NO318784B1 - Pyrrolo(2,3-d)pyrimidinforbindelser samt anvendelse derav og farmasoytisk sammensetning - Google Patents
Pyrrolo(2,3-d)pyrimidinforbindelser samt anvendelse derav og farmasoytisk sammensetning Download PDFInfo
- Publication number
- NO318784B1 NO318784B1 NO20006453A NO20006453A NO318784B1 NO 318784 B1 NO318784 B1 NO 318784B1 NO 20006453 A NO20006453 A NO 20006453A NO 20006453 A NO20006453 A NO 20006453A NO 318784 B1 NO318784 B1 NO 318784B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- methyl
- pyrrolo
- lrms
- hydroxy
- Prior art date
Links
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- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 103
- 150000003839 salts Chemical class 0.000 claims description 40
- 108010019421 Janus Kinase 3 Proteins 0.000 claims description 33
- 102000006500 Janus Kinase 3 Human genes 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 241000124008 Mammalia Species 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- 208000035475 disorder Diseases 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 13
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- 229910052736 halogen Inorganic materials 0.000 claims description 9
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- 238000002360 preparation method Methods 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 5
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- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 4
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 3
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- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 2
- RVXVIKRNUXPSPD-OWYJLGKBSA-N n-methyl-n-[(5s)-2-methyl-5-prop-1-en-2-ylcyclohexyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound CC1CC[C@H](C(C)=C)CC1N(C)C1=NC=NC2=C1C=CN2 RVXVIKRNUXPSPD-OWYJLGKBSA-N 0.000 claims description 2
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
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- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8986698P | 1998-06-19 | 1998-06-19 | |
US10478798P | 1998-10-19 | 1998-10-19 | |
PCT/IB1999/001100 WO1999065908A1 (en) | 1998-06-19 | 1999-06-14 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
Publications (3)
Publication Number | Publication Date |
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NO20006453D0 NO20006453D0 (no) | 2000-12-18 |
NO20006453L NO20006453L (no) | 2001-02-05 |
NO318784B1 true NO318784B1 (no) | 2005-05-09 |
Family
ID=26781018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20006453A NO318784B1 (no) | 1998-06-19 | 2000-12-18 | Pyrrolo(2,3-d)pyrimidinforbindelser samt anvendelse derav og farmasoytisk sammensetning |
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US (3) | US6610847B2 (pt) |
EP (1) | EP1087970B1 (pt) |
JP (3) | JP4666762B2 (pt) |
KR (1) | KR100415791B1 (pt) |
CN (1) | CN1128800C (pt) |
AP (1) | AP1021A (pt) |
AR (1) | AR016499A1 (pt) |
AT (1) | ATE265458T1 (pt) |
AU (1) | AU3951899A (pt) |
BG (1) | BG65119B1 (pt) |
BR (1) | BR9911365A (pt) |
CA (1) | CA2335492C (pt) |
CZ (1) | CZ20004727A3 (pt) |
DE (1) | DE69916833T2 (pt) |
DK (1) | DK1087970T3 (pt) |
EA (1) | EA005852B1 (pt) |
ES (1) | ES2219018T3 (pt) |
FR (1) | FR14C0019I2 (pt) |
GE (1) | GEP20074227B (pt) |
GT (1) | GT199900090A (pt) |
HK (1) | HK1036801A1 (pt) |
HR (1) | HRP20000885B1 (pt) |
HU (1) | HUP0102574A3 (pt) |
ID (1) | ID26698A (pt) |
IL (1) | IL139586A0 (pt) |
MA (1) | MA26654A1 (pt) |
MY (1) | MY125916A (pt) |
NO (1) | NO318784B1 (pt) |
NZ (1) | NZ518444A (pt) |
OA (1) | OA11572A (pt) |
PA (1) | PA8476001A1 (pt) |
PE (1) | PE20000698A1 (pt) |
PL (1) | PL198640B1 (pt) |
PT (1) | PT1087970E (pt) |
RS (1) | RS50087B (pt) |
SA (1) | SA99200283B1 (pt) |
SK (1) | SK286640B6 (pt) |
TN (1) | TNSN99126A1 (pt) |
TR (1) | TR200003719T2 (pt) |
TW (1) | TW505646B (pt) |
WO (1) | WO1999065908A1 (pt) |
