NO166466C - Fremgangsmaate for detektering eller bestemmelse av et peptid inneholdende en antigenisk aktiv sekvens av aminosyrer. - Google Patents

Fremgangsmaate for detektering eller bestemmelse av et peptid inneholdende en antigenisk aktiv sekvens av aminosyrer.

Info

Publication number
NO166466C
NO166466C NO84844296A NO844296A NO166466C NO 166466 C NO166466 C NO 166466C NO 84844296 A NO84844296 A NO 84844296A NO 844296 A NO844296 A NO 844296A NO 166466 C NO166466 C NO 166466C
Authority
NO
Norway
Prior art keywords
detecting
determining
amino acids
peptides
sequence
Prior art date
Application number
NO84844296A
Other languages
English (en)
Norwegian (no)
Other versions
NO166466B (no
NO844296L (no
Inventor
Hendrik Mario Geysen
Original Assignee
Coselco Mimotopes Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3770023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO166466(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Coselco Mimotopes Pty Ltd filed Critical Coselco Mimotopes Pty Ltd
Publication of NO844296L publication Critical patent/NO844296L/no
Publication of NO166466B publication Critical patent/NO166466B/no
Publication of NO166466C publication Critical patent/NO166466C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
NO84844296A 1983-03-08 1984-10-29 Fremgangsmaate for detektering eller bestemmelse av et peptid inneholdende en antigenisk aktiv sekvens av aminosyrer. NO166466C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPF834883 1983-03-08
PCT/AU1984/000039 WO1984003564A1 (en) 1983-03-08 1984-03-08 Method of determining antigenically active amino acid sequences

Publications (3)

Publication Number Publication Date
NO844296L NO844296L (no) 1984-10-29
NO166466B NO166466B (no) 1991-04-15
NO166466C true NO166466C (no) 1991-07-24

Family

ID=3770023

Family Applications (1)

Application Number Title Priority Date Filing Date
NO84844296A NO166466C (no) 1983-03-08 1984-10-29 Fremgangsmaate for detektering eller bestemmelse av et peptid inneholdende en antigenisk aktiv sekvens av aminosyrer.

Country Status (10)

Country Link
US (1) US5595915A (de)
EP (1) EP0138855B2 (de)
JP (1) JPH063445B2 (de)
AT (1) ATE69890T1 (de)
CA (1) CA1220420A (de)
DE (1) DE3485299D1 (de)
DK (1) DK164529C (de)
NO (1) NO166466C (de)
NZ (1) NZ207394A (de)
WO (1) WO1984003564A1 (de)

Families Citing this family (491)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4599230A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599231A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
AU579148B2 (en) * 1984-03-09 1988-11-17 Scripps Clinic And Research Foundation Synthetic hepatitis b virus vaccine including both t cell and b cell determinants
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
WO1986000991A1 (en) * 1984-07-24 1986-02-13 Commonwealth Serum Laboratories Commission Method for determining mimotopes
AU592311B2 (en) * 1984-07-24 1990-01-11 Coselco Mimotopes Pty Ltd Method for determining mimotopes
US4798787A (en) * 1984-09-19 1989-01-17 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
US4762706A (en) * 1984-10-17 1988-08-09 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
NZ215865A (en) * 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
WO1986006487A1 (en) 1985-04-22 1986-11-06 Commonwealth Serum Laboratories Commission Method for determining mimotopes
AU592560B2 (en) * 1985-04-22 1990-01-18 Coselco Mimotopes Pty Ltd Improved method for determining mimotopes
IL79881A (en) * 1985-08-28 1995-12-08 Pieczenik George Populations of random coding series of oligonucleotides and peptides
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US5075211A (en) * 1986-03-26 1991-12-24 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
IE64356B1 (en) * 1986-07-28 1995-07-26 Bioscience Int Inc Diagnosis severity prediction and monitoring of disease by immunoassay of free activation peptides of pancreatic zymogens
GB8709274D0 (en) * 1987-04-16 1987-05-20 Wellcome Found Peptides
US4981782A (en) * 1987-05-14 1991-01-01 Sri International Synthetic peptides for diagnosis and prevention of influenza virus infection and their use
US5780038A (en) * 1987-11-16 1998-07-14 Roche Diagnostic Systems, Inc. HIV-2 envelope polypeptides
US5200320A (en) * 1987-12-07 1993-04-06 National Jewish Center For Immunology And Respiratory Medicine Method for identifying useful polypeptide vaccines
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US7811751B2 (en) 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
FR2631451A1 (fr) * 1988-05-13 1989-11-17 Inst Nat Sante Rech Med Procede de caracterisation de l'epitope intervenant dans une reaction antigene anticorps, kit ou necessaire pour la mise en oeuvre du procede
US5003043A (en) * 1988-05-25 1991-03-26 Triton Biosciences Inc. Peptides representing epitopic sites for the major HTLV-I envelope protein, antibodies thereto, and uses thereof
DE3911794A1 (de) * 1989-04-11 1990-10-18 Thomae Gmbh Dr K Monoklonale antikoerper gegen rekombinaten humanen gewebeplasminogenaktivator mit definierter epitopspezifitaet, deren herstellung und deren verwendung
US5243030A (en) * 1989-05-24 1993-09-07 Sri International Conjugates of a synthetic peptide for diagnosis and prevention of influenza virus infection
US5136019A (en) * 1989-05-24 1992-08-04 Sri International Synthetic peptides for diagnosis and prevention of influenza virus infection and their use
US5286789A (en) * 1989-05-26 1994-02-15 Applied Immune Sciences, Inc. Solid phase multiple peptide synthesis
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US20030225254A1 (en) * 1989-08-07 2003-12-04 Rathjen Deborah Ann Tumour necrosis factor binding ligands
DE69027121T3 (de) * 1989-08-07 2001-08-30 Peptech Ltd., Dee Why Bindeligande für tumornekrosisfaktor
US5959087A (en) * 1989-08-07 1999-09-28 Peptide Technology, Ltd. Tumour necrosis factor binding ligands
DE3935572A1 (de) * 1989-10-25 1991-05-02 Biotechnolog Forschung Gmbh Verfahren zur peptidsynthese und traeger dafuer
FI910245A (fi) * 1990-01-24 1991-07-25 United Biomedical Inc Syntetiska peptidkompositioner med immunoreaktivitet mot htlv-antikroppar.
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
EP0445801A3 (en) * 1990-03-08 1992-07-01 Kuraray Co., Ltd. Peptide and its use
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992009300A1 (en) * 1990-11-21 1992-06-11 Iterex Pharmaceuticals Ltd. Partnership Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
US6197529B1 (en) 1990-11-21 2001-03-06 Torrey Pines Institute For Molecular Studies Linear substituted oligoalkyleneimine libraries
JPH06504997A (ja) * 1990-12-06 1994-06-09 アフィメトリックス，　インコーポレイテッド 非常に大きい規模の固定化されたポリマーの合成
EP0600036A1 (de) * 1991-08-21 1994-06-08 Receptor Laboratories, Inc. Verfahren zur erzeugung und sortierung von nuetzlichen peptiden
WO1993004204A1 (en) * 1991-08-23 1993-03-04 Isis Pharmaceuticals, Inc. Synthetic unrandomization of oligomer fragments
US5747253A (en) * 1991-08-23 1998-05-05 Isis Pharmaceuticals, Inc. Combinatorial oligomer immunoabsorbant screening assay for transcription factors and other biomolecule binding
AU669489B2 (en) * 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5811246A (en) * 1991-12-17 1998-09-22 The Research Foundation Of State University Of New York Process for immobilization onto the surfaces of ELISA plates of a compound carrier complex and for immunization
JP3151054B2 (ja) * 1992-06-25 2001-04-03 協和醗酵工業株式会社 抗ｄｃｃ遺伝子産物モノクローナル抗体
EP0582450A3 (de) * 1992-08-03 1994-11-23 Rohto Pharma Antikörper gegen Oxytocin-Rezeptor und deren Herstellung.
