-09-02 Incont, Inc. Bone anchor, insertion tool and surgical kit employing same
US5643288A (en) 1995-06-14 1997-07-01 Incont, Inc. Apparatus and method for laparoscopic urethropexy
US6042583A (en) * 1995-06-14 2000-03-28 Medworks Corporation Bone anchor-insertion tool and surgical method employing same
WO1997002038A1 (en) * 1995-06-30 1997-01-23 Capelli Christopher C Silver-based pharmaceutical compositions
US5723008A (en) 1995-07-20 1998-03-03 Gordon; Leonard Splint for repair of tendons or ligaments and method
US6102947A (en) 1995-07-20 2000-08-15 Gordon; Leonard Splint with flexible body for repair of tendons or ligaments and method
US5669935A (en) 1995-07-28 1997-09-23 Ethicon, Inc. One-way suture retaining device for braided sutures
JPH0990421A (ja) * 1995-09-27 1997-04-04 Sharp Corp 液晶表示装置およびその製造方法
JPH09103477A (ja) 1995-10-12 1997-04-22 Unitika Ltd 縫合糸
US6509098B1 (en) 1995-11-17 2003-01-21 Massachusetts Institute Of Technology Poly(ethylene oxide) coated surfaces
US5645568A (en) * 1995-11-20 1997-07-08 Medicinelodge, Inc. Expandable body suture
USD386583S (en) 1996-01-02 1997-11-18 Acufex Microsurgical, Inc. Proximal end of a surgical suture slotted knot pusher
USD387161S (en) 1996-01-02 1997-12-02 Acufex Microsurgical, Inc. Surgical suture knot pusher with hooks
US5810853A (en) 1996-01-16 1998-09-22 Yoon; Inbae Knotting element for use in suturing anatomical tissue and methods therefor
US5702462A (en) 1996-01-24 1997-12-30 Oberlander; Michael Method of meniscal repair
JP3327765B2 (ja) 1996-02-16 2002-09-24 株式会社アズウェル 針付縫合糸の製造装置
JP3659525B2 (ja) 1996-02-16 2005-06-15 アルフレッサファーマ株式会社 針付縫合糸の製造装置
US5702397A (en) 1996-02-20 1997-12-30 Medicinelodge, Inc. Ligament bone anchor and method for its use
FI107124B (fi) 1996-03-01 2001-06-15 Rolf E A Nordstroem Kirurginen ommellanka
RU2139690C1 (ru) 1996-03-25 1999-10-20 Плетиков Сергей Михайлович Способ наложения сухожильного шва
US6149660A (en) 1996-04-22 2000-11-21 Vnus Medical Technologies, Inc. Method and apparatus for delivery of an appliance in a vessel
US6491714B1 (en) 1996-05-03 2002-12-10 William F. Bennett Surgical tissue repair and attachment apparatus and method
DE19618891C1 (de) 1996-05-10 1997-04-03 Barbara Bloch Verfahren zum Herstellen eines Mähfadens sowie Mähfaden aus einem verstreckten und extrudierten Kunststoff
US5893856A (en) 1996-06-12 1999-04-13 Mitek Surgical Products, Inc. Apparatus and method for binding a first layer of material to a second layer of material
US6063105A (en) 1996-06-18 2000-05-16 United States Surgical Medical devices fabricated from elastomeric alpha-olefins
US5843178A (en) 1996-06-20 1998-12-01 St. Jude Medical, Inc. Suture guard for annuloplasty ring
US6117162A (en) 1996-08-05 2000-09-12 Arthrex, Inc. Corkscrew suture anchor
US5683417A (en) 1996-08-14 1997-11-04 Cooper; William I. Suture and method for endoscopic surgery
US5919234A (en) 1996-08-19 1999-07-06 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US7611521B2 (en) 1996-09-13 2009-11-03 Tendon Technology, Ltd. Apparatus and methods for tendon or ligament repair
US6083244A (en) 1996-09-13 2000-07-04 Tendon Technology, Ltd. Apparatus and method for tendon or ligament repair
CA2217406C (en) 1996-10-04 2006-05-30 United States Surgical Corporation Suture anchor installation system with disposable loading unit
US5897572A (en) 1996-10-11 1999-04-27 Cornell Research Foundation, Inc. Microsurgical suture needle
US5891166A (en) 1996-10-30 1999-04-06 Ethicon, Inc. Surgical suture having an ultrasonically formed tip, and apparatus and method for making same
US6331181B1 (en) 1998-12-08 2001-12-18 Intuitive Surgical, Inc. Surgical robotic tools, data architecture, and use
FR2757371B1 (fr) 1996-12-20 1999-03-26 Mxm Dispositif elastique a grande capacite d'allongement pour l'extension de tissu vivant
US5972024A (en) 1996-12-24 1999-10-26 Metacardia, Inc. Suture-staple apparatus and method
US6074419A (en) 1996-12-31 2000-06-13 St. Jude Medical, Inc. Indicia for prosthetic device
US5843087A (en) 1997-01-30 1998-12-01 Ethicon, Inc. Suture anchor installation tool
US5884859A (en) 1997-02-07 1999-03-23 Ma; Mark Joen-Shen Coil winder for use in large umbrellas
US5782864A (en) 1997-04-03 1998-07-21 Mitek Surgical Products, Inc. Knotless suture system and method
US6867248B1 (en) * 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US5931855A (en) 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
US5814051A (en) 1997-06-06 1998-09-29 Mitex Surgical Products, Inc. Suture anchor insertion system
JPH1113091A (ja) 1997-06-23 1999-01-19 Hitachi Constr Mach Co Ltd 建設機械の油圧駆動装置
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US5916224A (en) 1997-07-09 1999-06-29 The United States Of America As Represented By The Secretary Of The Army Tendon repair clip implant
US5895395A (en) 1997-07-17 1999-04-20 Yeung; Teresa T. Partial to full thickness suture device & method for endoscopic surgeries
US20050216059A1 (en) 2002-09-05 2005-09-29 Bonutti Peter M Method and apparatus for securing a suture
US6159234A (en) 1997-08-01 2000-12-12 Peter M. Bonutti Method and apparatus for securing a suture
US6241771B1 (en) * 1997-08-13 2001-06-05 Cambridge Scientific, Inc. Resorbable interbody spinal fusion devices
US5906617A (en) 1997-08-15 1999-05-25 Meislin; Robert J. Surgical repair with hook-and-loop fastener
IL121752A0 (en) 1997-09-11 1998-02-22 Gaber Benny Stitching tool
US5887594A (en) 1997-09-22 1999-03-30 Beth Israel Deaconess Medical Center Inc. Methods and devices for gastroesophageal reflux reduction
US5935138A (en) 1997-09-24 1999-08-10 Ethicon, Inc. Spiral needle for endoscopic surgery
US5950633A (en) 1997-10-02 1999-09-14 Ethicon, Inc. Microsurgical technique for cosmetic surgery
AU1075699A (en) * 1997-10-10 1999-05-03 Allegheny Health, Education And Research Foundation Hybrid nanofibril matrices for use as tissue engineering devices
DE69834375T2 (de) 1997-10-10 2007-03-15 Ethicon, Inc. Geflochtenes Nahtmaterial mit verbesserter Knotenfestigkeit
US6409674B1 (en) 1998-09-24 2002-06-25 Data Sciences International, Inc. Implantable sensor with wireless communication
AU4794197A (en) 1997-10-29 1999-05-17 Nahm-Gun Oh Suture needle
US6056778A (en) 1997-10-29 2000-05-02 Arthrex, Inc. Meniscal repair device
US5964783A (en) 1997-11-07 1999-10-12 Arthrex, Inc. Suture anchor with insert-molded suture
US5954747A (en) 1997-11-20 1999-09-21 Clark; Ron Meniscus repair anchor system
US6001111A (en) 1998-01-16 1999-12-14 Cardiothoracic Systems, Inc. Low profile vessel occluder with and without detachable applicator
IL122994A (en) 1998-01-19 2001-12-23 Wisebands Ltd Suture tightening device for closing wounds and a method for its use
US6146406A (en) 1998-02-12 2000-11-14 Smith & Nephew, Inc. Bone anchor
KR100415373B1 (ko) 1998-02-23 2004-01-16 엠네모사이언스 게엠베하 형상 기억 중합체
ES2221363T3 (es) 1998-02-23 2004-12-16 Massachusetts Institute Of Technology Polimeros biodegradables con memoria de forma.
