BR0008060A - Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica - Google Patents

Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica

Info

Publication number
BR0008060A
BR0008060A BR0008060-8A BR0008060A BR0008060A BR 0008060 A BR0008060 A BR 0008060A BR 0008060 A BR0008060 A BR 0008060A BR 0008060 A BR0008060 A BR 0008060A
Authority
BR
Brazil
Prior art keywords
cyclooxygenase
therapeutic efficacy
rapid onset
compositions
inhibitory compositions
Prior art date
Application number
BR0008060-8A
Other languages
English (en)
Inventor
Tugrul T Kararli
Mark J Kontny
Subhash Desai
Michael J Hageman
Royal J Haskell
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46125549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0008060(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0008060A publication Critical patent/BR0008060A/pt

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    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Abstract

"COMPOSIçõES INIBIDORAS DE CICLOOXIGENASE-2 TENDO RáPIDO INìCIO DE EFICáCIA TERAPêUTICA". A presente invenção refere-se a composições farmacêuticas que compreendem uma ou mais unidades de dose de administração oral, compreendendo cada uma, uma droga inibidora seletiva de ciclooxigenase-2 de baixa solubilidade em água, em uma quantidade terapeuticamente eficaz, em que a droga está presente sob a forma de partículas sólidas, de cerca de 25% a 100% em peso das quais são menores que 1 <109>m. As composições são úteis no tratamento ou profilaxia de condições ou distúrbios mediados por ciclooxigenase-2 e apresentam vantagens particulares onde é desejado um início rápido de eficácia terapêutica.
BR0008060-8A 1999-12-08 2000-12-06 Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica BR0008060A (pt)

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AU1805901A (en) 2001-06-18
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NO20013859L (no) 2001-10-08
CZ20013162A3 (cs) 2002-06-12
DK1175214T3 (da) 2006-07-17
HUP0201463A2 (hu) 2004-05-28
ES2236007T3 (es) 2005-07-16
PT1175214E (pt) 2005-04-29
HUP0201463A3 (en) 2004-06-28
WO2001041760A2 (en) 2001-06-14
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NZ513960A (en) 2004-02-27
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KR20020045582A (ko) 2002-06-19
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