US3608539A - Method for the biopsy of subcutaneous masses - Google Patents

Method for the biopsy of subcutaneous masses Download PDF

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US3608539A
US3608539A US3608539DA US3608539A US 3608539 A US3608539 A US 3608539A US 3608539D A US3608539D A US 3608539DA US 3608539 A US3608539 A US 3608539A
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cannula
mass
skin
stylet
method
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Daniel G Miller
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Daniel G Miller
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0266Pointed or sharp biopsy instruments means for severing sample

Abstract

An instrument for the biopsy of subcutaneous masses includes an arcuate cannula having a serrated distal cutting end and is provided for alternative insertion, a correspondingly curved pointed stylet and a flexible ejector element. In performing a biopsy, and the skin is punctured and the cannula engaged stylet inserted through the puncture into the surface of the mass from its lateral or inferior aspect. The stylet is removed and the cannula advanced through the mass to cut and draw a specimen thereof into the cannula and the cannula is pushed through the overlying tissue to the skin, which is then punctured and the distal end of the cannula pushed through the puncture. The ejector is then pushed through the proximal end of the cannula to eject the specimen.

Description

United States Patent [72] lnventor Daniel G. Miller 430 E. 86th St., New York, N.Y. 10028 [21] Appl. No. 773,787 [22] Filed Nov. 6, 1968 [45] Patented Sept. 28, 1971 [54] METHOD FOR THE BIOPSY OF SUBCUTANEOUS MASSES 6 Claims, 9 Drawing Figs.

[52] 11.8. CI. 128/2, 128/314, 128/329, 128/347 [51] Int. Cl ..A61bl0/00, A61b 17/34, A61b 17/32 [50] Field of Search 128/2, 305, v 314, 329, 347

[56] References Cited UNITED STATES PATENTS 2,919,692 l/1960 v Ackermann 128/314 X 3,342,175 9/1967 Bulloch 128/2 1,485,298 2/l924 Schroyer 128/347 UX 2,865,374 12/1958 Brown et al.... 128/347 X 3,496,932 2/1970 Prisk et a1. 129/347 X Primary Examiner-Channing L. Pace Attorney-Howard C. Miskin ABSTRACT: An instrument for the biopsy of subcutaneous masses includes an arcuate cannula having a serrated distal cutting end and is provided for alternative insertion, a correspondingly curved pointed stylet and a flexible ejector element. In performing a biopsy, and the skin is punctured and the cannula engaged stylet inserted through the puncture into the surface of the mass from its lateral or inferior aspect. The stylet is removed and the cannula advanced through the mass to cut and draw a specimen thereof into the cannula and the cannula is pushed through the overlying tissue to the skin. which is then punctured and the distal end of the cannula pushed through the puncture. The ejector is then pushed through the proximal end of the cannula to eject the specimen.

PATENTED SEP28I9TI 3.808.539

SHEET 1 BF 2 INVEN'I'OR. DANIEL G. MILLER AT TORNEY PATENTED SEP28 I97! 3.608.539

sum 2 0F 2 EN'I'UR. DAME MILLER ATTORNEY METHOD FOR THE BIOPSY OF SUBCUTANEOUS MASSES BACKGROUND OF THE INVENTION The present invention relates generally to improvements in sampling methods and instruments and it relates particularly to an improved method and instrument for obtaining biopsy specimens from subcutaneous masses, such as lymph nodes or tumors. I

The procedures conventionally employed for obtaining biopsy specimens pose numerous drawbacks and disadvantages, particularly when applied to subcutaneous masses. They are usually accompanied by damage to the surrounding tissue as the result of surgical incision and disection, and frequently effect the transfer of some of the sampled mass to the surrounding tissue, a consequence which is highly undesirable and should be assiduously avoided. Moreover, when straight needles are employed to obtain biopsies of lymph nodes or subcutaneous masses, the plug which is impaled in the barrel, in most instances will remain in situ when the needle is withdrawn, because its distal end has not been severed from the bulk of the mass. These tissues possess an inherent elasticity and connective tissue framework, which is resilient and has sufficient strength to retain a specimen which is cut on only three sides. It is because of this common experience that needles previously used for this purpose employed various undercutting mechanisms for retaining the cut plug, e.g. a screw, a hook, compressible jaws or a side cutting device.