US7297142B2 (en) 1998-02-24 2007-11-20 Hansen Medical, Inc. Interchangeable surgical instrument
US20020087148A1 (en) 1998-02-24 2002-07-04 Brock David L. Flexible instrument
US6494898B1 (en) 1998-02-25 2002-12-17 United States Surgical Corporation Absorbable copolymers and surgical articles fabricated therefrom
JP2002509753A (ja) 1998-04-01 2002-04-02 ビオンクス インプランツ オサケユイチア 組織を処置するための生物学的に吸収可能な外科用留め具
US5964765A (en) 1998-04-16 1999-10-12 Axya Medical, Inc. Soft tissue fixation device
US6056751A (en) 1998-04-16 2000-05-02 Axya Medical, Inc. Sutureless soft tissue fixation assembly
US6106545A (en) 1998-04-16 2000-08-22 Axya Medical, Inc. Suture tensioning and fixation device
NL1009028C2 (nl) 1998-04-28 1999-10-29 Adri Marinus Blomme Hechtmiddelen voor het verbinden van een buisvormige vaatprothese met een bloedvat in het lichaam alsmede aftakkingsmiddelen, een vaatprothese, een inrichting voor het in het lichaam inbrengen en aanhechten van een vaatprothese en een vaatprothesesysteem.
JP3983888B2 (ja) 1998-05-07 2007-09-26 オリンパス株式会社 縫合具及び経内視鏡用縫合アッセンブリ
FI981203A (fi) 1998-05-29 1999-11-30 Rolf E A Nordstroem Silikonielastomeeria olevan kirurgisen ommellangan ja neulan välinen liitos
US6165306A (en) 1998-06-01 2000-12-26 Kimberly-Clark Worldwide, Inc. Process and apparatus for cutting of discrete components of a multi-component workpiece and depositing them with registration on a moving web of material
DE69921817T2 (de) 1998-06-02 2005-11-24 Cook Inc., Bloomington Aus mehreren seiten bestehende intrluminale medizinische vorrichtung
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US6641593B1 (en) 1998-06-03 2003-11-04 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US6607541B1 (en) 1998-06-03 2003-08-19 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US6945980B2 (en) 1998-06-03 2005-09-20 Medtronic, Inc. Multiple loop tissue connector apparatus and methods
US6613059B2 (en) 1999-03-01 2003-09-02 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US6361559B1 (en) 1998-06-10 2002-03-26 Converge Medical, Inc. Thermal securing anastomosis systems
DE19833703A1 (de) 1998-07-27 2000-02-03 Cetex Chemnitzer Textilmaschin Verfahren und Vorrichtung zum Aufwickeln von kontinuierlich angeliefertem Spulgut zu einer Präzisionskreuzspule
US6214030B1 (en) 1998-08-10 2001-04-10 Mani, Inc. Suture needle
US6355066B1 (en) 1998-08-19 2002-03-12 Andrew C. Kim Anterior cruciate ligament reconstruction hamstring tendon fixation system
US6146407A (en) 1998-09-11 2000-11-14 Bio Innovation, Ltd. Suture anchor installation devices and methods
US6165203A (en) 1998-09-11 2000-12-26 Bio Innovation, Ltd. Suture anchor installation devices and methods
US6921811B2 (en) 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6235869B1 (en) 1998-10-20 2001-05-22 United States Surgical Corporation Absorbable polymers and surgical articles fabricated therefrom
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US7387634B2 (en) 1998-11-23 2008-06-17 Benderev Theodore V System for securing sutures, grafts and soft tissue to bone and periosteum
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US6522906B1 (en) 1998-12-08 2003-02-18 Intuitive Surgical, Inc. Devices and methods for presenting and regulating auxiliary information on an image display of a telesurgical system to assist an operator in performing a surgical procedure
US7125403B2 (en) 1998-12-08 2006-10-24 Intuitive Surgical In vivo accessories for minimally invasive robotic surgery
US6645228B2 (en) 2001-11-13 2003-11-11 Playtex Products, Inc. Nipple
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US20070225764A1 (en) 1999-02-02 2007-09-27 Benavitz William C Insert molded suture anchor
US7211088B2 (en) 1999-02-02 2007-05-01 Arthrex, Inc. Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using the same
FR2789314B1 (fr) 1999-02-09 2001-04-27 Virsol Materiau de suture de plaies a base de methylidene malonate
US6656489B1 (en) * 1999-02-10 2003-12-02 Isotis N.V. Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
US6319231B1 (en) 1999-02-12 2001-11-20 Abiomed, Inc. Medical connector
US8118822B2 (en) 1999-03-01 2012-02-21 Medtronic, Inc. Bridge clip tissue connector apparatus and methods
MXPA01008903A (es) 1999-03-01 2003-07-21 Johnson & Jonhson Composicion que comprende un material de tramadol y un farmaco inhibidor de cox-2 selectivo.
RU2139734C1 (ru) 1999-03-03 1999-10-20 Суламанидзе Марлен Андреевич Хирургическая нить для косметических операций
US6554802B1 (en) 1999-03-31 2003-04-29 Medtronic, Inc. Medical catheter anchor
US6045571A (en) * 1999-04-14 2000-04-04 Ethicon, Inc. Multifilament surgical cord
US6689153B1 (en) 1999-04-16 2004-02-10 Orthopaedic Biosystems Ltd, Inc. Methods and apparatus for a coated anchoring device and/or suture
GB9909301D0 (en) 1999-04-22 1999-06-16 Kci Medical Ltd Wound treatment apparatus employing reduced pressure
US6383201B1 (en) * 1999-05-14 2002-05-07 Tennison S. Dong Surgical prosthesis for repairing a hernia
CA2337187C (en) 1999-05-29 2011-02-22 Guanghui Zhang Bioabsorbable blends and surgical articles therefrom
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
EP1581162B1 (de) 1999-06-09 2011-04-20 Ethicon, Inc. Vorrichtung zum justieren von polymerimplantaten an weichen oberflächen
US6626899B2 (en) 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
DE60006348T2 (de) 1999-07-16 2004-12-02 Med Institute, Inc., West Lafayette Stent zur verhedderfreien entfaltung
US6776340B2 (en) 1999-07-23 2004-08-17 Tri Star Technologies, A General Partnership Duplicate laser marking discrete consumable articles
US6610071B1 (en) 1999-07-26 2003-08-26 Beth Israel Deaconess Medical Center Suture system
AU6526100A (en) 1999-08-06 2001-03-05 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
US6592609B1 (en) 1999-08-09 2003-07-15 Bonutti 2003 Trust-A Method and apparatus for securing tissue
US6554852B1 (en) 1999-08-25 2003-04-29 Michael A. Oberlander Multi-anchor suture
EP1078602A3 (de) 1999-08-26 2001-04-04 Mani, Inc. Nähnadel zu einem medizinischen Zweck
WO2001016210A1 (en) 1999-08-27 2001-03-08 Cohesion Technologies, Inc. Compositions that form interpenetrating polymer networks for use as high strength medical sealants
AU5812299A (en) 1999-09-07 2001-04-10 Microvena Corporation Retrievable septal defect closure device
USD433753S (en) 1999-09-24 2000-11-14 Wisebands Ltd. Suture band tightening device for closing wounds
US7014645B2 (en) * 1999-10-04 2006-03-21 Microvention Inc. Method of manufacturing expansile filamentous embolization devices
US6613254B1 (en) 1999-10-19 2003-09-02 Ethicon, Inc. Method for making extruded, oriented fiber
US7004970B2 (en) 1999-10-20 2006-02-28 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US7615076B2 (en) 1999-10-20 2009-11-10 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US6231911B1 (en) * 1999-10-29 2001-05-15 Clarence Steinback Ultra high speed hot dog incisor
US6641592B1 (en) 1999-11-19 2003-11-04 Lsi Solutions, Inc. System for wound closure
KR100774534B1 (ko) 1999-12-30 2007-11-08 펄 테크놀러지 홀딩스, 엘엘씨 안면 당김성형 장치
US6623492B1 (en) 2000-01-25 2003-09-23 Smith & Nephew, Inc. Tissue fastener
EP1251888A1 (de) 2000-02-03 2002-10-30 Nexia Biotechnologies, Inc. Chirurgisches nahtmaterial mit spinnenseide
US6478809B1 (en) 2000-02-04 2002-11-12 Gregory R. Brotz Suture and method of use
