NO934122D0 - Peptid-nukleinsyrer - Google Patents

Peptid-nukleinsyrer

Info

Publication number
NO934122D0
NO934122D0 NO934122A NO934122A NO934122D0 NO 934122 D0 NO934122 D0 NO 934122D0 NO 934122 A NO934122 A NO 934122A NO 934122 A NO934122 A NO 934122A NO 934122 D0 NO934122 D0 NO 934122D0
Authority
NO
Norway
Prior art keywords
nucleic acids
peptide nucleic
peptide
strongly
compounds
Prior art date
Application number
NO934122A
Other languages
English (en)
Other versions
NO934122L (no
NO312516B1 (no
Inventor
Ole Buchardt
Michael Egholm
Peter Eigil Nielsen
Rolf Henrik Berg
Original Assignee
Ole Buchardt
Michael Egholm
Peter Eigil Nielsen
Berg Rolf H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27220741&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO934122(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK98791A external-priority patent/DK98791D0/da
Priority claimed from DK98691A external-priority patent/DK98691D0/da
Application filed by Ole Buchardt, Michael Egholm, Peter Eigil Nielsen, Berg Rolf H filed Critical Ole Buchardt
Publication of NO934122D0 publication Critical patent/NO934122D0/no
Publication of NO934122L publication Critical patent/NO934122L/no
Publication of NO312516B1 publication Critical patent/NO312516B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO19934122A 1991-05-24 1993-11-15 Peptid-nukleinsyrer NO312516B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK98791A DK98791D0 (da) 1991-05-24 1991-05-24 Fremgangsmaade til sekvensspecifik genkendelse af et dobbeltstrenget polynucleotid
DK98691A DK98691D0 (da) 1991-05-24 1991-05-24 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
PCT/EP1992/001219 WO1992020702A1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids

Publications (3)

Publication Number Publication Date
NO934122D0 true NO934122D0 (no) 1993-11-15
NO934122L NO934122L (no) 1994-01-11
NO312516B1 NO312516B1 (no) 2002-05-21

Family

ID=27220741

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19934122A NO312516B1 (no) 1991-05-24 1993-11-15 Peptid-nukleinsyrer
NO19934235A NO313201B1 (no) 1991-05-24 1993-11-23 Nukleinsyreanalog, anvendelse derav, in vitro-fremgangsmåte og kit

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO19934235A NO313201B1 (no) 1991-05-24 1993-11-23 Nukleinsyreanalog, anvendelse derav, in vitro-fremgangsmåte og kit

Country Status (16)

Country Link
US (11) US6357163B1 (no)
EP (5) EP0586474B1 (no)
JP (6) JP2758988B2 (no)
KR (1) KR0133131B1 (no)
AT (3) ATE515569T1 (no)
AU (2) AU1884392A (no)
BR (1) BR9206049A (no)
CA (2) CA2109320C (no)
DE (2) DE69232055T2 (no)
DK (3) DK51092D0 (no)
ES (2) ES2107552T3 (no)
FI (1) FI118424B (no)
GR (1) GR3025018T3 (no)
HU (1) HU221003B1 (no)
NO (2) NO312516B1 (no)
WO (2) WO1992020703A1 (no)

Families Citing this family (359)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852182A (en) * 1990-01-11 1998-12-22 Isis Pharmaceuticals Inc. Thiol-derivatized oligonucleosides
US5783682A (en) * 1990-07-27 1998-07-21 Isis Pharmaceuticals, Inc. Oligonucleotide mimics having nitrogen-containing linkages
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US5766855A (en) * 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6451968B1 (en) * 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US6713602B1 (en) * 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US6414112B1 (en) 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
AU3250093A (en) 1991-12-12 1993-07-19 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
CA2126691C (en) * 1991-12-24 2003-05-06 Phillip Dan Cook Gapped 2' modified oligonucleotides
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US6033884A (en) * 1992-03-20 2000-03-07 Baylor College Of Medicine Nucleic acid transporter systems and methods of use
US6770738B1 (en) 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
GB9211979D0 (en) * 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US7825215B1 (en) 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
GB9311386D0 (en) * 1993-06-02 1993-07-21 Pna Diagnostics As Nucleic acid analogue assay procedures
AU7206794A (en) * 1993-06-11 1995-01-03 Isis Pharmaceuticals, Inc. Oligomers for modulating ras oncogene
AU7523794A (en) * 1993-08-09 1995-02-28 Isis Pharmaceuticals, Inc. Oligomers for modulating viral processes
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331011A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit C-Verzweigung für Therapie und Diagnostik
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