SUMMARY OF THE INVENTION It is a principal object of the present invention to provide an improved sampling method and instrument.

Another object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens.

Still another object of the presentinvention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses.

A further object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses with a minimum of damage to the surrounding tissue and the obviation of any transfer of the sampled mass to the surrounding tissue.

Still a further object of the present invention is to provide a method of the above nature, characterized by its convenience, simplicity, high reliability, versatility and minimum discomforture to the subject.

The above and other objects of the present invention will become apparent from a reading of the following description taken in conjunction with the accompanying drawing, which illustrates a preferred embodiment thereof.

In a sense the present invention contemplates the provision of the method for obtaining a biopsy of a subcutaneous masscomprising the steps of advancing a curved cannula through a first area of the skin, through said mass to cut and receive a specimen thereof, and thence through a second area of the skin, and thereafter ejecting said specimen from said cannula while projecting through the skin of the second area. The cannula is advantageously curved and preferably arcuate with a radius of curvature advantageously between 3 and centimeters and advantageously extends between 45 and 180 preferably between 120 and 130, and is of a length between 5 and 12 centimeters. The distal end of the cannula is provided with a serrated cutting edge and the proximal end is provided with finger engageable wings. A similarly curved stylet is slidably received within the cannula and is provided with a proximal button and a distal pointed tip projecting through the cannula distal end. A blunt ended flexible ejector is slidably received within the cannula alternatively with the stylet. According to the preferred procedure, the skin on one side of the mass is punctured and the stylet engaged cannula inserted therethrough and advanced into engagement with the mass. The stylet is then removed and the cannula advanced through The improved procedure is simple, rapid, convenient, versatile and reliable. It results in a minimum of damage to the surrounding tissue and prevents any transfer of the biopsied mass to the surrounding tissue.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a front elevational view of the cannula section of an instrument embodying the present invention;

FIG. 2 is a front elevational view of the stylet section thereof;

FIG. 3 is a front elevational view of the ejector section thereof;

FIG. 4 is a enlarged longitudinal sectional view of the distal end of the assembled instrument;

FIG. 5 is an elevational view illustrating a step of preparing the site in the practice of the improved process;

FIG. 6 illustrates the insertion of the cannula into the explored mass;

FIG. 7 illustrates the obtaining of the biopsy specimen;

FIG. 8 illustrates the preparation of the skin exit site; and

FIG. 9 illustrates the ejection of the biopsy specimen.

DESCRIPTION THE PREFERRED EMBODIMENT Referring now to the drawing, and particularly FIGS. 1 to 4 thereof, which illustrate an instrument embodying the present invention, the improved instrument includes a cannula 11, a stylet or piercing member 12, and an ejector member 13. The cannula 11 comprises an arcuate tubular body member or barrel 14, provided at its distal end with a sharp serrated cutting edge 16, as bestseen in FIG. I. The bore of the cannula barrel 14 is uniform throughout its length, the outer face at the distal end being tapered to the cutting edge 16.

An annulus 17 is fitted over the proximal end of the barrel 14 and a wing-shaped finger piece provided with a medial opening is also fitted over the proximal border of the barrel l4 and rests on the annulus 17. A standard Luer-lok receptacle or coupling collar 19engages the distal end of the barrel l4 and is affixed to the barrel 14 with the annulus l7 and finger piece 18, by soldering, welding or the like.

The stylet 12 includes an accurately shaped rod 20 of the same curvature as the cannula barrel l4, and is of lesser crosssectional diameter than the bore of the barrel 14. The rod 20 terminates at its distal end in an enlarged pointed tip 21 and is provided at its proximal end with a thumb rest or button 22. The cannula l1 and stylet 12 are so dimensioned that when the stylet 12 is fully inserted in the cannula 11, the button 22 rests on the coupling collar 19 and the tip 21 projects through the distal end of the cannula barrel 14 with its face forming a smooth continuous surface with the outside face of the cannula barrel distal border, as seen best in FIG. 4.

The ejector member 13, is a flexible rod or wire of an outside diameter, about equal to the inside diameter of the barrel l4, and is provided with a blunt distal end face 23. The ejector member 13 is advantageously formed of Teflon rod or other suitable material.

