ATE346950T1 - Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen - Google Patents

Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen

Info

Publication number
ATE346950T1
ATE346950T1 AT02719163T AT02719163T ATE346950T1 AT E346950 T1 ATE346950 T1 AT E346950T1 AT 02719163 T AT02719163 T AT 02719163T AT 02719163 T AT02719163 T AT 02719163T AT E346950 T1 ATE346950 T1 AT E346950T1
Authority
AT
Austria
Prior art keywords
kits
combination oligomers
methods
compositions relating
pna
Prior art date
Application number
AT02719163T
Other languages
English (en)
Inventor
James M Coull
Mark J Fiandaca
Mark D Kristjanson
Jens J Hyldig-Nielsen
Theresa M Creasey
Original Assignee
Boston Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Probes Inc filed Critical Boston Probes Inc
Application granted granted Critical
Publication of ATE346950T1 publication Critical patent/ATE346950T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Sealing Material Composition (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Prostheses (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Electric Connection Of Electric Components To Printed Circuits (AREA)
AT02719163T 2001-03-09 2002-03-09 Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen ATE346950T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27454701P 2001-03-09 2001-03-09

Publications (1)

Publication Number Publication Date
ATE346950T1 true ATE346950T1 (de) 2006-12-15

Family

ID=23048654

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02719163T ATE346950T1 (de) 2001-03-09 2002-03-09 Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
AT06023675T ATE496139T1 (de) 2001-03-09 2002-03-09 Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06023675T ATE496139T1 (de) 2001-03-09 2002-03-09 Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen

Country Status (9)

Country Link
US (9) US7256275B2 (de)
EP (2) EP1748078B1 (de)
JP (2) JP4408628B2 (de)
AT (2) ATE346950T1 (de)
AU (1) AU2002250262B9 (de)
CA (1) CA2439750A1 (de)
DE (2) DE60216468T2 (de)
DK (1) DK1412517T3 (de)
WO (1) WO2002072865A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60216468T2 (de) 2001-03-09 2007-09-27 Boston Probes, Inc., Bedford Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
US20040137469A1 (en) 2002-09-08 2004-07-15 Casale Ralph A Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis
WO2004074447A2 (en) * 2003-02-18 2004-09-02 Applera Corporation Compositions and methods for multiplex analysis of polynucleotides
EP1674581A1 (de) * 2004-12-21 2006-06-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Doppelsonden und ihre Verwendung zum Nachweis von SNPS
US7892737B2 (en) * 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
GB2433505A (en) * 2005-12-20 2007-06-27 Sharp Kk Capture agents for binding a ligand
GB2433591A (en) * 2005-12-20 2007-06-27 Sharp Kk Method for functionalising a hydrophobic substrate
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
US9677123B2 (en) * 2006-03-15 2017-06-13 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
JPWO2008018305A1 (ja) * 2006-08-08 2009-12-24 アークレイ株式会社 変異の検出方法およびそれに用いるキット
US20100120031A1 (en) * 2006-09-22 2010-05-13 The United States Of America, As Represented By The Secretary, Dept. Of Synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate
GB0718255D0 (en) * 2007-09-19 2007-10-31 Univ Edinburgh Nucleobase characterisation
JP2012502911A (ja) * 2008-09-14 2012-02-02 インサイター インコーポレイテッド ナノスケール分子合成
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
WO2011120049A1 (en) * 2010-03-26 2011-09-29 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
AU2011299233B2 (en) 2010-09-07 2016-09-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
CN103534358B (zh) * 2011-03-29 2015-03-25 Seegene株式会社 基于pto切割以及延伸-依赖性切割的靶核酸序列的检测
JP5876890B2 (ja) * 2012-01-07 2016-03-02 株式会社ボナック アミノ酸骨格を有する一本鎖核酸分子
CA2864523C (en) * 2012-03-05 2019-02-05 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by pto cleavage and extension assay
US9663784B2 (en) 2012-05-26 2017-05-30 Bonac Corporation Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
US10167391B2 (en) 2012-08-02 2019-01-01 Bioneer Corporation Azo compound, use thereof and method for preparing same
GB201316644D0 (en) * 2013-09-19 2013-11-06 Kymab Ltd Expression vector production & High-Throughput cell screening
WO2015099122A1 (ja) 2013-12-26 2015-07-02 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
BR112016014986A2 (pt) 2013-12-27 2018-01-23 Bonac Corporation mirna tipo correspondência artificial, composição e método para suprimir expressão de um gene alvo, composição farmacêutica, método para tratar uma doença, e, ácido nucleico de fita única
MX2017008587A (es) 2014-12-27 2017-10-20 Bonac Corp Mirna natural para controlar la expresion de gen y uso del mismo.
US11142769B2 (en) 2015-03-27 2021-10-12 Bonac Corporation Single-stranded nucleic acid molecule having delivery function and gene expression regulating ability
WO2017143042A2 (en) 2016-02-16 2017-08-24 Yale University Compositions for enhancing targeted gene editing and methods of use thereof
KR102403904B1 (ko) * 2019-12-24 2022-06-02 주식회사 시선바이오머티리얼스 용액공정상 pna 올리고머의 제조방법
CN113322523B (zh) * 2021-06-17 2024-03-19 翌圣生物科技(上海)股份有限公司 Rna快速建库方法及其应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5252293A (en) 1989-01-17 1993-10-12 Vladimir Drbal Analytical slide with porous filter membrane
DE3943522A1 (de) 1989-07-26 1991-02-07 Boehringer Mannheim Gmbh Heterobifunktionelle verbindungen
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5700922A (en) 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2289677A (en) 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5705333A (en) 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US6280964B1 (en) 1995-04-14 2001-08-28 The Regents Of The University Of California Binding sites for phosphotyrosine binding domains
WO1996040709A1 (en) * 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
DE19532553A1 (de) * 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
CA2218440A1 (en) * 1996-12-21 1998-06-21 Boehringer Mannheim Gmbh Method of analysis using signal amplification
EP0857791B1 (de) * 1996-12-21 2004-03-31 PNA Diagnostics A/S Analyseverfahren basierend auf Signalverstärkung
US6080418A (en) 1997-04-07 2000-06-27 3M Innovative Properties Company Suspensions of microcapsules containing biologically active ingredients and adhesive microspheres
US6107470A (en) 1997-05-29 2000-08-22 Nielsen; Peter E. Histidine-containing peptide nucleic acids
AU745094B2 (en) * 1997-06-13 2002-03-14 Gryphon Sciences Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
EP0897991B1 (de) 1997-08-22 2004-12-08 PNA Diagnostics ApS kurze PNA Oligonukleotide in Triplexkomplexen
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US6485901B1 (en) * 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
EP1025120B1 (de) 1997-10-27 2010-08-18 Boston Probes, Inc. Sich auf "pna molecular beacons" beziehende verfahren, testsätze und zusammensetzungen
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
EP1053355B1 (de) 1998-02-11 2001-11-14 PE Corporation (NY) Konjugate von dns und pns und verfahren zu deren herstellung
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
DE69941690D1 (de) 1998-04-29 2010-01-07 Boston Probes Inc Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
US6287772B1 (en) * 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
WO2000002899A1 (en) 1998-07-09 2000-01-20 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
US6248884B1 (en) 1999-06-03 2001-06-19 The Perkin-Elmer Corporation Extended rhodamine compounds useful as fluorescent labels
US6316230B1 (en) 1999-08-13 2001-11-13 Applera Corporation Polymerase extension at 3′ terminus of PNA-DNA chimera
US6140500A (en) 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US6297016B1 (en) * 1999-10-08 2001-10-02 Applera Corporation Template-dependent ligation with PNA-DNA chimeric probes
US6472153B1 (en) 1999-10-26 2002-10-29 Epoch Biosciences, Inc. Hybridization-triggered fluorescent detection of nucleic acids
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
DE60216468T2 (de) 2001-03-09 2007-09-27 Boston Probes, Inc., Bedford Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen

Also Published As

Publication number Publication date
JP2007209346A (ja) 2007-08-23
US20080125332A1 (en) 2008-05-29
JP4408628B2 (ja) 2010-02-03
DE60216468T2 (de) 2007-09-27
DK1412517T3 (da) 2007-03-05
US20090163381A1 (en) 2009-06-25
EP1748078A2 (de) 2007-01-31
US7851155B2 (en) 2010-12-14
US20030077608A1 (en) 2003-04-24
DE60216468D1 (de) 2007-01-11
EP1412517A4 (de) 2004-07-07
EP1748078B1 (de) 2011-01-19
ATE496139T1 (de) 2011-02-15
EP1748078A3 (de) 2007-02-28
US7605253B2 (en) 2009-10-20
US20070105145A1 (en) 2007-05-10
EP1412517A2 (de) 2004-04-28
US7674585B2 (en) 2010-03-09
US20080220987A1 (en) 2008-09-11
US7884053B2 (en) 2011-02-08
AU2002250262B9 (en) 2006-11-30
WO2002072865A3 (en) 2003-11-27
US7745126B2 (en) 2010-06-29
AU2002250262B2 (en) 2006-10-26
WO2002072865A2 (en) 2002-09-19
CA2439750A1 (en) 2002-09-19
US20080085837A1 (en) 2008-04-10
US7256275B2 (en) 2007-08-14
US20080269074A1 (en) 2008-10-30
EP1412517B1 (de) 2006-11-29
US7566420B1 (en) 2009-07-28
JP2004524032A (ja) 2004-08-12
US20080206747A1 (en) 2008-08-28
US7638279B2 (en) 2009-12-29
DE60239020D1 (de) 2011-03-03

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