MX381541B - Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas. - Google Patents

Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas.

Info

Publication number
MX381541B
MX381541B MX2016006454A MX2016006454A MX381541B MX 381541 B MX381541 B MX 381541B MX 2016006454 A MX2016006454 A MX 2016006454A MX 2016006454 A MX2016006454 A MX 2016006454A MX 381541 B MX381541 B MX 381541B
Authority
MX
Mexico
Prior art keywords
sample
integrated device
light source
probing
detecting
Prior art date
Application number
MX2016006454A
Other languages
English (en)
Spanish (es)
Other versions
MX2016006454A (es
Inventor
Ali Kabiri
Anthony Bellofiore
Benjamin Cipriany
Brett J Gyarfas
Gerard Schmid
Jack Jewell
Jason W Sickler
Jeremy Lackey
Jonathan M Rothberg
Lawrence West
Michael Ferrigno
Paul E Glenn
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of MX2016006454A publication Critical patent/MX2016006454A/es
Publication of MX381541B publication Critical patent/MX381541B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/7746—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the waveguide coupled to a cavity resonator
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/101—DNA polymerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/101—Modifications characterised by incorporating non-naturally occurring nucleotides, e.g. inosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/157—A reaction step characterised by the number of molecules incorporated or released
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/103—Nucleic acid detection characterized by the use of physical, structural and functional properties luminescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G01N2201/0612—Laser diodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/068—Optics, miscellaneous
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/125—Digital circuitry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making
    • Y10T29/49016—Antenna or wave energy "plumbing" making

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
MX2016006454A 2013-11-17 2014-11-17 Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas. MX381541B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361905282P 2013-11-17 2013-11-17
US201361917926P 2013-12-18 2013-12-18
US201461941916P 2014-02-19 2014-02-19
PCT/US2014/066013 WO2015074004A1 (en) 2013-11-17 2014-11-17 Integrated device with external light source for probing detecting and analyzing molecules

Publications (2)

Publication Number Publication Date
MX2016006454A MX2016006454A (es) 2016-12-09
MX381541B true MX381541B (es) 2025-03-12

Family

ID=52014380

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2016006454A MX381541B (es) 2013-11-17 2014-11-17 Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas.
MX2016006453A MX378010B (es) 2013-11-17 2014-11-17 Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas.
MX2016006455A MX380165B (es) 2013-11-17 2014-11-17 Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos.
MX2020013247A MX392471B (es) 2013-11-17 2014-11-17 Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas

Family Applications After (3)

Application Number Title Priority Date Filing Date
MX2016006453A MX378010B (es) 2013-11-17 2014-11-17 Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas.
MX2016006455A MX380165B (es) 2013-11-17 2014-11-17 Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos.
MX2020013247A MX392471B (es) 2013-11-17 2014-11-17 Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas

Country Status (10)

