ATE205504T1 - Peptidnukleinsäuren - Google Patents

Peptidnukleinsäuren

Info

Publication number
ATE205504T1
ATE205504T1 AT92911165T AT92911165T ATE205504T1 AT E205504 T1 ATE205504 T1 AT E205504T1 AT 92911165 T AT92911165 T AT 92911165T AT 92911165 T AT92911165 T AT 92911165T AT E205504 T1 ATE205504 T1 AT E205504T1
Authority
AT
Austria
Prior art keywords
nucleic acids
peptide nucleic
peptide
strongly
compounds
Prior art date
Application number
AT92911165T
Other languages
English (en)
Inventor
Ole Buchardt
Michael Egholm
Peter Eigil Prof Dr Nielsen
Rolf Hendrik Berg
Original Assignee
Ole Buchardt
Michael Egholm
Peter Eigil Prof Dr Nielsen
Rolf Hendrik Berg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27220741&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE205504(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK98691A external-priority patent/DK98691D0/da
Priority claimed from DK98791A external-priority patent/DK98791D0/da
Application filed by Ole Buchardt, Michael Egholm, Peter Eigil Prof Dr Nielsen, Rolf Hendrik Berg filed Critical Ole Buchardt
Application granted granted Critical
Publication of ATE205504T1 publication Critical patent/ATE205504T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT92911165T 1991-05-24 1992-05-22 Peptidnukleinsäuren ATE205504T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK98691A DK98691D0 (da) 1991-05-24 1991-05-24 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
DK98791A DK98791D0 (da) 1991-05-24 1991-05-24 Fremgangsmaade til sekvensspecifik genkendelse af et dobbeltstrenget polynucleotid
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
PCT/EP1992/001219 WO1992020702A1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids

Publications (1)

Publication Number Publication Date
ATE205504T1 true ATE205504T1 (de) 2001-09-15

Family

ID=27220741

Family Applications (3)

Application Number Title Priority Date Filing Date
AT00203148T ATE515569T1 (de) 1991-05-24 1992-05-22 Peptidnucleinsäuren
AT92923579T ATE155483T1 (de) 1991-05-24 1992-05-22 Verwendung von nukleinsäureanaloga in diagnostischen und analytischen verfahren
AT92911165T ATE205504T1 (de) 1991-05-24 1992-05-22 Peptidnukleinsäuren

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT00203148T ATE515569T1 (de) 1991-05-24 1992-05-22 Peptidnucleinsäuren
AT92923579T ATE155483T1 (de) 1991-05-24 1992-05-22 Verwendung von nukleinsäureanaloga in diagnostischen und analytischen verfahren

Country Status (16)

Country Link
US (11) US6357163B1 (de)
EP (5) EP0586618B1 (de)
JP (6) JP3982828B2 (de)
KR (1) KR0133131B1 (de)
AT (3) ATE515569T1 (de)
AU (2) AU666480B2 (de)
BR (1) BR9206049A (de)
CA (2) CA2109320C (de)
DE (2) DE69232055T2 (de)
DK (3) DK51092D0 (de)
ES (2) ES2164052T3 (de)
FI (1) FI118424B (de)
GR (1) GR3025018T3 (de)
HU (1) HU221003B1 (de)
NO (2) NO312516B1 (de)
WO (2) WO1992020703A1 (de)

Families Citing this family (374)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852182A (en) * 1990-01-11 1998-12-22 Isis Pharmaceuticals Inc. Thiol-derivatized oligonucleosides
US5783682A (en) * 1990-07-27 1998-07-21 Isis Pharmaceuticals, Inc. Oligonucleotide mimics having nitrogen-containing linkages
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US7223833B1 (en) * 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5766855A (en) * 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US6713602B1 (en) * 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US6451968B1 (en) * 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US6414112B1 (en) 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
AU3250093A (en) 1991-12-12 1993-07-19 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
EP1044987B1 (de) * 1991-12-24 2006-02-15 Isis Pharmaceuticals, Inc. Unterbrochene 2'-modifizierte Oligonukleotide
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US6033884A (en) * 1992-03-20 2000-03-07 Baylor College Of Medicine Nucleic acid transporter systems and methods of use
US6770738B1 (en) 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
GB9211979D0 (en) * 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
WO1998053801A1 (en) * 1997-05-28 1998-12-03 Isis Pharmaceuticals, Inc. Conjugated peptide nucleic acids having enhanced cellular uptake
US7825215B1 (en) 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
GB9311386D0 (en) * 1993-06-02 1993-07-21 Pna Diagnostics As Nucleic acid analogue assay procedures
WO1994028720A1 (en) * 1993-06-11 1994-12-22 Isis Pharmaceuticals, Inc. Oligomers for modulating ras oncogene
WO1995004748A1 (en) * 1993-08-09 1995-02-16 Isis Pharmaceuticals, Inc. Oligomers for modulating viral processes
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331011A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit C-Verzweigung für Therapie und Diagnostik
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
EP0720615B1 (de) * 1993-09-21 2000-07-26 Amersham Pharmacia Biotech UK Limited Elongation, amplifikation und sequenzierung unter verwendung eines chimären oligonucleotids
US6710164B1 (en) * 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2289677A (en) * 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