US6270517B1 (en) 2000-02-04 2001-08-07 Gregory R. Brotz Suture assembly and method
US6264675B1 (en) 2000-02-04 2001-07-24 Gregory R. Brotz Single suture structure
US6296659B1 (en) 2000-02-29 2001-10-02 Opus Medical, Inc. Single-tailed suturing method and apparatus
US9138222B2 (en) 2000-03-13 2015-09-22 P Tech, Llc Method and device for securing body tissue
US6712830B2 (en) 2000-03-15 2004-03-30 Esplin Medical Inventions, L.L.C. Soft tissue anchor
DE10021122C1 (de) 2000-04-29 2001-11-08 Aesculap Ag & Co Kg Faden-Anker-System zum Verbinden von Gewebeteilen und Instrument zum Einsetzen eines Ankerimplantats
US20040260340A1 (en) 2000-05-19 2004-12-23 Jacobs Daniel Irwin Remotely anchored tissue fixation device and method
US6645226B1 (en) 2000-05-19 2003-11-11 Coapt Systems, Inc. Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US7172615B2 (en) 2000-05-19 2007-02-06 Coapt Systems, Inc. Remotely anchored tissue fixation device
US20050119694A1 (en) 2000-05-19 2005-06-02 Jacobs Daniel I. Remotely anchored tissue fixation device and method
US6575976B2 (en) 2000-06-12 2003-06-10 Arthrex, Inc. Expandable tissue anchor
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
US6746443B1 (en) 2000-07-27 2004-06-08 Intuitive Surgical Inc. Roll-pitch-roll surgical tool
JP3471004B2 (ja) 2000-08-09 2003-11-25 株式会社医研工業 糸付縫合針の製造方法
EP1309279A4 (de) 2000-08-17 2008-04-09 Tyco Healthcare Nähte und beschichtungen aus therapeutischen absorbierbarem glas
US20020029011A1 (en) 2000-09-05 2002-03-07 Dyer Wallace K. Methods and devices for surgery
US6746458B1 (en) 2000-09-07 2004-06-08 William G. Cloud Mesh material to repair hernias
US6994725B1 (en) 2000-10-03 2006-02-07 Medicinelodge, Inc. Method and apparatus for reconstructing a ligament
US6756000B2 (en) 2000-10-03 2004-06-29 Ethicon, Inc. Process of making multifilament yarn
US6527795B1 (en) 2000-10-18 2003-03-04 Ethicon, Inc. Knotless suture anchor system and method of use
AU2001218090A1 (en) 2000-10-31 2002-05-21 East Carolina University Tissue lockable connecting structures
WO2002064012A2 (en) * 2000-11-07 2002-08-22 Artemis Medical, Inc. Target tissue localization assembly and method
US6506197B1 (en) * 2000-11-15 2003-01-14 Ethicon, Inc. Surgical method for affixing a valve to a heart using a looped suture combination
US6463719B2 (en) 2000-12-13 2002-10-15 Ethicon Suture winding machine, suture tray package, and method of winding sutures
DE10062881A1 (de) 2000-12-16 2002-07-11 Inst Textil & Faserforschung Nahtmaterial für die Chirurgie, Verfahren zu seiner Herstellung und Verwendung
US20020111641A1 (en) 2001-01-08 2002-08-15 Incisive Surgical, Inc. Bioabsorbable surgical clip with engageable expansion structure
RU2175855C1 (ru) 2001-01-22 2001-11-20 Московская медицинская академия им. И.М. Сеченова Устройство для проведения лигатуры
USD462766S1 (en) 2001-02-16 2002-09-10 Coapt Systems, Inc. Brow lift device
US6783554B2 (en) 2001-02-20 2004-08-31 Atrium Medical Corporation Pile mesh prosthesis
US20040254609A1 (en) 2001-03-14 2004-12-16 Esplin Vermon S. Soft tissue anchor
US7048748B1 (en) 2001-03-21 2006-05-23 Uestuener Emin Tuncay Automatic surgical suturing instrument and method
GB0107175D0 (en) 2001-03-22 2001-05-09 Michel David Chassis for grass treatment machine
CA2380689A1 (en) 2001-04-05 2002-10-05 Mcgill University Shape memory surgical polypectomy tool
US6776789B2 (en) 2001-04-16 2004-08-17 Todd Bryant Cinch suture and method for using
US20020173803A1 (en) 2001-05-01 2002-11-21 Stephen Ainsworth Self-closing surgical clip for tissue
US20020173822A1 (en) 2001-05-17 2002-11-21 Justin Daniel F. Threaded suture anchor
US20050065533A1 (en) 2001-05-31 2005-03-24 Magen Hugh E. Apparatus for assembling anterior cruciate ligament reconstruction system
US20040153153A1 (en) 2001-05-31 2004-08-05 Elson Robert J. Anterior cruciate ligament reconstruction system and method of implementing same
GB0113697D0 (en) 2001-06-06 2001-07-25 Smith & Nephew Fixation devices for tissue repair
US7144401B2 (en) 2001-06-07 2006-12-05 Olympus Optical Co., Ltd. Suturing device for endoscope
US7033379B2 (en) 2001-06-08 2006-04-25 Incisive Surgical, Inc. Suture lock having non-through bore capture zone
EP1406545B1 (de) 2001-06-14 2015-10-28 Endoevolution, Llc Gerät und verfahren zur anbringung chirurgischer nähte mit fadenmanagement
US6712859B2 (en) * 2001-06-28 2004-03-30 Ethicon, Inc. Hernia repair prosthesis and methods for making same
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
GB0116247D0 (en) 2001-07-04 2001-08-29 Univ Loughborough Surgical techniques and devices
WO2003010198A1 (en) 2001-07-26 2003-02-06 Kenton Srl Identification of specific tumour antigens by selection of cdna libraries with sera and use of said antigens in diagnostic techniques
US6848152B2 (en) 2001-08-31 2005-02-01 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
BE1014364A6 (fr) 2001-09-07 2003-09-02 Collette Michel Organe de suture.
US6716234B2 (en) 2001-09-13 2004-04-06 Arthrex, Inc. High strength suture material
US20050055051A1 (en) * 2001-09-13 2005-03-10 Grafton R. Donald High strength suture with silk trace
US7294357B2 (en) 2001-09-28 2007-11-13 Tyco Healthcare Group Lp Plasma coated sutures
US6860891B2 (en) 2001-09-28 2005-03-01 Ethicen, Inc. Arrangement and method for vascular anastomosis
US6648921B2 (en) 2001-10-03 2003-11-18 Ams Research Corporation Implantable article
GB0125746D0 (en) * 2001-10-26 2001-12-19 Cathnet Science Holding Anti-restenosis agent
US6749616B1 (en) 2001-11-21 2004-06-15 Baylor College Of Medicine Surgical system for repairing and grafting severed nerves and methods of repairing and grafting severed nerves
US6645227B2 (en) 2001-11-21 2003-11-11 Stryker Endoscopy Suture anchor
US7182771B1 (en) 2001-12-20 2007-02-27 Russell A. Houser Vascular couplers, techniques, methods, and accessories
US20030149447A1 (en) 2002-02-01 2003-08-07 Morency Steven David Barbed surgical suture
DE10208211A1 (de) 2002-02-26 2003-09-11 Mnemoscience Gmbh Polymere Netzwerke
AU2002367772A1 (en) 2002-03-14 2003-09-29 Jeffrey E. Yeung Suture anchor and approximating device
JP3841710B2 (ja) 2002-03-26 2006-11-01 泉工医科工業株式会社 血管用クリップ
US7070610B2 (en) 2002-03-30 2006-07-04 Samyang Corporation Monofilament suture and manufacturing method thereof
DE10217350C1 (de) 2002-04-18 2003-12-18 Mnemoscience Gmbh Polyesterurethane
DE10217351B3 (de) 2002-04-18 2004-02-12 Mnemoscience Gmbh Interpenetrierende Netzwerke
US6951565B2 (en) 2002-04-24 2005-10-04 Linvatec Biomaterials Ltd. Device for inserting surgical implants
US20030204193A1 (en) 2002-04-25 2003-10-30 Stefan Gabriel Suture anchor insertion tool
US6960233B1 (en) 2002-12-10 2005-11-01 Torax Medical, Inc. Methods and apparatus for improving the function of biological passages
AU2003231229A1 (en) * 2002-04-30 2003-11-17 Cook Biotech Incorporated Sling for supporting tissue
DE10219860A1 (de) 2002-05-03 2003-11-20 Ethicon Gmbh Chirurgischer Faden und chirurgisches Implantat mit einem derartigen Faden
GB0212976D0 (en) 2002-06-06 2002-07-17 Tonejet Corp Pty Ltd Ejection method and apparatus
US7416556B2 (en) 2002-06-06 2008-08-26 Abbott Laboratories Stop-cock suture clamping system
RU2268752C2 (ru) 2002-06-07 2006-01-27 Марлен Андреевич Суламанидзе Хирургическая нить "aptos" для косметических операций
MXPA04012293A (es) 2002-06-07 2005-07-25 Marlen Andreevich Sulamanidze Hilo quirurgico aptos para cirugia cosmetica.