US5846731A (en) * 1993-06-17 1998-12-08 Torry Pines Institute For Molecular Studies Peralkylated oligopeptide mixtures
US5480971A (en) * 1993-06-17 1996-01-02 Houghten Pharmaceuticals, Inc. Peralkylated oligopeptide mixtures
US6448379B1 (en) * 1993-09-14 2002-09-10 Chiron Corporation IL8 inhibitors
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US6287787B1 (en) 1993-11-24 2001-09-11 Torrey Pines Institute For Molecular Studies Dimeric oligopeptide mixture sets
US5559023A (en) * 1994-02-10 1996-09-24 Cancer Institute Tumor suppressor gene
US5834245A (en) * 1994-07-29 1998-11-10 Cancer Institute PRLTS proteins and DNA's encoding the same
ATE209660T1 (de) 1994-08-12 2001-12-15 Myriad Genetics Inc 17q-verbundenes ovarial- und brustkrebs empfindlichkeitsgen
AU686004B2 (en) 1994-08-12 1998-01-29 Myriad Genetics, Inc. In vivo mutations and polymorphisms in the 17q-linked breast and ovarian cancer susceptibility gene
US5582997A (en) * 1994-08-24 1996-12-10 Torrey Pines Institute For Molecular Studies Lysine/leucine polypeptides, mixture sets and libraries thereof
US5645996A (en) * 1994-08-24 1997-07-08 Torrey Pines Institute For Molecular Studies Melittin-related polypeptides, mixture sets and libraries thereof
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
US6121489A (en) * 1996-03-05 2000-09-19 Trega Biosciences, Inc. Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein
DE69735872T2 (de) 1996-03-07 2006-12-28 Eisai Co., Ltd. Menschliches adhäsionsmolekül occludin
JP3894381B2 (ja) * 1996-04-10 2007-03-22 株式会社ペプチド研究所 抗Ｇｌｕ▲１７▼−オステオカルシン抗体
EP0920505B1 (de) 1996-08-16 2008-06-04 Schering Corporation Zelloberflächen-antigen aus säugetieren und verwandte reagenzien
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6093809A (en) * 1996-10-01 2000-07-25 University Technology Corporation Telomerase
GB2321642B8 (en) 1996-10-01 2006-08-22 Geron Corp Human telomerase reverse transcriptase promoter
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
GB9907461D0 (en) 1999-03-31 1999-05-26 King S College London Neurite regeneration
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US6441172B1 (en) 1996-11-07 2002-08-27 Torrey Pines Institute For Molecular Studies Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
EP1995318A1 (de) 1996-12-13 2008-11-26 Schering Corporation Säugerzelloberflächenantigene und damit zusammenhängende Reagenzien
JP3618497B2 (ja) * 1996-12-27 2005-02-09 富士通株式会社 タンパク質の抗原決定基予測方法及びシステム
US5981201A (en) 1997-01-08 1999-11-09 Beth Israel Deaconess Medical Center Methods of detection and treatment of breast cancer
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
WO1999060127A2 (en) 1998-05-15 1999-11-25 Genentech, Inc. Il-17 homologous polypeptides and therapeutic uses thereof
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
IL133494A0 (en) 1997-07-09 2001-04-30 Schering Corp Isolated dendritic cell membrane protein genes
CO4810232A1 (es) 1997-07-25 1999-06-30 Schering Corp Citoquinas de mamiferos y sus secuencias codificadoras
PT1003861E (pt) 1997-08-01 2007-01-31 Schering Corp Proteínas de membrana de células de mamíferos;reagentes relacionados
EP1659131B1 (de) 1997-09-17 2009-11-04 Genentech, Inc. Polypeptide und dafür kodierende Nukleinsäure
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
NZ527900A (en) 1997-12-03 2005-02-25 Genentech Inc PRO361 polypeptides and nucleic acids with homology to mucin and chitinase
US6780609B1 (en) 1998-10-23 2004-08-24 Genome Therapeutics Corporation High bone mass gene of 1.1q13.3
EP2050762A3 (de) 1998-03-10 2009-07-08 Genentech, Inc. Neue Polypeptide und für diese kodierende Nukleinsäuren
AU760794B2 (en) 1998-03-10 2003-05-22 Regents Of The University Of California, The Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding
US6225456B1 (en) 1998-05-07 2001-05-01 University Technololy Corporation Ras suppressor SUR-5
EP1865061A3 (de) 1998-05-15 2007-12-19 Genentech, Inc. IL-17-homologe Polypeptide und ihre therapeutische Verwendung
EP3112468A1 (de) 1998-05-15 2017-01-04 Genentech, Inc. Il-17-homologe polypeptide und therapeutische verwendung davon
US6506889B1 (en) 1998-05-19 2003-01-14 University Technology Corporation Ras suppressor SUR-8 and related compositions and methods
US6322976B1 (en) 1998-05-28 2001-11-27 Medical Research Council Compositions and methods of disease diagnosis and therapy
US7060431B2 (en) * 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
EP1090118A2 (de) 1998-06-26 2001-04-11 Incyte Pharmaceuticals, Inc. Menschliche proteine mit signalpeptid
US20020172678A1 (en) 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
JP2002526079A (ja) 1998-09-21 2002-08-20 シェーリング コーポレイション ヒトインターロイキン−ｂ５０、治療的使用
EP0997476A3 (de) 1998-09-25 2000-07-19 Schering-Plough Antikörper gegen ein Antigen auf Langerhans Zellen in Säugetieren und deren Verwendungen
EP2075335A3 (de) 1998-12-22 2009-09-30 Genentech, Inc. Verfahren und Zusammensetzungen zur Hemmung des neoplastischen Zellenwachstums
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
EP1159299B1 (de) 1999-03-11 2009-01-14 Schering Corporation Cytokine aus säugetieren, verwandte reagenzien und verfahren
PT1609863E (pt) 1999-03-23 2009-01-02 Genentech Inc Polipéptidos segregados e transmembranares e ácidos nucleicos que os codificam
ATE315787T1 (de) * 1999-05-14 2006-02-15 Univ Mcgill Methoden zur identifizierung von modulatoren wechselwirkender proteine
EP1684077A1 (de) * 1999-05-14 2006-07-26 McGill University Verfahren zur Identifizierung von Modulatoren wechselwirkender Proteine
EP1953173B1 (de) 1999-06-15 2009-11-18 Genentech, Inc. Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
CN1365391A (zh) 1999-07-30 2002-08-21 先灵公司 哺乳动物细胞因子以及相关试剂
ATE422556T1 (de) 1999-08-20 2009-02-15 Univ Texas Hdac4- und hdac5-abhängige regulation der genexpression im herzen
EP1905832A3 (de) 1999-09-09 2009-09-09 Schering Corporation Säuger Interleukin-12 P40 und Interleukin B30, Antikörper, Verwendungen in pharmazeutischen Zusammenstellungen
US6432409B1 (en) * 1999-09-14 2002-08-13 Antigen Express, Inc. Hybrid peptides modulate the immune response
US9289487B2 (en) * 1999-09-14 2016-03-22 Antigen Express, Inc. II-key/antigenic epitope hybrid peptide vaccines
US20030235594A1 (en) * 1999-09-14 2003-12-25 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
JP4931310B2 (ja) 1999-10-20 2012-05-16 ジェネンテック， インコーポレイテッド ヘルパーｔ細胞性疾患の治療のためのｔ細胞分化の調節
DE19953775A1 (de) 1999-11-09 2001-05-10 Bayer Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
EP1690872A3 (de) 1999-12-01 2006-08-23 Genentech, Inc. Zusammensetzung und Verfahren zur Diagnose eines Tumors
EP1897944B1 (de) 1999-12-23 2011-08-10 Genentech, Inc. IL-17-homologe Polypeptide und ihre therapeutische Verwendung
ES2323220T3 (es) 2000-01-13 2009-07-09 Genentech, Inc. Polipeptidos humanos stra6.
