DK1412517T3 - Fremgangsmåder, kits og sammensætninger af kombinationsoligomerer - Google Patents

Fremgangsmåder, kits og sammensætninger af kombinationsoligomerer

Info

Publication number
DK1412517T3
DK1412517T3 DK02719163T DK02719163T DK1412517T3 DK 1412517 T3 DK1412517 T3 DK 1412517T3 DK 02719163 T DK02719163 T DK 02719163T DK 02719163 T DK02719163 T DK 02719163T DK 1412517 T3 DK1412517 T3 DK 1412517T3
Authority
DK
Denmark
Prior art keywords
kits
compositions
combination oligomers
methods
pna
Prior art date
Application number
DK02719163T
Other languages
Danish (da)
English (en)
Inventor
James M Coull
Mark J Fiandaca
Mark D Kristjanson
Jens J Hyldig-Nielsen
Theresa M Creasey
Original Assignee
Boston Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Probes Inc filed Critical Boston Probes Inc
Application granted granted Critical
Publication of DK1412517T3 publication Critical patent/DK1412517T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00Methods specially adapted for identifying library members
    • C40B20/04Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Sealing Material Composition (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Prostheses (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Electric Connection Of Electric Components To Printed Circuits (AREA)
DK02719163T 2001-03-09 2002-03-09 Fremgangsmåder, kits og sammensætninger af kombinationsoligomerer DK1412517T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27454701P 2001-03-09 2001-03-09
PCT/US2002/007050 WO2002072865A2 (en) 2001-03-09 2002-03-09 Methods, kits and compositions of combination oligomers

Publications (1)

Publication Number Publication Date
DK1412517T3 true DK1412517T3 (da) 2007-03-05

Family

ID=23048654

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02719163T DK1412517T3 (da) 2001-03-09 2002-03-09 Fremgangsmåder, kits og sammensætninger af kombinationsoligomerer

Country Status (9)