Country Link
US (12) US9983135B2 (enExample)
EP (6) EP3068901B1 (enExample)
JP (5) JP6673843B2 (enExample)
KR (4) KR102240166B1 (enExample)
CN (5) CN105980580B (enExample)
AU (4) AU2014348302B2 (enExample)
BR (3) BR112016011061B1 (enExample)
CA (3) CA2930836A1 (enExample)
MX (4) MX381541B (enExample)
WO (3) WO2015074005A1 (enExample)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9593371B2 (en) 2013-12-27 2017-03-14 Intel Corporation Integrated photonic electronic sensor arrays for nucleic acid sequencing
KR102240166B1 (ko) 2013-11-17 2021-04-14 퀀텀-에스아이 인코포레이티드 분자들을 프로빙 검출 및 분석하기 위한 외부 광원을 구비한 통합 디바이스
US11287484B2 (en) 2014-02-03 2022-03-29 Innovaura Corporation Method and apparatus for triage of electronic items using magnetic field detection
WO2015117157A1 (en) * 2014-02-03 2015-08-06 Electromagnetic Landmarks Inc. Magnetic sensor array and system
US11747407B2 (en) 2014-02-03 2023-09-05 Innovaura Corporation System and method for characterizing defects in electronic items using magnetic field detection
EP3194934B1 (en) 2014-08-08 2024-03-06 Quantum-Si Incorporated Integrated device for use with an external light source for probing, detecting, and analyzing molecules by luminescence lifetime measurements
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
CN107112333B (zh) 2014-08-08 2020-07-10 宽腾矽公司 基于入射光子到达时间的识别、成像、测序法及存储介质
CA2957543A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
US9721751B2 (en) * 2014-08-22 2017-08-01 The Board Of Trustees Of The Leland Stanford Junior University Electron microscopy specimen and method of fabrication
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US10184892B2 (en) * 2014-10-29 2019-01-22 Horiba Instruments Incorporated Determination of water treatment parameters based on absorbance and fluorescence
TR201910871T4 (tr) 2015-01-20 2019-08-21 Hyris Ltd Sıvı bir numunede floresans ölçümü için dedektör.
US10018608B2 (en) * 2015-02-27 2018-07-10 Vitaly Talyansky System to authenticate and identify items
CN107615121B (zh) 2015-03-16 2021-04-16 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US9874693B2 (en) 2015-06-10 2018-01-23 The Research Foundation For The State University Of New York Method and structure for integrating photonics with CMOs
CA2989344C (en) 2015-06-12 2023-09-26 Pacific Biosciences Of California, Inc. Integrated target waveguide devices and systems for optical coupling
TWI697674B (zh) * 2015-07-27 2020-07-01 體學生物科技股份有限公司 感測模組及感測方法
WO2017019768A1 (en) * 2015-07-30 2017-02-02 The Regents Of The University Of California Optical cavity pcr
TW201723482A (zh) * 2015-08-18 2017-07-01 新加坡科技研究局 光學結構及光學光偵測系統
US9733188B2 (en) * 2015-09-21 2017-08-15 International Business Machines Corporation Enhancing on-chip fluorescence detection
CA3002955A1 (en) 2015-10-22 2017-04-27 Jacob Schneiderman Systems and methods for identifying and treating biological materials
KR101720434B1 (ko) * 2015-11-10 2017-03-28 한국과학기술원 광 위상배열 안테나
US10248838B2 (en) * 2015-12-04 2019-04-02 The Regents Of The University Of California Method and device for single molecule imaging
WO2017151207A2 (en) * 2015-12-14 2017-09-08 Massachusetts Institute Of Technology Apparatus and methods for spectroscopy and broadband light emission using two-dimensional plasmon fields
WO2017123658A1 (en) 2016-01-12 2017-07-20 Sxaymiq Technologies Llc Light emitting diode display
KR102763291B1 (ko) 2016-01-28 2025-02-04 로스웰 엠이 아이엔씨. 대량 병렬 ｄｎａ 시퀀싱 장치
US11624725B2 (en) 2016-01-28 2023-04-11 Roswell Blotechnologies, Inc. Methods and apparatus for measuring analytes using polymerase in large scale molecular electronics sensor arrays
CA3053103A1 (en) 2016-02-09 2017-08-17 Roswell Biotechnologies, Inc. Electronic label-free dna and genome sequencing
JP2019512090A (ja) 2016-02-17 2019-05-09 テッセラクト ヘルス インコーポレイテッドＴｅｓｓｅｒａｃｔ Ｈｅａｌｔｈ，Ｉｎｃ． 寿命イメージングおよび検出用途のためのセンサおよびデバイス
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
CA3018582A1 (en) * 2016-03-25 2017-09-28 Bioceryx Inc. Apparatuses and methods for assessing target sequence numbers
CN113916788B (zh) * 2016-04-22 2024-12-10 伊鲁米那股份有限公司 在发光成像中使用的设备和组成物及使用其的方法
US10451518B2 (en) * 2016-05-10 2019-10-22 Rd2, Llc All fiber temperature and air density sensor
WO2017205868A1 (en) * 2016-05-27 2017-11-30 Singulex, Inc. Camera-based single molecule reader
US11529213B2 (en) 2016-05-30 2022-12-20 David Akselrod Backscatter device-based dental imaging apparatus
US11389277B2 (en) 2016-07-18 2022-07-19 David Akselrod Material property monitoring using backscatter devices
EP4009330A1 (en) 2016-06-01 2022-06-08 Quantum-si Incorporated Pulse caller and base caller
CN114674788A (zh) * 2016-06-01 2022-06-28 宽腾矽公司 用于检测及分析分子的集成装置
US10758153B2 (en) * 2016-07-18 2020-09-01 David Akselrod Material property monitoring and detection using wireless devices
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
EP3491380B1 (en) 2016-08-01 2021-06-16 Genprime, Inc. System and method to interpret tests that change color to indicate the presence or non-presence of a compound
US10656088B2 (en) * 2016-08-12 2020-05-19 Silanna UV Technologies Pte Ltd Ultraviolet biosensor
EP3285052A1 (en) 2016-08-19 2018-02-21 IMEC vzw Photonic circuit with integrated light coupler
KR20220151011A (ko) 2016-09-23 2022-11-11 알베오 테크놀로지스 인크. 분석물을 검출하기 위한 방법 및 조성물
TWI777989B (zh) 2016-11-03 2022-09-21 大陸商深圳華大智造科技有限公司 用於生物或化學分析的生物感測器以及製造其的方法
FR3058521B1 (fr) * 2016-11-08 2021-01-08 Univ Montpellier Dispositif et procede de detection de presence de molecules determinees, biocapteur
JP6770197B2 (ja) * 2016-12-15 2020-10-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 適応ナノ細孔信号圧縮
BR112019012069A2 (pt) 2016-12-16 2019-11-12 Quantum-Si Incorporated conjunto de modelagem e direcionamento de feixe compacto
JP2018100959A (ja) * 2016-12-16 2018-06-28 シャープ株式会社 検出器、ならびに、検出器の校正方法、補正方法、検出装置
CN110088993B (zh) * 2016-12-16 2022-02-08 宽腾矽公司 紧密的锁模雷射模块
TW201837184A (zh) 2016-12-19 2018-10-16 美商寬騰矽公司 分子載入樣品孔以供分析
US10845308B2 (en) 2016-12-22 2020-11-24 Quantum-Si Incorporated Integrated photodetector with direct binning pixel
CA3052062A1 (en) 2017-01-10 2018-07-19 Roswell Biotechnologies, Inc. Methods and systems for dna data storage