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP1125905A1 (de) * 2000-02-16 2001-08-22 Pepscan Systems B.V. Synthese von Segmenten
CA2405557C (en) 2000-04-12 2013-09-24 Human Genome Sciences, Inc. Albumin fusion proteins
EP1272208B1 (de) 2000-04-12 2011-10-05 VIB vzw Verwendung von vegf 165 und homologen zur behandlung von neurologischen störungen
CA2304494A1 (en) 2000-04-20 2001-10-20 Philippe Seguela A novel heteromultimeric ion channel receptor and uses thereof
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
EP1297016B1 (de) 2000-05-12 2006-03-22 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Verwendung von inhibitoren des plazenta wachstumsfactors für die behandlung einer pathologischen angiogenese, pathologischen arteriogenese, entzündung, tumorbildung und/oder gefässdurchlässigkeit (ödem)
US6573370B1 (en) 2000-05-19 2003-06-03 Regents Of The University Of Michigan PON3 and uses thereof
US6656700B2 (en) * 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
US6686188B2 (en) * 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US20020039577A1 (en) 2000-06-09 2002-04-04 Townsend Robert M. Methods for regulating a lymphocyte-mediated immune response by blocking costimulatory signals and blocking LFA-1 mediated adhesion in lymphocytes
WO2001098323A2 (en) 2000-06-16 2001-12-27 Incyte Genomics, Inc. G-protein coupled receptors
EP2792747A1 (de) 2000-06-23 2014-10-22 Genentech, Inc. Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Erkrankungen in Verbindung mit Angiogenese
CA2648051A1 (en) 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
DE60136281D1 (de) 2000-08-24 2008-12-04 Genentech Inc Methode zur inhibierung von il-22 induziertem pap1
EP1944317A3 (de) 2000-09-01 2008-09-17 Genentech, Inc. Sekretierte und Transmembran-Polypeptide sowie Nukleinsäure zu deren Kodierung
WO2002024325A2 (en) 2000-09-25 2002-03-28 Picoliter, Inc. Acoustic ejection of fluids from a plurality of reservoirs
US20020123474A1 (en) * 2000-10-04 2002-09-05 Shannon Mark E. Human GTP-Rho binding protein2
EP1197755A1 (de) 2000-10-11 2002-04-17 Pepscan Systems B.V. Bestimmung von Protein-Bindungsstellen
AU2002210403A1 (en) * 2000-10-20 2002-04-29 Como Biotech Aps Pregnancy-associated plasma protein-a2 (papp-a2)
US7060442B2 (en) 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
US7608704B2 (en) 2000-11-08 2009-10-27 Incyte Corporation Secreted proteins
WO2002072601A2 (en) * 2001-02-07 2002-09-19 The Burnham Institute Apoptosis modulator bcl-b and methods for making and using same
CN1564826A (zh) 2001-02-09 2005-01-12 人类基因组科学公司 人类g蛋白趋化因子受体(ccr5)hdgnr10
US20020160527A1 (en) 2001-02-26 2002-10-31 3M Innovative Properties Company Combinatorial library comprising pouches as packages for library members and method therefor
US6849449B2 (en) 2001-03-01 2005-02-01 Regents Of The University Of Michigan Orphanin FQ receptor nucleic acids
US7514263B2 (en) 2001-04-02 2009-04-07 3M Innovative Properties Company Continuous process for the production of combinatorial libraries of materials
US20020193295A1 (en) * 2001-05-04 2002-12-19 Emanuel Calenoff Immunogenic peptides and uses thereof
SK14432003A3 (sk) * 2001-04-26 2004-07-07 Biogen, Inc. Protilátka špecifická pre Cripto, kompozícia obsahujúca takúto protilátku a jej použitie
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
KR100628425B1 (ko) 2001-06-20 2006-09-28 제넨테크, 인크. 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
GB0116453D0 (en) 2001-07-05 2001-08-29 Imp College Innovations Ltd Method
DE60222422D1 (de) 2001-07-18 2007-10-25 Bionomics Ltd Mutationen in ionenkanälen
AU2003904154A0 (en) 2003-08-07 2003-08-21 Bionomics Limited Mutations in ion channels
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
US6867189B2 (en) 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
WO2013034682A1 (en) 2011-09-08 2013-03-14 Umc Utrecht Holding B.V. Vaccine based on staphylococcal superantigen- line 3 protein (ssl3)
AU2002330015B2 (en) 2001-09-18 2008-02-07 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
JP4486815B2 (ja) 2001-09-27 2010-06-23 バイオノミックス リミテッド ヒト血管形成遺伝子に対するｄｎａ配列
US7354898B2 (en) 2001-10-02 2008-04-08 University Of Chicago Identification of novel factors that block programmed cell death or apoptosis by targeting JNK
EP1440083B1 (de) 2001-10-25 2013-01-02 Medical Research Council Moleküle
DE10294485T5 (de) 2001-10-29 2004-04-29 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Mit Mnk-Kinase homologe Proteine, die in die Regulation der Energiehomöostase und den Organellenmetabolismus involviert sind
US7462472B2 (en) 2001-11-02 2008-12-09 The University Of Chicago Methods and compositions relating to anthrax pathogenesis
CA2471431A1 (en) 2002-01-02 2003-07-17 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
CA2472927A1 (en) 2002-01-10 2003-07-17 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw A novel splice variant of myd88 and uses thereof
US6861523B2 (en) 2002-02-08 2005-03-01 Torrey Pines Institute For Molecular Studies 1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
WO2003070902A2 (en) 2002-02-20 2003-08-28 Incyte Corporation Receptors and membrane-associated proteins
JP2005535290A (ja) 2002-02-22 2005-11-24 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための組成物と方法
AU2003230874A1 (en) 2002-04-16 2003-11-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
AU2003231740A1 (en) 2002-04-19 2003-11-03 The Government Of The United States Of America As Represented By The Secretary, Department Of Health Compositions and methods for diagnostics and therapeutics for hydrocephalus
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
CA2483868A1 (en) * 2002-05-03 2004-05-21 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
JP2005527614A (ja) 2002-05-29 2005-09-15 デヴェロゲン アクチエンゲゼルシャフト フュア エントヴィックルングスビオローギッシェ フォルシュング 膵臓特異性タンパク質
EP2305710A3 (de) 2002-06-03 2013-05-29 Genentech, Inc. Synthetische Antikörperphagenbibliotheken
CA2486252C (en) 2002-06-07 2012-07-24 Genentech, Inc. Methods for screening for agents that modulate hepatocellular carcinoma development
WO2004004649A2 (en) 2002-07-08 2004-01-15 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20040121370A1 (en) 2002-09-11 2004-06-24 Genentech, Inc. Novel composition and methods for the treatment of immune related diseases
JP2006512903A (ja) 2002-09-11 2006-04-20 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための新規組成物と方法
JP2006521082A (ja) 2002-09-11 2006-09-21 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための新規組成物と方法
US20070010434A1 (en) 2002-09-16 2007-01-11 Genetech, Inc. Novel compositions and methods for the treatment of immune related diseases
US7179645B2 (en) * 2002-09-24 2007-02-20 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
AU2003294220A1 (en) 2002-09-17 2004-04-23 Antigen Express, Inc. Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES
AU2003279084A1 (en) 2002-09-25 2004-04-19 Genentech, Inc. Novel compositions and methods for the treatment of psoriasis
CN1891826B (zh) 2002-10-22 2011-09-14 卫材R&D管理有限公司 在分裂停止后的产多巴胺型神经元前体细胞中特异性表达的基因
EP2322201A3 (de) 2002-10-29 2011-07-27 Genentech, Inc. Gestaltungen und Methoden für die behandlung von Immune verwandte Krankheiten
JP2006516094A (ja) 2002-11-08 2006-06-22 ジェネンテック・インコーポレーテッド ナチュラルキラー細胞関連疾患の治療のための組成物と方法
EP2314676A1 (de) 2002-11-26 2011-04-27 Genentech, Inc. Zusammensetzung und Verfahren zur Behandlung von Immunerkrankungen
AU2003299314A1 (en) 2002-12-16 2004-07-09 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Fwd, pp2c1, adk3, cg3860, cdk4, cg7134, eip75b involved in the regulation of energy homeostasis
GB0300718D0 (en) 2003-01-13 2003-02-12 Ares Trading Sa Proteins
WO2004065000A1 (en) * 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
US6910785B2 (en) * 2003-01-22 2005-06-28 Cooper Technologies Company Industrial luminaire with prismatic refractor
EP1452868A2 (de) 2003-02-27 2004-09-01 Pepscan Systems B.V. Verfahren zur Selektion eines potenziellen Arzneimittels
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
AU2003901425A0 (en) 2003-03-27 2003-04-10 Bionomics Limited A diagnostic method for epilepsy
AU2003901511A0 (en) 2003-03-28 2003-04-17 Bionomics Limited Nucleic acid molecules associated with angiogenesis II
BRPI0409638A (pt) 2003-04-23 2006-04-25 Hexima Ltd molécula de ácido nucleico isolada, vetor, célula modificada geneticamente, quimiotripsina isolada de helicoveipa spp., antagonista, composição, planta geneticamente modificada, sementes ou outro material de reprodução, métodos para modular atividade de hpch5 ou um homólogo ou variante da mesma em um inseto, para modular expressão de hpf5 ou homólogo ou variante em um inseto, para isolar e separar isoformas individuais de quimiotripsina, para selecionar um antagonista de uma quimiotripsina insensìvel a napi de helicoverpa spp., e, inibidor isolado
US7829682B1 (en) 2003-04-30 2010-11-09 Incyte Corporation Human β-adrenergic receptor kinase nucleic acid molecule
US7173010B2 (en) 2003-05-19 2007-02-06 Regents Of The University Of Michigan Orphanin FQ receptor
AU2003241006B2 (en) 2003-05-21 2011-03-24 Ares Trading S.A. TNF-like secreted protein
MX341074B (es) 2003-07-08 2016-08-05 Genentech Inc Polipeptidos heterologos il-17 a/f y usos terapeuticos de los mismos.