DE69425379T2 (de) * 1993-09-21 2000-11-30 Amersham Pharm Biotech Uk Ltd Elongation, amplifikation und sequenzierung unter verwendung eines chimären oligonucleotids
US6710164B1 (en) 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2285445A (en) * 1993-12-06 1995-07-12 Pna Diagnostics As Protecting nucleic acids and methods of analysis
GB2289677A (en) * 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
DE69430704T2 (de) * 1993-12-22 2003-01-30 Perseptive Biosystems Inc Guaninsynthone für die synthese von nucleinsäuren und verfahren zu deren herstellung
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (da) * 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
DE4408533A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
DE4408531A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
AU2369895A (en) * 1994-04-29 1995-11-29 Perseptive Biosystems, Inc. Activated esters of 1-phenylpyrazolin-5-one for labelling amine-functionalized molecules
AU2522095A (en) * 1994-05-19 1995-12-18 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
US5629152A (en) * 1994-08-01 1997-05-13 Isis Pharmaceuticals, Inc. Trisubstituted β-lactams and oligo β-lactamamides
DE4427980A1 (de) * 1994-08-08 1996-02-15 Bayer Ag Nukleinsäuren-bindende Oligomere für Therapie und Diagnostik
US6558633B1 (en) 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
JP3307945B2 (ja) * 1994-10-06 2002-07-29 アイシス・ファーマシューティカルス・インコーポレーテッド ペプチド核酸コンジュゲート
US5629178A (en) * 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
UA48150C2 (uk) * 1994-11-02 2002-08-15 Ай-Сі-Ен Фармасьютикалз Похідні амінокислот або аміноспиртів, олігонуклеотид
WO1996015143A1 (en) * 1994-11-14 1996-05-23 Chiron Corporation SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH
CA2207629A1 (en) * 1994-12-22 1996-06-27 Abbott Laboratories Methods of immobilizing oligonucleotides to solid support materials and methods of using support bound oligonucleotides
ATE201453T1 (de) * 1995-03-04 2001-06-15 Pna Diagnostics As Modulation von bindungseigenschaften der nukleinsäure bindungspartner
US6475721B2 (en) 1995-03-04 2002-11-05 Boston Probes, Inc. Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
EP0830368A1 (en) 1995-06-07 1998-03-25 Genta Incorporated Novel carbamate-based cationic lipids
JP2001518054A (ja) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド Ｐｎａ−ｄｎａキメラと、このキメラ合成用のｐｎａシントン
JPH11511642A (ja) * 1995-06-22 1999-10-12 ダコ アクティーゼルスカブ Ｐｎａ／核酸複合体に結合し得る組換え抗体
JPH11507202A (ja) * 1995-06-22 1999-06-29 ダコ アクティーゼルスカブ Ｐｎａ／核酸複合体に結合することができるモノクローナル抗体
GB9519299D0 (en) * 1995-09-21 1995-11-22 Farrar Gwyneth J Genetic strategy
EP1477572A3 (en) * 1995-10-06 2006-02-15 Perseptive Biosystems, Inc. Methods and kit for hybridization analysis using peptide nucleic acid probes
EP0854937B9 (en) * 1995-10-06 2006-06-28 Perseptive Biosystems, Inc. Methods and kit for hybridization analysis using peptide nucleic acid probes
ATE362546T1 (de) 1995-10-12 2007-06-15 Lansdorp Peter M Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
US5874532A (en) * 1997-01-08 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides and peptides
US6001966A (en) * 1995-10-19 1999-12-14 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
WO1997014793A1 (en) * 1995-10-20 1997-04-24 Trustees Of Boston University Nucleic acid clamps
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
EP0862650B1 (en) * 1995-11-16 2007-08-01 Dako Denmark A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
CA2190430A1 (en) * 1995-12-12 1997-06-13 Margret Barbara Basinski Method for measuring genetic messages
US6180767B1 (en) 1996-01-11 2001-01-30 Thomas Jefferson University Peptide nucleic acid conjugates
US20030069195A1 (en) * 1996-03-01 2003-04-10 Farrar Gwenyth Jane Suppression of polymorphic alleles
US6020126A (en) * 1996-03-21 2000-02-01 Hsc, Reasearch And Development Limited Partnership Rapid genetic screening method
WO1997036005A1 (en) * 1996-03-26 1997-10-02 Lynx Therapeutics, Inc. Oligonucleotide treatments and compositions for human melanoma
US20040234999A1 (en) * 1996-04-02 2004-11-25 Farrar Gwenyth Jane Genetic suppression and replacement
GB9606961D0 (en) 1996-04-02 1996-06-05 Farrar Gwyneth J Genetic strategy III
US8551970B2 (en) * 1996-04-02 2013-10-08 Optigen Patents Limited Genetic suppression and replacement
GB9608803D0 (en) * 1996-04-27 1996-07-03 Univ Newcastle Mitochondrial dna defects
SE506700C2 (sv) * 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US20040171030A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