GB2285445A (en) * 1993-12-06 1995-07-12 Pna Diagnostics As Protecting nucleic acids and methods of analysis
EP0736027B1 (de) * 1993-12-22 2002-05-29 Perseptive Biosystems, Inc. Guaninsynthone für die synthese von nucleinsäuren und verfahren zu deren herstellung
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (da) * 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
DE4408533A1 (de) 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
DE4408531A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe
AU2369895A (en) * 1994-04-29 1995-11-29 Perseptive Biosystems, Inc. Activated esters of 1-phenylpyrazolin-5-one for labelling amine-functionalized molecules
US6169169B1 (en) 1994-05-19 2001-01-02 Dako A/S PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis
US5629152A (en) * 1994-08-01 1997-05-13 Isis Pharmaceuticals, Inc. Trisubstituted β-lactams and oligo β-lactamamides
DE4427980A1 (de) * 1994-08-08 1996-02-15 Bayer Ag Nukleinsäuren-bindende Oligomere für Therapie und Diagnostik
US6558633B1 (en) * 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
DE69527857T2 (de) * 1994-10-06 2003-05-28 Buchardt, Dorte Peptid-nukleinsäure-konjugate
US5629178A (en) * 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
UA48150C2 (uk) * 1994-11-02 2002-08-15 Ай-Сі-Ен Фармасьютикалз Похідні амінокислот або аміноспиртів, олігонуклеотид
WO1996015143A1 (en) * 1994-11-14 1996-05-23 Chiron Corporation SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH
EP0795032A2 (de) * 1994-12-22 1997-09-17 Abbott Laboratories Verfahren zur immobilisierung von oligonukleotiden auf festen trägermaterial und verfahren zur anwendung träger gebundener oligonukleotiden
US6475721B2 (en) * 1995-03-04 2002-11-05 Boston Probes, Inc. Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes
DK0815259T3 (da) * 1995-03-04 2001-09-17 Pna Diagnostics As Modulation af nucleinsyre-bindingspartneres bindingsegenskaber
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
CA2223088A1 (en) 1995-06-07 1996-12-19 Bob Dale Brown Novel carbamate-based cationic lipids
JP2001518054A (ja) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド Ｐｎａ−ｄｎａキメラと、このキメラ合成用のｐｎａシントン
EP0837884A2 (de) * 1995-06-22 1998-04-29 Dako A/S Rekombinanter antikörper der fähig ist an pna/nukleinsäure-komplexen zu binden
EP0840751A1 (de) * 1995-06-22 1998-05-13 Dako A/S Monoklonaler antikörper der fähig ist, an pna/nukleinsäurekomplexen zu binden
GB9519299D0 (en) * 1995-09-21 1995-11-22 Farrar Gwyneth J Genetic strategy
WO1997012995A1 (en) * 1995-10-06 1997-04-10 Perseptive Biosystems, Inc. Methods and kit for hybridization analysis using peptide nucleic acid probes
EP1477572A3 (de) * 1995-10-06 2006-02-15 Perseptive Biosystems, Inc. Verfahren und Testsystem zur Hybridisierungsanalyse unter Verwendung von Peptidnukleinsäure-sonden
ATE362546T1 (de) 1995-10-12 2007-06-15 Lansdorp Peter M Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
US6001966A (en) * 1995-10-19 1999-12-14 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
US5874532A (en) 1997-01-08 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides and peptides
WO1997014793A1 (en) * 1995-10-20 1997-04-24 Trustees Of Boston University Nucleic acid clamps
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
WO1997018325A1 (en) * 1995-11-16 1997-05-22 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
CA2190430A1 (en) * 1995-12-12 1997-06-13 Margret Barbara Basinski Method for measuring genetic messages
US6180767B1 (en) 1996-01-11 2001-01-30 Thomas Jefferson University Peptide nucleic acid conjugates
US20030069195A1 (en) * 1996-03-01 2003-04-10 Farrar Gwenyth Jane Suppression of polymorphic alleles
US6020126A (en) * 1996-03-21 2000-02-01 Hsc, Reasearch And Development Limited Partnership Rapid genetic screening method
WO1997036005A1 (en) * 1996-03-26 1997-10-02 Lynx Therapeutics, Inc. Oligonucleotide treatments and compositions for human melanoma
US20040234999A1 (en) * 1996-04-02 2004-11-25 Farrar Gwenyth Jane Genetic suppression and replacement
US8551970B2 (en) * 1996-04-02 2013-10-08 Optigen Patents Limited Genetic suppression and replacement
GB9606961D0 (en) 1996-04-02 1996-06-05 Farrar Gwyneth J Genetic strategy III
GB9608803D0 (en) * 1996-04-27 1996-07-03 Univ Newcastle Mitochondrial dna defects
SE506700C2 (sv) * 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US20050118605A9 (en) * 1996-06-06 2005-06-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20040171030A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
US20050032068A1 (en) * 2002-11-05 2005-02-10 Prakash Thazha P. Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US20050042647A1 (en) * 1996-06-06 2005-02-24 Baker Brenda F. Phosphorous-linked oligomeric compounds and their use in gene modulation
JP3306073B2 (ja) * 1996-07-24 2002-07-24 ブヒャルト，ドルテ 増加した結合親和性、配列特異性および溶解性を有するペプチド核酸
US5858683A (en) 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
DE19637339A1 (de) * 1996-09-13 1998-03-19 Hoechst Ag Verfahren zur Amplifikation von Nukleinsäuren
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US6444202B1 (en) 1996-11-25 2002-09-03 Bundesrepublic Deutschland, Vertreten Durch Den Bundesminister Fur Gesundheit Processed polypeptides with IL-16 activity, processes for their production and their use