EP2289908B1 (de) 2003-07-11 2013-08-07 Evotec International GmbH Verwendung von DG177 sekretierter Proteinprodukte zur Prevention und Behandlung von Pankreaserkrankungen und/oder Fettleibigkeit und/oder metabolischem Syndrom
EP1644027B1 (de) 2003-07-16 2014-04-09 Evotec International GmbH Verwendung von pleiotrophin zur behandlung von bauchspeicheldrüsenkrankheiten, fettsucht und metabolischem syndrom
AU2004203373A1 (en) 2003-07-25 2005-02-10 University Of Chicago Identification of novel factors that block programmed cell death or apoptosis by targeting JNK
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7662929B2 (en) 2003-10-10 2010-02-16 Alchemia Oncology Pty Limited Antibody that specifically binds hyaluronan synthase
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
WO2005047478A2 (en) 2003-11-12 2005-05-26 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for regulation of tumor necrosis factor-alpha
SI2295073T1 (sl) 2003-11-17 2014-07-31 Genentech, Inc. Protitelo proti CD22 za zdravljenje tumorja hematopoetskega izvora
EP2135618B1 (de) 2003-11-19 2014-01-15 Evotec International GmbH SF6 zur Verwendung zur Behandlung von Diabetes und/oder Fettleibigkeit, Screeningverfahren für Modulatoren und Kit
US7432057B2 (en) 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
EP1729795B1 (de) 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Albuminfusionsproteine
GB0403864D0 (en) 2004-02-20 2004-03-24 Ucl Ventures Modulator
DK2096120T3 (da) 2004-02-20 2012-07-09 Develogen Ag Anvendelse af sekreterede proteinprodukter til at forebygge og behandle pankreatiske sygdomme og/eller obesitet og/eller metabolsk syndrom
EP2017620A3 (de) 2004-04-28 2009-04-22 Bayer HealthCare AG Diagnostika und Therapeutika für mit Dipeptidyl-peptidase 1 (DPP1) assoziierten Krankheiten
CN102212132A (zh) 2004-05-27 2011-10-12 克鲁塞尔荷兰公司 能中和狂犬病病毒的结合分子及其应用
KR101375603B1 (ko) 2004-07-22 2014-04-01 에자이 알앤드디 매니지먼트 가부시키가이샤 Ｌｒｐ４／Ｃｏｒｉｎ 도파민 생산 뉴런 전구 세포 마커
CA2576435A1 (en) 2004-08-09 2006-03-23 Research Development Foundation Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis
EP2338994B1 (de) 2004-09-02 2014-03-19 Yale University Regulierung von Onkogenen durch mikro-RNAs
GB0426960D0 (en) 2004-12-08 2005-01-12 Ares Trading Sa TGR-3 like protein receptor
US20100111980A1 (en) 2004-12-10 2010-05-06 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Binding partners of antibodies specific for dendritic cell antigens
CA2591665C (en) 2004-12-20 2015-05-05 Crucell Holland B.V. Binding molecules capable of neutralizing west nile virus and uses thereof
EP1838350B1 (de) 2005-01-20 2014-08-20 Ryboquin Company Limited Modulatoren für itch-ubiquitinase-aktivität
WO2006101629A2 (en) 2005-02-17 2006-09-28 Vertex Pharmaceuticals Incorporated SODIUM CHANNEL PROTEIN TYPE III α-SUBUNIT SPLICE VARIANT
JP2008535796A (ja) 2005-03-10 2008-09-04 ジェネンテック・インコーポレーテッド 脈管の完全性を調節するための方法及び組成物
CA2601400A1 (en) 2005-03-19 2006-09-28 Medical Research Council Improvements in or relating to treatment and prevention of viral infections
RS52372B (en) 2005-03-24 2012-12-31 Thrombogenics N.V. NOVA ANTITELA PROTIV PLGF
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US8076293B2 (en) 2005-04-19 2011-12-13 Gabriel Stavros Panayi Use of BiP or a variant, homologue, derivative or fragment thereof in the manufacture of a medicament for the prevention or treatment of bone loss or bone resorption
US8052974B2 (en) 2005-05-12 2011-11-08 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
NZ563341A (en) 2005-06-06 2009-10-30 Genentech Inc Methods for identifying agents that modulate a gene that encodes for a PRO1568 polypeptide
TW200643171A (en) 2005-06-07 2006-12-16 Temasek Life Sciences Lab Ltd Porcine circovirus type 2 vaccines
US8354384B2 (en) 2005-06-23 2013-01-15 Yale University Anti-aging micrornas
WO2006135985A1 (en) 2005-06-24 2006-12-28 The Walter And Eliza Hall Institute Of Medical Research Therapeutic pro-apoptotic bh3-like molecules and methods for generating and/or selecting the same
WO2007003609A1 (en) 2005-06-30 2007-01-11 Vib Vzw Treatment of liver cirrhosis and its complications
CA2619577A1 (en) 2005-08-15 2007-02-22 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
CA2619736C (en) 2005-08-18 2012-05-22 Eisai R & D Management Co., Ltd. Dopaminergic neuron proliferative progenitor cell marker msx1/2
CA2624135C (en) 2005-09-29 2015-06-30 Eisai R & D Management Co., Ltd. T-cell adhesion molecule and antibody thereto
US7972813B2 (en) 2005-09-30 2011-07-05 Vertex Pharmaceuticals Incorporated Tetrodotoxin-resistant sodium channel alpha subunit
JP2009516514A (ja) 2005-11-21 2009-04-23 ジェネンテック・インコーポレーテッド 新規遺伝子破壊、それらに関する組成物および方法
RU2426742C2 (ru) 2005-12-02 2011-08-20 Дженентек, Инк. Составы и способы лечения заболеваний и нарушений, связанных с передачей сигналов цитокинами
WO2007087113A2 (en) 2005-12-28 2007-08-02 The Scripps Research Institute Natural antisense and non-coding rna transcripts as drug targets
WO2007087153A2 (en) 2006-01-06 2007-08-02 University Of Georgia Research Foundation Cyst nematode resistant transgenic plants
US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
EP3360965A1 (de) 2006-01-20 2018-08-15 Cell Signaling Technology, Inc. Translokation und mutante ros-kinase in humanem nichtkleinzelligem bronchialkarzinom
ZA200807714B (en) 2006-02-17 2010-01-27 Genentech Inc Gene disruptions, compositions and methods relating thereto
US7935349B2 (en) 2006-03-17 2011-05-03 The Royal Institution For The Advancement Of Learning/Mcgill University CRMP4b inhibitory peptide
CA2647277A1 (en) 2006-04-05 2007-11-08 Genentech, Inc. Method for using boc/cdo to modulate hedgehog signaling
EP2006382B1 (de) 2006-04-11 2016-08-03 Eisai R&D Management Co., Ltd. Dopamin produzierender neuronenvorläuferzellmarker 187a5
SI2450437T1 (sl) 2006-04-14 2017-12-29 Cell Signaling Technology Inc. Okvarjenost genov in mutantna ALK kinaza v človeških solidnih tumorjih
CA2649387A1 (en) 2006-04-19 2008-03-27 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
US8202977B2 (en) 2006-04-21 2012-06-19 Minister for Primary Industries For And On Behalf Of The State Of New South Wales Pestivirus species
US7723564B2 (en) 2006-05-10 2010-05-25 Board Of Regents Of The University Of Nebraska Compositions and methods for modulation of KSR1 and KSR2 interactions
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
US8211431B2 (en) 2006-06-06 2012-07-03 Crucell Holland B.V. Human binding molecules having killing activity against staphylococci and uses thereof
KR20220031126A (ko) 2006-06-06 2022-03-11 얀센 백신스 앤드 프리벤션 비.브이. 장내구균에 대한 사멸활성을 갖는 인간결합분자 및 그것의 용도
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
GB0614042D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
ATE543097T1 (de) 2006-07-27 2012-02-15 Univ Maryland Zellulärer rezeptor für antiproliferativen faktor
MX2009001281A (es) 2006-08-01 2009-04-16 Univ Texas Identificacion de un micro-arn que activa la expresion de la cadena pesada de beta-miosina.
EP2057465A4 (de) 2006-08-09 2010-04-21 Homestead Clinical Corp Organspezifische proteine und anwendungsverfahren dafür
EP2450377A1 (de) 2006-09-07 2012-05-09 Crucell Holland B.V. Zur Neutralisierung des Influenzavirus H5N1 fähige humane Bindungsmoleküle sowie deren Verwendungen
PT2059532E (pt) 2006-09-07 2013-03-07 Crucell Holland Bv Moléculas de ligação humanas capazes de neutralizar o vírus da gripe h5n1 e seus usos
ES2372217T3 (es) 2006-09-12 2012-01-17 Genentech, Inc. Procedimientos y composiciones para el diagnóstico y tratamiento del cáncer de pulmón utilizando el gen de pdgfra, kit o kdr como marcador genético.
MX2009003090A (es) 2006-09-21 2009-04-02 Probiodrug Ag Genes novedosos relacionados con ciclasa de glutaminilo.
JPWO2008035527A1 (ja) * 2006-09-21 2010-01-28 隆弘 越智 抗Ｃ１ｑモノクローナル抗体
US20100166743A1 (en) 2006-10-06 2010-07-01 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
US7645616B2 (en) 2006-10-20 2010-01-12 The University Of Hong Kong Use of lipocalin-2 as a diagnostic marker and therapeutic target
NZ576445A (en) 2006-11-02 2012-03-30 Daniel J Capon Hybrid immunoglobulins with moving parts
WO2008060448A2 (en) 2006-11-10 2008-05-22 Massachusetts Institute Of Technology Small molecule pak inhibitors
EP3225251B1 (de) 2006-12-21 2020-02-12 H. Lundbeck A/S Modulation der proneurotrophinaktivität
US20100129358A1 (en) 2006-12-22 2010-05-27 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
AU2008218199B2 (en) 2007-02-22 2013-10-31 Genentech, Inc. Methods for detecting inflammatory bowel disease
JPWO2008111464A1 (ja) 2007-03-05 2010-06-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 スプライシング異常を指標とする抗ガン剤の作用検定方法
US20100086931A1 (en) 2007-03-05 2010-04-08 Eisai R&D Management Co., Ltd. Method for assaying action of antitumor agent using decrease in gene expression level as index
AU2008269689A1 (en) 2007-06-27 2008-12-31 Auckland Uniservices Limited Polypeptides and polynucleotides for artemin and related ligands, and methods of use thereof
WO2009018493A1 (en) 2007-07-31 2009-02-05 The Board Of Regents Of The University Of Texas System A micro-rna family that modulates fibrosis and uses thereof
AR068551A1 (es) 2007-09-25 2009-11-18 Pastoral Greenhouse Gas Res Lt Peptidos y polipeptidos permeabilizantes celulares para celulas microbianas
WO2009043104A1 (en) 2007-10-04 2009-04-09 Bionomics Limited Markers of endothelial cells and uses thereof
ES2576650T3 (es) 2007-10-18 2016-07-08 Cell Signaling Technology, Inc. Translocación y ROS quinasa mutante en el carcinoma pulmonar no microcítico humano
ES2662845T3 (es) 2007-11-07 2018-04-10 Genentech, Inc. IL-22 para su uso en el tratamiento de trastornos microbianos
WO2009087379A2 (en) 2008-01-09 2009-07-16 Amura Therapeutics Limited Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases
SI2257643T1 (sl) 2008-02-19 2018-12-31 The Children's Hospital Of Philadelphia Identifikacija predelov vnetne črevesne bolezni z začetkom v otroštvu in metode za njeno uporabo za diagnozo in zdravljenje te bolezni
GB0804702D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
CN102036689B (zh) 2008-03-17 2014-08-06 得克萨斯系统大学董事会 神经肌肉突触维持和再生中涉及的微小rna的鉴定
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
JP6095889B2 (ja) 2008-05-16 2017-03-15 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ 染色体２１ｑ、６ｑ、および１５ｑの遺伝子変異およびこれらを使用して１型糖尿病を診断および治療する方法
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
JP2011529708A (ja) 2008-08-04 2011-12-15 ユニバーシティ オブ マイアミ 自然免疫応答の調節因子ｓｔｉｎｇ（インターフェロン遺伝子の刺激因子）
BRPI0920224A2 (pt) 2008-10-02 2017-06-27 Life Sciences Res Partners Vzw inibição de plgf para tratar leucemia positiva para cromossoma filadélfia
KR20110084280A (ko) * 2008-11-03 2011-07-21 알레시아 바이오쎄라퓨틱스 인코포레이티드 종양 항원의 생물 활성을 특이적으로 차단하는 항체
WO2010054328A2 (en) 2008-11-07 2010-05-14 Research Development Foundation Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling
CN102361985B (zh) 2008-12-04 2017-06-20 库尔纳公司 通过抑制肿瘤抑制基因的天然反义转录物治疗肿瘤抑制基因相关性疾病
MX2011005910A (es) 2008-12-04 2011-06-17 Opko Curna Llc Tratamiento de enfermedades relacionadas con eritropoyetina (epo) mediante inhibicion del transcrito antisentido natural a eritropoyetina.
JP5971948B2 (ja) 2008-12-04 2016-08-17 クルナ・インコーポレーテッド Ｖｅｇｆに対する天然アンチセンス転写物の抑制による血管内皮増殖因子（ｖｅｇｆ）関連疾患の治療
CN102245640B (zh) 2008-12-09 2014-12-31 霍夫曼-拉罗奇有限公司 抗-pd-l1抗体及它们用于增强t细胞功能的用途
WO2010071610A1 (en) 2008-12-19 2010-06-24 Agency For Science, Technology And Research (A*Star) Severe chikungunya biomarkers
JP2012516350A (ja) * 2009-01-28 2012-07-19 アンティジェン・エクスプレス・インコーポレーテッド インフルエンザに対する免疫応答を調節するＩｉ−Ｋｅｙハイブリッドペプチド
PT2396038E (pt) 2009-02-12 2016-02-19 Curna Inc Tratamento das doenças associadas com o factor neurotrófico derivado do cérebro (bdnf) por inibição do produto antisenso natural da transcrição para bdnf
SI2881402T1 (sl) 2009-02-12 2017-12-29 Cell Signaling Technology, Inc. Ekspresija mutantnega ros pri humanem raku jeter
GB0903759D0 (en) 2009-03-04 2009-04-15 Medical Res Council Compound
JP6116242B2 (ja) 2009-03-16 2017-04-19 クルナ・インコーポレーテッド 核因子（赤血球由来２）様２（ｎｒｆ２）に対する天然アンチセンス転写物の抑制によるｎｒｆ２関連疾患の治療
US9708604B2 (en) 2009-03-17 2017-07-18 Curna, Inc. Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1
EP2408772B1 (de) 2009-03-19 2015-07-01 Medical Research Council Technology Verbindungen
KR101835889B1 (ko) 2009-05-06 2018-03-08 큐알엔에이, 인크. 지질 수송 및 대사 유전자에 대한 천연 안티센스 전사체의 억제에 의해 지질 수송 및 대사 유전자 관련된 질환의 치료
JP6250930B2 (ja) 2009-05-06 2017-12-20 クルナ・インコーポレーテッド トリステトラプロリン（ｔｔｐ）に対する天然アンチセンス転写物の抑制によるｔｔｐ関連疾患の治療
CA2761248C (en) 2009-05-08 2023-03-14 Joseph Collard Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
WO2010130636A1 (en) 2009-05-11 2010-11-18 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof
NO2432881T3 (de) 2009-05-18 2018-04-14
CN102549158B (zh) 2009-05-22 2017-09-26 库尔纳公司 通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病
US8791085B2 (en) 2009-05-28 2014-07-29 Curna, Inc. Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
CN102612560B (zh) 2009-06-16 2017-10-17 库尔纳公司 通过抑制针对对氧磷酶1(pon1)的天然反义转录物来治疗pon1相关的疾病
CN102695797B (zh) 2009-06-16 2018-05-25 库尔纳公司 通过抑制针对胶原基因的天然反义转录物来治疗胶原基因相关的疾病
WO2010148365A2 (en) 2009-06-19 2010-12-23 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona For And On Behalf Of Arizona State University Compound arrays for sample profiling
ES2618894T3 (es) 2009-06-24 2017-06-22 Curna, Inc. Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2
JP5907866B2 (ja) 2009-06-26 2016-04-26 クルナ・インコーポレーテッド ダウン症候群遺伝子に対する天然アンチセンス転写物の抑制によるダウン症候群遺伝子関連疾患の治療
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
KR101801407B1 (ko) 2009-07-24 2017-11-24 큐알엔에이, 인크. 시르투인 (ｓｉｒｔ)에 대한 천연 안티센스 전사체의 억제에 의한 시르투인 관련된 질환의 치료
ES2585360T3 (es) 2009-08-05 2016-10-05 Curna, Inc. Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS)
JP6189594B2 (ja) 2009-08-11 2017-08-30 クルナ・インコーポレーテッド アディポネクチン（ａｄｉｐｏｑ）に対する天然アンチセンス転写物の抑制によるアディポネクチン（ａｄｉｐｏｑ）関連疾患の治療
KR101805213B1 (ko) 2009-08-21 2017-12-06 큐알엔에이, 인크. Ｃｈｉｐ에 대한 천연 안티센스 전사체의 억제에 의한 “ｈｓｐ70-상호작용 단백질(ｃｈｉｐ)의 ｃ-말단” 관련된 질환의 치료
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN102482671B (zh) 2009-08-25 2017-12-01 库尔纳公司 通过抑制‘含有iq模体的gtp酶激活蛋白’(iqgap)的天然反义转录物而治疗iqgap相关疾病
NZ795881A (en) 2009-08-27 2024-07-05 Pastoral Greenhouse Gas Res Ltd Complete genome sequence of the methanogen methanobrevibacter ruminantium
GB0915332D0 (en) 2009-09-02 2009-10-07 Univ Leuven Kath New methods for diagnosing autoimmune diseases
CA2772945A1 (en) 2009-09-25 2011-03-31 Xoma Technology Ltd. Screening methods
DK2480669T3 (en) 2009-09-25 2018-02-12 Curna Inc TREATMENT OF FILAGGRIN- (FLG) RELATED DISEASES BY MODULATING FLG EXPRESSION AND ACTIVITY
WO2011041789A1 (en) 2009-10-02 2011-04-07 The Trustees Of Columbia University In The City Of New York Piscine reovirus immunogenic compositions
ES2564207T3 (es) 2009-10-22 2016-03-18 F. Hoffmann-La Roche Ag Métodos y composiciones para modular la activación con hepsina de la proteína estimuladora de macrófagos
WO2011054359A2 (en) 2009-11-06 2011-05-12 University Of Copenhagen Method for early detection of cancer
WO2011054976A2 (en) 2009-11-09 2011-05-12 Genepod Therapeutics Ab Novel viral vector construct for neuron specific optimized continuous dopa synthesis in vivo
EP3002297B1 (de) 2009-11-30 2020-04-08 F. Hoffmann-La Roche AG Antikörper zur behandlung und der diagnose slc34a2 (tat211) exprimierender tumore.
