MX378010B - Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas. - Google Patents

Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas.

Info

Publication number
MX378010B
MX378010B MX2016006453A MX2016006453A MX378010B MX 378010 B MX378010 B MX 378010B MX 2016006453 A MX2016006453 A MX 2016006453A MX 2016006453 A MX2016006453 A MX 2016006453A MX 378010 B MX378010 B MX 378010B
Authority
MX
Mexico
Prior art keywords
sample
emission energy
assay chip
sensor
sample well
Prior art date
Application number
MX2016006453A
Other languages
English (en)
Other versions
MX2016006453A (es
Inventor
Adam E Cohen
Ali Kabiri
Anthony Bellofiore
Benjamin Cipriany
Brett J Gyarfas
Gerard Schmid
Jack Jewell
Jason W Sickler
Jeremy Lackey
Jonathan M Rothberg
Lawrence West
Michael Ferrigno
Paul E Glenn
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of MX2016006453A publication Critical patent/MX2016006453A/es
Publication of MX378010B publication Critical patent/MX378010B/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G—PHYSICS
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    • G—PHYSICS
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    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • C—CHEMISTRY; METALLURGY
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    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/101—Modifications characterised by incorporating non-naturally occurring nucleotides, e.g. inosine
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    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/157—A reaction step characterised by the number of molecules incorporated or released
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
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    • G—PHYSICS
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
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  • Plasma & Fusion (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La presente invención se refiere a un aparato y métodos para analizar una sola molécula y realizar la secuenciación de un ácido nucleico; un aparato puede incluir un chip de ensayo que incluye múltiples pixeles con pocillos de muestra configurados para recibir una muestra que, cuando es excitada, emite energía de emisión; por lo menos un elemento para dirigir la energía de emisión en una dirección particular; y una trayectoria de luz a lo largo de la cual viaja la energía de emisión del pocillo de muestra hacia un sensor; el aparato también incluye un instrumento que interacciona con el chip de ensayo; el instrumento incluye una fuente de luz de excitación para excitar la muestra de cada pocillo de muestra; una pluralidad de sensores que corresponden a los pocillos de muestra; cada sensor puede detectar energía de emisión de una muestra en una pocillo de muestra respectivo; el instrumento incluye por lo menos un elemento óptico que dirige la energía de emisión de cada pocillo de muestra hacia un sensor respectivo de la pluralidad de sensores.
MX2016006453A 2013-11-17 2014-11-17 Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas. MX378010B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361905282P 2013-11-17 2013-11-17
US201361917926P 2013-12-18 2013-12-18
US201461941916P 2014-02-19 2014-02-19
PCT/US2014/066010 WO2015074001A1 (en) 2013-11-17 2014-11-17 Optical system and assay chip for probing, detecting and analyzing molecules

Publications (2)

Publication Number Publication Date
MX2016006453A MX2016006453A (es) 2016-12-09
MX378010B true MX378010B (es) 2025-03-10

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Family Applications (4)

Application Number Title Priority Date Filing Date
MX2020013247A MX392471B (es) 2013-11-17 2014-11-17 Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas
MX2016006454A MX381541B (es) 2013-11-17 2014-11-17 Dispositivo integrado con fuente de luz externa para sondear, detectar y analizar moléculas.
MX2016006455A MX380165B (es) 2013-11-17 2014-11-17 Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos.
MX2016006453A MX378010B (es) 2013-11-17 2014-11-17 Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas.

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