MX380165B - Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos. - Google Patents

Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos.

Info

Publication number
MX380165B
MX380165B MX2016006455A MX2016006455A MX380165B MX 380165 B MX380165 B MX 380165B MX 2016006455 A MX2016006455 A MX 2016006455A MX 2016006455 A MX2016006455 A MX 2016006455A MX 380165 B MX380165 B MX 380165B
Authority
MX
Mexico
Prior art keywords
sample
biological
active source
rapid analysis
pixel device
Prior art date
Application number
MX2016006455A
Other languages
English (en)
Other versions
MX2016006455A (es
Inventor
Ali Kabiri
Brett J Gyarfas
Gerard Schmid
Jason W Sickler
Jeremy Lackey
Jonathan M Rothberg
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of MX2016006455A publication Critical patent/MX2016006455A/es
Publication of MX380165B publication Critical patent/MX380165B/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G—PHYSICS
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    • B01L2300/0829—Multi-well plates; Microtitration plates
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • C—CHEMISTRY; METALLURGY
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/101—Modifications characterised by incorporating non-naturally occurring nucleotides, e.g. inosine
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    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/157—A reaction step characterised by the number of molecules incorporated or released
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La presente invención se refiere a un dispositivo integrado de fuente-píxel activo capaz de realizar detección y/o análisis de biomoléculas, tal como la secuenciación de ácido nucleico de una sola molécula; un píxel activo del dispositivo integrado incluye un pocillo de muestra en el que se puede difundir una muestra por analizar, una fuente de excitación para proveer energía de excitación al pocillo de muestra y un sensor configurado para detectar la emisión de la muestra; el sensor puede comprender dos o más segmentos que producen una serie de señales que son analizadas para diferenciar entre etiquetas que están unidas o asociadas con la muestra e identificarlas; la diferenciación de etiquetas puede estar basada en el espectro y/o tiempo; la identificación de las etiquetas se puede usar para detectar, analizar y/o secuenciar la biomolécula.
MX2016006455A 2013-11-17 2014-11-17 Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos. MX380165B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361905282P 2013-11-17 2013-11-17
US201361917926P 2013-12-18 2013-12-18
US201461941916P 2014-02-19 2014-02-19
PCT/US2014/066014 WO2015074005A1 (en) 2013-11-17 2014-11-17 Active-source-pixel, integrated device for rapid analysis of biological and chemical speciments

Publications (2)

Publication Number Publication Date
MX2016006455A MX2016006455A (es) 2016-12-09
MX380165B true MX380165B (es) 2025-03-12

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
MX2016006455A MX380165B (es) 2013-11-17 2014-11-17 Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos.
MX2016006454A MX381541B (es) 2013-11-17 2014-11-17 Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas.
MX2020013247A MX392471B (es) 2013-11-17 2014-11-17 Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas
MX2016006453A MX378010B (es) 2013-11-17 2014-11-17 Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas.

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MX2016006454A MX381541B (es) 2013-11-17 2014-11-17 Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas.
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