ES2661813T3 (es) 2009-12-16 2018-04-04 Curna, Inc. Tratamiento de enfermedades relacionadas con la peptidasa del factor de transcripción de membrana, sitio 1 (mbtps1) mediante inhibición del transcrito antisentido natural al gen mbtps1
KR101891352B1 (ko) 2009-12-23 2018-08-24 큐알엔에이, 인크. 간세포 성장 인자(ｈｇｆ)에 대한 천연 안티센스 전사체의 억제에 의한 ｈｇｆ 관련 질환의 치료
KR101793753B1 (ko) 2009-12-23 2017-11-03 큐알엔에이, 인크. 커플링방지 단백질 ２(ｕｃｐ２)에 대한 천연 안티센스 전사체의 저해에 의한 ｕｃｐ２ 관련 질환의 치료
RU2611186C2 (ru) 2009-12-29 2017-02-21 Курна, Инк. ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С ОПУХОЛЕВЫМ БЕЛКОМ 63 (р63), ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К р63
KR101838305B1 (ko) 2009-12-29 2018-03-13 큐알엔에이, 인크. ＮＲＦ1(Ｎｕｃｌｅａｒ Ｒｅｓｐｉｒａｔｏｒｙ Ｆａｃｔｏｒ 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료
CN102791862B (zh) 2009-12-31 2017-04-05 库尔纳公司 通过抑制胰岛素受体底物2(irs2)和转录因子e3(tfe3)的天然反义转录物而治疗irs2相关疾病
NO2521784T3 (de) 2010-01-04 2018-05-05
JP5963680B2 (ja) 2010-01-06 2016-08-03 カッパーアールエヌエー，インコーポレイテッド 膵臓発生遺伝子に対する天然アンチセンス転写物の阻害による膵臓発生遺伝子疾患の治療
US9200277B2 (en) 2010-01-11 2015-12-01 Curna, Inc. Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG
DK2529015T3 (en) 2010-01-25 2018-02-26 Curna Inc TREATMENT OF RNASE H1-RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO RNASE H1
CN102892779B (zh) 2010-02-18 2016-12-21 基因泰克公司 神经调节蛋白拮抗剂及其在治疗癌症中的用途
GB201002911D0 (en) 2010-02-19 2010-04-07 Medical Res Council Compound
CN102844435B (zh) 2010-02-22 2017-05-10 库尔纳公司 通过抑制吡咯啉‑5‑羧酸还原酶1(pycr1)的天然反义转录物而治疗pycr1相关疾病
AR080243A1 (es) 2010-02-23 2012-03-21 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores
GB201004850D0 (en) 2010-03-23 2010-05-05 Natural Environment Res Council Proteins
RU2612884C2 (ru) 2010-04-02 2017-03-13 Курна, Инк. Лечение заболеваний, связанных с колониестимулирующим фактором 3 (csf3), путем ингибирования природного антисмыслового транскрипта k csf3
US9441032B2 (en) 2010-04-07 2016-09-13 Agency For Science, Technology And Research Binding molecules against Chikungunya virus and uses thereof
EP2374816B1 (de) 2010-04-07 2016-09-28 Agency For Science, Technology And Research Bindemoleküle gegen Chikungunya-Virus und Verwendungen davon
JP5978203B2 (ja) 2010-04-09 2016-08-24 カッパーアールエヌエー，インコーポレイテッド Ｆｇｆ２１に対する天然アンチセンス転写物の阻害による線維芽細胞増殖因子（ｆｇｆ２１）線維芽細胞増殖因子ｆｇｆ２１）関連疾患の治療
KR20130079384A (ko) 2010-05-03 2013-07-10 제넨테크, 인크. 종양의 진단 및 치료를 위한 조성물 및 방법
CN107988228B (zh) 2010-05-03 2022-01-25 库尔纳公司 通过抑制沉默调节蛋白(sirt)的天然反义转录物而治疗沉默调节蛋白(sirt)相关疾病
GB201008134D0 (en) 2010-05-14 2010-06-30 Medical Res Council Technology Compounds
TWI531370B (zh) 2010-05-14 2016-05-01 可娜公司 藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
CN102947451B (zh) 2010-05-26 2017-09-22 库尔纳公司 通过抑制无调同源物1(atoh1)的天然反义转录物而治疗atoh1相关疾病
CN102971423B (zh) 2010-05-26 2018-01-26 库尔纳公司 通过抑制蛋氨酸硫氧化物还原酶a(msra)的天然反义转录物而治疗msra相关疾病
US9771579B2 (en) 2010-06-23 2017-09-26 Curna, Inc. Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural antisense transcript to SCNA
DK2593547T3 (en) 2010-07-14 2018-02-26 Curna Inc Treatment of Discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG
US20120101108A1 (en) 2010-08-06 2012-04-26 Cell Signaling Technology, Inc. Anaplastic Lymphoma Kinase In Kidney Cancer
CA2813901C (en) 2010-10-06 2019-11-12 Curna, Inc. Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4
WO2012051306A2 (en) 2010-10-12 2012-04-19 Gencia Corporation Compositions and methods for modulating mitochondrial proteases
CA2815212A1 (en) 2010-10-22 2012-04-26 Curna, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
WO2012068340A2 (en) 2010-11-18 2012-05-24 Opko Curna Llc Antagonat compositions and methods of use
US8987225B2 (en) 2010-11-23 2015-03-24 Curna, Inc. Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG
WO2012071436A1 (en) 2010-11-24 2012-05-31 Genentech, Inc. Method of treating autoimmune inflammatory disorders using il-23r loss-of-function mutants
EP2658568A1 (de) 2010-12-29 2013-11-06 Intervet International B.V. Impfstoffantigen von babesiose des hundes
GB201104669D0 (en) 2011-03-18 2011-05-04 Medical Res Council Technology Compound
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
US10352936B2 (en) 2011-04-14 2019-07-16 Apoplogic Pharmaceuticals, Inc. Use of tumor Fas expression to determine response to anti-cancer therapy
WO2012143488A1 (en) 2011-04-21 2012-10-26 The University Court Of The University Of Aberdeen Protein for use as a medicament
WO2012162514A2 (en) 2011-05-26 2012-11-29 Regents Of The University Of Michigan Epigenetic co-repressors of the gamma-globin gene and methods of using same
WO2012170740A2 (en) 2011-06-07 2012-12-13 University Of Hawaii Biomarker of asbestos exposure and mesothelioma
US9561274B2 (en) 2011-06-07 2017-02-07 University Of Hawaii Treatment and prevention of cancer with HMGB1 antagonists
KR102043422B1 (ko) 2011-06-09 2019-11-11 큐알엔에이, 인크. 프라탁신 (fxn)에 대한 자연 안티센스 전사체의 저해에 의한 프라탁신 (fxn) 관련된 질환의 치료
MX346206B (es) 2011-07-14 2017-03-09 Crucell Holland Bv Moleculas de enlace humanas capaces de neutralizar los virus de la influenza a del grupo filogenetico 1 y grupo filogenetico 2 y virus de la influenza b.
