EA201400870A1 - Микрожидкостный проточный анализатор для обнаружения патологии и способ обнаружения патологии - Google Patents

Микрожидкостный проточный анализатор для обнаружения патологии и способ обнаружения патологии

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Publication number
EA201400870A1
EA201400870A1 EA201400870A EA201400870A EA201400870A1 EA 201400870 A1 EA201400870 A1 EA 201400870A1 EA 201400870 A EA201400870 A EA 201400870A EA 201400870 A EA201400870 A EA 201400870A EA 201400870 A1 EA201400870 A1 EA 201400870A1
Authority
EA
Eurasian Patent Office
Prior art keywords
channels
optical
pathology detection
flow analyzer
pathology
Prior art date
Application number
EA201400870A
Other languages
English (en)
Other versions
EA029557B1 (ru
Inventor
Таслимариф Сайед
Судип Мондал
Анил Прабхакар
Х. Кришнамурти
Original Assignee
Сентр Фор Сельюлар Энд Молекьюлар Плэтформз (С-Кэмп)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Сентр Фор Сельюлар Энд Молекьюлар Плэтформз (С-Кэмп) filed Critical Сентр Фор Сельюлар Энд Молекьюлар Плэтформз (С-Кэмп)
Publication of EA201400870A1 publication Critical patent/EA201400870A1/ru
Publication of EA029557B1 publication Critical patent/EA029557B1/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4915—Blood using flow cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Ecology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Изобретение относится к микрожидкостному проточному анализатору для обнаружения патологии. Микрожидкостный проточный анализатор содержит множество буферных каналов, канал образца, центральный проточный канал, множество оптических каналов возбуждения и множество приемных оптических каналов. Множество оптических каналов возбуждения и множество приемных оптических каналов размещены под заданным углом к центральному проточному каналу. Множество оптических каналов возбуждения возбуждают клетку в растворе образца, протекающем через центральный проточный канал. Возбужденная клетка генерирует один или более оптических сигналов. Один или более оптические сигналы принимаются множеством приемных оптических каналов. Микрожидкостный проточный анализатор содержит множество детекторов, размещенных на каждом из множества приемных оптических каналов, для обнаружения одного из указанных одного или более оптических сигналов. Обнаруженный оптический сигнал передается в вычислительный блок для обнаружения патологии.
EA201400870A 2012-02-04 2013-02-01 Микрожидкостный проточный анализатор для обнаружения патологии и способ обнаружения патологии EA029557B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4067CH2011 2012-02-04
PCT/IB2013/050871 WO2013114333A1 (en) 2012-02-04 2013-02-01 Microfluidic flow analyzer for pathological detection and method thereof

Publications (2)

Publication Number Publication Date
EA201400870A1 true EA201400870A1 (ru) 2015-01-30
EA029557B1 EA029557B1 (ru) 2018-04-30

Family

ID=48904495

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400870A EA029557B1 (ru) 2012-02-04 2013-02-01 Микрожидкостный проточный анализатор для обнаружения патологии и способ обнаружения патологии

Country Status (8)

Country Link
US (1) US9304122B2 (ru)
EP (1) EP2810063B1 (ru)
KR (1) KR102038400B1 (ru)
CN (1) CN104136922B (ru)
AP (1) AP2014007893A0 (ru)
EA (1) EA029557B1 (ru)
WO (1) WO2013114333A1 (ru)
ZA (1) ZA201406473B (ru)

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CN104965082B (zh) * 2015-05-21 2016-08-24 大连理工大学 一种同时检测尿液中膀胱癌细胞、结石、血细胞和细菌的微流控芯片
JP2017083263A (ja) 2015-10-27 2017-05-18 ソニー株式会社 微粒子検出装置
CN105388139B (zh) * 2015-12-26 2018-03-27 嘉兴凯实生物科技有限公司 一种流式荧光检测器
CN105699671A (zh) * 2016-01-18 2016-06-22 北京理工大学 一种用于生物微粒分型分析的小型微流控芯片系统
GB201604246D0 (en) 2016-03-11 2016-04-27 Univ Hull Radioactivity detection
US10190961B2 (en) 2016-03-18 2019-01-29 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Sample analyzer and sample analyzing method thereof
CN106085838B (zh) * 2016-08-01 2018-05-04 上海市刑事科学技术研究院 基于pdms芯片的片上细胞检测系统及方法
EP3690425B1 (en) * 2017-09-29 2023-07-19 Air Water Biodesign Inc. Measurement device and measurement method for hematoctrit
CN107824232B (zh) * 2017-10-25 2019-12-20 中国科学院电子学研究所 用于肌酐检测的微流控芯片、其制备方法及肌酐检测方法
JP2020051936A (ja) 2018-09-27 2020-04-02 ソニー株式会社 微小粒子測定装置及び微小粒子測定方法
US20220355298A1 (en) 2019-07-03 2022-11-10 Centre For Cellular And Molecular Platforms A microfluidic analyser
JP2023541613A (ja) * 2020-09-10 2023-10-03 ベクトン・ディキンソン・アンド・カンパニー フローストリーム中の試料を照射するためのレーザ光伝搬システム、及びそれを使用するための方法
CN116337728B (zh) * 2023-05-30 2023-08-18 天津大学 一种单片集成微流式细胞仪荧光检测装置

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WO2008036083A1 (en) * 2006-09-19 2008-03-27 Vanderbilt University Microfluidic flow cytometer and applications of same
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Also Published As

Publication number Publication date
CN104136922A (zh) 2014-11-05
JP2015512615A (ja) 2015-04-30
EP2810063B1 (en) 2021-08-25
ZA201406473B (en) 2015-11-25
EA029557B1 (ru) 2018-04-30
EP2810063A4 (en) 2015-10-28
JP6138163B2 (ja) 2017-05-31
CN104136922B (zh) 2017-03-01
WO2013114333A1 (en) 2013-08-08
KR20140124388A (ko) 2014-10-24
US9304122B2 (en) 2016-04-05
AP2014007893A0 (en) 2014-08-31
EP2810063A1 (en) 2014-12-10
US20140374630A1 (en) 2014-12-25
KR102038400B1 (ko) 2019-11-26

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU