LU87290A1 - Derives de 4'-phosphates de glucosides d'epipodophyllotoxine - Google Patents

Derives de 4'-phosphates de glucosides d'epipodophyllotoxine Download PDF

Info

Publication number
LU87290A1
LU87290A1 LU87290A LU87290A LU87290A1 LU 87290 A1 LU87290 A1 LU 87290A1 LU 87290 A LU87290 A LU 87290A LU 87290 A LU87290 A LU 87290A LU 87290 A1 LU87290 A1 LU 87290A1
Authority
LU
Luxembourg
Prior art keywords
compound
formula
alkyl
substituted
pharmaceutically acceptable
Prior art date
Application number
LU87290A
Other languages
English (en)
French (fr)
Inventor
John F Kadow
Mark G Saulnier
Peter D Senter
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of LU87290A1 publication Critical patent/LU87290A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cable Accessories (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
LU87290A 1987-08-04 1988-07-22 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine LU87290A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US8149387 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives
US19973188 1988-05-27

Publications (1)

Publication Number Publication Date
LU87290A1 true LU87290A1 (fr) 1990-02-07

Family

ID=26765636

Family Applications (2)

Application Number Title Priority Date Filing Date
LU87290A LU87290A1 (fr) 1987-08-04 1988-07-22 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine
LU90138C LU90138I2 (fr) 1987-08-04 1997-09-24 Etoposide phosphate et ses sels et dérivés pharmaceutiquement acceptables (etopophos)

Family Applications After (1)

Application Number Title Priority Date Filing Date
LU90138C LU90138I2 (fr) 1987-08-04 1997-09-24 Etoposide phosphate et ses sels et dérivés pharmaceutiquement acceptables (etopophos)

Country Status (34)