TW202114735A (zh) 2011-08-01 2021-04-16 美商建南德克公司 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法
KR101991980B1 (ko) 2011-09-06 2019-06-21 큐알엔에이, 인크. 소형 분자로 전압-개폐된 나트륨 채널 (SCNxA)의 알파 아단위에 관련된 질환의 치료
WO2013036799A2 (en) 2011-09-09 2013-03-14 Fred Hutchinson Cancer Research Center Methods and compositions involving nkg2d inhibitors and cancer
EP2756300A1 (de) 2011-09-15 2014-07-23 F.Hoffmann-La Roche Ag Verfahren zur förderung der differenzierung
EP2760463B1 (de) 2011-09-20 2018-11-21 The University of North Carolina At Chapel Hill Regulierung der natriumkanäle durch plunc-proteine
WO2013044029A1 (en) 2011-09-23 2013-03-28 University Of Louisville Research Foundation, Inc. Methods and compositions for expanding cells and improving engraftment
HUE039133T2 (hu) 2011-10-14 2018-12-28 Hoffmann La Roche Anti-HtrA1 antitestek és felhasználási módszerek
MX2014004426A (es) 2011-10-15 2014-07-09 Genentech Inc Metodos de uso de antagonistas de scd1.
PL396675A1 (pl) 2011-10-17 2013-04-29 Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Pan Gen Grainyhead-like 1 i czynnik transkrypcyjny Grainyhead-like 1 do zastosowania w regulowaniu cisnienia krwi u ssaków
JP6465655B2 (ja) 2011-10-28 2019-02-06 アイテック ベンチャーズ ピーティーワイ エルティーディーＩｔｅｋ Ｖｅｎｔｕｒｅｓ Ｐｔｙ Ｌｔｄ 発作障害及び運動障害に関連する遺伝子及びその変異
BR112014012590A8 (pt) 2011-11-23 2017-12-19 Igenica Inc Anticorpos anti-cd98 e métodos de uso dos mesmos
ES2628321T3 (es) 2011-12-01 2017-08-02 Thrombogenics N.V. Mejora del resultado de una trabeculectomía
BR112014017626A2 (pt) 2012-01-18 2018-05-22 Genentech Inc métodos para tratar uma doença ou disfunção, métodos de identificação de um indivíduo, método para prever se um indivíduo com uma doença ou disfunção tem mais ou menos probabilidade para desenvolver toxicidade ao tratamento, método para determinar se um indivíduo com uma doença ou disfunção deve continuar ou suspender o tratamento que compreende um modulador de fgf19, método de otimização de eficácia terapêutica e método de ensaio
WO2013113865A1 (en) 2012-02-03 2013-08-08 The Pirbright Institute Eimeria vector vaccine for campylobacter jejuni
MX366804B (es) 2012-02-11 2019-07-25 Genentech Inc Translocaciones de la r-espondina y sus metodos de uso.
US9708411B2 (en) 2012-02-16 2017-07-18 The Penn Research Foundation Modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
CA2865594C (en) 2012-03-08 2021-07-27 Crucell Holland B.V. Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof
CN110438125A (zh) 2012-03-15 2019-11-12 科纳公司 通过抑制脑源神经营养因子(bdnf)的天然反义转录物治疗bdnf相关疾病
MX2014010943A (es) 2012-03-16 2014-11-26 Genentech Inc Proteinas estabilizadas conformacionalmente de ingenieria.
JP2015511598A (ja) 2012-03-16 2015-04-20 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｐａｋ１阻害剤を用いて黒色腫を治療する方法
US9139863B2 (en) 2012-03-16 2015-09-22 Genentech, Inc. Engineered conformationally-stabilized proteins
GB201204985D0 (en) 2012-03-21 2012-05-02 Genentech Inc Compounds
HUE037856T2 (hu) 2012-04-18 2018-09-28 Cell Signaling Technology Inc EGFR és ROS1 rákban
GB2517857A (en) 2012-04-25 2015-03-04 Biodesy Inc Methods for detecting allosteric modulators of proteins
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
BR112014029887A8 (pt) 2012-05-31 2021-09-14 Genentech Inc Método para tratar ou retardar a progressão do câncer, kits e uso de um antagonista de ligação do eixo pd-1, oxaliplatina, leucovorina e 5-fu
KR20150070181A (ko) 2012-09-27 2015-06-24 크루셀 홀란드 비.브이. B형 간염 바이러스에 결합하고 이를 중화시킬 수 있는 인간 결합 분자 및 그의 용도
CA2887129A1 (en) 2012-10-09 2014-04-17 Igenica, Inc. Anti-c16orf54 antibodies and methods of use thereof
GB201220843D0 (en) 2012-11-20 2013-01-02 Univ College Cork Nat Univ Ie Compound
WO2014114812A1 (en) 2013-01-28 2014-07-31 Danmarks Tekniske Universitet A single or multistage mycobacterium avium subsp. paratuberculosis subunit vaccine
BR112015018418A2 (pt) 2013-02-22 2017-07-18 Hoffmann La Roche métodos para tratar câncer, para aumentar a eficácia de um tratamento, para adiar e/ou prevenir o desenvolvimento de câncer, para aumentar a sensibilidade a um terapêutico direcionado, para estender o período de sensibilidade, para estender a duração de resposta a um terapêutico direcionado e produto farmacêutico
JP2016510751A (ja) 2013-03-06 2016-04-11 ジェネンテック， インコーポレイテッド 抗がん剤耐性を治療及び予防する方法
BR112015022604A2 (pt) 2013-03-14 2017-10-24 Genentech Inc usos de um modulador de modificador de cromatina e um antagonista de egfr
SG10201701380TA (en) 2013-03-15 2017-04-27 Genentech Inc Biomarkers and methods of treating pd-1 and pd-l1 related conditions
WO2014144850A1 (en) 2013-03-15 2014-09-18 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
LT2970422T (lt) 2013-03-15 2018-06-25 F. Hoffmann-La Roche Ag Il-22 polipeptidai ir il-22 su fc sulieti baltymai bei panaudojimo būdai
JP6715766B2 (ja) 2013-06-21 2020-07-01 ザ ジョンズ ホプキンス ユニバーシティ ヒト膜蛋白質の機能および相互作用をプロファイリングするためのビリオンディスプレイアレイ
JP6636920B2 (ja) 2013-07-16 2020-01-29 ジェネンテック， インコーポレイテッド Ｐｄ−１軸結合アンタゴニスト及びｔｉｇｉｔ阻害剤を使用するがんの治療方法
WO2015095410A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
HUE050279T2 (hu) 2014-01-24 2020-11-30 Ngm Biopharmaceuticals Inc Béta-klotho 2-es doménjéhez kötõdõ antitestek és azok alkalmazási módszerei
WO2015116902A1 (en) 2014-01-31 2015-08-06 Genentech, Inc. G-protein coupled receptors in hedgehog signaling
WO2015166036A1 (en) 2014-05-02 2015-11-05 Morphosys Ag Peptide libraries
MX2016014504A (es) 2014-05-05 2017-05-23 Regeneron Pharma Animales c5 y c3 humanizados.