KR102601324B1 (ko) 2017-01-19 2023-11-10 로스웰 바이오테크놀로지스 인코포레이티드 2차원 레이어 재료를 포함하는 솔리드 스테이트 시퀀싱 디바이스들
US11419703B2 (en) 2017-01-27 2022-08-23 David Akselrod Orthodontic braces and feet orthotics with backscatter based sensors
KR101847334B1 (ko) * 2017-02-02 2018-04-10 한국기초과학지원연구원 형광 이미지 획득 장치 및 방법
GB201701829D0 (en) * 2017-02-03 2017-03-22 Norwegian Univ Of Science And Tech (Ntnu) Device
CA3052809A1 (en) * 2017-02-08 2018-08-23 Essenlix Corporation Qmax assays and applications
CA3056765C (en) * 2017-03-17 2024-04-02 Apton Biosystems, Inc. Sequencing and high resolution imaging
KR102657576B1 (ko) * 2017-03-20 2024-04-12 엠쥐아이 테크 컴퍼니 엘티디. 생물학적 또는 화학적 분석을 위한 바이오센서 및 그 제조 방법
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
CA3057151A1 (en) 2017-04-25 2018-11-01 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
JP7356909B2 (ja) 2017-05-05 2023-10-05 クアンタム－エスアイ インコーポレイテッド 生物学的反応における表面反応性と防汚特性が改変された基板
EP3622086A4 (en) 2017-05-09 2021-04-21 Roswell Biotechnologies, Inc LINK PROBE CIRCUITS FOR MOLECULAR SENSORS
KR102387341B1 (ko) * 2017-05-23 2022-04-15 하마마츠 포토닉스 가부시키가이샤 배향 특성 측정 방법, 배향 특성 측정 프로그램, 및 배향 특성 측정 장치
EP3639013A4 (en) * 2017-06-16 2021-06-30 Duke University Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation
CN109103090B (zh) * 2017-06-21 2020-12-04 清华大学 纳米带的制备方法
KR102083396B1 (ko) * 2017-06-28 2020-03-02 주식회사 파나진 양자점을 분산광원으로 하는 표적 핵산 검출 방법
CN107390172B (zh) * 2017-07-17 2020-04-28 北京大学 一种无接触感知定位方法
BR112020000826A2 (pt) 2017-07-24 2020-07-21 Quantum-Si Incorporated instrumento bio-optoeletrônico maciçamente paralelo portátil
JP7212030B2 (ja) * 2017-07-24 2023-01-24 クアンタム－エスアイ インコーポレイテッド 光拒絶フォトニック構造
CN107402199B (zh) * 2017-07-31 2019-09-10 京东方科技集团股份有限公司 基因测序芯片及其测序方法以及基因测序装置
EP3669018A4 (en) 2017-08-18 2021-05-26 Nautilus Biotechnology, Inc. Binding reagent selection methods
CN111373049A (zh) 2017-08-30 2020-07-03 罗斯威尔生命技术公司 用于dna数据存储的进行性酶分子电子传感器
US10784103B2 (en) 2017-09-19 2020-09-22 Mgi Tech Co., Ltd. Water level sequencing flow cell fabrication
US11100404B2 (en) 2017-10-10 2021-08-24 Roswell Biotechnologies, Inc. Methods, apparatus and systems for amplification-free DNA data storage
EP3501651B1 (en) * 2017-12-22 2024-03-06 IMEC vzw Microfluidic routing
AU2019205383B8 (en) * 2018-01-08 2023-09-28 Quantum-Si Incorporated System and methods for electrokinetic loading of sub-micron-scale reaction chambers
CA3065934A1 (en) * 2018-01-08 2019-07-11 Illumina, Inc. High-throughput sequencing with semiconductor-based detection
CN108197052B (zh) * 2018-01-17 2021-02-26 上海聚星仪器有限公司 一种新型测试测量仪器
CA3088687A1 (en) 2018-01-26 2019-08-01 Quantum-Si Incorporated Machine learning enabled pulse and base calling for sequencing devices
IT201800004146A1 (it) * 2018-03-30 2019-09-30 St Microelectronics Srl Apparecchio di analisi di molecole tramite rilevamento di segnali fluorescenti e relativo metodo
US10965102B2 (en) * 2018-04-12 2021-03-30 Samsung Electronics Co., Ltd. Structured light projector and electronic apparatus including the same
WO2019241733A1 (en) 2018-06-15 2019-12-19 Quantum-Si Incorporated Data acquisition control for advanced analytic instruments having pulsed optical sources
EP3581919B1 (en) * 2018-06-15 2022-03-23 IMEC vzw An imaging apparatus and a method for imaging an object
KR102546320B1 (ko) * 2018-06-18 2023-06-22 삼성전자주식회사 구조광 프로젝터 및 이를 포함하는 전자 장치
WO2019246328A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
WO2020023496A1 (en) * 2018-07-23 2020-01-30 The University Of Chicago Resonator-based ion-selective sensor
MX2021002414A (es) * 2018-08-29 2021-04-28 Quantum Si Inc Sistema y metodos para la deteccion de vida util usando fotodetectores de conteo de fotones.
WO2020047272A1 (en) * 2018-08-29 2020-03-05 Quantum-Si Incorporated Sample well fabrication techniques and structures for integrated sensor devices
JP6906489B2 (ja) 2018-09-14 2021-07-21 株式会社東芝 ケミカルセンサキット及び分析方法
US11509116B2 (en) * 2018-10-23 2022-11-22 Analog Photonics LLC Athermal angular output by combining a laser with a grating based antenna
CN111135878B (zh) 2018-11-06 2021-10-15 京东方科技集团股份有限公司 微流体通道结构及制作方法、微流体检测装置及使用方法
WO2020094233A1 (de) * 2018-11-08 2020-05-14 Diamontech Ag Vorrichtung und verfahren zum analysieren eines stoffs
KR20250162948A (ko) 2018-11-15 2025-11-19 퀀텀-에스아이 인코포레이티드 단백질 시퀀싱을 위한 방법 및 조성물
CN113316638A (zh) 2018-11-20 2021-08-27 诺迪勒思生物科技公司 亲和试剂的设计和选择
JP2020085666A (ja) * 2018-11-26 2020-06-04 ソニーセミコンダクタソリューションズ株式会社 生体由来物質検出用チップ、生体由来物質検出装置及び生体由来物質検出システム
US12179204B2 (en) 2018-12-03 2024-12-31 Quantum-Si Incorporated Sample well fabrication techniques and structures for integrated sensor
CA3124120A1 (en) 2018-12-20 2020-06-25 Alveo Technologies, Inc. Handheld impedance-based diagnostic test system for detecting analytes
TW202041847A (zh) * 2019-01-03 2020-11-16 美商寬騰矽公司 用於傳遞光至光子元件之陣列的光學波導及耦合器
TWI687687B (zh) * 2019-01-11 2020-03-11 國立中正大學 雙光柵感測器、檢測方法及其製備方法
WO2020180426A1 (en) * 2019-03-04 2020-09-10 Immunolight, Llc. Energy augmentation structures, energy emitters or energy collectors containing the same, and their use in methods and systems for treating cell proliferation disorders
KR20210132176A (ko) 2019-03-05 2021-11-03 퀀텀-에스아이 인코포레이티드 통합 디바이스를 위한 광학 흡수 필터
WO2020181362A1 (en) 2019-03-08 2020-09-17 Infinite Potential Laboratories Lp Quantum control devices and methods
CN113597558B (zh) * 2019-03-20 2024-12-10 启正生命科学有限公司 用于验证生物分析仪的标准材料组合物和使用其的标准条带
WO2020210981A1 (en) 2019-04-16 2020-10-22 Boe Technology Group Co., Ltd. Micro-channel device and manufacturing method thereof and micro-fluidic system
CA3135206A1 (en) 2019-04-29 2020-11-05 Pierre Indermuhle Methods and systems for integrated on-chip single-molecule detection
CN110066723A (zh) * 2019-05-05 2019-07-30 京东方科技集团股份有限公司 基因测序芯片、设备、制造方法
MX2021015497A (es) 2019-06-14 2022-04-18 Quantum Si Inc Acoplador de rejilla cortada con mayor sensibilidad de alineación del haz.
US11085878B2 (en) 2019-06-18 2021-08-10 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods
CN110229747A (zh) * 2019-06-18 2019-09-13 京东方科技集团股份有限公司 基因测序芯片、设备及制备方法
US11009611B2 (en) 2019-06-18 2021-05-18 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods
AU2020297509A1 (en) 2019-06-19 2022-01-27 Quantum-Si Incorporated Optical nanostructure rejecter for an integrated device and related methods
US11793399B2 (en) 2019-06-20 2023-10-24 Cilag Gmbh International Super resolution and color motion artifact correction in a pulsed hyperspectral imaging system
US11280737B2 (en) * 2019-06-20 2022-03-22 Cilag Gmbh International Super resolution and color motion artifact correction in a pulsed fluorescence imaging system
WO2020262092A1 (ja) * 2019-06-26 2020-12-30 ソニー株式会社 光学測定装置及び光学測定システム
JP2022539633A (ja) * 2019-07-08 2022-09-13 イルミナ インコーポレイテッド 光検出デバイス上の光結合構造による導波路統合
MX2022001614A (es) 2019-08-08 2022-05-26 Quantum Si Inc Eficiencia mejorada de recolección de emisiones en dispositivos ópticos integrados.
WO2021041874A1 (en) 2019-08-29 2021-03-04 Martin David C Biofunctional thiophene monomers
WO2021045900A1 (en) 2019-09-06 2021-03-11 Roswell Biotechnologies, Inc. Methods of fabricating nanoscale structures usable in molecular sensors and other devices
US10957731B1 (en) 2019-10-04 2021-03-23 Visera Technologies Company Limited Sensor device and method for manufacturing the same
US11630062B2 (en) * 2019-10-10 2023-04-18 Visera Technologies Company Limited Biosensor and method of forming the same
US11705472B2 (en) 2019-10-10 2023-07-18 Visera Technologies Company Limited Biosensor and method of distinguishing a light
US11105745B2 (en) 2019-10-10 2021-08-31 Visera Technologies Company Limited Biosensor
KR20220079943A (ko) 2019-10-11 2022-06-14 퀀텀-에스아이 인코포레이티드 증기 상에서의 표면 개질
US12011716B2 (en) 2019-10-29 2024-06-18 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
TWI704342B (zh) * 2019-11-28 2020-09-11 雷科股份有限公司 Aoi(自動光學檢測)應用在雷射蝕薄銅線圈的方法及其設備
KR102351249B1 (ko) * 2020-01-03 2022-01-14 한국과학기술원 분자 다중 이미징 방법 및 장치
US11703454B2 (en) 2020-01-03 2023-07-18 Korea Advanced Institute Of Science And Technology Method and apparatus for multiplexed imaging of spectrally-similar fluorophores
US11784416B2 (en) * 2020-01-06 2023-10-10 Raytheon Company Tunable radio frequency (RF) absorber and thermal heat spreader
EP4088351A1 (en) 2020-01-14 2022-11-16 Quantum-si Incorporated Amplitude-modulated laser
TW202143465A (zh) 2020-01-14 2021-11-16 美商寬騰矽公司 用於壽命特性分析之整合感應器
KR20220140523A (ko) 2020-01-14 2022-10-18 퀀텀-에스아이 인코포레이티드 수명 플러스 스펙트럼 특성화를 위한 센서
WO2021150984A1 (en) * 2020-01-24 2021-07-29 Deepdivebio, Inc. Optical array qpcr
CN111308530B (zh) * 2020-02-17 2021-12-03 中国人民解放军战略支援部队信息工程大学 一种基于二维波达方向的短波多站和单星协同直接定位方法
WO2021178438A1 (en) 2020-03-02 2021-09-10 Quantum-Si Incorporated Integrated sensor for multi-dimensional signal analysis
US11573180B2 (en) 2020-04-08 2023-02-07 Quantum-Si Incorporated Integrated sensor with reduced skew
CN111533083B (zh) * 2020-05-08 2023-09-05 中北大学 一种基于石墨烯的微型分子光镊
JP2023527764A (ja) 2020-05-20 2023-06-30 クアンタム－エスアイ インコーポレイテッド タンパク質シーケンスのための方法及び組成物
WO2021252800A1 (en) 2020-06-11 2021-12-16 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
CN116472302A (zh) * 2020-07-07 2023-07-21 特韦斯特生物科学公司 用于光引导聚合物合成的装置和方法
WO2022020731A2 (en) * 2020-07-23 2022-01-27 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
KR102628182B1 (ko) * 2020-08-28 2024-01-24 한국과학기술원 상호정보량 최소화를 통한 다색 분리 방법 및 장치
EP3961194B1 (en) 2020-08-25 2023-11-08 Korea Advanced Institute of Science and Technology Method and apparatus for multiplexed imaging of biomolecules through iterative unmixing of fluorophore signals
KR102423723B1 (ko) * 2020-08-27 2022-07-21 성균관대학교산학협력단 플라즈모닉 우물 기반 핵산 검출장치 및 롤투롤 공정을 이용한 이의 제조방법
GB2599729A (en) * 2020-10-12 2022-04-13 Sumitomo Chemical Co Method comprising light emitting marker
KR20230097103A (ko) * 2020-10-27 2023-06-30 퀀텀-에스아이 인코포레이티드 광표백 정보를 이용한 단일 분자 검출 시스템
TWI824273B (zh) * 2020-12-03 2023-12-01 仁寶電腦工業股份有限公司 天線裝置和配置該天線裝置的方法
JP2023554368A (ja) 2020-12-15 2023-12-27 クアンタム－エスアイ インコーポレイテッド 単一分子速度論による分子バーコード分析
CA3203535A1 (en) 2021-01-21 2022-07-28 Gregory KAPP Systems and methods for biomolecule preparation
CN112837620B (zh) * 2021-01-22 2023-07-04 武汉京东方光电科技有限公司 柔性显示屏及电子设备
CN112864258B (zh) * 2021-03-05 2025-01-10 南京扬字源科技有限公司 像素结构、红外图像传感器和电子设备
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
US20230035224A1 (en) * 2021-05-04 2023-02-02 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices with reduced-scale unit cell
DE102021111787A1 (de) * 2021-05-06 2022-11-10 Gesellschaft für angewandte Mikro- und Optoelektronik mit beschränkter Haftung - AMO GmbH Verfahren zur Herstellung einer Lochblende, Lochblende sowie Verwendung einer Lochblende in einem optischen Aufbau
CN112986206B (zh) * 2021-05-20 2021-07-30 北京百奥纳芯生物科技有限公司 一种检测基因芯片杂交结果的方法
US11703445B2 (en) * 2021-05-28 2023-07-18 Visera Technologies Company Limited Biosensor with grating array
WO2023038859A1 (en) 2021-09-09 2023-03-16 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
AU2022352593A1 (en) 2021-09-22 2024-02-15 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
EP4416491A1 (en) * 2021-10-11 2024-08-21 Quantum-Si Incorporated Light coupling device
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US20230152211A1 (en) * 2021-11-11 2023-05-18 California Institute Of Technology System for Optically Analyzing a Test Sample and Method Therefor
WO2023114209A1 (en) * 2021-12-14 2023-06-22 Quantum-Si Incorporated Methods for loading and data acquisition
EP4463694A1 (en) * 2022-01-12 2024-11-20 Quantum-Si Incorporated Labeled binding reagents and methods of use thereof
US11924963B2 (en) 2022-02-03 2024-03-05 Raytheon Company Printed-circuit isolation barrier for co-site interference mitigation
CN119053846A (zh) * 2022-02-28 2024-11-29 生物辐射实验室股份有限公司 宽谱分析系统
CA3245990A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary Inc INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES
EP4500124A2 (en) * 2022-03-29 2025-02-05 Pattern Computer, Inc. System and method for spectral-based disease detection
US20250376716A1 (en) 2022-06-21 2025-12-11 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US12353011B2 (en) * 2022-06-27 2025-07-08 Taiwan Semiconductor Manufacturing Co., Ltd. Photonic package and method of manufacture
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
EP4379355A1 (en) * 2022-11-29 2024-06-05 Gnothis Holding AG High throughput analysis of single molecule events
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US12109019B2 (en) 2022-12-15 2024-10-08 Adaptyx Biosciences, Inc. Systems and methods for analyte detection
WO2024130000A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
AU2024232531A1 (en) * 2023-03-09 2025-09-18 University Of Cincinnati Optical aptamer biosensors for in-vivo sensing
WO2024206122A1 (en) 2023-03-24 2024-10-03 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
WO2024213741A1 (en) 2023-04-13 2024-10-17 Lucas Meyer Cosmetics Emulsifying agent based on lignin fraction and uses thereof
WO2024229244A2 (en) * 2023-05-03 2024-11-07 Mirvie, Inc. Methods and systems for determining a pregnancy-related state of a subject
US20240394902A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US12373188B2 (en) 2023-07-06 2025-07-29 Bank Of America Corporation Systems, methods, and apparatuses for improving computer energy consumption and computer processing by implementing a pluggable carbon emission gateway
ES2958785B2 (es) * 2023-07-17 2024-07-24 Univ Valencia Politecnica Dispositivo de medida para el analisis de la respuesta optica de materiales biosensibles difractivos
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025047492A1 (ja) * 2023-08-30 2025-03-06 富士フイルム株式会社 測定装置
WO2025094175A1 (en) * 2023-10-29 2025-05-08 B.G. Negev Technologies And Applications Ltd. All optical single photon detector
WO2025128588A1 (en) 2023-12-11 2025-06-19 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
US20250205706A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Family Cites Families (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006716A (en) 1989-02-22 1991-04-09 Research Corporation Technologies, Inc. Method and system for directional, enhanced fluorescence from molecular layers
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
JP3018687B2 (ja) * 1991-12-12 2000-03-13 松下電器産業株式会社 走査型レーザー顕微鏡
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
IL108497A0 (en) 1993-02-01 1994-05-30 Seq Ltd Methods and apparatus for dna sequencing
JP3169742B2 (ja) * 1993-06-18 2001-05-28 松下電器産業株式会社 光分岐装置および光ディスク装置
US5495462A (en) * 1993-06-18 1996-02-27 Matsushita Electric Industrial Co., Ltd. Light beam splitting apparatus
JPH07182686A (ja) * 1993-12-21 1995-07-21 Matsushita Electric Ind Co Ltd 光モード変換装置および光分岐装置
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
US6570617B2 (en) 1994-01-28 2003-05-27 California Institute Of Technology CMOS active pixel sensor type imaging system on a chip
WO1995033197A1 (en) 1994-05-27 1995-12-07 Ciba-Geigy Ag Process for detecting evanescently excited luminescence
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5990506A (en) 1996-03-20 1999-11-23 California Institute Of Technology Active pixel sensors with substantially planarized color filtering elements
EP0938656B1 (de) 1996-11-18 2005-10-26 Novartis AG Messvorrichtung mit einem planaren optischen wellenleiter
EP1009802B1 (en) 1997-02-12 2004-08-11 Eugene Y. Chan Methods for analyzimg polymers
EP0983364B1 (en) 1997-03-12 2002-06-12 PE Corporation (NY) Dna polymerases having improved labeled nucleotide incorporation properties
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
JPH11173987A (ja) 1997-12-12 1999-07-02 Hamamatsu Photonics Kk マイクロタイタビューア
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
WO1999049082A2 (en) 1998-03-23 1999-09-30 Invitrogen Corporation Modified nucleotides and methods useful for nucleic acid sequencing
CA2330673C (en) 1998-05-01 2009-05-26 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
JP2000004871A (ja) 1998-06-29 2000-01-11 Olympus Optical Co Ltd 培養容器、及び培養容器内の試料を観察する顕微鏡
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
ATE319857T1 (de) 1998-12-14 2006-03-15 Li Cor Inc Kit und methode zur nukleinsäuresequenzierung einzelner moleküle durch polymerase synthese
US6134002A (en) * 1999-01-14 2000-10-17 Duke University Apparatus and method for the rapid spectral resolution of confocal images
ES2310514T3 (es) 1999-03-10 2009-01-16 Asm Scientific, Inc. Un metodo para la secuenciacion directa de acido nucleico.
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
EP1681357A3 (en) 1999-05-19 2006-07-26 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
FR2797053B1 (fr) * 1999-07-13 2001-08-31 Commissariat Energie Atomique Support d'analyse a transmission de lumiere de fluorescence
US6596483B1 (en) * 1999-11-12 2003-07-22 Motorola, Inc. System and method for detecting molecules using an active pixel sensor
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
DE50006533D1 (de) * 1999-12-17 2004-06-24 Zeptosens Ag Witterswil Anordnung von probenbehältnissen und deren verwendung zur multianalytbestimmung
JP3978307B2 (ja) * 2000-02-09 2007-09-19 株式会社日立製作所 紫外レーザ光発生装置並びに欠陥検査装置およびその方法
US6704104B2 (en) * 2000-03-16 2004-03-09 Spectrumedix Llc Multi-wavelength array reader for biological assay
JP2003532123A (ja) * 2000-04-28 2003-10-28 エッジライト バイオサイエンシズ インコーポレイテッド マイクロアレーエバネッセント波蛍光検出装置
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
EP1287154A4 (en) 2000-06-07 2010-12-15 Pacific Biosciences California NUCLEOTIDES WITH CHARGE SWITCHING
EP1311824A4 (en) 2000-06-25 2010-12-08 Affymetrix Inc OPTICALLY ACTIVE SUBSTRATES
US7277166B2 (en) 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
EP1320596A4 (en) 2000-08-30 2005-01-12 Univ Rochester REVERSE TRANSCRIPTION REACTION METHOD USING REVERSE TRANSCRIPTASE CODED BY RETROTRANSPOSON NON-LTR
AU2001284681A1 (en) 2000-09-11 2002-03-26 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
AU2001210599A1 (en) 2000-10-23 2002-05-06 Diachip Limited High precision and intellectual biochip arrayer having function of respotting
JP3695340B2 (ja) * 2001-03-30 2005-09-14 株式会社日立製作所 Ｄｎａ検査方法及びその装置並びに蛍光検出方法
AU2002258997A1 (en) 2001-04-24 2002-11-05 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymerases
US7223541B2 (en) 2001-08-29 2007-05-29 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides and methods of use