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PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
AU3951899A (en) * | 1998-06-19 | 2000-01-05 | Pfizer Products Inc. | Pyrrolo(2,3-d)pyrimidine compounds |
AP1905A (en) * | 1999-12-10 | 2008-10-20 | Pfizer Prod Inc | Pyrrolo[2,3-d] Pyrimidine Compounds. |
UA74370C2 (uk) * | 2000-06-26 | 2005-12-15 | Пфайзер Продактс Інк. | Піроло(2,3-d)піримідинові сполуки як імуносупресори |
BR0114020A (pt) | 2000-09-20 | 2003-07-22 | Merck Patent Gmbh | 4-amino-quinazolinas |
US7067550B2 (en) * | 2000-11-03 | 2006-06-27 | Massachusetts Institute Of Technology | Treatments for neurotoxicity in Alzheimer's Disease |
DE10063294A1 (de) * | 2000-12-19 | 2002-07-04 | Aventis Pharma Gmbh | Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP1363702A4 (en) * | 2001-01-30 | 2007-08-22 | Cytopia Pty Ltd | PROCESS FOR INHIBITING KINASES |
HU229604B1 (en) | 2001-02-12 | 2014-02-28 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them |
US7301023B2 (en) * | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
GB0115393D0 (en) * | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
PT1401415E (pt) | 2001-06-29 | 2006-09-29 | Ab Science | Utilizacao de derivados de n-fenil-2-pirimidino-amina para o tratamento de doencas inflamatorias |
US7700610B2 (en) | 2001-06-29 | 2010-04-20 | Ab Science | Use of tyrosine kinase inhibitors for treating allergic diseases |
ATE343415T1 (de) * | 2001-06-29 | 2006-11-15 | Ab Science | Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen |
EP1434991B1 (en) | 2001-06-29 | 2007-10-17 | AB Science | New potent, selective and non toxic c-kit inhibitors |
DE60227709D1 (de) * | 2001-06-29 | 2008-08-28 | Ab Science | Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen |
US7323469B2 (en) | 2001-08-07 | 2008-01-29 | Novartis Ag | 7H-pyrrolo[2,3-d]pyrimidine derivatives |
GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
GT200200234A (es) | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
US20040014755A1 (en) | 2002-01-10 | 2004-01-22 | Dhanapalan Nagarathnam | Rho-kinase inhibitors |
ATE381557T1 (de) | 2002-01-23 | 2008-01-15 | Bayer Pharmaceuticals Corp | Rho-kinase inhibitoren |
JP4469179B2 (ja) | 2002-01-23 | 2010-05-26 | バイエル ファーマセチカル コーポレーション | Rhoキナーゼ阻害剤としてのピリミジン誘導体 |
GB0202679D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
EP1388541A1 (en) | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
BR0316487A (pt) * | 2002-11-26 | 2005-10-11 | Pfizer Prod Inc | Método todo de tratamento da rejeição de transplantes |
EP1682564A1 (en) * | 2003-10-27 | 2006-07-26 | Genelabs Technologies, Inc. | METHODS FOR PREPARING 7-(2 -SUBSTITUTED-s-D-RIBOFURANO SYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO 2,3-D|PYRIMIDINE DERIVATIVES |
EP1689407A1 (en) * | 2003-11-25 | 2006-08-16 | Pfizer Products Inc. | Method of treatment of atherosclerosis |
RU2373197C2 (ru) * | 2004-03-30 | 2009-11-20 | Тайсо Фармасьютикал Ко., Лтд. | Пиримидиновые производные, обладающие активностью в отношении мсн |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
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MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
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EP1910358A2 (en) | 2005-07-14 | 2008-04-16 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
CN102127078A (zh) * | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
EP1926735A1 (en) | 2005-09-22 | 2008-06-04 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
RU2008117151A (ru) * | 2005-09-30 | 2009-11-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Деазапурины, пригодные в качестве ингибиторов янус-киназ |
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CN101679440A (zh) * | 2007-04-02 | 2010-03-24 | 帕劳制药股份有限公司 | 作为jak3抑制剂的吡咯并嘧啶衍生物 |
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