AU2003248671B2 (en) 2002-06-12 2009-03-26 Boston Scientific Limited Suturing instruments
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7125413B2 (en) 2002-06-20 2006-10-24 Scimed Life Systems, Inc. Endoscopic fundoplication devices and methods for treatment of gastroesophageal reflux disease
US6726705B2 (en) 2002-06-25 2004-04-27 Incisive Surgical, Inc. Mechanical method and apparatus for bilateral tissue fastening
US7112214B2 (en) 2002-06-25 2006-09-26 Incisive Surgical, Inc. Dynamic bioabsorbable fastener for use in wound closure
US7950559B2 (en) 2002-06-25 2011-05-31 Incisive Surgical, Inc. Mechanical method and apparatus for bilateral tissue fastening
US8074857B2 (en) 2002-06-25 2011-12-13 Incisive Surgical, Inc. Method and apparatus for tissue fastening with single translating trigger operation
US20060036266A1 (en) 2002-07-10 2006-02-16 Sulamanidze Marlen A Endoprosthesis for reparative anaplastic surgery
EP1545326B1 (de) 2002-07-17 2012-05-30 Tyco Healthcare Group LP Nadel mit gleichförmigem belastungsprofil
US8016881B2 (en) 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US7410495B2 (en) 2002-08-21 2008-08-12 Kci Licensing, Inc. Medical closure clip system and method
US7413571B2 (en) 2002-08-21 2008-08-19 Kci Licensing, Inc. Flexible medical closure screen and method
US7413570B2 (en) 2002-08-21 2008-08-19 Kci Licensing, Inc. Medical closure screen installation systems and methods
US7351250B2 (en) 2002-08-21 2008-04-01 Kci Licensing, Inc. Circumferential medical closure device and method
US7381211B2 (en) 2002-08-21 2008-06-03 Kci Licensing, Inc. Medical closure screen device and method
US8074654B2 (en) 2002-09-06 2011-12-13 Koninklijke Philips Electronics N.V. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080066764A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US7845356B2 (en) 2002-09-06 2010-12-07 Koninklijke Philips Electronics N.V. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US8707959B2 (en) 2002-09-06 2014-04-29 Koninklijke Philips N.V. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
DE10245025A1 (de) 2002-09-25 2004-04-15 Gerdes Kunststoff-Technik Gmbh & Co. Kunststoffstanzverfahren und Vorrichtungen zur Durchführung des Verfahrens
WO2004030600A2 (en) 2002-09-30 2004-04-15 Damage Control Surgical Technologies, Inc. Rapid deployment chest drainage
US20040068294A1 (en) 2002-10-04 2004-04-08 Howard Scalzo Braided antimicrobial suture
US6877934B2 (en) 2002-10-28 2005-04-12 Rem Sales, Inc. Milling head for thread whirling
DE10253391A1 (de) 2002-11-15 2004-06-03 Mnemoscience Gmbh Amorphe polymere Netzwerke
RU2241389C2 (ru) 2002-12-15 2004-12-10 Зотов Вадим Александрович Способ ушивания кожных ран. устройство для ушивания кожных ран
DE10300271A1 (de) 2003-01-08 2004-07-22 Mnemoscience Gmbh Photosensitive polymere Netzwerke
US20040138683A1 (en) 2003-01-09 2004-07-15 Walter Shelton Suture arrow device and method of using
GB0303362D0 (en) 2003-02-13 2003-03-19 Enact Pharma Plc Tissue regeneration
US20040167572A1 (en) 2003-02-20 2004-08-26 Roth Noah M. Coated medical devices
ATE419879T1 (de) 2003-03-31 2009-01-15 Memry Corp Medizinprodukte mit arzneimittel-elutions- eigenschaften und herstellungsverfahren dafür
US6996880B2 (en) 2003-04-01 2006-02-14 Velcro Industries B.V. Fastener elements and methods of manufacture
DE10316573A1 (de) * 2003-04-10 2004-11-04 Mnemoscience Gmbh Blends mit Form-Gedächtnis-Eigenschaften
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
US7081135B2 (en) 2003-06-09 2006-07-25 Lane Fielding Smith Mastopexy stabilization apparatus and method
US7150757B2 (en) 2003-06-11 2006-12-19 Fallin T Wade Adjustable line locks and methods
WO2004112853A1 (es) 2003-06-20 2004-12-29 Trevino Schwarz Jose Hilos quirurgicos con inclusión de dientes para su anclaje
US7144412B2 (en) 2003-06-25 2006-12-05 Wolf Medical Enterprises, Inc. Gold suture and method of use in wound closure
USD532107S1 (en) 2003-06-25 2006-11-14 Incisive Surgical, Inc. Tissue fastening instrument
US20040267309A1 (en) 2003-06-27 2004-12-30 Garvin Dennis D. Device for sutureless wound closure
US20050033324A1 (en) 2003-07-14 2005-02-10 Dexteus Surgical tissue guard
WO2005007209A1 (en) 2003-07-17 2005-01-27 Bioretec Oy Synthetic, bioabsorbable polymer materials and implants
US7021316B2 (en) 2003-08-07 2006-04-04 Tools For Surgery, Llc Device and method for tacking a prosthetic screen
US6915623B2 (en) 2003-08-14 2005-07-12 Ethicon, Inc. Method for assembling a package for sutures
CN2640420Y (zh) 2003-08-19 2004-09-15 邵立 美容整形锯齿线
JP2007504885A (ja) 2003-09-11 2007-03-08 エヌエムティー メディカル， インコーポレイティッド 組織を縫合するためのデバイス、システムおよび方法
US7481826B2 (en) 2003-09-30 2009-01-27 Ethicon, Inc. Fluid emitting suture needle
US7678134B2 (en) 2003-10-10 2010-03-16 Arthrex, Inc. Knotless anchor for tissue repair
US7682374B2 (en) 2003-10-21 2010-03-23 Arthrocare Corporation Knotless suture lock and bone anchor implant method
US20050096698A1 (en) 2003-10-29 2005-05-05 Lederman Andrew B. Suture needles and methods of use
AU2004286305A1 (en) 2003-10-30 2005-05-12 Applied Medical Resources Corporation Surface treatments and modifications using nanostructure materials
US7217279B2 (en) 2003-11-14 2007-05-15 Ethicon, Inc. Suture loop anchor
WO2005049516A1 (ja) * 2003-11-18 2005-06-02 Fujikura Ltd. 光ファイバ裸線の線引方法、光ファイバ素線の製造方法、光ファイバ素線
JP2007514472A (ja) 2003-11-20 2007-06-07 アンジオテック インターナショナル アーゲー 軟組織移植片および瘢痕化抑制剤
US20050154255A1 (en) 2003-11-20 2005-07-14 The Children's Hospital Of Philadelphia Surgical device
US8257393B2 (en) 2003-12-04 2012-09-04 Ethicon, Inc. Active suture for the delivery of therapeutic fluids
JP4512597B2 (ja) 2003-12-09 2010-07-28 ジーアイ・ダイナミックス・インコーポレーテッド 胃腸管内に固定される装置および固定方法
US7357810B2 (en) 2003-12-18 2008-04-15 Ethicon, Inc. High strength suture with absorbable core and suture anchor combination
US7329271B2 (en) * 2003-12-18 2008-02-12 Ethicon, Inc. High strength suture with absorbable core
KR20050072908A (ko) 2004-01-08 2005-07-13 황연희 다방향 다중밀도 주름제거용 봉합사
ES2375930T5 (es) 2004-01-23 2014-10-31 Apollo Endosurgery, Inc. Sistema de fijación de dispositivos implantables
US20050186261A1 (en) 2004-01-30 2005-08-25 Angiotech International Ag Compositions and methods for treating contracture
US20060058799A1 (en) 2004-02-10 2006-03-16 Robert Elson Ligament repair apparatus and method
US20050197699A1 (en) 2004-02-10 2005-09-08 Jacobs Daniel I. Tissue repair apparatus and method
DE102004009218B4 (de) * 2004-02-26 2006-03-09 Olympus Winter & Ibe Gmbh Kupplungsverbindung eines Lichtleiteranschlusskabels mit einer Endoskopoptik
US20050209612A1 (en) 2004-03-02 2005-09-22 Nakao Naomi L Endoscopic suturing assembly and associated methodology using a temperature biased suture needle
US7057135B2 (en) 2004-03-04 2006-06-06 Matsushita Electric Industrial, Co. Ltd. Method of precise laser nanomachining with UV ultrafast laser pulses
US20050199249A1 (en) 2004-03-15 2005-09-15 Karram Mickey M. Apparatus and method for incision-free vaginal prolapse repair
WO2005087283A1 (fr) 2004-03-15 2005-09-22 Marlen Andreevich Sulamanidze Fil chirurgical et procede pour realiser une operation chirurgicale
US20050209542A1 (en) 2004-03-16 2005-09-22 Jacobs Daniel I Tissue approximation sling and method
US8236027B2 (en) 2004-04-07 2012-08-07 Tze Liang Woffles Wu Surgical thread
WO2005096956A1 (en) 2004-04-07 2005-10-20 Tze Liang Woffles Wu Surgical thread
WO2005096955A1 (en) 2004-04-07 2005-10-20 Tze Liang Woffles Wu Surgical thread
US7645293B2 (en) * 2004-04-21 2010-01-12 United States Surgical Corporation Suture anchor installation system and method