US6117973A (en) * 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
ATE279534T1 (de) * 1997-02-24 2004-10-15 Georgia Tech Res Inst Verfahren zur bestimmung einer nukleinsäure
US6692912B1 (en) * 1997-03-05 2004-02-17 Matrix Technologies Corporation Nucleic acid-containing polymerizable complex
US5932711A (en) * 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US6015887A (en) * 1997-04-11 2000-01-18 Isis Pharmaceuticals, Inc. Chiral peptide nucleic acids and methods for preparing same
SE522077C2 (sv) * 1997-09-05 2004-01-13 Lightup Technologies Ab Förfarande att välja sekvens hos sond för nukleinsyrahybridisering
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
DE69831113T2 (de) * 1997-05-30 2006-05-24 Pna Diagnostics A/S 2- oder 3-dimensionale geometrische struktur aus peptidnukleinsäuren
AU8147798A (en) * 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
DK0897991T3 (da) * 1997-08-22 2005-07-25 Pna Diagnostics Aps Små triplexdannende PNA-oligoer
US6300318B1 (en) 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
DE19741739B4 (de) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
US6723560B2 (en) 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6028183A (en) * 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
DE19816550A1 (de) 1997-12-24 1999-06-24 Roche Diagnostics Gmbh Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung
US6030997A (en) * 1998-01-21 2000-02-29 Eilat; Eran Acid labile prodrugs
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6361942B1 (en) * 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US20040063618A1 (en) * 2002-09-30 2004-04-01 Muthiah Manoharan Peptide nucleic acids having improved uptake and tissue distribution
DE19824900B4 (de) 1998-06-04 2006-05-04 Roche Diagnostics Gmbh DNA-Nachweis über einen Strangreassoziationskomplex
US6664045B1 (en) * 1998-06-18 2003-12-16 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
ATE343586T1 (de) 1998-07-09 2006-11-15 Biocept Inc Verfahren zur verwendung einer universellen bibliothek von peptid-nukleinsäuren zur optimierung der dns-hybridisierung
US6548651B1 (en) 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
JP4975905B2 (ja) 1999-03-18 2012-07-11 エクシコン エ／エス 複合生物試料における核酸の単工程調製及び検出
US20020049173A1 (en) * 1999-03-26 2002-04-25 Bennett C. Frank Alteration of cellular behavior by antisense modulation of mRNA processing
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
DE19927783A1 (de) * 1999-06-18 2000-12-21 Roche Diagnostics Gmbh Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts
AU6629200A (en) * 1999-08-25 2001-03-19 Philip P Garner Alpha-helical peptide nucleic acid alpha-pna
US6348583B1 (en) * 1999-08-30 2002-02-19 Bio-Rad Laboratories, Inc. Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
WO2001016149A2 (en) 1999-08-30 2001-03-08 Roche Diagnostics Gmbh 2-azapurine compounds and their use
US6994964B1 (en) 1999-09-01 2006-02-07 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US6660845B1 (en) 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
CA2714081C (en) 2000-02-10 2013-08-06 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
AU2001247414A1 (en) 2000-03-14 2001-09-24 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
ATE456668T1 (de) 2000-04-03 2010-02-15 Cytyc Corp Nachweis und typisierung des papillomavirus mittels pna-sonden
US6936443B2 (en) 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
US7211381B1 (en) 2000-04-04 2007-05-01 Abbott Laboratories β2 andrenergic polymorphism detection
US6593092B2 (en) 2000-04-04 2003-07-15 Abbott Laboratories Beta 2 adrenergic polymorphism detection
DE10019135A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019136A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
AU2001278517A1 (en) 2000-08-03 2002-02-18 F. Hoffman-La Roche Ag Nucleic acid binding compounds containing pyrazolo(3,4-d)pyrimidine analogues of purin-2,6-diamine and their uses
ES2437093T3 (es) 2000-08-08 2014-01-08 Technion Research And Development Foundation, Ltd. Composiciones farmacéuticas y procedimientos útiles para modular la angiogénesis
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
US7183394B1 (en) * 2000-08-11 2007-02-27 Garner Philip P Helical nucleopeptides
WO2002038738A2 (en) * 2000-11-09 2002-05-16 Cold Spring Harbor Laboratory Chimeric molecules to modulate gene expression
WO2002051797A1 (en) * 2000-12-26 2002-07-04 Applied Biosystems Japan Ltd Novel functional peptide nucleic acid monomer and process for producing the same
DE60236144D1 (de) 2001-01-29 2010-06-10 Bio Rad Laboratories Nukleinsäurederivative
GB0102388D0 (en) * 2001-01-31 2001-03-14 Secr Defence Polymers
EP1236804A1 (de) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Nukleinsäuren mittels einer Kontrolle
DE60216468T2 (de) 2001-03-09 2007-09-27 Boston Probes, Inc., Bedford Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
MXPA03009415A (es) 2001-04-16 2004-01-29 Wyeth Corp ESTRUCTURAS NOVEDOSAS DE LECTURA ABIERTA DE STREPTOCOCCUS PNEUMONIAE QUE CODIFICAN ANTIGENOS DE POLIPePTIDOS Y USOS DE LAS MISMAS.
