PT892791E - N-¬¬4-(5-metil-3-fenilisoxazol-4-il|fenil|sulfonil-propilamida e seu sal de sodio como pro-farmacos de inibidores de cox-2 - Google Patents

N-¬¬4-(5-metil-3-fenilisoxazol-4-il|fenil|sulfonil-propilamida e seu sal de sodio como pro-farmacos de inibidores de cox-2

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Publication number
PT892791E
PT892791E PT97921092T PT97921092T PT892791E PT 892791 E PT892791 E PT 892791E PT 97921092 T PT97921092 T PT 97921092T PT 97921092 T PT97921092 T PT 97921092T PT 892791 E PT892791 E PT 892791E
Authority
PT
Portugal
Prior art keywords
phenylisoxazol
propylamide
cox
pro
inhibitors
Prior art date
Application number
PT97921092T
Other languages
English (en)
Portuguese (pt)
Inventor
Stephen R Bertenshaw
Thomas D Penning
John J Talley
James W Malecha
Donald J Rogier Jr
Richard M Weier
Jeffery S Carter
David L Brown
Srinivasan Nagarajan
Matthew J Graneto
Xiangdong Xu
Jinglin Li
Ish K Khanna
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT892791E publication Critical patent/PT892791E/pt

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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