ES2638301T3 (es) 2004-05-14 2017-10-19 Ethicon Llc Dispositivos de sutura
US7862583B2 (en) 2004-05-27 2011-01-04 Ethicon Endo-Surgery, Inc. Fusible suture and method for suturing therewith
US8628465B2 (en) 2004-06-14 2014-01-14 Boston Scientific Scimed, Inc. Systems, methods and devices relating to implantable supportive slings
US7468068B2 (en) 2004-06-30 2008-12-23 Alwin Kolster Suture for wound closure, tissue approximation, tissue support, suspension and/or fixation
US7582105B2 (en) 2004-06-30 2009-09-01 Silhouette Lift Societad Limitada Suture for wound closure, tissue approximation, tissue support, suspension and/or fixation
BRPI0402762C1 (pt) 2004-07-13 2006-04-11 Jose Antonio Encinas Beramendi fio flexìvel para cirurgias reparadoras e dispositivo para sua fabricação
EP1778305B1 (de) * 2004-08-03 2010-07-07 Tepha, Inc. Nichtkräuselnde polyhydroxyalkanoatnähte
CA2576424C (en) * 2004-08-19 2013-05-07 Tyco Healthcare Group Lp Water-swellable copolymers and articles and coatings made therefrom
US20090105753A1 (en) * 2004-08-26 2009-04-23 Prodesco, Inc. Sutures and methods of making the same
WO2006026325A2 (en) * 2004-08-26 2006-03-09 Pathak Chandrashekhar P Implantable tissue compositions and method
US20060058844A1 (en) 2004-09-13 2006-03-16 St. Jude Medical Puerto Rico B.V. Vascular sealing device with locking system
US7244270B2 (en) 2004-09-16 2007-07-17 Evera Medical Systems and devices for soft tissue augmentation
GB2418159B (en) 2004-09-17 2008-02-13 Quill Internat Ind Plc A blasting nozzle
DE102004047974A1 (de) 2004-10-01 2006-04-06 Ethicon Gmbh Chirurgischer Haken
US20060085016A1 (en) 2004-10-15 2006-04-20 Sorin Eremia Suture instrument and method of suturing in cosmetic surgery
US20060089672A1 (en) 2004-10-25 2006-04-27 Jonathan Martinek Yarns containing filaments made from shape memory alloys
US7144415B2 (en) 2004-11-16 2006-12-05 The Anspach Effort, Inc. Anchor/suture used for medical procedures
ITRM20040599A1 (it) 2004-12-06 2005-03-06 Promoitalia Internat S R L Filo chirurgico per operazioni di chirurgia plastica, dermatologiche, estetiche, e per suture chirurgiche.
EP1827245A4 (de) 2004-12-06 2010-01-13 Socovar S E C Bindekomponente
US7572275B2 (en) 2004-12-08 2009-08-11 Stryker Endoscopy System and method for anchoring suture to bone
US20060142784A1 (en) 2004-12-28 2006-06-29 Stavros Kontos Device and method for suturing internal structures puncture wounds
DE102005004317B3 (de) 2005-01-31 2006-06-01 Ethicon Gmbh Gewebeverbinder und Verfahren zur Herstellung
DE102005004318A1 (de) 2005-01-31 2006-08-10 Ethicon Gmbh Chirurgisches Nahtsystem
DE102005006718A1 (de) 2005-02-04 2006-08-17 Aesculap Ag & Co. Kg Resorbierbares chirurgisches Nahtmaterial
US20060207607A1 (en) 2005-02-08 2006-09-21 Mark Hirotsuka System and method for percutaneous palate remodeling
EP1855618A2 (de) 2005-03-07 2007-11-21 Georgia Tech Research Corporation Nanofilament-gerüst zur gewebewiederherstellung
WO2006099703A2 (en) 2005-03-21 2006-09-28 Jose Antonio Encinas Beramendi Surgery thread and surgery thread manufacturing device
US7981140B2 (en) 2005-03-30 2011-07-19 Arthrex, Inc. Knotless fixation of tissue to bone with suture chain
US7591850B2 (en) 2005-04-01 2009-09-22 Arthrocare Corporation Surgical methods for anchoring and implanting tissues
US20060229671A1 (en) 2005-04-08 2006-10-12 Musculoskeletal Transplant Foundation Suture anchor and suture anchor installation tool
US7771441B2 (en) 2005-04-20 2010-08-10 Arthroscopic Innovations Llc Method and apparatus for providing suture in a passageway
US7467710B2 (en) 2005-05-04 2008-12-23 Ethicon, Inc. Molded package
US20060253126A1 (en) 2005-05-04 2006-11-09 Bernard Medical, Llc Endoluminal suturing device and method
US10555775B2 (en) 2005-05-16 2020-02-11 Intuitive Surgical Operations, Inc. Methods and system for performing 3-D tool tracking by fusion of sensor and/or camera derived data during minimally invasive robotic surgery
US20060276808A1 (en) 2005-06-06 2006-12-07 Arnal Kevin R Minimally Invasive Methods and Apparatus for Accessing and Ligating Uterine Arteries with Sutures
US20060272979A1 (en) 2005-06-07 2006-12-07 Lubbers Lawrence M Surgical Tray
US9545191B2 (en) 2005-06-13 2017-01-17 Ethicon Endo-Surgery, Inc. Method for suture lacing
US20060287676A1 (en) 2005-06-15 2006-12-21 Rita Prajapati Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use
US20060287675A1 (en) 2005-06-15 2006-12-21 Prajapati Rita T Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use
US20060286289A1 (en) 2005-06-15 2006-12-21 Rita Prajapati Method of intraoperative coating therapeutic agents onto sutures
WO2006138300A2 (en) 2005-06-15 2006-12-28 Poly-Med, Inc. Bioswellable sutures
AU2006202427A1 (en) * 2005-07-13 2007-02-01 Tyco Healthcare Group Lp Monofilament sutures made from a composition containing ultra high molecular weight polyethylene
US20070027475A1 (en) * 2005-08-01 2007-02-01 Ancel Surgical R&D, Inc. Scaled suture thread
EP1921711B1 (de) 2005-09-02 2017-12-27 Fujitsu Limited Hf-etikett und verfahren zum herstellen eines hf-etiketts
DK1931702T3 (da) 2005-10-05 2013-04-15 Commw Scient Ind Res Org Silkeproteiner
WO2007047743A2 (en) 2005-10-18 2007-04-26 Cook Biotech Incorporated Medical device with affixation means
EP1959840B1 (de) 2005-10-31 2012-02-08 Ethicon, Inc. Ausgabesystem für einen verschluss mit widerhaken
US20070135840A1 (en) 2005-12-14 2007-06-14 Arthrex, Inc. High strength suture formed of UHMWPE and PBT
US20070156175A1 (en) 2005-12-29 2007-07-05 Weadock Kevin S Device for attaching, relocating and reinforcing tissue and methods of using same
US20070151961A1 (en) 2006-01-03 2007-07-05 Klaus Kleine Fabrication of an implantable medical device with a modified laser beam
WO2007081876A2 (en) 2006-01-04 2007-07-19 Liquidia Technologies, Inc. Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
US20090226500A1 (en) 2006-01-31 2009-09-10 Angiotech Pharmaceuticals, Inc Sutures and anti-scarring agents
US20070225763A1 (en) 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Marked Suture
US20070224237A1 (en) 2006-03-24 2007-09-27 Julia Hwang Barbed sutures having a therapeutic agent thereon
US20070227914A1 (en) 2006-03-30 2007-10-04 Cerwin Robert J Suture package
US7763036B2 (en) 2006-03-31 2010-07-27 Ethicon Endo-Surgery, Inc. Endoscopic instrument with secondary vacuum source
WO2007131019A2 (en) 2006-05-04 2007-11-15 Ethicon, Inc. Tissue holding devices and methods for making the same
ATE497730T1 (de) 2006-05-16 2011-02-15 Marlen Andreevich Sulamanidze Chirurgisches nahtmaterial
WO2007145614A2 (en) 2006-06-08 2007-12-21 Eremia Sorin M D Suture instrument and method of suturing in cosmetic surgery
JP4255960B2 (ja) 2006-06-16 2009-04-22 克弥 高須 形成外科用手術糸
WO2008002409A2 (en) * 2006-06-26 2008-01-03 Vance Products Incorporated Doing Business As Cook Urological Incorporated Tension free pelvic floor repair
US20080046094A1 (en) 2006-06-27 2008-02-21 Kwang Hee Han Linear tension material for plastic surgery
US7923075B2 (en) 2006-07-17 2011-04-12 The Hong Kong University Of Science And Technology Methods for preparing nanotextured surfaces and applications thereof
US8563117B2 (en) 2006-08-04 2013-10-22 Phillip B. Messersmith Biomimetic modular adhesive complex: materials, methods and applications therefore
US8348973B2 (en) 2006-09-06 2013-01-08 Covidien Lp Bioactive substance in a barbed suture
EP2279700B1 (de) 2006-09-06 2018-10-03 Covidien LP Nahtfaden mit Widerhaken und einer bioaktiven Substanz
AU2007303137B2 (en) 2006-10-03 2014-04-10 Sinclair Pharmaceuticals Limited Minimally invasive tissue support