US20050042647A1 (en) * 1996-06-06 2005-02-24 Baker Brenda F. Phosphorous-linked oligomeric compounds and their use in gene modulation
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20050032068A1 (en) * 2002-11-05 2005-02-10 Prakash Thazha P. Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20050118605A9 (en) * 1996-06-06 2005-06-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
AU717387B2 (en) * 1996-07-24 2000-03-23 Rolf H. Berg Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5858683A (en) * 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
DE19637339A1 (de) * 1996-09-13 1998-03-19 Hoechst Ag Verfahren zur Amplifikation von Nukleinsäuren
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US6444202B1 (en) 1996-11-25 2002-09-03 Bundesrepublic Deutschland, Vertreten Durch Den Bundesminister Fur Gesundheit Processed polypeptides with IL-16 activity, processes for their production and their use
AU6822598A (en) * 1997-02-24 1998-09-09 Georgia Tech Research Corporation Method for determining a nucleic acid
US6117973A (en) * 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US5932711A (en) * 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US6692912B1 (en) * 1997-03-05 2004-02-17 Matrix Technologies Corporation Nucleic acid-containing polymerizable complex
US6015887A (en) * 1997-04-11 2000-01-18 Isis Pharmaceuticals, Inc. Chiral peptide nucleic acids and methods for preparing same
SE522077C2 (sv) * 1997-09-05 2004-01-13 Lightup Technologies Ab Förfarande att välja sekvens hos sond för nukleinsyrahybridisering
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
CA2291839A1 (en) * 1997-05-28 1998-12-03 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
DE69831113T2 (de) * 1997-05-30 2006-05-24 Pna Diagnostics A/S 2- oder 3-dimensionale geometrische struktur aus peptidnukleinsäuren
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
WO1998058256A1 (en) * 1997-06-16 1998-12-23 The University Of North Carolina At Chapel Hill PEPTIDO OLIGONUCLEOTIDES (PONs) AND THEIR COMBINATORIAL LIBRARIES
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
EP0897991B1 (en) * 1997-08-22 2004-12-08 PNA Diagnostics ApS Small Triplex Forming PNA Oligos
US6300318B1 (en) 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
DE19741739B4 (de) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6723560B2 (en) 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6028183A (en) * 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
DE19816550A1 (de) 1997-12-24 1999-06-24 Roche Diagnostics Gmbh Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung
US6030997A (en) * 1998-01-21 2000-02-29 Eilat; Eran Acid labile prodrugs
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6361942B1 (en) * 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US20040063618A1 (en) * 2002-09-30 2004-04-01 Muthiah Manoharan Peptide nucleic acids having improved uptake and tissue distribution
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
DE19824900B4 (de) 1998-06-04 2006-05-04 Roche Diagnostics Gmbh DNA-Nachweis über einen Strangreassoziationskomplex
US6664045B1 (en) * 1998-06-18 2003-12-16 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
AU4965499A (en) 1998-07-09 2000-02-01 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
US6548651B1 (en) * 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
ATE314488T1 (de) * 1999-03-18 2006-01-15 Exiqon As Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben
US20020049173A1 (en) * 1999-03-26 2002-04-25 Bennett C. Frank Alteration of cellular behavior by antisense modulation of mRNA processing
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
DE19927783A1 (de) 1999-06-18 2000-12-21 Roche Diagnostics Gmbh Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts
AU6629200A (en) * 1999-08-25 2001-03-19 Philip P Garner Alpha-helical peptide nucleic acid alpha-pna
US6348583B1 (en) * 1999-08-30 2002-02-19 Bio-Rad Laboratories, Inc. Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
WO2001016149A2 (en) 1999-08-30 2001-03-08 Roche Diagnostics Gmbh 2-azapurine compounds and their use
CA2317179A1 (en) 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US6660845B1 (en) * 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
JP2003530146A (ja) 2000-02-10 2003-10-14 マサチューセッツ・アイ・アンド・イア・インファーマリー 眼の状態を処置するための光力学的治療
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
EP1263773A4 (en) 2000-03-14 2005-08-31 Active Motif OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF IMPLEMENTATION