AU2002257284A1 (en) 2001-05-18 2002-12-03 Boston Probes, Inc. Pna probes, probe sets, methods and kits pertaining to the detection of candida
WO2002097134A2 (en) * 2001-05-25 2002-12-05 Isis Pharmaceuticals, Inc. Modified peptide nucleic acid
US7053195B1 (en) 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
EP1925672A1 (de) 2001-06-22 2008-05-28 Syngeta Participations AG Auf abiotischen Stress ansprechende Polynukleotide und Polypeptide
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
WO2003027328A2 (en) * 2001-09-24 2003-04-03 Boston Probes, Inc. Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
JP2005508196A (ja) 2001-11-07 2005-03-31 アプレラ コーポレイション 核酸分析の汎用ヌクレオチド
EP1448800A4 (de) 2001-11-21 2007-05-16 Applera Corp Digitaler assay
US7255874B1 (en) 2001-12-21 2007-08-14 Closure Medical Corporation Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
KR100464261B1 (ko) 2002-01-24 2005-01-03 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
JP2005516300A (ja) 2002-01-25 2005-06-02 アプレラ コーポレイション 製品およびサービスに対する注文を発注し、受理し、および充足する方法
AU2003230717A1 (en) * 2002-03-21 2003-10-08 Boston Probes, Inc. Pna oligomers, oligomers sets, methods and kits pertaining to the detection of bacillus anthracis
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
US7052840B2 (en) 2002-04-03 2006-05-30 Capitol Genomix, Inc. Reversible association of nucleic acid with a carboxylated substrate
US7026120B2 (en) 2002-04-15 2006-04-11 Abbott Laboratories Probes for detecting tumor cells
KR20030084444A (ko) 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US7015317B2 (en) 2002-05-02 2006-03-21 Abbott Laboratories Polynucleotides for the detection and quantification of hepatitis B virus nucleic acids
JP2006507798A (ja) * 2002-05-17 2006-03-09 アプレラ　コーポレイション Ｌｉｓｔｅｒｉａの決定に関するＰＮＡプローブ、プローブセット、方法およびキット
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
WO2004022578A2 (en) * 2002-09-08 2004-03-18 Applera Corporation Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
CA2502610A1 (en) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
AU2003301353A1 (en) * 2002-10-18 2004-05-04 Cylene Pharmaceuticals Processes for identifying quadruplex-targeted antiviral molecules
AU2003295387A1 (en) * 2002-11-05 2004-06-03 Isis Parmaceuticals, Inc. Modified oligonucleotides for use in rna interference
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
EP1562971B1 (de) * 2002-11-05 2014-02-12 Isis Pharmaceuticals, Inc. Polyzyklischen zuckerersatz beinhaltende oligomere verbindungen und zusammensetzungen zur verwendung bei der genmodulation
US9150606B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
EP1576188B1 (de) * 2002-11-21 2008-10-15 Epicentre Technologies Verfahren zur verwendung von riboprimern zur strangverdrängungsreplikation von zielsequenzen
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
US7736909B2 (en) 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
EP1588145B1 (de) 2003-01-30 2011-07-06 Life Technologies Corporation Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung
US20040171149A1 (en) * 2003-02-11 2004-09-02 Wraight Christopher J. Modulation of insulin like growth factor I receptor expression
NZ541637A (en) * 2003-02-11 2008-07-31 Antisense Therapeutics Pty Ltd Modulation of insulin like growth factor I receptor
EP1595953B1 (de) 2003-02-21 2012-04-04 Eisai R&D Management Co., Ltd. Signalverstärkungsverfahren zum nachweis eines mutanten gens
GB2422196B (en) * 2003-05-20 2008-05-07 Investigen Inc System for detecting polynucleotides
WO2005012546A2 (en) * 2003-07-25 2005-02-10 Andreas Braun Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences
JPWO2005010181A1 (ja) * 2003-07-25 2007-09-27 株式会社クレディアジャパン 核酸検出方法
WO2005016364A1 (en) * 2003-08-14 2005-02-24 Guthy-Renker Corporation Skin care composition including hexapeptide complexes and methods of their manufacture
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
CN1910289B (zh) 2004-01-07 2012-05-23 日立化成研究中心公司 用于检测hiv的引物和探针
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
ATE431433T1 (de) 2004-03-24 2009-05-15 Applied Biosystems Llc Ligation und amplifikationsreaktionen zur bestimmung von zielmolekülen
DE602005023002D1 (de) 2004-04-28 2010-09-30 Eisai R&D Man Co Ltd Hybridisierungsverfahren
WO2005111235A2 (en) * 2004-05-04 2005-11-24 Dak Denmark A/S Methods for detecting chromosome aberrations
CA2569419A1 (en) * 2004-06-03 2005-12-22 Isis Pharmaceuticals, Inc. Double strand compositions comprising differentially modified strands for use in gene modulation
