FR2751966B1 - Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique - Google Patents

Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique

Info

Publication number
FR2751966B1
FR2751966B1 FR9609741A FR9609741A FR2751966B1 FR 2751966 B1 FR2751966 B1 FR 2751966B1 FR 9609741 A FR9609741 A FR 9609741A FR 9609741 A FR9609741 A FR 9609741A FR 2751966 B1 FR2751966 B1 FR 2751966B1
Authority
FR
France
Prior art keywords
diarylindoles
derivatives
novel
therapeutic uses
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9609741A
Other languages
English (en)
Other versions
FR2751966A1 (fr
Inventor
Timur Gungor
Jean Marie Charles Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNION PHARMA SCIENT APPL
UPSA SAS
Original Assignee
UNION PHARMA SCIENT APPL
UPSA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNION PHARMA SCIENT APPL, UPSA SAS filed Critical UNION PHARMA SCIENT APPL
Priority to FR9609741A priority Critical patent/FR2751966B1/fr
Priority to US08/723,450 priority patent/US5723485A/en
Priority to EP97936720A priority patent/EP0915848A1/fr
Priority to AU39444/97A priority patent/AU729386B2/en
Priority to CA002261783A priority patent/CA2261783A1/fr
Priority to JP10507674A priority patent/JP2000515162A/ja
Priority to PCT/FR1997/001432 priority patent/WO1998005639A1/fr
Publication of FR2751966A1 publication Critical patent/FR2751966A1/fr
Application granted granted Critical
Publication of FR2751966B1 publication Critical patent/FR2751966B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
FR9609741A 1996-08-01 1996-08-01 Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique Expired - Fee Related FR2751966B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR9609741A FR2751966B1 (fr) 1996-08-01 1996-08-01 Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique
US08/723,450 US5723485A (en) 1996-08-01 1996-10-07 1,2-Diarylindole derivatives, processes for their preparation and their uses in therapeutics
AU39444/97A AU729386B2 (en) 1996-08-01 1997-07-31 1,2-diarylindole as cox-2 inhibitors
CA002261783A CA2261783A1 (fr) 1996-08-01 1997-07-31 1,2-diarylindole en tant qu'inhibiteurs cox-2
EP97936720A EP0915848A1 (fr) 1996-08-01 1997-07-31 1,2-diarylindoles en tant qu'inhibiteurs de cox-2
JP10507674A JP2000515162A (ja) 1996-08-01 1997-07-31 Ｃｏｘ―２阻害剤としての１，２―ジアリールインドール
PCT/FR1997/001432 WO1998005639A1 (fr) 1996-08-01 1997-07-31 1,2-diarylindoles en tant qu'inhibiteurs de cox-2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609741A FR2751966B1 (fr) 1996-08-01 1996-08-01 Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique

Publications (2)

Publication Number Publication Date
FR2751966A1 FR2751966A1 (fr) 1998-02-06
FR2751966B1 true FR2751966B1 (fr) 1998-10-30

Family

ID=9494743

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9609741A Expired - Fee Related FR2751966B1 (fr) 1996-08-01 1996-08-01 Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique

Country Status (7)

Country Link
US (1) US5723485A (fr)
EP (1) EP0915848A1 (fr)
JP (1) JP2000515162A (fr)
AU (1) AU729386B2 (fr)
CA (1) CA2261783A1 (fr)
FR (1) FR2751966B1 (fr)
WO (1) WO1998005639A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649645B1 (en) * 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
DE19951360A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
BR0008060A (pt) * 1999-12-08 2002-02-05 Pharmacia Corp Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica
US6353007B1 (en) * 2000-07-13 2002-03-05 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents
CA2414674A1 (fr) * 2000-07-13 2002-01-24 Pharmacia Corporation Utilisation d'inhibiteurs de cox-2 pour le traitement et la prevention de troubles oculaires a mediation cox-2
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
US6737550B2 (en) * 2001-06-13 2004-05-18 Biogal Gryogyszergyar Rt. Process for preparing rac-bicalutamide and its intermediates
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
ATE342722T1 (de) 2003-05-07 2006-11-15 Osteologix As Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
WO2005009993A1 (fr) * 2003-07-15 2005-02-03 Smithkline Beecham Corporation Nouveaux composes
AU2005294404A1 (en) * 2004-10-04 2006-04-20 Myriad Genetics, Inc. Compounds for Alzheimer's disease
DOP2006000016A (es) * 2005-01-26 2006-07-31 Aventis Pharma Inc 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2.
CN100543015C (zh) * 2005-10-28 2009-09-23 中国人民解放军军事医学科学院毒物药物研究所 环氧合酶-2选择性抑制剂及其医药用途
JP2010516679A (ja) * 2007-01-19 2010-05-20 マリンクロット インコーポレイテッド 診断用および治療用シクロオキシゲナーゼ−２結合リガンド
US7947723B2 (en) 2008-02-01 2011-05-24 Spelman College Synthesis and anti-proliferative effect of benzimidazole derivatives
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639567A1 (fr) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Derive d'indole
US5521213A (en) * 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5510368A (en) * 1995-05-22 1996-04-23 Merck Frosst Canada, Inc. N-benzyl-3-indoleacetic acids as antiinflammatory drugs

Also Published As

Publication number Publication date
US5723485A (en) 1998-03-03
FR2751966A1 (fr) 1998-02-06
EP0915848A1 (fr) 1999-05-19
AU729386B2 (en) 2001-02-01
AU3944497A (en) 1998-02-25
CA2261783A1 (fr) 1998-02-12
WO1998005639A1 (fr) 1998-02-12
JP2000515162A (ja) 2000-11-14

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Effective date: 20130430