ES2113399T3 - Derivados de beta-oxo-beta-bencenopropano-tio-amida. - Google Patents

Derivados de beta-oxo-beta-bencenopropano-tio-amida.

Info

Publication number
ES2113399T3
ES2113399T3 ES92121020T ES92121020T ES2113399T3 ES 2113399 T3 ES2113399 T3 ES 2113399T3 ES 92121020 T ES92121020 T ES 92121020T ES 92121020 T ES92121020 T ES 92121020T ES 2113399 T3 ES2113399 T3 ES 2113399T3
Authority
ES
Spain
Prior art keywords
group
beta
hydrogen atom
alkyl
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92121020T
Other languages
English (en)
Inventor
Tetsuo Sekiya
Mikio Tsutsui
Tetsuro Shimpuku
Tatsuo Nagano
Junko Hayashi
Asami Seino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of ES2113399T3 publication Critical patent/ES2113399T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/12—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/46—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESETA UN DERIVADO DE BETA-OXO-BETA-BENCENOPROPANOTIOAMIDO DE LA FORMULA GENERAL (I) R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, UN GRUPO DE ALQUIL C1-C6 O UN GRUPO DE CICLOALQUIL C1-C6 O UN GRUPO DE CICLOALQUIL C3-C6, O R1 Y R2, CUANDO SE TOMAN JUNTAS, REPRESENTAN UN GRUPO DE ALQUILENO C3-C6; R3 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO DE ALQUIL C1-C6; O UN GRUPO DE CICLOALQUIL C3-C6; R4 REPRESENTA UN GRUPO DE ALQUIL C1-C6 O UN GRUPO DE CICLOALQUIL C3-C6; O R3 Y R4, CUANDO SE TOMAN JUNTAS, REPRESENTAN UN GRUPO DE ALQUILENO C2-C5; X1, X2 Y X3 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO DE ALQUIL C1-C6, UN GRUPO DE CICLOALQUIL C3-C6, UN GRUPO DE ALCOXIDO C1-C6, UN GRUPO DE TRIFLUOROMETIL, UN GRUPO DE CIANO, UN GRUPO DE NITRO, UN GRUPO DE DIALQUILAMINO C2-C12, UN GRUPO DE SULFAMOIL, UN GRUPO HETEROCICLICO DE 5 O 6 MIEMBROS QUE CONTIENE UN ATOMO DE HIDROGENO COMO ATOMO HETERO. EL COMPUESTO TIENE UNA ACCION DE ABERTURA SOBRE EL CANAL DE POTASIO Y ES UTIL PARA EL TRATAMIENTO DE LA HIPERTENSION, EL ASMA, EL SINDROME DE COLON HIPERSENSIBLE, Y PRESENTA ACCIONES FARMACOLOGICAS TALES COMO LA DILATACION DE LOS VASOS SANGUINEOS, LA DILATACION DEL TRACTO BRONQUIAL, LA RELAJACION DEL MUSCULO LISO DEL TRACTO GASTROINTESTINAL, Y SIMILARES. LA INVENCION TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE, COMO INGREDIENTE ACTIVO, EL COMPUESTO DE LA INVENCION Y A UN METODO PARA PRODUCIR EL MISMO.
ES92121020T 1991-12-26 1992-12-09 Derivados de beta-oxo-beta-bencenopropano-tio-amida. Expired - Lifetime ES2113399T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34565791 1991-12-26

Publications (1)

Publication Number Publication Date
ES2113399T3 true ES2113399T3 (es) 1998-05-01

Family

ID=18378084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92121020T Expired - Lifetime ES2113399T3 (es) 1991-12-26 1992-12-09 Derivados de beta-oxo-beta-bencenopropano-tio-amida.

Country Status (11)

Country Link
US (2) US5332833A (es)
EP (1) EP0548680B1 (es)
JP (1) JP2707936B2 (es)
KR (1) KR930012698A (es)
AT (1) ATE163410T1 (es)
CA (1) CA2086210A1 (es)
DE (1) DE69224507T2 (es)
DK (1) DK0548680T3 (es)
ES (1) ES2113399T3 (es)
GR (1) GR3026240T3 (es)
TW (1) TW242138B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2113399T3 (es) * 1991-12-26 1998-05-01 Mitsubishi Chem Corp Derivados de beta-oxo-beta-bencenopropano-tio-amida.
WO1996022086A1 (en) * 1995-01-17 1996-07-25 Mitsubishi Chemical Corporation MEDICINE CONTAINING β-OXO-β-BENZENEPROPANE-THIOAMIDE DERIVATIVE
KR20010034114A (ko) * 1998-01-14 2001-04-25 니뽄 신야쿠 가부시키가이샤 칼륨 채널 활성화제
HUP0303829A3 (en) * 2001-04-16 2006-02-28 Tanabe Seiyaku Co Large conductance calcium-acitvated k channel opener compounds, use thereof and pharmaceutical compositions containing them
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
RS53599B1 (sr) 2005-05-10 2015-02-27 Intermune, Inc. Piridon derivati za modulaciju stresom aktiviranog sistema proteinskih kinaza
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
US10112929B2 (en) 2015-03-09 2018-10-30 Bristol-Myers Squibb Company Lactams as inhibitors of rock
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460909C2 (de) * 1974-12-21 1986-02-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von alpha- Oxothiodimethylamiden
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
US4299845A (en) * 1980-04-14 1981-11-10 Schering Corporation Dermatological compositions and methods of use therefor
GB8530015D0 (en) * 1985-12-05 1986-01-15 Ici Plc Biologically active amide derivatives
US4851526A (en) * 1987-09-04 1989-07-25 Schering A.G. 1-(4-Substituted phenyl)-1H-imidazoles compounds
US5185375A (en) * 1987-12-18 1993-02-09 May & Baker Limited Thioformamide derivatives
ES2113399T3 (es) * 1991-12-26 1998-05-01 Mitsubishi Chem Corp Derivados de beta-oxo-beta-bencenopropano-tio-amida.

Also Published As

Publication number Publication date
DE69224507D1 (de) 1998-04-02
EP0548680B1 (en) 1998-02-25
JP2707936B2 (ja) 1998-02-04
KR930012698A (ko) 1993-07-21
US5332833A (en) 1994-07-26
ATE163410T1 (de) 1998-03-15
CA2086210A1 (en) 1993-06-27
DE69224507T2 (de) 1998-08-20
JPH05246980A (ja) 1993-09-24
US5439927A (en) 1995-08-08
TW242138B (es) 1995-03-01
EP0548680A1 (en) 1993-06-30
GR3026240T3 (en) 1998-05-29
DK0548680T3 (da) 1998-09-23

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