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
US6936443B2 (en) 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
US20020155427A1 (en) 2000-04-03 2002-10-24 Cohenford Menashi A. Detection and typing of human papillomavirus using PNA probes
US7211381B1 (en) 2000-04-04 2007-05-01 Abbott Laboratories β2 andrenergic polymorphism detection
US6593092B2 (en) 2000-04-04 2003-07-15 Abbott Laboratories Beta 2 adrenergic polymorphism detection
DE10019136A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019135A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
CA2416631C (en) 2000-08-03 2011-11-22 F. Hoffmann-La Roche Ag Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
DE60143754D1 (de) 2000-08-08 2011-02-10 Technion Res And Dev Of Foundation Ltd Pharmazeutische zusammensetzungen und methoden nützlich zur behandlung von krebs oder leberfibrose
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
US7183394B1 (en) * 2000-08-11 2007-02-27 Garner Philip P Helical nucleopeptides
WO2002038738A2 (en) * 2000-11-09 2002-05-16 Cold Spring Harbor Laboratory Chimeric molecules to modulate gene expression
US7282575B2 (en) 2000-12-26 2007-10-16 Credia Japan Co., Ltd. Functional peptide nucleic acid monomer and process for producing the same
CA2436665C (en) 2001-01-29 2012-01-10 Bio-Rad Laboratories, Inc. Nucleic acid derivatives
GB0102388D0 (en) * 2001-01-31 2001-03-14 Secr Defence Polymers
EP1236804A1 (en) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh A method for determination of a nucleic acid using a control
CA2439750A1 (en) 2001-03-09 2002-09-19 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
EP1572868A4 (en) 2001-04-16 2007-04-04 Wyeth Corp NOVEL OPEN READING FRAMES OF STREPTOCOCCUS PNEUMONIAE ENCODING POLYPEPTIDE ANTIGENS AND USES THEREOF
EP1417333B1 (en) 2001-05-18 2011-10-05 Boston Probes, Inc. Pna probes, probe sets, methods and kits pertaining to the detection of candida
WO2002097134A2 (en) * 2001-05-25 2002-12-05 Isis Pharmaceuticals, Inc. Modified peptide nucleic acid
US7053195B1 (en) 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US20030129626A1 (en) 2001-09-24 2003-07-10 Nielsen Kirsten Vang Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
AU2002347981A1 (en) 2001-11-07 2003-05-19 Applera Corporation Universal nucleotides for nucleic acid analysis
JP2005517900A (ja) 2001-11-21 2005-06-16 アプレラ コーポレイション デジタルアッセイ
KR100464261B1 (ko) 2002-01-24 2005-01-03 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
WO2003065146A2 (en) 2002-01-25 2003-08-07 Applera Corporation Methods for placing, accepting, and filling orders for products and services
EP1487858A4 (en) * 2002-03-21 2006-01-04 Boston Probes Inc PNA OLIGOMERS, OLIGOMER SETS, PROCESSES AND KITS FOR DETECTION OF BACILLUS ANTHRACIS
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
US7052840B2 (en) 2002-04-03 2006-05-30 Capitol Genomix, Inc. Reversible association of nucleic acid with a carboxylated substrate
US7026120B2 (en) 2002-04-15 2006-04-11 Abbott Laboratories Probes for detecting tumor cells
KR20030084444A (ko) 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US7015317B2 (en) 2002-05-02 2006-03-21 Abbott Laboratories Polynucleotides for the detection and quantification of hepatitis B virus nucleic acids
EP1543150A2 (en) * 2002-05-17 2005-06-22 Applera Corporation Pna probes, probe sets, method and kits pertaining to the determination of listeria
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
ATE449103T1 (de) 2002-09-08 2009-12-15 Applera Corp Festphasengebundene pna-dimere und deren synthese
WO2005003291A2 (en) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
AU2003301353A1 (en) * 2002-10-18 2004-05-04 Cylene Pharmaceuticals Processes for identifying quadruplex-targeted antiviral molecules
WO2004041889A2 (en) * 2002-11-05 2004-05-21 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
WO2004044136A2 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2’-modified nucleosides for use in gene modulation
US9150606B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
WO2004048594A2 (en) 2002-11-21 2004-06-10 Epicentre Technologies Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US7736909B2 (en) 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
ATE515702T1 (de) * 2003-01-30 2011-07-15 Life Technologies Corp Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung
AU2003900609A0 (en) * 2003-02-11 2003-02-27 Antisense Therapeutics Ltd Modulation of insulin like growth factor i receptor expression