US8353931B2 (en) 2006-11-02 2013-01-15 Covidien Lp Long term bioabsorbable barbed sutures
US8128393B2 (en) 2006-12-04 2012-03-06 Liquidia Technologies, Inc. Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom
US20080132943A1 (en) 2006-12-05 2008-06-05 Nicholas Maiorino Knotless wound closure device
US20080195147A1 (en) 2007-02-09 2008-08-14 Tyco Healthcare Group Lp Surface eroding barbed sutures
US20080215072A1 (en) 2007-02-15 2008-09-04 Graham Kelly Methods and apparatus for utilization of barbed sutures in human tissue including a method for eliminating or improving blood flow in veins
US20080221618A1 (en) 2007-03-09 2008-09-11 Gaoyuan Chen Co-extruded tissue grasping monofilament
US20080281357A1 (en) 2007-05-09 2008-11-13 An-Min Jason Sung Looped tissue-grasping device
BRPI0812131B8 (pt) 2007-05-29 2021-06-22 Angiotech Pharm Inc embalagem de sutura e dispensador de sutura
US8747436B2 (en) 2007-06-13 2014-06-10 Ethicon, Inc. Bi-directional barbed suture
US8562644B2 (en) 2007-08-06 2013-10-22 Ethicon, Inc. Barbed suture with non-symmetric barbs
US8161618B2 (en) 2007-09-17 2012-04-24 Tyco Healthcare Group Lp Method of forming barbs on a suture
EP2200673B1 (de) * 2007-09-21 2011-12-21 Boston Scientific Scimed, Inc. Medizinische vorrichtungen mit oberflächen mit nanofaser-struktur
ES2488406T3 (es) 2007-09-27 2014-08-27 Ethicon Llc Suturas de auto-retención que incluyen elementos de retención a tejido con resistencia mejorada
US7956100B2 (en) * 2007-09-28 2011-06-07 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from block copolymers
US20090099597A1 (en) 2007-10-12 2009-04-16 Isse Nicanor G Suture assembly with tissue engaging elements
ES2477879T3 (es) 2007-10-17 2014-07-18 Davol, Inc. Medios de inmovilización entre una malla y unos medios de despliegue de malla especialmente útiles para cirugías de reparación de hernias
US20090112236A1 (en) * 2007-10-29 2009-04-30 Tyco Healthcare Group Lp Filament-Reinforced Composite Fiber
US20090112259A1 (en) 2007-10-31 2009-04-30 Angiotech Pharmaceuticals, Inc. Recombinant expressed bioadsorbable polyhydroxyalkonate monofilament and multi-filaments self-retaining sutures
US8225673B2 (en) 2007-10-31 2012-07-24 Ethicon, Inc. Method of manufacturing and testing monofilament and multi-filaments self-retaining sutures
WO2009059147A2 (en) * 2007-10-31 2009-05-07 Angiotech Pharmaceuticals, Inc. Combining synthetic, natural polymers and recombinant polymers to form monofilament and multifilament self-retaining sutures
US20090143819A1 (en) 2007-10-31 2009-06-04 D Agostino William L Coatings for modifying monofilament and multi-filaments self-retaining sutures
JP2009118967A (ja) 2007-11-13 2009-06-04 Daitaro Fukuoka 形成施術用糸
DE102007058256A1 (de) 2007-11-26 2009-05-28 Aesculap Ag Chirurgische Fadengeflecht
US9439746B2 (en) 2007-12-13 2016-09-13 Insightra Medical, Inc. Methods and apparatus for treating ventral wall hernia
WO2009086172A2 (en) * 2007-12-19 2009-07-09 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with heat-contact mediated retainers
US8118834B1 (en) * 2007-12-20 2012-02-21 Angiotech Pharmaceuticals, Inc. Composite self-retaining sutures and method
DE102008004574A1 (de) 2008-01-09 2009-07-16 Aesculap Ag Chirurgisches Nahtmaterial mit Verankerungselementen
EP2242430B1 (de) 2008-01-30 2016-08-17 Ethicon, LLC Vorrichtung und verfahren zur bildung von selbstfixierenden nähten
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US8222564B2 (en) 2008-02-13 2012-07-17 Tyco Healthcare Group, Lp Methods of altering surgical fiber
US8454653B2 (en) 2008-02-20 2013-06-04 Covidien Lp Compound barb medical device and method
US8888810B2 (en) 2008-02-20 2014-11-18 Covidien Lp Compound barb medical device and method
US8273105B2 (en) 2008-02-20 2012-09-25 Tyco Healthcare Group Lp Compound barb medical device and method
EP3533399A3 (de) * 2008-02-21 2019-10-23 Ethicon LLC Verfahren zum anheben von halterungen an selbsthaltenden nähten
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8641732B1 (en) * 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
US20090228021A1 (en) 2008-03-06 2009-09-10 Leung Jeffrey C Matrix material
US20090248066A1 (en) 2008-03-28 2009-10-01 David Hjalmar Wilkie Elastic barbed suture and tissue support system
US8932327B2 (en) 2008-04-01 2015-01-13 Covidien Lp Anchoring device
US10376261B2 (en) 2008-04-01 2019-08-13 Covidien Lp Anchoring suture
US8256613B2 (en) 2008-04-07 2012-09-04 Tyco Healthcare Group Lp Suture packaging for barbed sutures
US20090259251A1 (en) 2008-04-11 2009-10-15 Cohen Matthew D Loop suture
US8864776B2 (en) 2008-04-11 2014-10-21 Covidien Lp Deployment system for surgical suture
CA2720847C (en) 2008-04-15 2016-06-28 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with bi-directional retainers or uni-directional retainers
ES2551714T3 (es) 2008-04-24 2015-11-23 Ethicon Llc Suturas de auto-retención con memoria de forma, métodos de fabricación y métodos de uso
US9011489B2 (en) 2008-05-14 2015-04-21 Boston Scientific Scimed, Inc. Surgical composite barbed suture
AU2009257866B2 (en) 2008-05-16 2015-02-05 Ethicon Llc Coded heterofunctional sutures and methods
US7967841B2 (en) 2008-06-02 2011-06-28 Ethicon, Inc. Methods for using looped tissue-grasping devices
US8888796B2 (en) 2008-06-07 2014-11-18 Ethicon, Inc. Devices for tensioning barbed sutures and methods therefor
US8403947B2 (en) 2008-06-17 2013-03-26 Derek H. OCHIAI Method of suturing
US8202531B2 (en) * 2008-07-23 2012-06-19 Warsaw Orthopedic, Inc. Drug depots having one or more anchoring members
US10016196B2 (en) 2008-09-11 2018-07-10 Covidien Lp Tapered looped suture
US8056599B2 (en) 2008-09-24 2011-11-15 Tyco Healthcare Group Lp System and method of making tapered looped suture
US8403017B2 (en) 2008-10-27 2013-03-26 Covidien Lp System, method and apparatus for making tapered looped suture
SG196767A1 (en) * 2008-11-03 2014-02-13 Ethicon Llc Length of self-retaining suture and method and device for using the same
DE102008057218A1 (de) 2008-11-06 2010-05-12 Aesculap Ag Chirurgisches Nahtmaterial mit im unverstreckten Zustand eingeschnittenen Widerhaken
US20100140115A1 (en) 2008-12-08 2010-06-10 David Kirsch Suture Packaging
US8226684B2 (en) 2008-12-22 2012-07-24 Ethicon, Inc. Surgical sutures having collapsible tissue anchoring protrusions and methods therefor
ATE551035T1 (de) 2008-12-30 2012-04-15 Medartis Ag Implantat zur behandlung des obstruktiven schlafapnoesyndroms
WO2010111232A2 (en) 2009-03-23 2010-09-30 Micell Technologies, Inc. Drug delivery medical device
RU2558459C2 (ru) 2009-08-25 2015-08-10 АРГУС НЬЮРООПТИКС, ЭлЭлСи Системы и способы для стимуляции нейрональной активности
US20110106110A1 (en) 2009-10-30 2011-05-05 Warsaw Orthopedic, Inc. Devices and methods for implanting a plurality of drug depots having one or more anchoring members
EP2501300B1 (de) 2009-11-16 2018-07-11 Ethicon LLC Selbsthaltende geflochtene nahten und verfahren dafür
US9398943B2 (en) 2009-11-30 2016-07-26 Covidien Lp Ventral hernia repair with barbed suture
WO2011090628A2 (en) 2009-12-29 2011-07-28 Angiotech Pharmaceuticals, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
AU2011248466B2 (en) 2010-04-29 2015-03-19 Angiotech Pharmaceuticals, Inc. High-density self-retaining sutures, manufacturing equipment and methods
NZ603886A (en) 2010-05-04 2014-12-24 Ethicon Llc Self-retaining systems having laser-cut retainers
US20130204295A1 (en) 2010-05-05 2013-08-08 William L. Hunter Surface texture configuration for self-retaining sutures and methods for forming same
IT1400838B1 (it) * 2010-07-08 2013-07-02 Assut Europ S P A Filo di sutura.