Country Link
US (3) US4904768A (de)
JP (1) JPH0699465B2 (de)
KR (1) KR900006230B1 (de)
CN (1) CN1027169C (de)
AT (1) AT398974B (de)
BE (1) BE1002982A4 (de)
CA (1) CA1310637C (de)
CH (1) CH676716A5 (de)
CY (1) CY1625A (de)
CZ (1) CZ286893B6 (de)
DD (2) DD299067A5 (de)
DE (1) DE3826562A1 (de)
DK (2) DK169344B1 (de)
ES (1) ES2010775A6 (de)
FI (1) FI87790C (de)
FR (1) FR2622193B1 (de)
GB (1) GB2207674B (de)
GR (1) GR1000490B (de)
HK (1) HK6392A (de)
HU (3) HU202547B (de)
IE (1) IE61040B1 (de)
IL (1) IL87290A (de)
IT (1) IT1226825B (de)
LU (2) LU87290A1 (de)
MX (1) MX173843B (de)
MY (1) MY104321A (de)
NL (2) NL192683C (de)
NO (4) NO170284C (de)
NZ (1) NZ225615A (de)
PT (1) PT88186B (de)
SE (1) SE502214C2 (de)
SG (1) SG101291G (de)
SK (1) SK279325B6 (de)
YU (3) YU143688A (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (de) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
ATE268187T1 (de) * 1996-04-01 2004-06-15 Epix Medical Inc Bioaktivierte diagnostische bilderzeugungskontrastmittel
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
BR0206206A (pt) * 2001-10-26 2005-01-11 Centre Nat Rech Scient Derivados de etoposide e análogos, e composições farmacêuticas contendo os mesmos
CN104225610B (zh) 2002-07-15 2017-03-01 得克萨斯大学体系董事会 与阴离子磷脂和氨基磷脂结合的选定抗体及其治疗用途
EP1583562B1 (de) * 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, verwandte verbindungen, und deren verwnedungen
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
BRPI0520032A2 (pt) * 2005-02-18 2009-04-14 Angiochem Inc moléculas para transportar um composto através da barreira hematoencefálica
BRPI0613005A8 (pt) * 2005-07-15 2017-12-26 Angiochem Inc uso de polipeptídeos de aprotinina como veículos em conjugados farmacêuticos.
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
WO2009036106A1 (en) * 2007-09-13 2009-03-19 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
PE20091523A1 (es) 2007-12-20 2009-10-29 Novartis Ag Derivados de tiazol como inhibidores de la enzima fosfatidilinositol 3-cinasa (pi3k)
PT2279008T (pt) * 2008-04-18 2019-05-20 Angiochem Inc Composições farmacêuticas de paclitaxel, análogos de paclitaxel ou conjugados de paclitaxel e métodos relacionados de preparação e utilização
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
CN102307904A (zh) * 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US9161988B2 (en) 2009-07-02 2015-10-20 Angiochem Inc. Multimeric peptide conjugates and uses thereof
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
US8440651B2 (en) 2010-02-22 2013-05-14 F. Hoffmann-La Roche Ag Pyrido[3,2-d]pyrimidine PI3K delta inhibitor compounds and methods of use
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
UY33883A (es) 2011-01-31 2012-08-31 Novartis Ag Novedosos derivados heterocíclicos
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
WO2013061305A1 (en) 2011-10-28 2013-05-02 Novartis Ag Novel purine derivatives and their use in the treatment of disease
EP2788003A4 (de) * 2011-12-09 2015-05-27 Demerx Inc Phosphatester von noribogain
US10213432B2 (en) 2012-05-16 2019-02-26 Novartis Ag Dosage regimen for a PI-3 kinase inhibitor
US9783535B2 (en) 2012-12-20 2017-10-10 Demerx, Inc. Substituted noribogaine
JP2016539149A (ja) 2013-12-06 2016-12-15 ノバルティス アーゲー アルファ−アイソフォーム選択的ホスファチジルイノシトール３−キナーゼ阻害剤の投薬レジメン
JP6823055B2 (ja) 2015-06-15 2021-01-27 アンジオケム インコーポレーテッド 軟髄膜癌腫症の治療方法
AU2016347881A1 (en) 2015-11-02 2018-05-10 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (de) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH544752A (de) * 1966-12-13 1974-01-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
IL87290A (en) 1993-01-31
DE3826562A1 (de) 1989-02-16
NZ225615A (en) 1991-06-25
FI883596A0 (fi) 1988-08-01
CZ541288A3 (cs) 1999-12-15
NO883299D0 (no) 1988-07-26
NO170284C (no) 1992-09-30
JPH0699465B2 (ja) 1994-12-07
SE8802815L (sv) 1989-02-05
GB8818462D0 (en) 1988-09-07
HUT47303A (en) 1989-02-28
NO920277L (no) 1989-02-24
ATA195588A (de) 1994-07-15
DK434088A (da) 1989-02-05
AU2030688A (en) 1989-06-08
CY1625A (en) 1992-07-10
FI87790C (fi) 1993-02-25
HU202547B (en) 1991-03-28
NO170284B (no) 1992-06-22
CN1027169C (zh) 1994-12-28
JPH01100188A (ja) 1989-04-18
NL192683B (de) 1997-08-01
IE882378L (en) 1989-02-04
GB2207674A (en) 1989-02-08
GR1000490B (el) 1992-07-30
CZ286893B6 (cs) 2000-07-12
GB2207674B (en) 1991-09-11
IL87290A0 (en) 1989-01-31
CN1061225A (zh) 1992-05-20
NO1998002I1 (no) 1998-01-14
DK11992D0 (da) 1992-01-31
NO883299L (no) 1989-02-24
DK169344B1 (da) 1994-10-10
SG101291G (en) 1992-01-17
LU90138I2 (fr) 1997-11-26
ES2010775A6 (es) 1989-12-01
PT88186B (pt) 1995-07-03
DD274423A5 (de) 1989-12-20
HU905862D0 (en) 1991-03-28
DK11992A (da) 1992-01-31
US4904768A (en) 1990-02-27
NL8801934A (nl) 1989-03-01
YU143688A (en) 1990-04-30
MX173843B (es) 1994-03-30
USRE35524E (en) 1997-06-03
DE3826562C2 (de) 1993-04-08
SE502214C2 (sv) 1995-09-18
HU208147B (en) 1993-08-30
FR2622193A1 (fr) 1989-04-28
DK434088D0 (da) 1988-08-03
NL192683C (nl) 1997-12-02
CA1310637C (en) 1992-11-24
IT8821535A0 (it) 1988-07-28
PT88186A (pt) 1989-06-30
FR2622193B1 (fr) 1993-12-17
YU10390A (en) 1990-06-30
NO920665L (no) 1989-02-24
YU10490A (en) 1990-06-30
MY104321A (en) 1994-03-31
SK541288A3 (en) 1998-10-07
SE8802815D0 (sv) 1988-08-03
DD299067A5 (de) 1992-03-26
CH676716A5 (de) 1991-02-28
KR890003790A (ko) 1989-04-18
IT1226825B (it) 1991-02-19
HK6392A (en) 1992-01-17
MX9202851A (es) 1992-06-30
US5041424A (en) 1991-08-20
GR880100512A (en) 1989-05-25
NL970042I1 (nl) 1998-03-02
AU610619B2 (en) 1991-05-23
SK279325B6 (sk) 1998-10-07
NO172440C (no) 1993-07-21
FI883596A (fi) 1989-02-05
NO920277D0 (no) 1992-01-22
KR900006230B1 (ko) 1990-08-27
HU211960A9 (en) 1996-01-29
IE61040B1 (en) 1994-09-07
BE1002982A4 (fr) 1991-10-15
FI87790B (fi) 1992-11-13
AT398974B (de) 1995-02-27
NO920665D0 (no) 1992-02-20
NO172440B (no) 1993-04-13
NL970042I2 (de) 2005-06-01

Similar Documents

Publication Publication Date Title
LU87290A1 (fr) Derives de 4'-phosphates de glucosides d'epipodophyllotoxine
EP0099068B1 (de) Neue Glycerinderivate zur Synthese von Phospholipiden
EP0787135B1 (de) Wasserlösliche derivate epipodophyllotoxine, verfahren zu ihrer herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
DK167810B1 (da) Alkylphyosphonoserin, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse
EP0318392B1 (de) N-(vinblastinoyl-23)-Derivate von 1-Aminomethylposphonsäure, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
CA2100228C (en) Phospholipid derivatives
EP0229128B1 (de) Glycero-3(2)-phospho-l-serinderivate und diese enthaltende pharmazeutischen präparate
EP2542560B1 (de) Arylfluorphosphathemmer eines natrium-/phosphat-transports durch apikalmembranen im darm
FR2694935A1 (fr) Dérivés du désoxy-cyclitol, procédé pour leur préparation et leur utilisation dans des médicaments.
IL37224A (en) Pharmaceutical preparations containing 3 - acyloxypropyl - 2 - trimethyl ammonium (noble phosphates
DE19832238A1 (de) Fluorierte Etherlipide, Verfahren zu deren Herstellung und Verwendung als Arzneimittel
CH636595A5 (fr) Procede de preparation de derives de l'acide n-(phosphonoacetyl)-l-aspartique et derives nouveaux ainsi obtenus.
JPH04211387A (ja) ホスホリパーゼｄ−ｐによる塩基交換反応方法

Legal Events

Date Code Title Description
CCP Supplementary protection certificate

Free format text: 90138, EXPIRES:20110412