ES2400033T3 (es) * 2003-02-11 2013-04-05 Antisense Therapeutics Ltd Modulación de la expresión del receptor del factor de crecimiento I similar a la insulina
JP4255472B2 (ja) 2003-02-21 2009-04-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 変異遺伝子検出のためのシグナル増幅方法
EA009302B1 (ru) * 2003-05-20 2007-12-28 Инвестиген, Инк. Система обнаружения полинуклеотидов
WO2005012546A2 (en) * 2003-07-25 2005-02-10 Andreas Braun Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences
WO2005010181A1 (ja) * 2003-07-25 2005-02-03 Credia Japan Co., Ltd. 核酸検出方法
US20050063932A1 (en) * 2003-08-14 2005-03-24 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
CN1910289B (zh) 2004-01-07 2012-05-23 日立化成研究中心公司 用于检测hiv的引物和探针
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
WO2005098040A2 (en) 2004-03-24 2005-10-20 Applera Corporation Ligation and amplification reactions for determining target molecules
WO2005106031A1 (ja) 2004-04-28 2005-11-10 Eisai R & D Management Co., Ltd. ハイブリダイゼーション方法
US7306916B2 (en) * 2004-05-04 2007-12-11 Dako Denmark A/S Methods for detecting chromosome aberrations
JP2008501693A (ja) * 2004-06-03 2008-01-24 アイシス ファーマシューティカルズ、インク． 遺伝子調節で使用するための個別に調節された鎖を有する二本鎖組成物
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US20060057611A1 (en) 2004-06-30 2006-03-16 Applera Corporation Log-linear amplification
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US7306785B2 (en) * 2004-09-23 2007-12-11 General Electric Company Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
WO2007044031A2 (en) * 2004-12-06 2007-04-19 Bioveris Corporation Methods and compositions for detecting bacillus anthracis
KR20070093992A (ko) * 2004-12-11 2007-09-19 사이토제닉, 인크. 고품질 핵산의 무세포 생합성 및 그것의 사용
EP2208796B1 (en) 2005-01-06 2014-06-18 Applied Biosystems, LLC Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
WO2006110314A2 (en) 2005-03-25 2006-10-19 Ambion, Inc. Methods and compositions for depleting abundant rna transcripts
US7229769B2 (en) * 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
CA2610710C (en) 2005-06-02 2016-10-11 Advandx, Inc. Peptide nucleic acid probes for analysis of microorganisms
EP1893777B1 (en) 2005-06-07 2014-10-01 Luminex Corporation Methods for detection and typing of nucleic acids
EP1907592B1 (en) * 2005-07-01 2011-03-09 Dako Denmark A/S Monomeric and polymeric linkers useful for conjugating biological molecules and other substances
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
EP2010677A4 (en) * 2006-02-24 2010-04-14 Investigen Inc METHODS AND COMPOSITIONS FOR DETECTION OF POLYNUCLEOTIDES
JPWO2007108378A1 (ja) 2006-03-15 2009-08-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 シグナルプローブポリマーの形成方法
US10829803B2 (en) 2006-05-10 2020-11-10 Dxterity Diagnostics Incorporated Detection of nucleic acid targets using chemically reactive oligonucleotide probes
WO2007137300A2 (en) 2006-05-23 2007-11-29 Bellicum Pharmaceuticals, Inc. Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
CA2656529A1 (en) 2006-06-30 2008-01-10 Applera Corporation Methods of analyzing binding interactions
EP2484781B1 (en) 2006-08-01 2017-08-23 Applied Biosystems, LLC Detection of analytes and nucleic acids
US20080096193A1 (en) * 2006-10-24 2008-04-24 Charles Robert Bupp Methods and compositions for detecting polynucleotides
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
US8324359B1 (en) 2006-12-04 2012-12-04 Luminex Corporation Oxocarbonamide peptide nucleic acids and methods of using same
CN101657548B (zh) 2006-12-13 2012-10-10 卢米耐克斯公司 用于实时pcr多重分析的系统和方法
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
AU2007339793A1 (en) * 2006-12-29 2008-07-10 Applied Biosystems, Llc Systems and methods for detecting nucleic acids
US20080241838A1 (en) * 2006-12-29 2008-10-02 Applera Corporation, Applied Biosystems Group Methods and systems for detecting nucleic acids
US7803543B2 (en) 2007-01-19 2010-09-28 Chang Gung University Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both PCR clamp and sensor probe
WO2008103702A2 (en) * 2007-02-23 2008-08-28 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
ES2668619T3 (es) * 2007-02-23 2018-05-21 The Research Foundation Of State University Of New York Compuestos que se dirigen a ARN y procedimientos para prepararlos y usarlos
US9260476B2 (en) 2007-02-23 2016-02-16 The Research Foundation For The State University Of New York RNA targeting compounds and methods for making and using same
ES2659145T3 (es) 2007-04-13 2018-03-14 Abbott Molecular Inc. Secuencia de cebador y sonda para detectar Chlamydia trachomatis