JP2017524371A (ja) 2014-05-23 2017-08-31 ジェネンテック， インコーポレイテッド Ｍｉｔバイオマーカーとその使用方法
CN107073121A (zh) 2014-06-13 2017-08-18 基因泰克公司 治疗及预防癌症药物抗性的方法
CN107074752B (zh) 2014-07-02 2021-10-26 英费列特斯生命科学公司 苯亚甲基胍衍生物在治疗蛋白质构象紊乱方面的治疗用途
RS59400B1 (sr) 2014-07-02 2019-11-29 Inflectis Bioscience O-alkil-benzilidengvanidinski derivati i terapijska upotreba za lečenje poremećaja povezanih sa akumulacijom pogrešno savijenih proteina
SG10202007111TA (en) 2014-07-15 2020-09-29 Genentech Inc Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
EP3188746B1 (de) 2014-09-05 2024-06-19 The Johns Hopkins University Capn9-aktivität als ziel für eine therapeutische strategie zur behandlung von myofibroblastendifferenzierung und assoziierten erkrankungen
EP3212811B1 (de) 2014-10-29 2020-09-09 The Children's Hospital of Philadelphia Diagnose von genetischen veränderungen im zusammenhang mit eosinophiler ösophagitis
EP3789402B1 (de) 2014-11-20 2022-07-13 F. Hoffmann-La Roche AG Kombinationstherapie von t-zell-aktivierenden bispezifischen antigenbindenden molekülen und pd-1-achsen-bindenden antagonisten
US20160158360A1 (en) 2014-12-05 2016-06-09 Genentech, Inc. Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
WO2016124682A1 (en) 2015-02-05 2016-08-11 Janssen Vaccines & Prevention B.V. Human neutralizing antibodies binding to influenza neuraminidase
KR20170107562A (ko) 2015-02-05 2017-09-25 얀센 백신스 앤드 프리벤션 비.브이. 인플루엔자 적혈구응집소에 대한 결합 분자 및 이의 용도
CA2981068C (en) 2015-03-26 2021-12-14 Women & Infants Hospital Of Rhode Island Therapy for malignant disease comprising the inhibition of human epididymal secretory protein e4 and immune checkpoint inhibitors
GB201508747D0 (en) 2015-05-21 2015-07-01 Univ Edinburgh Compounds
AU2016267059B2 (en) 2015-05-22 2020-08-13 Translational Drug Development Llc Benzamide and active compound compositions and methods of use
US20180188257A1 (en) 2015-06-19 2018-07-05 University Of Rochester Septin proteins as novel biomarkers for detection and treatment of müllerian cancers
US10385398B2 (en) 2015-08-21 2019-08-20 The Children's Hospital Of Philadelphia Methods for use in combination for the treatment and diagnosis of autoimmune diseases
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
CA3000386A1 (en) 2015-09-30 2017-04-06 Merck Patent Gmbh Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer
US10421821B2 (en) 2015-10-30 2019-09-24 Genentech, Inc. Anti-HtrA1 antibodies and methods of use thereof
WO2017079442A1 (en) 2015-11-04 2017-05-11 Icahn School Of Medicine At Mount Sinai Methods of treating tumors and cancer, and identifying candidate subjects for such treatment
GB201520500D0 (en) 2015-11-20 2016-01-06 Medical Res Council Technology Compounds
GB201520499D0 (en) 2015-11-20 2016-01-06 Medical Res Council Technology Compounds
WO2017112956A1 (en) 2015-12-23 2017-06-29 Moonshot Pharma Llc Methods for inducing an immune response
WO2017148889A1 (en) 2016-03-01 2017-09-08 Janssen Vaccines & Prevention B.V. Human neutralizing antibodies binding to influenza b neuraminidase
EP3448881B1 (de) 2016-04-26 2023-06-07 Icahn School of Medicine at Mount Sinai Behandlung von hippo-pfad-mutanten tumoren und verfahren zur identifizierung von probanden als kandidaten für die behandlung
EP3472171A4 (de) 2016-06-15 2019-12-18 Suzhou Yabao Pharmaceutical R&D Co., Ltd. Substituierte tricyclische heterocyclische verbindungen und verwendung davon
WO2017223116A2 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
WO2017223117A1 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for diagnosis and treatment of autoimmune diseases
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
EP3538893A4 (de) 2016-11-11 2020-09-23 Healthtell Inc. Verfahren zur identifizierung von biomarker-kandidaten
AU2017363337B2 (en) 2016-11-23 2021-07-01 Translational Drug Development, Llc Benzamide and active compound compositions and methods of use
GB201622365D0 (en) 2016-12-29 2017-02-15 Medical Res Council Tech Compounds
GB201622362D0 (en) 2016-12-29 2017-02-15 Medical Res Council Tech Compounds
WO2018152496A1 (en) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Compositions and methods for the diagnosis and treatment of zika virus infection
CA3054167A1 (en) 2017-02-27 2018-08-30 Regeneron Pharmaceuticals, Inc. Humanized model of kidney and liver disorders
WO2018170464A1 (en) 2017-03-17 2018-09-20 The Johns Hopkins University Targeted epigenetic therapy against distal regulatory element of tgfb2 expression
EP3624820A1 (de) 2017-04-21 2020-03-25 H. Hoffnabb-La Roche Ag Verwendung von klk5-antagonisten zur behandlung einer krankheit
US11236151B2 (en) 2017-04-25 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies and methods for the diagnosis and treatment of Epstein Barr virus infection
US11654135B2 (en) 2017-06-22 2023-05-23 Moonshot Pharma Llc Methods for treating colon cancer with compositions comprising amlexanox and immune checkpoint inhibitors
CN111278858B (zh) 2017-07-11 2024-07-23 指南针制药有限责任公司 结合人cd137的激动剂抗体及其用途
WO2019018629A1 (en) 2017-07-19 2019-01-24 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services ANTIBODIES AND METHODS FOR DIAGNOSING AND TREATING INFECTION WITH HEPATITIS B VIRUS
ES2947336T3 (es) 2017-09-01 2023-08-07 Univ Johns Hopkins Terapia epigenética dirigida para el aneurisma aórtico hereditario
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
US11718679B2 (en) 2017-10-31 2023-08-08 Compass Therapeutics Llc CD137 antibodies and PD-1 antagonists and uses thereof
US11851497B2 (en) 2017-11-20 2023-12-26 Compass Therapeutics Llc CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
WO2019126472A1 (en) 2017-12-22 2019-06-27 Genentech, Inc. Use of pilra binding agents for treatment of a disease
WO2020033925A2 (en) 2018-08-09 2020-02-13 Compass Therapeutics Llc Antibodies that bind cd277 and uses thereof
BR112021008795A2 (pt) 2018-11-13 2021-08-31 Compass Therapeutics Llc Construtos de ligação multiespecíficos contra moléculas de ponto de verificação e seus usos
CN113474371A (zh) 2019-01-16 2021-10-01 指南针制药有限责任公司 与人cd137结合的抗体的制剂及其用途
CN113365661A (zh) 2019-01-31 2021-09-07 新加坡科技研究局 用于治疗或预防癌症的cnx/erp57抑制剂
WO2020239558A1 (en) 2019-05-24 2020-12-03 Pfizer Inc. Combination therapies using cdk inhibitors
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer
US11459389B2 (en) 2019-10-24 2022-10-04 Massachusetts Institute Of Technology Monoclonal antibodies that bind human CD161
WO2021099446A1 (en) 2019-11-20 2021-05-27 Intervet International B.V. A novel vaccine against heamophilus parasuis
JP2023503057A (ja) 2019-11-20 2023-01-26 インターベット インターナショナル ベー． フェー． ヘモフィルス・パラスイスに対する新規ワクチン
US20220378900A1 (en) 2019-11-20 2022-12-01 Intervet Inc. A novel vaccine against heamophilus parasuis
WO2022084210A1 (en) 2020-10-20 2022-04-28 F. Hoffmann-La Roche Ag Combination therapy of pd-1 axis binding antagonists and lrrk2 inhitibors
CN114426542B (zh) 2020-10-29 2023-06-30 苏州亚宝药物研发有限公司 取代的二芳基胺化合物及其药物组合物、制备方法和用途
US20220168293A1 (en) 2020-12-02 2022-06-02 Pfizer Inc. Time to resolution of axitinib-related adverse events
WO2022258600A1 (en) 2021-06-09 2022-12-15 F. Hoffmann-La Roche Ag Combination of a particular braf inhibitor (paradox breaker) and a pd-1 axis binding antagonist for use in the treatment of cancer
JP2024534265A (ja) 2021-08-23 2024-09-18 イミュニタス セラピューティクス，インコーポレーテッド 抗ｃｄ１６１抗体及びその使用
TW202327595A (zh) 2021-10-05 2023-07-16 美商輝瑞大藥廠 用於治療癌症之氮雜內醯胺化合物的組合
TWI846353B (zh) 2022-02-25 2024-06-21 大陸商蘇州亞寶藥物研發有限公司 取代的稠環化合物及其藥物組合物、製備方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56115727A (en) * 1980-02-19 1981-09-11 Kuraray Co Ltd Carrier for immobilizing physiologically active substance
FI83662C (fi) * 1980-07-17 1991-08-12 Scripps Clinic Res Diagnostik antikropp och foerfarande foer dess framstaellning.
IL61904A (en) * 1981-01-13 1985-07-31 Yeda Res & Dev Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same
ZA831854B (en) * 1982-03-26 1984-01-25 Biogen Nv Small peptides with the specificity of foot and mouth disease viral antigens
US4438208A (en) * 1982-05-27 1984-03-20 The Regents Of The University Of California Region-specific determinants for vitamin K dependent bone protein
US4544629A (en) * 1982-11-19 1985-10-01 Minnesota Mining And Manufacturing Company Receptor-based histamine assay
US4504586A (en) * 1983-02-03 1985-03-12 Amgen Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1
WO1984003506A1 (en) * 1983-03-08 1984-09-13 Commw Serum Lab Commission Antigenically active amino acid sequences
EP0138854B1 (de) * 1983-03-08 1992-11-04 Chiron Mimotopes Pty. Ltd. Antigen aktive aminosäuresequenzen

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DE3485299D1 (de) 1992-01-09
NZ207394A (en) 1987-03-06
NO166466B (no) 1991-04-15
ATE69890T1 (de) 1991-12-15
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EP0138855B2 (de) 1999-09-08
DK532284A (da) 1984-11-08
JPH063445B2 (ja) 1994-01-12
EP0138855B1 (de) 1991-11-27
JPS60500684A (ja) 1985-05-09
DK164529C (da) 1992-11-23
EP0138855A1 (de) 1985-05-02
DK164529B (da) 1992-07-06
WO1984003564A1 (en) 1984-09-13
NO844296L (no) 1984-10-29
DK532284D0 (da) 1984-11-08
EP0138855A4 (de) 1986-02-10
CA1220420A (en) 1987-04-14

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