US7256019B2 (en) 2001-08-29 2007-08-14 Ge Healthcare Bio-Sciences Corp. Terminal phosphate blocked nucleoside polyphosphates
US7727722B2 (en) 2001-08-29 2010-06-01 General Electric Company Ligation amplification
DE60235376D1 (de) 2001-08-29 2010-04-01 Ge Healthcare Bio Sciences Markierte nukleosidpolyphosphate
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
WO2003020488A1 (de) * 2001-08-30 2003-03-13 Zeptosens Ag Verfahren zur herstellung von abformkörpern, insbesondere optischen strukturen, und deren verwendung
US20070020622A1 (en) 2001-09-14 2007-01-25 Invitrogen Corporation DNA Polymerases and mutants thereof
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US6924887B2 (en) 2002-03-27 2005-08-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
WO2004072238A2 (en) 2003-02-05 2004-08-26 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides with new linkers
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US20040258563A1 (en) 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
CN1209619C (zh) 2003-07-18 2005-07-06 华中科技大学 塑料生物芯片的键合和封装装置
US20050118060A1 (en) * 2003-08-04 2005-06-02 Irm, Llc Multi-well container positioning devices and related systems and methods
WO2005073407A1 (en) 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
US20050079102A1 (en) 2003-10-14 2005-04-14 Staton Kenneth L. Interrogation apparatus
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20070281288A1 (en) 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
EP1786932A4 (en) * 2004-08-23 2010-10-27 Us Genomics Inc SYSTEMS AND METHOD FOR THE DETECTION AND ANALYSIS OF POLYMERS
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
EP1790202A4 (en) 2004-09-17 2013-02-20 Pacific Biosciences California APPARATUS AND METHOD FOR ANALYZING MOLECULES
US8293430B2 (en) * 2005-01-27 2012-10-23 Applied Materials, Inc. Method for etching a molybdenum layer suitable for photomask fabrication
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
CN100401041C (zh) * 2005-06-09 2008-07-09 上海交通大学 光波导吸收式气体传感器及测量系统
US7645866B2 (en) 2005-06-28 2010-01-12 Life Technologies Corporation Methods of producing and sequencing modified polynucleotides
EP1919930B1 (en) 2005-07-01 2016-09-14 Dako Denmark A/S New nucleic acid base pairs
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US20160355869A1 (en) * 2005-08-02 2016-12-08 University Of Utah Research Foundation Biosensors including metallic nanocavities
JP2009503548A (ja) * 2005-08-02 2009-01-29 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 金属ナノキャビティを含むバイオセンサー
US7453916B2 (en) * 2005-09-08 2008-11-18 Intel Corporation High throughput optical micro-array reader capable of variable pitch and spot size array processing for genomics and proteomics
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
TWI296044B (en) * 2005-11-03 2008-04-21 Ind Tech Res Inst Coupled waveguide-surface plasmon resonance biosensor
WO2007070542A2 (en) 2005-12-12 2007-06-21 The Government Of The United States Of America As Represented By The Secretary Of The Deptartment Ofhealth And Human Services Nanoprobes for detection or modification of molecules
EP3056575B1 (en) 2005-12-22 2017-10-11 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
AU2006331512B2 (en) 2005-12-22 2012-02-23 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US7750316B2 (en) * 2006-05-10 2010-07-06 Dublin City University Polymer biochip for detecting fluorescence
EP2021113A2 (en) 2006-05-11 2009-02-11 Raindance Technologies, Inc. Microfluidic devices
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
EP3936857B1 (en) 2006-09-01 2023-06-21 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
CA2666517A1 (en) 2006-10-23 2008-05-02 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US9218944B2 (en) * 2006-10-30 2015-12-22 Applied Materials, Inc. Mask etch plasma reactor having an array of optical sensors viewing the workpiece backside and a tunable element controlled in response to the optical sensors
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
WO2008114148A2 (en) 2007-03-22 2008-09-25 Universite Louis Pasteur Device for sorting and concentrating electromagnetic energy and apparatus comprising at least one such device
EP2134871B1 (en) 2007-03-30 2012-03-07 Pacific Biosciences of California, Inc. Systems and methods for enhancing fluorescent signals
JP5222599B2 (ja) * 2007-07-20 2013-06-26 株式会社日立ハイテクノロジーズ 核酸分析デバイス及びそれを用いた核酸分析装置
JP2009022247A (ja) * 2007-07-23 2009-02-05 Toshiba Corp 培養容器及び培養組織回収方法
US9410892B2 (en) * 2007-08-30 2016-08-09 Cornell University Nanoscale optofluidic devices for molecular detection
EP2212679A1 (en) * 2007-09-18 2010-08-04 Applied Biosystems Inc. Methods, systems and apparatus for light concentrating mechanisms
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
GB0723725D0 (en) 2007-12-05 2008-01-16 Ge Healthcare Uk Ltd Apparatus and method for detecting dna damage
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
WO2009091847A2 (en) 2008-01-14 2009-07-23 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
EP2252625B1 (en) 2008-02-07 2017-12-20 Pacific Biosciences of California, Inc. Cis reactive oxygen quenchers integrated into linkers
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
AU2009215193A1 (en) 2008-02-12 2009-08-20 Pacific Biosciences Of California, Inc. Compositions and methods for use in analytical reactions
EP2263087B1 (en) 2008-03-13 2017-08-09 Pacific Biosciences of California, Inc. Labeled reactants and their uses
US20090243584A1 (en) * 2008-03-25 2009-10-01 Guigen Zhang Fabrication of microstructures integrated with nanopillars along with their applications as electrodes in sensors
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
MX2010010600A (es) 2008-03-28 2011-03-30 Pacific Biosciences California Inc Composiciones y metodos para secuenciacion de acidos nucleicos.
US8143030B2 (en) 2008-09-24 2012-03-27 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8236499B2 (en) 2008-03-28 2012-08-07 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
EP2881736B1 (en) 2008-03-31 2017-06-07 Pacific Biosciences of California, Inc. Single polymerase molecule loading methods and compositions
