|
PT2347775T
(pt)
|
2005-12-13 |
2020-07-14 |
The President And Fellows Of Harvard College |
Estruturas em andaime para transplante celular
|
|
JP6104806B2
(ja)
|
2010-10-06 |
2017-03-29 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
材料に基づく細胞治療のための注射可能孔形成性ハイドロゲル
|
|
US9675561B2
(en)
|
2011-04-28 |
2017-06-13 |
President And Fellows Of Harvard College |
Injectable cryogel vaccine devices and methods of use thereof
|
|
CN104244929B
(zh)
|
2012-04-16 |
2017-04-05 |
哈佛学院董事会 |
用于调节免疫反应的介孔二氧化硅组合物
|
|
CN104507538B
(zh)
|
2012-06-08 |
2018-04-06 |
艾杜罗生物科技公司 |
癌症免疫疗法的组合物和方法
|
|
PL2931738T3
(pl)
*
|
2012-12-13 |
2019-07-31 |
Aduro Biotech, Inc. |
Kompozycje zawierające cykliczne dinukleotydy purynowe o zdefiniowanej stereochemii i sposoby ich otrzymywania i zastosowania
|
|
WO2014179335A1
(en)
|
2013-04-29 |
2014-11-06 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
|
WO2014179760A1
(en)
|
2013-05-03 |
2014-11-06 |
The Regents Of The University Of California |
Cyclic di-nucleotide induction of type i interferon
|
|
US9549944B2
(en)
|
2013-05-18 |
2017-01-24 |
Aduro Biotech, Inc. |
Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
|
|
RS59500B1
(sr)
|
2013-05-18 |
2019-12-31 |
Aduro Biotech Inc |
Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
|
|
EP3027227A4
(en)
*
|
2013-07-31 |
2018-05-23 |
Memorial Sloan Kettering Cancer Center |
Sting crystals and modulators
|
|
US10570204B2
(en)
|
2013-09-26 |
2020-02-25 |
The Medical College Of Wisconsin, Inc. |
Methods for treating hematologic cancers
|
|
JP2016538344A
(ja)
*
|
2013-11-19 |
2016-12-08 |
ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ |
癌処置としてのｓｔｉｎｇアゴニストの使用
|
|
WO2015109391A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
|
SG10201900002QA
(en)
|
2014-01-24 |
2019-02-27 |
Dana Farber Cancer Institue Inc |
Antibody molecules to pd-1 and uses thereof
|
|
EP3099717B1
(en)
|
2014-01-31 |
2019-03-27 |
Novartis AG |
Antibody molecules to tim-3 and uses thereof
|
|
US20150259420A1
(en)
|
2014-03-14 |
2015-09-17 |
Novartis Ag |
Antibody molecules to lag-3 and uses thereof
|
|
JP7348708B2
(ja)
|
2014-04-30 |
2023-09-21 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
組み合わせワクチン装置および癌細胞を殺滅する方法
|
|
PE20170198A1
(es)
|
2014-06-04 |
2017-04-08 |
Glaxosmithkline Ip Dev Ltd |
Dinucleotidos ciclicos como moduladores de sting
|
|
ES2771926T3
(es)
|
2014-09-13 |
2020-07-07 |
Novartis Ag |
Terapias de combinación
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
TWI716362B
(zh)
|
2014-10-14 |
2021-01-21 |
瑞士商諾華公司 |
針對ｐｄ－ｌ１之抗體分子及其用途
|
|
WO2016079899A1
(ja)
*
|
2014-11-20 |
2016-05-26 |
国立研究開発法人医薬基盤・健康・栄養研究所 |
異なる核酸アジュバントの組み合わせによる、新規Ｔｈ１誘導性アジュバントおよびその用途
|
|
EP3546473B1
(en)
|
2014-12-16 |
2025-12-10 |
Kayla Therapeutics |
Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction
|
|
GB201501462D0
(en)
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
HK1247861A1
(zh)
|
2015-01-30 |
2018-10-05 |
President And Fellows Of Harvard College |
用於癌症治疗的肿瘤周围和肿瘤内部材料
|
|
SG11201806623VA
(en)
|
2015-02-11 |
2018-09-27 |
Univ Johns Hopkins |
Bacteria over-expressing c-di-amp and therapeutic methods
|
|
HK1248603A1
(zh)
|
2015-03-10 |
2018-10-19 |
Aduro Biotech, Inc. |
用於活化"干扰素基因的刺激剂"依懒性信号传导的组合物和方法
|
|
WO2016164705A1
(en)
|
2015-04-10 |
2016-10-13 |
Omar Abdel-Rahman Ali |
Immune cell trapping devices and methods for making and using the same
|
|
RU2749113C2
(ru)
|
2015-04-22 |
2021-06-04 |
Куревак Аг |
Содержащая рнк композиция для лечения опухолевых заболеваний
|
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
US20180222982A1
(en)
|
2015-07-29 |
2018-08-09 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
|
DK3317301T3
(da)
|
2015-07-29 |
2021-06-28 |
Immutep Sas |
Kombinationsterapier omfattende antistofmolekyler mod lag-3
|
|
CN106692967A
(zh)
*
|
2015-08-12 |
2017-05-24 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合PD1的抗体（Nivolumab）在制备抗肿瘤药物中的应用
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
CR20180101A
(es)
|
2015-08-13 |
2018-04-12 |
Merck Sharp & Dohme |
Compuestos di-nucleóticos cíclicos como agonistas de sting
|
|
CN106540255A
(zh)
*
|
2015-09-18 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合贝伐珠单抗在抗肿瘤中的应用
|
|
CA3002236A1
(en)
|
2015-10-28 |
2017-05-04 |
Aduro Biotech, Inc. |
Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
|
|
TN2018000112A1
(en)
|
2015-10-29 |
2019-10-04 |
Novartis Ag |
Antibody conjugates comprising toll-like receptor agonist
|
|
TWI704154B
(zh)
|
2015-12-03 |
2020-09-11 |
英商葛蘭素史克智慧財產發展有限公司 |
新穎化合物
|
|
RU2729116C2
(ru)
|
2015-12-16 |
2020-08-04 |
