MA29499B1 - Procede de modulation du systeme de la proteine-kinase activee par le stress - Google Patents

Procede de modulation du systeme de la proteine-kinase activee par le stress

Info

Publication number
MA29499B1
MA29499B1 MA30442A MA30442A MA29499B1 MA 29499 B1 MA29499 B1 MA 29499B1 MA 30442 A MA30442 A MA 30442A MA 30442 A MA30442 A MA 30442A MA 29499 B1 MA29499 B1 MA 29499B1
Authority
MA
Morocco
Prior art keywords
stress
activated protein
modulating
sapk
kinase system
Prior art date
Application number
MA30442A
Other languages
English (en)
Inventor
Lawrence M Blatt
Scott D Seiwert
Leonid Beigelman
Ramachandran Radhakrishnan
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of MA29499B1 publication Critical patent/MA29499B1/fr

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Abstract

Sont décrits des procédés pour la modulation d'un système de protéine kinase activée par le stress (SAPK) avec un composé actif, dans lesquels le composé actif révèle une faible puissance pour l'inhibition d'au moins une p38 MAPK ; et dans lesquels la mise en contact est menée à une concentration de modulation de la SAPK qui est à une concentration inhibitrice de faible pourcentage pour l'inhibition de la au moins une p38 MAPK par le composé. Sont aussi décrits des dérivés du pirfenidone. Ces dérivés peuvent moduler un système de protéine kinase activée par le stress (SAPK).
MA30442A 2005-05-10 2007-11-30 Procede de modulation du systeme de la proteine-kinase activee par le stress MA29499B1 (fr)

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ES2524922T3 (es) 2014-12-15
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US20140228310A1 (en) 2014-08-14
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US10010536B2 (en) 2018-07-03
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