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
CA2720046C (en) 2008-03-31 2018-07-24 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8133672B2 (en) 2008-03-31 2012-03-13 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
US10114213B2 (en) 2008-04-04 2018-10-30 Cvi Laser, Llc Laser systems and optical devices for manipulating laser beams
JP5268444B2 (ja) * 2008-06-23 2013-08-21 株式会社日立ハイテクノロジーズ 単分子リアルタイムシーケンス装置，核酸分析装置及び単分子リアルタイムシーケンス方法
EP2148187A1 (de) * 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
US7999454B2 (en) * 2008-08-14 2011-08-16 Global Oled Technology Llc OLED device with embedded chip driving
EP2326733A2 (en) 2008-09-05 2011-06-01 Pacific Biosciences of California, Inc. Engineering polymerases and reaction conditions for modified incorporation properties
FR2936099A1 (fr) * 2008-09-12 2010-03-19 Thales Sa Dispositif de detection d'images ameliore pour un imageur multispectral et imageur multispectral comportant ce dispositif
EP3629011B1 (en) 2008-09-16 2023-11-01 Pacific Biosciences Of California, Inc. Integrated optical device
US8921046B2 (en) 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8383369B2 (en) 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
CN102227659B (zh) 2008-09-30 2014-12-24 加利福尼亚太平洋生物科学股份有限公司 超高多路分析系统和方法
EP2182523B1 (en) 2008-10-31 2013-01-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line
KR101045206B1 (ko) * 2008-10-31 2011-06-30 삼성전자주식회사 여기광 흡수 도파로가 삽입된 집적된 바이오칩 및 그 제조방법
KR101065077B1 (ko) * 2008-11-05 2011-09-15 삼성전자주식회사 시료 검출용 기판, 이를 채용한 바이오칩, 시료 검출용 기판의 제조방법 및 바이오 물질 검출장치
WO2010057185A1 (en) 2008-11-17 2010-05-20 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
US9222082B2 (en) 2009-01-30 2015-12-29 Oxford Nanopore Technologies Limited Hybridization linkers
US8921280B2 (en) * 2009-02-11 2014-12-30 Samsung Electronics Co., Ltd. Integrated bio-chip and method of fabricating the integrated bio-chip
WO2010111686A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Labeled enzyme compositions, methods & systems
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP5707030B2 (ja) * 2009-04-02 2015-04-22 株式会社日立ハイテクノロジーズ 核酸分析デバイス、及び核酸分析装置
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
JP5462548B2 (ja) * 2009-08-12 2014-04-02 株式会社日立ハイテクノロジーズ 核酸分析素子及びそれを用いた核酸分析装置
WO2011040971A2 (en) 2009-09-30 2011-04-07 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
WO2011068569A1 (en) 2009-12-04 2011-06-09 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
WO2011090745A1 (en) 2009-12-29 2011-07-28 Life Technologies Corporation Single molecule detection and sequencing using fluorescence lifetime imaging
CA2790393C (en) 2010-02-19 2019-03-12 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US9482615B2 (en) * 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
TWI466278B (zh) 2010-04-06 2014-12-21 勝開科技股份有限公司 晶圓級影像感測器構裝結構及其製造方法
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
EP2439512A1 (en) * 2010-10-01 2012-04-11 Aqsens Oy A device for holding a sample
EP2441520A1 (en) 2010-10-12 2012-04-18 Eppendorf AG Real-time amplification and micro-array based detection of nucleic acid targets in a flow chip assay
EP2646154A2 (en) 2010-11-30 2013-10-09 Quantumdx Group Limited The design, fabrication and use of a microfluidics multitemperature flexible reaction device
EP2647060A2 (en) 2010-11-30 2013-10-09 Tshwane University Of Technology Cmos based micro-photonic systems
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
JP2013045857A (ja) 2011-08-24 2013-03-04 Sony Corp イメージセンサ及びその製造方法並びに検査装置
FR2982028B1 (fr) 2011-10-26 2020-02-21 Aryballe Technologies Puce microstructuree comprenant des surfaces convexes pour analyse par resonance des plasmons de surface, dispositif d'analyse contenant ladite puce microstructuree et utilisation dudit dispositif
US8778849B2 (en) 2011-10-28 2014-07-15 Illumina, Inc. Microarray fabrication system and method
US9606060B2 (en) 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP3590948A1 (en) 2012-02-15 2020-01-08 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
US9059250B2 (en) * 2012-02-17 2015-06-16 International Business Machines Corporation Lateral-dimension-reducing metallic hard mask etch
EP2831283A4 (en) * 2012-03-30 2015-11-04 Pacific Biosciences California METHODS AND COMPOSITION FOR SEQUENCING MODIFIED NUCLEIC ACIDS
JP6301311B2 (ja) * 2012-04-10 2018-03-28 ザ トラスティーズ オブ プリンストン ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 超高感度センサ
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) * 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
US8654427B1 (en) 2012-08-31 2014-02-18 Rosemount Aerospace Inc. Ruggedized two-axis optical beam steering device
EP4123294A1 (en) 2012-12-18 2023-01-25 Pacific Biosciences Of California, Inc. An optical analytical device
EP2959283B1 (en) * 2013-02-22 2022-08-17 Pacific Biosciences of California, Inc. Integrated illumination of optical analytical devices
CA2906728C (en) 2013-03-15 2022-07-12 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US9654680B2 (en) * 2013-10-17 2017-05-16 Canon Kabushiki Kaisha Image capturing apparatus and control method therefor
KR102240166B1 (ko) 2013-11-17 2021-04-14 퀀텀-에스아이 인코포레이티드 분자들을 프로빙 검출 및 분석하기 위한 외부 광원을 구비한 통합 디바이스
WO2015141873A1 (ko) 2014-03-18 2015-09-24 서울대학교산학협력단 광영역 시료를 고속 정량 분석하는 라만 분석 방법 및 장치
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
CA2957543A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
CN107112333B (zh) 2014-08-08 2020-07-10 宽腾矽公司 基于入射光子到达时间的识别、成像、测序法及存储介质
EP3194934B1 (en) 2014-08-08 2024-03-06 Quantum-Si Incorporated Integrated device for use with an external light source for probing, detecting, and analyzing molecules by luminescence lifetime measurements
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
CN107615121B (zh) 2015-03-16 2021-04-16 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
CN105039147B (zh) 2015-06-03 2016-05-04 西安交通大学 一种高通量基因测序碱基荧光图像捕获系统装置及方法
BR112020000826A2 (pt) 2017-07-24 2020-07-21 Quantum-Si Incorporated instrumento bio-optoeletrônico maciçamente paralelo portátil