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
EP3620465A1 (en) 2007-07-03 2020-03-11 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
AU2008299784B9 (en) 2007-08-02 2015-06-18 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
EP2202319A4 (en) 2007-10-24 2010-10-20 Eisai R&D Man Co Ltd NUCLEIC ACID PROBE AND PROCESS FOR PRODUCING POLYMER FOR PROBE
EP2213751A1 (en) 2007-10-31 2010-08-04 Eisai R&D Management Co., Ltd. Polymer for detection of target substance, and method for detection of target substance
EP2222851B1 (en) 2007-11-20 2017-06-28 Ionis Pharmaceuticals, Inc. Modulation of cd40 expression
US8017338B2 (en) 2007-11-20 2011-09-13 Life Technologies Corporation Reversible di-nucleotide terminator sequencing
EP2245049B1 (en) 2008-01-10 2015-05-20 Research Development Foundation Vaccines and diagnostics for the ehrlichioses
EP2620511B1 (en) 2008-01-17 2018-02-28 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes
KR101072899B1 (ko) * 2008-01-21 2011-10-17 주식회사 파나진 아미노산 스페이서가 결합된 펩티드 핵산의 합성 및 그의응용
EP2271772B1 (en) 2008-03-11 2014-07-16 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
KR20090098710A (ko) 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
CN107254513B (zh) 2008-05-27 2021-04-20 安捷伦科技有限公司 使用新的杂交缓冲液用于检测染色体畸变的组合物和方法
WO2009152336A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
WO2010027326A1 (en) 2008-09-03 2010-03-11 Nanyang Technological University Peptide nucleic acid monomers and oligomers
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US10138485B2 (en) 2008-09-22 2018-11-27 Rxi Pharmaceuticals Corporation Neutral nanotransporters
WO2010037124A1 (en) 2008-09-29 2010-04-01 The Trustees Of The University Of Pennsylvania Tumor vascular marker-targeted vaccines
EP2337860B1 (en) 2008-10-15 2016-05-25 AXOLABS GmbH Oligonucleotide detection method
AU2009313255B2 (en) 2008-11-07 2014-08-07 Research Development Foundation Compositions and methods for the inhibition of Cripto/GRP78 complex formation and signaling
US8715732B2 (en) * 2009-01-05 2014-05-06 Cornell University Nucleic acid hydrogel via rolling circle amplification
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
WO2010087994A2 (en) 2009-01-30 2010-08-05 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
US7964355B2 (en) 2009-02-17 2011-06-21 Investigen, Inc. Assays based on detection of photobleaching reaction products from dye catalytic complex
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
EP2765205B1 (en) 2009-04-01 2016-05-18 DxTerity Diagnostics Incorporated Chemical ligation dependent probe amplification (CLPA)
WO2010118243A2 (en) 2009-04-08 2010-10-14 Genentech, Inc. Use of il-27 antagonists to treat lupus
KR20120122869A (ko) 2009-06-02 2012-11-07 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 신경변성 질환을 갖는 대상에서 항체에 의해 인식되는 소분자의 확인법
CN102686728B (zh) 2009-06-29 2018-09-18 卢米耐克斯公司 具有发夹构象的嵌合引物及其使用方法
US8614081B2 (en) 2009-07-23 2013-12-24 Codexis, Inc. Nitrilase biocatalysts
DK2462230T3 (en) * 2009-08-03 2015-10-19 Recombinetics Inc METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION
US8512990B2 (en) 2009-08-21 2013-08-20 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
TW201124726A (en) 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
US20130040294A1 (en) 2009-12-02 2013-02-14 Steen H. Matthiesen Compositions and methods for performing hybridizations with no denaturation
ES2577017T3 (es) 2009-12-22 2016-07-12 Sequenom, Inc. Procedimientos y kits para identificar la aneuploidia
US9404160B2 (en) 2009-12-22 2016-08-02 Becton, Dickinson And Company Methods for the detection of microorganisms
EP2550000A4 (en) 2010-03-24 2014-03-26 Advirna Inc RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING
WO2011133931A1 (en) 2010-04-22 2011-10-27 Genentech, Inc. Use of il-27 antagonists for treating inflammatory bowel disease
MX2017015093A (es) 2011-01-11 2023-03-10 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
US11078525B2 (en) 2011-03-29 2021-08-03 Seegene, Inc. Detection of target nucleic acid sequence by PTO cleavage and extension-dependent cleavage
CA2832553A1 (en) 2011-04-08 2012-10-11 Srinivas RAPIREDDY Conformationally-preorganized, minipeg-containing gamma-peptide nucleic acids
US8460872B2 (en) 2011-04-29 2013-06-11 Sequenom, Inc. Quantification of a minority nucleic acid species
MX342067B (es) 2011-05-04 2016-09-09 Seegene Inc Detección de secuencias de ácido nucleico objetivo por desdoblamiento e hibridización de oligonucleótido de sonda.
CN106434871B (zh) 2011-05-17 2020-08-18 德克斯特里蒂诊断公司 用于检测目标核酸的方法与组合物
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
GB201117482D0 (en) 2011-10-11 2011-11-23 Univ Dundee Targetiing of miRNA precursors
US11118226B2 (en) 2011-10-21 2021-09-14 Agilent Technologies, Inc. Hybridization compositions and methods
EP2594942A1 (en) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Long rigid spacers to enhance binding kinetics in immunoassays
WO2013085026A1 (ja) 2011-12-09 2013-06-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 塩基変異の検出方法及び検出用キット
EP2820129A1 (en) 2012-03-02 2015-01-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2669244T3 (es) 2012-03-05 2018-05-24 Seegene, Inc. Detección de variación de nucleótidos en una secuencia de ácido nucleico diana mediante escisión CTO y ensayo de extensión
US20150299788A1 (en) 2012-05-15 2015-10-22 Eisai R&D Management Co., Ltd. Rna detection method and detection kit
JP2015519899A (ja) 2012-05-21 2015-07-16 ザ スクリプス リサーチ インスティテュート リボソームポリヌクレオチドおよび関連する発現系
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
AU2013290102B2 (en) 2012-07-13 2018-11-15 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014033314A1 (en) 2012-09-03 2014-03-06 Uab Bioseka Antisense oligonucleotide targeting bacterial glucosyltransferases
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
EP2929050A1 (en) 2012-12-10 2015-10-14 AdvanDx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
ES2662825T3 (es) 2013-02-25 2018-04-09 Seegene, Inc. Detección de variación de nucleótido en una secuencia de ácidos nucleicos diana
US9289502B2 (en) 2013-03-08 2016-03-22 Emerald Therapeutics, Inc. Preparation of oligo conjugates
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
WO2014142575A1 (en) 2013-03-13 2014-09-18 Seegene, Inc. Quantification of target nucleic acid using melting peak analysis
CN105026580A (zh) 2013-03-15 2015-11-04 雅培分子公司 重亚硫酸盐转化的核苷酸序列的检测
US9347095B2 (en) 2013-03-15 2016-05-24 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
WO2014169206A2 (en) 2013-04-11 2014-10-16 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
WO2014169216A2 (en) 2013-04-11 2014-10-16 Carnegie Mellon University TEMPLATE-DIRECTED γPNA SYNTHESIS AND γPNA TARGETING COMPOUNDS
CA2912765C (en) 2013-07-12 2018-05-01 Emd Millipore Corporation A method of determining virus removal from a sample containing a target protein using activated carbon
WO2015008985A1 (en) 2013-07-15 2015-01-22 Seegene, Inc. Detection of target nucleic acid sequence by pto cleavage and extension-dependent immobilized oligonucleotide hybridization
LT6214B (lt) 2013-10-07 2015-08-25 Uab "Bioseka" Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai
JP2016537965A (ja) 2013-10-11 2016-12-08 ジェネンテック， インコーポレイテッド Ｎｓｐ４阻害剤及び使用方法
EP3057693A4 (en) 2013-10-16 2017-08-09 The University Of British Columbia Device for formulating particles at small volumes
WO2015057008A2 (en) 2013-10-18 2015-04-23 Seegene, Inc. Detection of target nucleic acid sequence on solid phase by pto cleavage and extension using hcto assay
CA2929555A1 (en) 2013-11-08 2015-05-14 Baylor Research Institute Nuclear localization of glp-1 stimulates myocardial regeneration and reverses heart failure
BR112016017152A2 (pt) 2014-01-28 2017-08-08 Dice Molecules Sv Llc Monólitos com compostos de reconhecimento fixados, matrizes dos mesmos e usos dos mesmos
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015172058A1 (en) 2014-05-08 2015-11-12 Carnegie Mellon University Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
CN106879252B (zh) 2014-06-10 2020-07-17 德克斯特里蒂诊断公司 用于收集和稳定生物样品的装置及方法
WO2015200377A1 (en) 2014-06-24 2015-12-30 Abbott Molecular Inc. Detection of single nucleotide polymorphisms in human kras
US10072306B2 (en) 2014-07-24 2018-09-11 Abbott Molecular Inc. Compositions and methods for the detection and analysis of mycobacterium tuberculosis
EP3183367B1 (en) 2014-08-19 2019-06-26 Pacific Biosciences Of California, Inc. Compositions and methods for enrichment of nucleic acids
WO2016134293A1 (en) 2015-02-20 2016-08-25 Baylor College Of Medicine p63 INACTIVATION FOR THE TREATMENT OF HEART FAILURE
AU2016276981B2 (en) 2015-06-12 2022-10-06 Alector Llc Anti-CD33 antibodies and methods of use thereof
JP2018518491A (ja) 2015-06-12 2018-07-12 アレクトル エルエルシー 抗ｃｄ３３抗体及びその使用方法
CN108184327A (zh) 2015-07-14 2018-06-19 雅培分子公司 用于鉴定耐药性结核的组合物和方法
CA2996059A1 (en) 2015-08-28 2017-03-09 Alector Llc Anti-siglec-7 antibodies and methods of use thereof
JP6937294B2 (ja) 2015-09-16 2021-09-22 ぺタオミクス， インコーポレイテッド ゲノムターゲットエンリッチメント及び選択的ｄｎａシーケンシングのための方法及び組成物
WO2017066643A1 (en) 2015-10-14 2017-04-20 Bio-Path Holding, Inc. P-ethoxy nucleic acids for liposomal formulation
KR20180084782A (ko) 2015-10-14 2018-07-25 엑스-써마 인코포레이티드 얼음 결정 형성을 감소시키기 위한 조성물 및 방법
WO2017075432A2 (en) 2015-10-29 2017-05-04 Alector Llc Anti-siglec-9 antibodies and methods of use thereof
EP3400097B1 (en) 2016-01-06 2021-01-27 The University Of British Columbia Bifurcating mixers and methods of their use and manufacture
US20190177391A1 (en) 2016-03-31 2019-06-13 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
US10400274B2 (en) 2016-06-18 2019-09-03 Jan Biotech, Inc. Fluorogenic probes and their use in quantitative detection of target RNA sequences
WO2018013924A1 (en) 2016-07-15 2018-01-18 Massachusetts Institute Of Technology Synthetic nanoparticles for delivery of immunomodulatory compounds
MX2019003070A (es) 2016-09-16 2019-10-14 Bio Path Holdings Inc Terapia de combinacion con oligonucleotidos antisentido liposomales.
CN109923105A (zh) 2016-09-26 2019-06-21 卡耐基梅隆大学 二价核碱基化合物及其用途
US11147249B2 (en) 2016-12-08 2021-10-19 Alector Llc Siglec transgenic mice and methods of use thereof
US11359014B2 (en) 2017-05-16 2022-06-14 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
EP3589658A1 (en) 2017-08-03 2020-01-08 Alector LLC Anti-cd33 antibodies and methods of use thereof
KR102380264B1 (ko) 2017-08-31 2022-03-29 주식회사 씨젠 다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가
KR102345601B1 (ko) 2017-09-29 2021-12-30 주식회사 씨젠 Pto 절단 및 연장-의존적 연장 분석에 의한 타겟 핵산 서열의 검출
US11470827B2 (en) 2017-12-12 2022-10-18 Alector Llc Transgenic mice expressing human TREM proteins and methods of use thereof
CA3086479A1 (en) * 2017-12-21 2019-06-27 Carnegie Mellon University Template-directed nucleic acid targeting compounds
WO2020023920A1 (en) 2018-07-27 2020-01-30 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
AU2019342197A1 (en) 2018-09-21 2021-04-15 President And Fellows Of Harvard College Methods and compositions for treating diabetes, and methods for enriching mRNA coding for secreted proteins
US20220251567A1 (en) 2019-07-10 2022-08-11 Inserm (Institut National De La Santè Et De La Recherche Médicale) Methods for the treatment of epilepsy
US20230016983A1 (en) 2019-11-19 2023-01-19 lNSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Antisense oligonucleotides and thier use for the treatment of cancer
US20210381039A1 (en) 2020-05-29 2021-12-09 Front Range Biosciences, Inc. Methods and compositions for pathogen detection in plants
WO2022006019A1 (en) 2020-06-29 2022-01-06 Front Range Biosciences, Inc. Characterization of cannabis cultivars based on terpene synthase gene profiles
EP4179091A1 (en) 2020-07-10 2023-05-17 Institut National De La Sante Et De La Recherche Medicale - Inserm Methods and compositions for treating epilepsy
CA3218220A1 (en) * 2021-05-11 2022-11-17 Russell Lewis Mccurdy Replaceable floating attractant accessories for fishing line
WO2023043280A1 (ko) 2021-09-17 2023-03-23 주식회사 씨젠 합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출
CN114409890A (zh) * 2022-02-28 2022-04-29 中国科学院长春应用化学研究所 一种氨基功能化的聚乙二醇衍生物及其制备方法
WO2024017990A1 (en) 2022-07-21 2024-01-25 Institut National de la Santé et de la Recherche Médicale Methods and compositions for treating chronic pain disorders

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2910130A1 (de) 1979-03-15 1980-09-25 Franz Rossmoeller Verbesserte befestigungsvorrichtung zum aufhaengen von paneelen und moebelelementen
DE2910129C2 (de) 1979-03-15 1986-01-23 Oskar 4354 Datteln Fleck Leiste zum Abdichten des Zwischenraums zwischen der Trauflatte eines Daches und den darüberliegenden traufseitigen Dacheindeckungsplatten
JPS5927900A (ja) 1982-08-09 1984-02-14 Wakunaga Seiyaku Kk 固定化オリゴヌクレオチド
ATE81872T1 (de) * 1985-03-15 1992-11-15 James Summerton Stereoregulare polynukleotiden bindende polymere.
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
WO1989003849A1 (en) 1987-10-28 1989-05-05 Howard Florey Institute Of Experimental Physiology Oligonucleotide-polyamide conjugates
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
DE68914843T2 (de) 1988-09-01 1994-11-10 Risoe Forskningscenter Peptid-synthese und fester träger zur verwendung dabei.
JPH02156895A (ja) * 1988-12-08 1990-06-15 Sumitomo Heavy Ind Ltd 好塩菌による５’‐ヌクレオチド類の製造法
JPH0635469B2 (ja) * 1989-09-13 1994-05-11 信 高橋 ジエチレントリアミン三酢酸化合物及びその製造中間体並びにそれらの製造法
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US6451968B1 (en) * 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US6414112B1 (en) * 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
MX9207334A (es) 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
US6770738B1 (en) * 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
WO1993024507A1 (en) * 1992-05-28 1993-12-09 Gilead Sciences, Inc. Conformationally restrained oligomers containing amide or carbamate linkages for sequence-specific binding
US5705333A (en) * 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US6472209B1 (en) * 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response

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