Country Link
US (9) US7256275B2 (de)
EP (2) EP1412517B1 (de)
JP (2) JP4408628B2 (de)
AT (2) ATE346950T1 (de)
AU (1) AU2002250262B9 (de)
CA (1) CA2439750A1 (de)
DE (2) DE60216468T2 (de)
DK (1) DK1412517T3 (de)
WO (1) WO2002072865A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE346950T1 (de) * 2001-03-09 2006-12-15 Boston Probes Inc Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
CA2495895A1 (en) 2002-09-08 2004-03-18 Applera Corporation Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
JP4608483B2 (ja) * 2003-02-18 2011-01-12 アプライド バイオシステムズ, エルエルシー ポリヌクレオチドの複合的分析のための組成物および方法
EP1674581A1 (de) * 2004-12-21 2006-06-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Doppelsonden und ihre Verwendung zum Nachweis von SNPS
US7892737B2 (en) * 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
GB2433505A (en) * 2005-12-20 2007-06-27 Sharp Kk Capture agents for binding a ligand
GB2433591A (en) * 2005-12-20 2007-06-27 Sharp Kk Method for functionalising a hydrophobic substrate
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
US9677123B2 (en) * 2006-03-15 2017-06-13 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
CN101421420B (zh) * 2006-08-08 2015-03-11 爱科来株式会社 突变的检测方法及用于该方法的试剂盒
US20100120031A1 (en) * 2006-09-22 2010-05-13 The United States Of America, As Represented By The Secretary, Dept. Of Synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate
GB0718255D0 (en) * 2007-09-19 2007-10-31 Univ Edinburgh Nucleobase characterisation
JP2012502911A (ja) * 2008-09-14 2012-02-02 インサイター インコーポレイテッド ナノスケール分子合成
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
US8916345B2 (en) 2010-03-26 2014-12-23 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
CA2809457C (en) 2010-09-07 2019-07-30 Integrated Dna Technologies, Inc. Modifications for antisense compounds
KR101569479B1 (ko) 2011-03-29 2015-11-16 주식회사 씨젠 Pto 절단 및 연장-의존적 절단에 의한 타겟 핵산서열의 검출
ES2645996T3 (es) 2012-01-07 2017-12-11 Bonac Corporation Molécula de ácido nucleico monocatenario que tiene una cadena principal de aminoácidos
RU2620955C2 (ru) * 2012-03-05 2017-05-30 Сиджен, Инк. Детекция нуклеотидной вариации в нуклеиновокислотной последовательности-мишени в анализе с расщеплением и удлинением зондирующего и метящего олигонуклеотида (рто)
WO2013180038A1 (ja) 2012-05-26 2013-12-05 株式会社ボナック デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子
CN104703971B (zh) 2012-08-02 2018-08-21 株式会社百奥尼 新型偶氮化合物及其利用、以及其制造方法
GB201316644D0 (en) * 2013-09-19 2013-11-06 Kymab Ltd Expression vector production & High-Throughput cell screening
JP6486836B2 (ja) 2013-12-26 2019-03-20 学校法人東京医科大学 遺伝子発現制御のための人工ミミックmiRNAおよびその用途
WO2015099187A1 (ja) 2013-12-27 2015-07-02 株式会社ボナック 遺伝子発現制御のための人工マッチ型miRNAおよびその用途
US11027023B2 (en) 2014-12-27 2021-06-08 Bonac Corporation Natural type miRNA for controlling gene expression, and use of same
CN108064289A (zh) 2015-03-27 2018-05-22 株式会社博纳克 具有递送功能和基因表达调控能力的单链核酸分子
EP3416976A2 (de) 2016-02-16 2018-12-26 Yale University Zusammensetzungen zur verbesserung von gezielter geneditierung und verfahren zur verwendung davon
KR102403904B1 (ko) * 2019-12-24 2022-06-02 주식회사 시선바이오머티리얼스 용액공정상 pna 올리고머의 제조방법
EP4211468A4 (de) * 2020-09-11 2024-10-09 Glympse Bio Inc Ex-vivo-proteaseaktivitätsdetektion für krankheitsnachweis/-diagnostik, einstufung, überwachung und behandlung
CN113322523B (zh) * 2021-06-17 2024-03-19 翌圣生物科技(上海)股份有限公司 Rna快速建库方法及其应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5252293A (en) 1989-01-17 1993-10-12 Vladimir Drbal Analytical slide with porous filter membrane
DE3943522A1 (de) * 1989-07-26 1991-02-07 Boehringer Mannheim Gmbh Heterobifunktionelle verbindungen
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5700922A (en) 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2289677A (en) 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5705333A (en) 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US6280964B1 (en) 1995-04-14 2001-08-28 The Regents Of The University Of California Binding sites for phosphotyrosine binding domains
EP0840741B1 (de) * 1995-06-07 2004-04-28 Perseptive Biosystems, Inc. Pna-dna-chimäre und pna-synthone zu deren herstellung
DE19532553A1 (de) 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
CA2218440A1 (en) 1996-12-21 1998-06-21 Boehringer Mannheim Gmbh Method of analysis using signal amplification
EP0857791B1 (de) * 1996-12-21 2004-03-31 PNA Diagnostics A/S Analyseverfahren basierend auf Signalverstärkung
US6080418A (en) 1997-04-07 2000-06-27 3M Innovative Properties Company Suspensions of microcapsules containing biologically active ingredients and adhesive microspheres
US6107470A (en) 1997-05-29 2000-08-22 Nielsen; Peter E. Histidine-containing peptide nucleic acids
WO1998056807A1 (en) 1997-06-13 1998-12-17 Gryphon Sciences Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution
DK0897991T3 (da) 1997-08-22 2005-07-25 Pna Diagnostics Aps Små triplexdannende PNA-oligoer
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
EP1025120B1 (de) 1997-10-27 2010-08-18 Boston Probes, Inc. Sich auf "pna molecular beacons" beziehende verfahren, testsätze und zusammensetzungen
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6080868A (en) * 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
US6326479B1 (en) 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
JP2002503456A (ja) 1998-02-11 2002-02-05 ピーイー コーポレイション (エヌワイ) Pnaおよびdna複合体およびその調製方法
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
EP1073767B1 (de) * 1998-04-29 2009-11-25 Boston Probes, Inc. Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
WO2000002899A1 (en) 1998-07-09 2000-01-20 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
US6248884B1 (en) 1999-06-03 2001-06-19 The Perkin-Elmer Corporation Extended rhodamine compounds useful as fluorescent labels
US6316230B1 (en) * 1999-08-13 2001-11-13 Applera Corporation Polymerase extension at 3′ terminus of PNA-DNA chimera
US6140500A (en) 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US6297016B1 (en) * 1999-10-08 2001-10-02 Applera Corporation Template-dependent ligation with PNA-DNA chimeric probes
US6472153B1 (en) 1999-10-26 2002-10-29 Epoch Biosciences, Inc. Hybridization-triggered fluorescent detection of nucleic acids
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
ATE346950T1 (de) 2001-03-09 2006-12-15 Boston Probes Inc Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen

Also Published As

Publication number Publication date
WO2002072865A3 (en) 2003-11-27
EP1412517A4 (de) 2004-07-07
DE60216468D1 (de) 2007-01-11
US7851155B2 (en) 2010-12-14
JP2007209346A (ja) 2007-08-23
US7605253B2 (en) 2009-10-20
US20080085837A1 (en) 2008-04-10
US20080269074A1 (en) 2008-10-30
US7884053B2 (en) 2011-02-08
US7745126B2 (en) 2010-06-29
US20080125332A1 (en) 2008-05-29
ATE346950T1 (de) 2006-12-15
AU2002250262B2 (en) 2006-10-26
US20080206747A1 (en) 2008-08-28
US20030077608A1 (en) 2003-04-24
US7256275B2 (en) 2007-08-14
EP1748078A3 (de) 2007-02-28
EP1748078A2 (de) 2007-01-31
JP4408628B2 (ja) 2010-02-03
DE60216468T2 (de) 2007-09-27
CA2439750A1 (en) 2002-09-19
EP1748078B1 (de) 2011-01-19
EP1412517B1 (de) 2006-11-29
US7638279B2 (en) 2009-12-29
WO2002072865A2 (en) 2002-09-19
US20070105145A1 (en) 2007-05-10
US20080220987A1 (en) 2008-09-11
DE60239020D1 (de) 2011-03-03
US7566420B1 (en) 2009-07-28
JP2004524032A (ja) 2004-08-12
AU2002250262B9 (en) 2006-11-30
US20090163381A1 (en) 2009-06-25
EP1412517A2 (de) 2004-04-28
US7674585B2 (en) 2010-03-09
ATE496139T1 (de) 2011-02-15

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