Also Published As

Publication number Publication date
US11287382B2 (en) 2022-03-29
US10533945B2 (en) 2020-01-14
KR20160108317A (ko) 2016-09-19
AU2020286308A1 (en) 2021-01-21
MX2016006455A (es) 2016-12-09
BR112016011084B8 (pt) 2021-11-09
US10712273B2 (en) 2020-07-14
AU2014348305A1 (en) 2016-06-16
CN110452809A (zh) 2019-11-15
BR112016011052B1 (pt) 2021-09-28
CN105917003A (zh) 2016-08-31
JP7015336B2 (ja) 2022-02-02
JP2020092710A (ja) 2020-06-18
EP3068901A1 (en) 2016-09-21
AU2014348302B2 (en) 2020-10-01
WO2015074004A1 (en) 2015-05-21
JP2016537999A (ja) 2016-12-08
EP3974814A1 (en) 2022-03-30
BR112016011061B1 (pt) 2021-10-13
JP2021090428A (ja) 2021-06-17
BR112016011084B1 (pt) 2021-09-28
CN106029904A (zh) 2016-10-12
AU2014348306A1 (en) 2016-06-16
EP3068901B1 (en) 2021-10-20
KR20210024219A (ko) 2021-03-04
US20180328850A1 (en) 2018-11-15
US20220214279A1 (en) 2022-07-07
KR102399962B1 (ko) 2022-05-20
US10712274B2 (en) 2020-07-14
CN105980580A (zh) 2016-09-28
KR20160108316A (ko) 2016-09-19
KR102296713B1 (ko) 2021-09-02
CN111235246B (zh) 2022-01-28
EP3068900B1 (en) 2020-01-08
EP3068900A1 (en) 2016-09-21
US20150141267A1 (en) 2015-05-21
BR112016011084A2 (pt) 2020-09-08
JP6573899B2 (ja) 2019-09-11
US20180348132A1 (en) 2018-12-06
EP3074531B1 (en) 2020-01-08
MX378010B (es) 2025-03-10
US20200371034A1 (en) 2020-11-26
US12163888B2 (en) 2024-12-10
CN110452809B (zh) 2022-07-01
MX2020013247A (es) 2022-05-19
KR20160108318A (ko) 2016-09-19
US20220170861A1 (en) 2022-06-02
BR112016011052A2 (pt) 2020-05-19
US12123834B2 (en) 2024-10-22
US10048208B2 (en) 2018-08-14
AU2014348302A1 (en) 2016-06-16
CA2930832A1 (en) 2015-05-21
MX380165B (es) 2025-03-12
AU2014348305B2 (en) 2020-10-01
JP7242727B2 (ja) 2023-03-20
CN105980580B (zh) 2020-03-03
AU2020286308B2 (en) 2022-02-17
KR102240166B1 (ko) 2021-04-14
US20150177150A1 (en) 2015-06-25
US20220364996A1 (en) 2022-11-17
MX392471B (es) 2025-03-24
EP3715831A1 (en) 2020-09-30
JP6673843B2 (ja) 2020-03-25
CN111235246A (zh) 2020-06-05
US9983135B2 (en) 2018-05-29
EP3709003A1 (en) 2020-09-16
BR112016011061A2 (enExample) 2017-08-08
CA2930836A1 (en) 2015-05-21
MX2016006454A (es) 2016-12-09
WO2015074005A1 (en) 2015-05-21
KR102221637B1 (ko) 2021-03-02
EP3074531A1 (en) 2016-10-05
AU2014348306B2 (en) 2020-11-12
CA2930834A1 (en) 2015-05-21
US20180088052A1 (en) 2018-03-29
US9863880B2 (en) 2018-01-09
US20180348133A1 (en) 2018-12-06
US11428635B2 (en) 2022-08-30
MX2016006453A (es) 2016-12-09
WO2015074001A1 (en) 2015-05-21
US20150141268A1 (en) 2015-05-21
JP2016537998A (ja) 2016-12-08
JP2017502310A (ja) 2017-01-19
US20200088643A1 (en) 2020-03-19

Similar Documents

Publication Publication Date Title
MX381541B (es) Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas.
MX383892B (es) Sistema optico y circuito integrado de valoración para sondear, detectar y analizar moleculas.
MX384725B (es) Dispositivo integrado con fuente de luz externa para el sondeo, detección y análisis de moléculas.
MX394779B (es) Dispositivo integrado para detectar y analizar moléculas.
CY1123264T1 (el) Μεθοδοι και συστηματα για αναλυση δεδομενων εικονας
CL2016000679A1 (es) Sensor fluorométrico multicanal y método de uso del mismo
CY1118748T1 (el) Πολυπλεγμενοι προσδιορισμοι βασιζομενοι σε απταμερη
DK3436998T3 (da) Instrument til overvågning af en analytkoncentration
MX2017006443A (es) Proceso para efectuar la prueba de alto rendimiento de la cromatografia liquida de alta resolucion.
MX2019015016A (es) Ensayos para la deteccion de una sola molecula y uso de los mismos.
SG10201913827SA (en) Multi-color fluorescent excitation and detection device and nucleic acid analysis apparatus employing same
AR098473A1 (es) Método para analizar una muestra que comprende por lo menos un primer y un segundo inhibidores de óxido
BR112015009901A2 (pt) elementos de ensaio , material reagente e método para a determinação dos primeiro e segundo analitos em uma amostra.
EP4220158A3 (en) Urine specimen analysis device and urine specimen analysis method
EA201400870A1 (ru) Микрожидкостный проточный анализатор для обнаружения патологии и способ обнаружения патологии
MX374656B (es) Método para determinar una concentración de un inhibidor de incrustaciones en una muestra.
EP4179973A4 (en) INSTALLATION UNIT OF AN ANALYTE DETECTION DEVICE
CY1123180T1 (el) Συστημα ανιχνευσης που αξιοποιει αλυσιδωτη αντιδραση πολυμερασης
EA201300009A1 (ru) Точные интегрированные электродные чипы для микроанализа и способ использования в системах с возбуждением электрохемилюминесценции горячими электронами
EA201500377A1 (ru) Способ обнаружения анализируемого вещества и определение его концентрации с использованием намагничиваемых гранул
BR112017020749A2 (pt) sistema de análise óptica, e, método de análise óptica
WO2015066716A3 (en) Device and method for gasochromic porosity sensing
BR112014006296A2 (pt) método para detectar um analito
MX2016016223A (es) Metodo para detectar y demostrar el daño termico al cabello por medio de la evaluacion de peptidos.
EP4408279A4 (en) Installation unit of analyte detection device