US8900616B2 (en) * 2010-10-22 2014-12-02 Covidien Lp System and method for satellite drug delivery
US9220499B2 (en) 2010-10-28 2015-12-29 Covidien Lp Wound closure device including barbed pins
RU2608237C2 (ru) 2010-11-03 2017-01-17 ЭТИКОН ЭлЭлСи Самоудерживающиеся шовные материалы, выделяющие лекарственные средства, и относящиеся к ним методы
KR101057377B1 (ko) * 2011-03-24 2011-08-17 한스바이오메드 주식회사 표면에 미세 돌기를 가지는 의료용 봉합사 및 그의 제조방법
US20130172931A1 (en) 2011-06-06 2013-07-04 Jeffrey M. Gross Methods and devices for soft palate tissue elevation procedures

Patent Citations (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123077A (en) * 1964-03-03 Surgical suture
US879758A (en) * 1907-06-14 1908-02-18 Frank Brooks Foster Needle.
US2232142A (en) * 1940-09-27 1941-02-18 Schumann Seymour Wound clip
US2779083A (en) * 1955-02-09 1957-01-29 Edward N Eaton Lip and mouth adjuster
US3234636A (en) * 1962-03-19 1966-02-15 Ernest C Wood Clip applicator
US3166072A (en) * 1962-10-22 1965-01-19 Jr John T Sullivan Barbed clips
US3494006A (en) * 1968-01-12 1970-02-10 George C Brumlik Self-gripping fastening device
US3557795A (en) * 1968-06-19 1971-01-26 Weck & Co Inc Edward Suture provided with wound healing coating
US3716058A (en) * 1970-07-17 1973-02-13 Atlanta Res Inst Barbed suture
US4008303A (en) * 1971-08-30 1977-02-15 American Cyanamid Company Process for extruding green polyglycolic acid sutures and surgical elements
US4182340A (en) * 1972-05-12 1980-01-08 Spencer Dudley W C Hoof repair
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4069825A (en) * 1976-01-28 1978-01-24 Taichiro Akiyama Surgical thread and cutting apparatus for the same
USD246911S (en) * 1976-02-27 1978-01-10 Bess Jr Kenneth B Automatic blind suturing machine
US4073298A (en) * 1976-08-03 1978-02-14 New Research & Development Lab., Inc. Wound clip
US4316469A (en) * 1976-09-07 1982-02-23 Kapitanov Nikolai N Surgical apparatus for suturing soft tissues with lengths of suturing material with spicules
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4311002A (en) * 1977-09-22 1982-01-19 Kabel Metallwerke Ghh Forming stranded stock
US4313448A (en) * 1980-01-28 1982-02-02 Medtronic, Inc. Myocardial sutureless lead
US4313448B1 (de) * 1980-01-28 1985-04-02
US4428376A (en) * 1980-05-02 1984-01-31 Ethicon Inc. Plastic surgical staple
US4372293A (en) * 1980-12-24 1983-02-08 Vijil Rosales Cesar A Apparatus and method for surgical correction of ptotic breasts
US4492075A (en) * 1982-01-26 1985-01-08 Asa S.A. Method for producing fiber spun yarns and the fiber spun yarns obtained with said method
US5601557A (en) * 1982-05-20 1997-02-11 Hayhurst; John O. Anchoring and manipulating tissue
US4430998A (en) * 1982-06-01 1984-02-14 Thoratec Laboratories Corporation Wound closing device
US4493323A (en) * 1982-12-13 1985-01-15 University Of Iowa Research Foundation Suturing device and method for using same
US4635637A (en) * 1984-03-29 1987-01-13 Schreiber Saul N Surgical suture
US4637380A (en) * 1985-06-24 1987-01-20 Orejola Wilmo C Surgical wound closures
US4895148A (en) * 1986-05-20 1990-01-23 Concept, Inc. Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member
US4719917A (en) * 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
US4898156A (en) * 1987-05-18 1990-02-06 Mitek Surgical Products, Inc. Suture anchor
US4899743A (en) * 1987-12-15 1990-02-13 Mitek Surgical Products, Inc. Suture anchor installation tool
US4900605A (en) * 1988-09-16 1990-02-13 Harold Thorgersen Bristle pile textile for garment applications
US4994073A (en) * 1989-02-22 1991-02-19 United States Surgical Corp. Skin fastener
US4981149A (en) * 1989-05-16 1991-01-01 Inbae Yoon Method for suturing with a bioabsorbable needle
US4994084A (en) * 1989-06-23 1991-02-19 Brennan H George Reconstructive surgery method and implant
US5084063A (en) * 1989-09-27 1992-01-28 United States Surgical Corporation Surgical needle-suture attachment
US5089010A (en) * 1989-09-27 1992-02-18 United States Surgical Corporation Surgical needle-suture attachment possessing weakened suture segment for controlled suture release
US5480403A (en) * 1991-03-22 1996-01-02 United States Surgical Corporation Suture anchoring device and method
US5179964A (en) * 1991-08-30 1993-01-19 Cook Melvin S Surgical stapling method
US5176692A (en) * 1991-12-09 1993-01-05 Wilk Peter J Method and surgical instrument for repairing hernia
US5480411A (en) * 1992-03-03 1996-01-02 United States Surgical Corporation Method of suturing using a polyetherimide ester suture
US5484451A (en) * 1992-05-08 1996-01-16 Ethicon, Inc. Endoscopic surgical instrument and staples for applying purse string sutures
US5282832A (en) * 1992-10-09 1994-02-01 United States Surgical Corporation Suture clip
US5380334A (en) * 1993-02-17 1995-01-10 Smith & Nephew Dyonics, Inc. Soft tissue anchors and systems for implantation
US20090018577A1 (en) * 1993-05-03 2009-01-15 Quill Medical, Inc. Barbed sutures
US5391173A (en) * 1994-02-10 1995-02-21 Wilk; Peter J. Laparoscopic suturing technique and associated device
US5863360A (en) * 1994-03-05 1999-01-26 The University Of Dundee Surface treatment of shape memory alloys
US5486197A (en) * 1994-03-24 1996-01-23 Ethicon, Inc. Two-piece suture anchor with barbs
US5494154A (en) * 1994-07-12 1996-02-27 Look Incorporated Surgical suture package
US5709692A (en) * 1994-09-16 1998-01-20 General Surgical Innovations Surgical instrument for placing suture or fasteners
US5716358A (en) * 1994-12-02 1998-02-10 Johnson & Johnson Professional, Inc. Directional bone fixation device
USRE37963E1 (en) * 1995-06-06 2003-01-07 Raymond Thal Knotless suture anchor assembly
US5716376A (en) * 1996-06-28 1998-02-10 United States Surgical Corporation Absorbable mixture and coatings for surgical articles fabricated therefrom
US6984241B2 (en) * 1996-09-13 2006-01-10 Tendon Technology, Ltd. Apparatus and methods for tendon or ligament repair
US20040024420A1 (en) * 1996-09-13 2004-02-05 Tendon Technology, Ltd. Apparatus and methods for securing tendons or ligaments to bone
US6187095B1 (en) * 1996-10-31 2001-02-13 Samsel K. Labrecque Process and apparatus for coating surgical sutures
US6012216A (en) * 1997-04-30 2000-01-11 Ethicon, Inc. Stand alone swage apparatus
US6027523A (en) * 1997-10-06 2000-02-22 Arthrex, Inc. Suture anchor with attached disk
US6015410A (en) * 1997-12-23 2000-01-18 Bionx Implants Oy Bioabsorbable surgical implants for endoscopic soft tissue suspension procedure
US6024757A (en) * 1998-04-14 2000-02-15 Ethicon, Inc. Method for cutting a surgical suture tip
US6506190B1 (en) * 1998-05-21 2003-01-14 Christopher J. Walshe Tissue anchor system
US6511488B1 (en) * 1998-06-23 2003-01-28 Orthopaedic Biosystems Ltd., Inc. Surgical knot manipulator
US6174324B1 (en) * 1998-07-13 2001-01-16 Axya Medical, Inc. Suture guide and fastener
US6334865B1 (en) * 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US6168633B1 (en) * 1998-08-10 2001-01-02 Itzhak Shoher Composite surface composition for an implant structure
US6183499B1 (en) * 1998-09-11 2001-02-06 Ethicon, Inc. Surgical filament construction
US6514265B2 (en) * 1999-03-01 2003-02-04 Coalescent Surgical, Inc. Tissue connector apparatus with cable release