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
WO2006085964A2 (en) 2004-06-30 2006-08-17 Applera Corporation Log-linear amplification
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US7306785B2 (en) * 2004-09-23 2007-12-11 General Electric Company Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
US20060223084A1 (en) * 2004-12-06 2006-10-05 Bioveris Corporation Methods and compositions for detecting Bacillus anthracis
AU2005314431B2 (en) * 2004-12-11 2011-02-17 Cytogenix, Inc. Cell free biosynthesis of high-quality nucleic acid and uses thereof
EP2208796B1 (de) 2005-01-06 2014-06-18 Applied Biosystems, LLC Polypeptide mit Nukleinsäurebindungsaktivität und Zusammensetzungen und Verfahren zur Nukleinsäurenamplifikation
US20090264635A1 (en) 2005-03-25 2009-10-22 Applera Corporation Methods and compositions for depleting abundant rna transcripts
US7229769B2 (en) * 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
JP5479731B2 (ja) 2005-06-02 2014-04-23 アドヴァンディーエックス，インコーポレイテッド 微生物を解析するためのペプチド核酸プローブ
CA3027954C (en) 2005-06-07 2021-11-02 Luminex Corporation Methods for detection and typing of nucleic acids
DE602006020577D1 (de) 2005-07-01 2011-04-21 Dako Denmark As Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
WO2007100711A2 (en) * 2006-02-24 2007-09-07 Investigen, Inc. Methods and compositions for detecting polynucleotides
JPWO2007108378A1 (ja) 2006-03-15 2009-08-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 シグナルプローブポリマーの形成方法
EP2677039B8 (de) 2006-05-10 2022-10-05 DxTerity Diagnostics Incorporated Erkennung von Nukleinsäuretargets mithilfe chemisch reaktiver Oligonnucleotidsonden
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
WO2008005674A2 (en) 2006-06-30 2008-01-10 Applera Corporation Methods of analyzing binding interactions
CA2659632A1 (en) 2006-08-01 2008-02-07 Applera Corporation Detection of analytes and nucleic acids
US20080096193A1 (en) * 2006-10-24 2008-04-24 Charles Robert Bupp Methods and compositions for detecting polynucleotides
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
EP2099816A1 (de) 2006-12-04 2009-09-16 Luminex Corporation Oxocarbonamid-peptidnukleinsäuren und verwendungsverfahren dafür
KR101433208B1 (ko) 2006-12-13 2014-08-22 루미넥스 코포레이션 실시간으로 ｐｃｒ의 다중 분석을 위한 시스템과 방법
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
CN101978070A (zh) * 2006-12-29 2011-02-16 应用生物系统公司 检测核酸的系统和方法
EP2118310B1 (de) * 2006-12-29 2013-03-06 Applied Biosystems, LLC Systeme und verfahren zum nachweis von nukleinsäuren
US7803543B2 (en) 2007-01-19 2010-09-28 Chang Gung University Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both PCR clamp and sensor probe
EP2129388B1 (de) * 2007-02-23 2012-09-12 The Research Foundation Of State University Of New York Rna-target-verbindungen und verfahren zu ihrer herstellung und verwendung
US9260476B2 (en) 2007-02-23 2016-02-16 The Research Foundation For The State University Of New York RNA targeting compounds and methods for making and using same
WO2008103702A2 (en) * 2007-02-23 2008-08-28 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
ES2386748T3 (es) 2007-04-13 2012-08-29 Abbott Laboratories Secuencias de cebador y sonda para detectar Chlamydia trachomatis
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
WO2009003493A2 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
ES2402334T3 (es) 2007-08-02 2013-04-30 Gilead Biologics, Inc Procedimientos y composiciones para el tratamiento y el diagnóstico de la fibrosis
SG185315A1 (en) 2007-10-24 2012-11-29 Eisai R&D Man Co Ltd Nucleic acid probe, and method of forming probe -polymer
WO2009057702A1 (ja) 2007-10-31 2009-05-07 Eisai R & D Management Co., Ltd. 標的物質検出用ポリマー及び標的物質の検出方法
US8017338B2 (en) 2007-11-20 2011-09-13 Life Technologies Corporation Reversible di-nucleotide terminator sequencing
US8916531B2 (en) 2007-11-20 2014-12-23 Isis Pharmaceuticals, Inc. Modulation of CD40 expression
KR101588736B1 (ko) 2008-01-10 2016-01-26 리서치 디벨롭먼트 파운데이션 얼리키아 샤피엔시스에 대한 백신 및 진단제
EP3699291B1 (de) 2008-01-17 2024-08-07 Sequenom, Inc. Einzelmolekülnukleinsäurensequenzanalyseverfahren und zusammensetzungen
KR101072899B1 (ko) * 2008-01-21 2011-10-17 주식회사 파나진 아미노산 스페이서가 결합된 펩티드 핵산의 합성 및 그의응용
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
KR20090098710A (ko) 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
EP3733871A1 (de) 2008-05-27 2020-11-04 Dako Denmark A/S Zusammensetzungen und verfahren zur erkennung von chromosomalen abweichungen mit neuen hybridisierungspuffern