As a specific example, the cannula barrel 14 is formed of stainless steel with an inside diameter of 3 millimeters and an outside diameter of 4 millimeters. The overall length of the cannula barrel 14 is 10 centimeters and the chord distance from end to end is about 9 centimeters. It has a radius of curvature of about 4.5 cm. and extends for about 120. The taper leading to the cutting edge 16 is about 4 millimeters long. The rod 20 is stainless steel of 2 millimeters diameter and the conical tip 21 is 6 millimeter long.

Considering now the practice of the improved method employing the instrument described above, and referring to FIGS. 5-.-9 of the drawing, the skin S, about 2 centimeters from the mass M which is to be biopsied, is infiltrated with procaine and from this side additional procaine is injected subcutaneously about mass M. Skin S is punctured, as seen in FIG. 5, with a surgical blade 26 in an area slightly offset from the side of mass M. The opening in the skin is further enlarged by stretching with a small curved hemostat or pointed scissors, not shown. With the same instrument a tract is made to the mass M by penetration and separation of the subutaneous tissue. The cannula l l with the pointed stylet 12 in place is then inserted along the prepared tract and inserted into the side of or the undersurface of the mass M, as seen in P10. 6. The free hand can often assist by holding the mass. After entry has been confirmed by moving the cannula 11 and mass M as one, the pointed stylet 12 is removed. With the thumb of the free hand, the mass M is pushed down and in this manner the open cannula ll traverses one entire diameter of the mass M, as seen in H0. 7. ln some situations it is advantageous to rock the proximal end of the cannula to and fro; this turns serrated cutting edge 16 of barrel l4 and facilitates its passage through the mass M. When the mass M has been penetrated, the arc is further extended to raise the skin S at the opposite side of the mass M. With procaine, puncture and tract prepared as above, as seen in FIG. 8, the specimen loaded cannula 11 emerges. The clearing stylet or ejector 13 is inserted in the cannula 11, as shown in FIG. 9, and the specimen is picked up on either a square of blotting paper or with thumb forceps and dropped into a bottle containing the fixing solution. The cannula 11, is easily withdrawn by reversing the direction of the arc. Pressure is applied to the punctures for 2 minutes and two Band- Aids are applied to each of the two puncture sites and left in place for 24 hours.

In employing the improved instrument in the method described above, highly satisfactory biopsy specimens were obtained and the proper diagnosis made in a large number of patients. No false negative diagnosis were encountered. It is important to note that there were no complications associated with the improved procedure. The specimens biopsied represented a variety of lesions from the point of view of size, consistency and diagnosis and the improved method has proven sufficiently versatile to adapt to most of the situations encountered.

While there has been described and illustrated a preferred embodiment of the present invention, it is apparent that numerous alterations, omissions and additions may be made without departing from the spirit thereof.

What I claim is:

l. The method for obtaining a biopsy of a subcutaneous mass comprising the steps of advancing a cannula inwardly through a first area of the skin laterally of the area above the mass and through said mass to undercut and receive a specimen from said mass and thence advancing outwardly cannula with the specimen therein out through a second area of the skin, on the side of the area above the mass opposite the first area and thereafter ejecting said specimen from said cannula while projecting through said skin.

2. The method of claim 1 wherein said cannula is advanced through said first skin area to said mass, while engaged by a stylet provided with a pointed end positioned at the distal end of said cannula, and removing said stylet from said cannula prior to said cannula being advanced through said mass.

3. The method of claim 1 wherein said specimen is ejected through said cannula by advancing a plunger through said cannula.

4. The method of claim 1 including the step of puncturing said first area of said skin with a sharp instrument prior to the insertion of said cannula.

5. The method of claim 1, including the step of puncturing the skin at said second area following the penetration of the mass by the cannula and before the emergence of the cannula through said second area.

6. The method of claim 1, including the step of applying pressure to said mass through the surrounding tissue in a direction towards said cannula during the advance of said cannula through said mass.

mg? NITEE STATES PATENT @F'FECE (IERHFECATE @F GORREQTEGN Patent No. 3,608, 539 Dated Becember 13, 1971 It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Abstract: 1. 5 "ment. In performing a biopsy, and

the skin is punctured and" Change to ment. In performing a biopsy, the skin is punctured, end-- Column 2, 1.. l9 "Fig. t is e enlarged longitudinal" Change to Fig. t is an enlarged longitudinal-- Column 4, l. i i-l5 said mess and thence advancing outwardly cannula with the specimen therein out through second area of the skin, on the Change to --said mass and thence advancing said cannula with the specimen therein outwardly through a second area of the skin, on the-- Signed and sealed this 25th day of April 1%?2.

