AU2014348302B2 - Optical system and assay chip for probing, detecting and analyzing molecules - Google Patents

Optical system and assay chip for probing, detecting and analyzing molecules Download PDF

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Publication number
AU2014348302B2
AU2014348302B2 AU2014348302A AU2014348302A AU2014348302B2 AU 2014348302 B2 AU2014348302 B2 AU 2014348302B2 AU 2014348302 A AU2014348302 A AU 2014348302A AU 2014348302 A AU2014348302 A AU 2014348302A AU 2014348302 B2 AU2014348302 B2 AU 2014348302B2
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sample
sample well
excitation
chip
instrument
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AU2014348302A1 (en
Inventor
Anthony BELLOFIORE
Benjamin CIPRIANY
Adam E. Cohen
Michael Ferrigno
Paul E. Glenn
Brett J. Gyarfas
Jack Jewell
Ali KABIRI
Jeremy Lackey
Jonathan M. Rothberg
Gerard Schmid
Jason W. Sickler
Lawrence West
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Quantum Si Inc
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Quantum Si Inc
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Priority to AU2020286308A priority Critical patent/AU2020286308B2/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
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    • C12Q2521/10—Nucleotidyl transfering
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
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    • C12Q2537/157—A reaction step characterised by the number of molecules incorporated or released
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
AU2014348302A 2013-11-17 2014-11-17 Optical system and assay chip for probing, detecting and analyzing molecules Active AU2014348302B2 (en)

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Application Number Priority Date Filing Date Title
AU2020286308A AU2020286308B2 (en) 2013-11-17 2020-12-11 Optical system and assay chip for probing, detecting and analyzing molecules

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US201361905282P 2013-11-17 2013-11-17
US61/905,282 2013-11-17
US201361917926P 2013-12-18 2013-12-18
US61/917,926 2013-12-18
US201461941916P 2014-02-19 2014-02-19
US61/941,916 2014-02-19
PCT/US2014/066010 WO2015074001A1 (en) 2013-11-17 2014-11-17 Optical system and assay chip for probing, detecting and analyzing molecules

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AU2020286308A Division AU2020286308B2 (en) 2013-11-17 2020-12-11 Optical system and assay chip for probing, detecting and analyzing molecules

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AU2014348302A1 AU2014348302A1 (en) 2016-06-16
AU2014348302B2 true AU2014348302B2 (en) 2020-10-01

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AU2014348306A Active AU2014348306B2 (en) 2013-11-17 2014-11-17 Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens
AU2014348305A Active AU2014348305B2 (en) 2013-11-17 2014-11-17 Integrated device with external light source for probing detecting and analyzing molecules
AU2020286308A Active AU2020286308B2 (en) 2013-11-17 2020-12-11 Optical system and assay chip for probing, detecting and analyzing molecules

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