EP2285958B1 (de) 2008-06-13 2016-03-09 Codexis, Inc. Verfahren zur synthese von polynukleotidvarianten
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
US8859490B2 (en) 2008-09-03 2014-10-14 Nanyang Technological University Peptide nucleic acid monomers and oligomers
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8796443B2 (en) 2008-09-22 2014-08-05 Rxi Pharmaceuticals Corporation Reduced size self-delivering RNAi compounds
EP2342334A4 (de) 2008-09-29 2012-03-14 Univ Pennsylvania Auf tumorgefässmarker gerichtete impfstoffe
JP2012505644A (ja) 2008-10-15 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー オリゴヌクレオチド検出法
JP5805538B2 (ja) 2008-11-07 2015-11-04 リサーチ ディベロップメント ファウンデーション Ｃｒｉｐｔｏ／ＧＳＰ７８複合体形成およびシグナル伝達を阻害するための組成物および方法
US8715732B2 (en) * 2009-01-05 2014-05-06 Cornell University Nucleic acid hydrogel via rolling circle amplification
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
EP2391714B2 (de) 2009-01-30 2019-07-24 Whitehead Institute for Biomedical Research Ligaturverfahren und ihre verwendung
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
US7964355B2 (en) 2009-02-17 2011-06-21 Investigen, Inc. Assays based on detection of photobleaching reaction products from dye catalytic complex
EP2401396B1 (de) 2009-02-26 2016-11-23 Dako Denmark A/S Verfahren zur durchführung eines stringenten waschschritts bei hybridisierungsanwendungen
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
AU2010232972B2 (en) 2009-04-01 2016-10-27 Dxterity Diagnostics Incorporated Chemical ligation dependent probe amplification (CLPA)
US20100297127A1 (en) 2009-04-08 2010-11-25 Ghilardi Nico P Use of il-27 antagonists to treat lupus
AU2010256880B2 (en) 2009-06-02 2015-01-22 Opko Health, Inc. Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
EP2789689B1 (de) 2009-06-29 2016-04-27 Luminex Corporation Chimäre Primer mit Haarnadel-Konformationen und Verfahren zur Verwendung davon
US8614081B2 (en) 2009-07-23 2013-12-24 Codexis, Inc. Nitrilase biocatalysts
NZ598457A (en) * 2009-08-03 2014-06-27 Recombinetics Inc Methods and compositions for targeted gene modification
SG178845A1 (en) 2009-08-21 2012-04-27 Gilead Biologics Inc Catalytic domains from lysyl oxidase and loxl2
WO2011047257A1 (en) 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
CA2781907C (en) 2009-12-02 2019-07-16 Dako Denmark A/S Compositions and methods for performing hybridizations with no denaturation
WO2011087789A2 (en) 2009-12-22 2011-07-21 Becton, Dickinson And Company Methods for the detection of microorganisms
US9926593B2 (en) 2009-12-22 2018-03-27 Sequenom, Inc. Processes and kits for identifying aneuploidy
RU2615143C2 (ru) 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
WO2011133931A1 (en) 2010-04-22 2011-10-27 Genentech, Inc. Use of il-27 antagonists for treating inflammatory bowel disease
MX340258B (es) 2011-01-11 2016-07-01 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
KR101569479B1 (ko) 2011-03-29 2015-11-16 주식회사 씨젠 Ｐｔｏ 절단 및 연장-의존적 절단에 의한 타겟 핵산서열의 검출
US9193758B2 (en) 2011-04-08 2015-11-24 Carnegie Mellon University Center For Technology Transfer & Enterprise Conformationally-preorganized, miniPEG-containing γ-peptide nucleic acids
CA2834218C (en) 2011-04-29 2021-02-16 Sequenom, Inc. Quantification of a minority nucleic acid species using inhibitory oligonucleotides
MX342067B (es) 2011-05-04 2016-09-09 Seegene Inc Detección de secuencias de ácido nucleico objetivo por desdoblamiento e hibridización de oligonucleótido de sonda.
EP2710145B1 (de) 2011-05-17 2015-12-09 Dxterity Diagnostics Incorporated Verfahren und zusammensetzungen zum nachweis von zielnukleinsäuren
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
GB201117482D0 (en) 2011-10-11 2011-11-23 Univ Dundee Targetiing of miRNA precursors
EP2768974B1 (de) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridisierungszusammensetzungen und -verfahren
EP2594942A1 (de) * 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Lange starre Abstandshalter zur Verbesserung der Bindekinetik in Immuntests
WO2013085026A1 (ja) 2011-12-09 2013-06-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 塩基変異の検出方法及び検出用キット
CA3191015A1 (en) 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
EP2820129A1 (de) 2012-03-02 2015-01-07 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
RU2620955C2 (ru) 2012-03-05 2017-05-30 Сиджен, Инк. Детекция нуклеотидной вариации в нуклеиновокислотной последовательности-мишени в анализе с расщеплением и удлинением зондирующего и метящего олигонуклеотида (рто)