US6838493B2 (en) * 1999-03-25 2005-01-04 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6981983B1 (en) * 1999-03-31 2006-01-03 Rosenblatt Peter L System and methods for soft tissue reconstruction
US7160312B2 (en) * 1999-06-25 2007-01-09 Usgi Medical, Inc. Implantable artificial partition and methods of use
US20040028655A1 (en) * 1999-08-06 2004-02-12 Nelson Kevin D. Drug releasing biodegradable fiber for delivery of therapeutics
US20020007218A1 (en) * 1999-10-20 2002-01-17 Cauthen Joseph C. Spinal disc annulus reconstruction method and spinal disc annulus stent
US7156858B2 (en) * 2000-04-20 2007-01-02 Ethicon G.M.B.H. Implant
US20040010275A1 (en) * 2000-05-19 2004-01-15 Daniel Jacobs Multi-point tissue tension distribution device and method, a custom-fittable variation
US20020022861A1 (en) * 2000-05-19 2002-02-21 Daniel Jacobs Multi-point tissue tension distribution device, a combined orbital rim repair and suspension variation, and a method of tissue approximation using the device
US7156862B2 (en) * 2000-05-19 2007-01-02 Coapt Systems, Inc. Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US20040010276A1 (en) * 2000-05-19 2004-01-15 Daniel Jacobs Multi-point tissue tension distribution device and method, a chin lift variation
US20040024169A1 (en) * 2000-10-27 2004-02-05 Shalaby Shalaby W. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US6991643B2 (en) * 2000-12-20 2006-01-31 Usgi Medical Inc. Multi-barbed device for retaining tissue in apposition and methods of use
US20030040795A1 (en) * 2001-05-31 2003-02-27 Elson Robert J. Anterior cruciate ligament reconstruction system
US20030014077A1 (en) * 2001-06-29 2003-01-16 Leung Jeffrey C. Suture method
US6986780B2 (en) * 2002-03-26 2006-01-17 Ethicon, Inc. Surgical element delivery system and method
US20040015187A1 (en) * 2002-04-18 2004-01-22 Mnemoscience Corporation Biodegradable shape memory polymeric sutures
US20110009902A1 (en) * 2002-08-09 2011-01-13 Quill Medical, Inc. Multiple suture thread configuration with an intermediate connector
US20040060409A1 (en) * 2002-09-30 2004-04-01 Leung Jeffrey C. Barb configurations for barbed sutures
US20040088003A1 (en) * 2002-09-30 2004-05-06 Leung Jeffrey C. Barbed suture in combination with surgical needle
US20050004601A1 (en) * 2003-04-29 2005-01-06 Kong James Kam Fu Coded surgical aids
US20070021779A1 (en) * 2003-06-27 2007-01-25 Garvin Dennis D Device for surgical repair, closure, and reconstruction
US20050004602A1 (en) * 2003-07-02 2005-01-06 Applied Medical Resources Corporation Interlocking suture clinch
US7166570B2 (en) * 2003-11-10 2007-01-23 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20060020272A1 (en) * 2004-06-24 2006-01-26 Gildenberg Philip L Semi-robotic suturing device
US20070005110A1 (en) * 2005-06-29 2007-01-04 Collier John P Braided barbed suture
US20070005109A1 (en) * 2005-06-29 2007-01-04 Popadiuk Nicholas M Barbed suture
US7322105B2 (en) * 2005-11-18 2008-01-29 Ultradent Products, Inc. Methods for manufacturing endodontic instruments by milling
US20080009902A1 (en) * 2006-01-30 2008-01-10 Angiotech Pharmaceuticals, Inc. Sutures and fibrosing agents
US20070213770A1 (en) * 2006-03-07 2007-09-13 Dreyfuss Peter J Tapered Suture
US20080004603A1 (en) * 2006-06-29 2008-01-03 Intuitive Surgical Inc. Tool position and identification indicator displayed in a boundary area of a computer display screen
US20080009838A1 (en) * 2006-06-30 2008-01-10 Intuitive Surgical Inc. Compact capstan
US20080009888A1 (en) * 2006-07-07 2008-01-10 Usgi Medical, Inc. Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US20080027273A1 (en) * 2006-07-27 2008-01-31 Gutterman Lee R Nonaugmentive mastopexy
US20080027486A1 (en) * 2006-07-28 2008-01-31 Angiotech Pharmaceuticals, Inc. Minimally-invasive nipple-lift procedure and apparatus
US20090012560A1 (en) * 2007-04-13 2009-01-08 Angiotech Pharmaceuticals, Inc. Self-retaining systems for surgical procedures
US20100023055A1 (en) * 2008-07-23 2010-01-28 Ethicon, Inc. Collapsible barbed sutures having reduced drag and methods therefor

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10548592B2 (en) 2004-05-14 2020-02-04 Ethicon, Inc. Suture methods and devices
US11723654B2 (en) 2004-05-14 2023-08-15 Ethicon, Inc. Suture methods and devices
US10779815B2 (en) 2004-05-14 2020-09-22 Ethicon, Inc. Suture methods and devices
US8793863B2 (en) 2007-04-13 2014-08-05 Ethicon, Inc. Method and apparatus for forming retainers on a suture
US8915943B2 (en) 2007-04-13 2014-12-23 Ethicon, Inc. Self-retaining systems for surgical procedures
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US9044225B1 (en) 2007-12-20 2015-06-02 Ethicon, Inc. Composite self-retaining sutures and method
US9125647B2 (en) 2008-02-21 2015-09-08 Ethicon, Inc. Method and apparatus for elevating retainers on self-retaining sutures
US8936619B2 (en) 2008-11-06 2015-01-20 Aesculap Ag Surgical suture material with barbs cut into it in the undrawn state
DE102008057218A1 (de) * 2008-11-06 2010-05-12 Aesculap Ag Chirurgisches Nahtmaterial mit im unverstreckten Zustand eingeschnittenen Widerhaken
US20100256676A1 (en) * 2009-04-06 2010-10-07 Hay Alan R Suture clips for securing sutures
US9636109B2 (en) * 2009-07-22 2017-05-02 Wisconsin Alumni Research Foundation Biologically active sutures for regenerative medicine
US20110022085A1 (en) * 2009-07-22 2011-01-27 Wisconsin Alumni Research Foundation Biologically active sutures for regenerative medicine
US10420546B2 (en) 2010-05-04 2019-09-24 Ethicon, Inc. Self-retaining systems having laser-cut retainers
US10952721B2 (en) 2010-05-04 2021-03-23 Ethicon, Inc. Laser cutting system and methods for creating self-retaining sutures
US11234692B2 (en) 2010-05-04 2022-02-01 Cilag Gmbh International Self-retaining system having laser-cut retainers
US9955962B2 (en) 2010-06-11 2018-05-01 Ethicon, Inc. Suture delivery tools for endoscopic and robot-assisted surgery and methods
US11007296B2 (en) 2010-11-03 2021-05-18 Ethicon, Inc. Drug-eluting self-retaining sutures and methods relating thereto
US9675341B2 (en) 2010-11-09 2017-06-13 Ethicon Inc. Emergency self-retaining sutures and packaging
US10492780B2 (en) 2011-03-23 2019-12-03 Ethicon, Inc. Self-retaining variable loop sutures
US11690614B2 (en) 2011-03-23 2023-07-04 Ethicon, Inc. Self-retaining variable loop sutures
US10188384B2 (en) 2011-06-06 2019-01-29 Ethicon, Inc. Methods and devices for soft palate tissue elevation procedures
US20130172931A1 (en) * 2011-06-06 2013-07-04 Jeffrey M. Gross Methods and devices for soft palate tissue elevation procedures

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KR101485327B1 (ko) 2015-01-22
EP2146646A1 (de) 2010-01-27
EP3409214A2 (de) 2018-12-05
CA2683819A1 (en) 2008-10-23
EP2146646B1 (de) 2018-07-04
CA2683819C (en) 2016-02-23
US8915943B2 (en) 2014-12-23
KR20100016471A (ko) 2010-02-12
JP2010523288A (ja) 2010-07-15
US8793863B2 (en) 2014-08-05
US20080255611A1 (en) 2008-10-16
US20090012560A1 (en) 2009-01-08
WO2008128113A1 (en) 2008-10-23
JP5562829B2 (ja) 2014-07-30
EP3409214A3 (de) 2018-12-19

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