At to e L:

MJNARD MJLEJJ EMEJR. ROBERT GOTTSCHALK Attesting Officer Commissioner of Patents

Claims (5)

  1. 2. The method of claim 1, wherein said cannula is advanced through said first skin area to said mass, while engaged by a stylet provided with a pointed end positioned at the distal end of said cannula, and removing said stylet from said cannula prior to said cannula being advanced through said mass.
  2. 3. The method of claim 1, wherein said specimen is ejected through said cannula by advancing a plunger through said cannula.
  3. 4. The method of claim 1, including the step of puncturing said first area of said skin with a sharp instrument prior to the insertion of said cannula.
  4. 5. The method of claim 1, including the step of puncturing the skin at said second area following the penetration of the mass by the cannula and before the emergence of the cannula through said second area.
  5. 6. The method of claim 1, including the step of applying pressure to said mass through the surrounding tissue in a direction towards said cannula during the advance of said cannula through said mass.
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US3870043A (en) * 1974-03-28 1975-03-11 Allan R Dunn U-shaped intravenous needle structure
US4013080A (en) * 1974-10-03 1977-03-22 Froning Edward C Cannula connector and direction indicator means for injection system
US4244370A (en) * 1978-11-20 1981-01-13 American Medical Systems, Inc. Tool for positioning implantable medical prosthetic device _and method of using same
USRE30966E (en) * 1977-09-30 1982-06-15 The Regents Of The University Of California Wick catheter pressure sensing probe and method of use
US4493323A (en) * 1982-12-13 1985-01-15 University Of Iowa Research Foundation Suturing device and method for using same
US4530359A (en) * 1983-02-08 1985-07-23 Helfgott Maxwell A Ophthalmic perforating instrument and surgical method employing said instrument
US4684369A (en) * 1982-04-14 1987-08-04 Wildemeersch Dirk A A Instrument for suprapubic drainage of the bladder, inserted through the urethra
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US4842589A (en) * 1986-11-26 1989-06-27 Sherwood Medical Company Intercavity catheter
US5025797A (en) * 1989-03-29 1991-06-25 Baran Gregory W Automated biopsy instrument
US5047040A (en) * 1987-11-05 1991-09-10 Devices For Vascular Intervention, Inc. Atherectomy device and method
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Cited By (163)

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Publication number Priority date Publication date Assignee Title
US3870043A (en) * 1974-03-28 1975-03-11 Allan R Dunn U-shaped intravenous needle structure
US4013080A (en) * 1974-10-03 1977-03-22 Froning Edward C Cannula connector and direction indicator means for injection system
USRE30966E (en) * 1977-09-30 1982-06-15 The Regents Of The University Of California Wick catheter pressure sensing probe and method of use
US4244370A (en) * 1978-11-20 1981-01-13 American Medical Systems, Inc. Tool for positioning implantable medical prosthetic device _and method of using same
US4684369A (en) * 1982-04-14 1987-08-04 Wildemeersch Dirk A A Instrument for suprapubic drainage of the bladder, inserted through the urethra
US4493323A (en) * 1982-12-13 1985-01-15 University Of Iowa Research Foundation Suturing device and method for using same
US4530359A (en) * 1983-02-08 1985-07-23 Helfgott Maxwell A Ophthalmic perforating instrument and surgical method employing said instrument
US4842589A (en) * 1986-11-26 1989-06-27 Sherwood Medical Company Intercavity catheter
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US5047040A (en) * 1987-11-05 1991-09-10 Devices For Vascular Intervention, Inc. Atherectomy device and method
US5025797A (en) * 1989-03-29 1991-06-25 Baran Gregory W Automated biopsy instrument
US5125413A (en) * 1989-03-29 1992-06-30 Baran Gregory W Automated biopsy instrument
US5417700A (en) * 1992-03-30 1995-05-23 Thomas D. Egan Automatic suturing and ligating device
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