WO2013172305A1 (ja) 2012-05-15 2013-11-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｒｎａの検出方法及び検出用キット
KR20150016336A (ko) 2012-05-21 2015-02-11 더 스크립스 리서치 인스티튜트 리보솜 폴리뉴클레오티드 및 관련 발현 시스템
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
WO2014011928A1 (en) 2012-07-13 2014-01-16 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014033314A1 (en) 2012-09-03 2014-03-06 Uab Bioseka Antisense oligonucleotide targeting bacterial glucosyltransferases
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
WO2014093291A1 (en) 2012-12-10 2014-06-19 Advandx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
AU2014200958B2 (en) 2013-02-25 2016-01-14 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence
US9289502B2 (en) 2013-03-08 2016-03-22 Emerald Therapeutics, Inc. Preparation of oligo conjugates
EP2971100A1 (de) 2013-03-13 2016-01-20 Sequenom, Inc. Primer zur analyse der dna-methylierung
WO2014142575A1 (en) 2013-03-13 2014-09-18 Seegene, Inc. Quantification of target nucleic acid using melting peak analysis
WO2014149356A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Detection of bisulfite converted nucleotide sequences
US9347095B2 (en) 2013-03-15 2016-05-24 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
US10370415B2 (en) 2013-04-11 2019-08-06 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US10221216B2 (en) 2013-04-11 2019-03-05 Carnegie Mellon University Template-directed γPNA synthesis process and γPNA targeting compounds
CN105339388B (zh) 2013-07-12 2021-06-15 Emd密理博公司 确定利用活性炭从包含靶蛋白的样品去除病毒的方法
WO2015008985A1 (en) 2013-07-15 2015-01-22 Seegene, Inc. Detection of target nucleic acid sequence by pto cleavage and extension-dependent immobilized oligonucleotide hybridization
LT6214B (lt) 2013-10-07 2015-08-25 Uab "Bioseka" Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai
JP2016537965A (ja) 2013-10-11 2016-12-08 ジェネンテック， インコーポレイテッド Ｎｓｐ４阻害剤及び使用方法
JP6640079B2 (ja) 2013-10-16 2020-02-05 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 小容積の粒子を調製するためのデバイス及び方法
WO2015057008A2 (en) 2013-10-18 2015-04-23 Seegene, Inc. Detection of target nucleic acid sequence on solid phase by pto cleavage and extension using hcto assay
EP3065706A4 (de) 2013-11-08 2017-11-29 Baylor Research Institute Nukleare lokalisierung von glp-1 zur stimulation der herzmuskelregenerierung und reversion von herzversagen
SG11201606921PA (en) 2014-01-28 2016-10-28 Dice Molecules Sv Llc Monoliths with attached recognition compounds, arrays thereof and uses thereof
EP3736344A1 (de) 2014-03-13 2020-11-11 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
WO2015172058A1 (en) 2014-05-08 2015-11-12 Carnegie Mellon University Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
EP3154696B1 (de) 2014-06-10 2020-04-08 DxTerity Diagnostics Incorporated Vorrichtungen und verfahren zur entnahme und stabilisierung biologischer proben
WO2015200377A1 (en) 2014-06-24 2015-12-30 Abbott Molecular Inc. Detection of single nucleotide polymorphisms in human kras
RU2697502C2 (ru) 2014-07-24 2019-08-14 Эбботт Молекьюлар Инк. Композиции и способы обнаружения и анализа микобактерии туберкулеза (mycobacterium tuberculosis)
EP3183367B1 (de) 2014-08-19 2019-06-26 Pacific Biosciences Of California, Inc. Zusammensetzungen und verfahren zur anreicherung von nukleinsäuren
WO2016134293A1 (en) 2015-02-20 2016-08-25 Baylor College Of Medicine p63 INACTIVATION FOR THE TREATMENT OF HEART FAILURE
WO2016138175A1 (en) 2015-02-24 2016-09-01 The University Of British Columbia Continuous flow microfluidic system
CA2988982A1 (en) 2015-06-12 2016-12-15 Alector Llc Anti-cd33 antibodies and methods of use thereof
EP3307779A2 (de) 2015-06-12 2018-04-18 Alector LLC Anti-cd33-antikörper und verfahren zur verwendung davon
WO2017011565A1 (en) 2015-07-14 2017-01-19 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis
KR20180054639A (ko) 2015-08-28 2018-05-24 알렉터 엘엘씨 항-siglec-7 항체 및 이의 사용 방법
AU2016324165B2 (en) 2015-09-16 2020-07-02 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
US12492423B2 (en) 2015-09-16 2025-12-09 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
EP4218833A1 (de) 2015-10-01 2023-08-02 Whitehead Institute for Biomedical Research Markierung von antikörpern
SG11201802718PA (en) 2015-10-14 2018-05-30 Bio Path Holdings Inc P-ethoxy nucleic acids for liposomal formulation
MX391259B (es) 2015-10-14 2025-03-21 X Therma Inc Composiciones y métodos para reducir la formación de cristales de hielo.
CN116003596A (zh) 2015-10-29 2023-04-25 艾利妥 抗siglec-9抗体及其使用方法
CN108778477B (zh) 2016-01-06 2022-02-25 不列颠哥伦比亚大学 分叉混合器及其使用和制造方法
CA3019635A1 (en) 2016-03-31 2017-10-05 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
US10400274B2 (en) 2016-06-18 2019-09-03 Jan Biotech, Inc. Fluorogenic probes and their use in quantitative detection of target RNA sequences
US10300145B2 (en) 2016-07-15 2019-05-28 Massachusetts Institute Of Technology Synthetic nanoparticles for delivery of immunomodulatory compounds
SG10202008771WA (en) 2016-09-16 2020-10-29 Bio Path Holdings Inc Combination therapy with liposomal antisense oligonucleotides
CN109923105A (zh) 2016-09-26 2019-06-21 卡耐基梅隆大学 二价核碱基化合物及其用途
US11147249B2 (en) 2016-12-08 2021-10-19 Alector Llc Siglec transgenic mice and methods of use thereof
US11359014B2 (en) 2017-05-16 2022-06-14 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
AU2018310985A1 (en) 2017-08-03 2019-11-07 Alector Llc Anti-CD33 antibodies and methods of use thereof
US11591645B2 (en) 2017-08-31 2023-02-28 Seegene, Inc. Evaluation of performance of components using a pair of dimer-forming primers
WO2019066461A2 (en) 2017-09-29 2019-04-04 Seegene, Inc. DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY CLEAVAGE ANALYSIS AND EXTENSION OF PTO
US11470827B2 (en) 2017-12-12 2022-10-18 Alector Llc Transgenic mice expressing human TREM proteins and methods of use thereof
AU2018392779B2 (en) 2017-12-21 2024-02-15 Carnegie Mellon University Template-directed nucleic acid targeting compounds
US12319712B2 (en) 2018-05-09 2025-06-03 Vibrant Holdings, Llc Methods of synthesizing a polynucleotide array using photoactivated agents
KR20210030341A (ko) 2018-06-08 2021-03-17 알렉터 엘엘씨 항-Siglec-7 항체 및 그의 사용 방법
KR20210049106A (ko) 2018-07-27 2021-05-04 알렉터 엘엘씨 항-siglec-5 항체 및 이의 사용 방법
SG11202101552SA (en) 2018-08-31 2021-03-30 Alector Llc Anti-cd33 antibodies and methods of use thereof
AU2019342197B2 (en) 2018-09-21 2025-10-16 President And Fellows Of Harvard College Methods and compositions for treating diabetes, and methods for enriching mRNA coding for secreted proteins
US20220251567A1 (en) 2019-07-10 2022-08-11 Inserm (Institut National De La Santè Et De La Recherche Médicale) Methods for the treatment of epilepsy
US20230016983A1 (en) 2019-11-19 2023-01-19 lNSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Antisense oligonucleotides and thier use for the treatment of cancer
KR102403904B1 (ko) * 2019-12-24 2022-06-02 주식회사 시선바이오머티리얼스 용액공정상 pna 올리고머의 제조방법
WO2021243271A2 (en) 2020-05-29 2021-12-02 Front Range Biosciences, Inc. Methods and compositions for pathogen detection in plants
WO2022006019A1 (en) 2020-06-29 2022-01-06 Front Range Biosciences, Inc. Characterization of cannabis cultivars based on terpene synthase gene profiles
WO2022011262A1 (en) 2020-07-10 2022-01-13 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating epilepsy
WO2022241007A1 (en) * 2021-05-11 2022-11-17 Mccurdy Russell Lewis Replaceable floating attractant accessories for fishing line
EP4403645A4 (de) 2021-09-17 2025-10-08 Seegene Inc Nachweis einer zielnukleinsäuresequenz unter verwendung eines synthetischen, eine nichtnatürliche base tragenden markeroligonukleotids
CN114409890A (zh) * 2022-02-28 2022-04-29 中国科学院长春应用化学研究所 一种氨基功能化的聚乙二醇衍生物及其制备方法
EP4558149A1 (de) 2022-07-21 2025-05-28 Institut National de la Santé et de la Recherche Médicale Verfahren und zusammensetzungen zur behandlung chronischer schmerzerkrankungen
WO2024146935A1 (en) 2023-01-06 2024-07-11 Institut National de la Santé et de la Recherche Médicale Intravenous administration of antisense oligonucleotides for the treatment of pain
WO2025008406A1 (en) 2023-07-04 2025-01-09 Institut National de la Santé et de la Recherche Médicale Antisense oligonucleotides and their use for the treatment of cancer
WO2025090427A1 (en) 2023-10-23 2025-05-01 University Of Rochester Glial-targeted relief of hyperexcitability in neurodegenerative diseases
WO2025237990A1 (en) 2024-05-14 2025-11-20 Institut National de la Santé et de la Recherche Médicale Antisense oligonucleotides and their use for the treatment of pulmonary fibrosis
CN119954890B (zh) * 2025-04-10 2025-10-17 广东工业大学 一种光学纯小肽类化学发光探针及其在结核分枝杆菌识别中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2910130A1 (de) 1979-03-15 1980-09-25 Franz Rossmoeller Verbesserte befestigungsvorrichtung zum aufhaengen von paneelen und moebelelementen
DE2910129C2 (de) 1979-03-15 1986-01-23 Oskar 4354 Datteln Fleck Leiste zum Abdichten des Zwischenraums zwischen der Trauflatte eines Daches und den darüberliegenden traufseitigen Dacheindeckungsplatten
JPS5927900A (ja) 1982-08-09 1984-02-14 Wakunaga Seiyaku Kk 固定化オリゴヌクレオチド
AU5661386A (en) * 1985-03-15 1986-10-13 Stirchak, E. Stereoregular polynucleotide-binding polymers
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
EP0972779A3 (de) 1987-10-28 2004-10-20 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotid-Polyamid Konjugate
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
CA1339987C (en) 1988-09-01 1998-08-04 Robert Bruce Merrifield Peptide synthesis method and solid support for use in the method
JPH02156895A (ja) * 1988-12-08 1990-06-15 Sumitomo Heavy Ind Ltd 好塩菌による５’‐ヌクレオチド類の製造法
JPH0635469B2 (ja) * 1989-09-13 1994-05-11 信 高橋 ジエチレントリアミン三酢酸化合物及びその製造中間体並びにそれらの製造法
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6414112B1 (en) * 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
US6451968B1 (en) * 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
MX9207334A (es) 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
US6770738B1 (en) * 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
WO1993024507A1 (en) * 1992-05-28 1993-12-09 Gilead Sciences, Inc. Conformationally restrained oligomers containing amide or carbamate linkages for sequence-specific binding
US5705333A (en) * 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US6472209B1 (en) * 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response

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