Гритстоун Онколоджи, Инк. |
Идентификация, производство и применение неоантигенов
|
|
US20180369268A1
(en)
*
|
2015-12-16 |
2018-12-27 |
Aduro Biotech, Inc. |
Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production
|
|
WO2017106656A1
(en)
|
2015-12-17 |
2017-06-22 |
Novartis Ag |
Antibody molecules to pd-1 and uses thereof
|
|
RS67188B1
(sr)
|
2016-01-11 |
2025-10-31 |
Innate Tumor Immunity Inc |
Ciklični dinukleotidi za lečenje stanja povezanih sa aktivnošću sting kao što je kancer
|
|
CN116003593A
(zh)
|
2016-01-11 |
2023-04-25 |
苏黎世大学 |
针对人白介素-2的免疫刺激性人源化单克隆抗体及其融合蛋白
|
|
WO2017123657A1
(en)
|
2016-01-11 |
2017-07-20 |
Gary Glick |
Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
|
|
CN106544319A
(zh)
*
|
2016-01-24 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法
|
|
EP3411475B1
(en)
|
2016-02-06 |
2025-08-27 |
President and Fellows of Harvard College |
Recapitulating the hematopoietic niche to reconstitute immunity
|
|
SG10201912074PA
(en)
*
|
2016-03-18 |
2020-02-27 |
Immune Sensor Llc |
Cyclic di-nucleotide compounds and methods of use
|
|
CN106540256A
(zh)
*
|
2016-03-27 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸-脂质体偶联单克隆抗体在抗肿瘤中的应用
|
|
HRP20220936T1
(hr)
|
2016-04-07 |
2022-10-28 |
Glaxosmithkline Intellectual Property Development Limited |
Heterociklički amidi korisni kao modulatori proteina
|
|
JP2019510802A
(ja)
|
2016-04-07 |
2019-04-18 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ |
タンパク質調節物質として有用な複素環アミド
|
|
US10533007B2
(en)
|
2016-04-19 |
2020-01-14 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
|
CA3021349A1
(en)
|
2016-04-19 |
2017-10-26 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
|
WO2018009466A1
(en)
*
|
2016-07-05 |
2018-01-11 |
Aduro Biotech, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
WO2018009652A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US11033569B2
(en)
*
|
2016-07-06 |
2021-06-15 |
Sperovie Biosciences, Inc. |
Compounds,Compositions, and methods for the treatment of disease
|
|
CN115404196A
(zh)
|
2016-07-13 |
2022-11-29 |
哈佛学院院长等 |
抗原呈递细胞模拟支架及其制备和使用方法
|
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
|
CN110418651A
(zh)
|
2016-08-02 |
2019-11-05 |
哈佛学院院长等 |
用于调节免疫应答的生物材料
|
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
|
CA3069780A1
(en)
|
2016-08-09 |
2018-02-15 |
Aarhus Universitet |
Modulation of ifi16 and sting activity
|
|
FI3922279T3
(fi)
|
2016-08-30 |
2025-02-04 |
Dana Farber Cancer Inst Inc |
Lääkkeenantokoostumuksia ja niiden käyttötapoja
|
|
WO2018053508A1
(en)
|
2016-09-19 |
2018-03-22 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for inducing an immune response
|
|
US10537590B2
(en)
*
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
US10414747B2
(en)
|
2016-10-04 |
2019-09-17 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene compounds as sting agonists
|
|
EP3523314A1
(de)
|
2016-10-07 |
2019-08-14 |
Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb GmbH |
Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen
|
|
AU2017341735B2
(en)
*
|
2016-10-11 |
2022-01-13 |
Helmholtz Center for Infection Research |
Hepatitis C virus immunogenic compositions comprising as an adjuvant a cyclic dinucleotide or an archaeosome and methods of use thereof
|
|
JOP20170188A1
(ar)
*
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
JP2018090562A
(ja)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
環状ジヌクレオチド
|
|
WO2018100558A2
(en)
|
2016-12-01 |
2018-06-07 |
Takeda Pharmaceutical Company Limited |
Cyclic dinucleotide
|
|
WO2018118665A1
(en)
*
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Cyclic dinucleotide sting agonists for cancer treatment
|
|
CA3047394A1
(en)
*
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Combinations of pd-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment
|
|
US11021511B2
(en)
|
2017-01-27 |
2021-06-01 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
US11492367B2
(en)
|
2017-01-27 |
2022-11-08 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
JP2020514321A
(ja)
|
2017-02-01 |
2020-05-21 |
モデルナティーエックス， インコーポレイテッド |
活性化がん遺伝子変異ペプチドをコードする免疫調節治療ｍＲＮＡ組成物
|
|
JP2018131427A
(ja)
*
|
2017-02-17 |
2018-08-23 |
国立研究開発法人理化学研究所 |
免疫細胞の制御技術
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
TWI674261B
(zh)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 調節劑
|
|
CA3053568A1
(en)
|
2017-02-21 |
2018-08-30 |
Board Of Regents, The University Of Texas System |
Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
|
|
CN106727331B
(zh)
*
|
2017-03-13 |
2022-02-01 |
杭州星鳌生物科技有限公司 |
免疫脂质体-环二核苷酸的组成、制备方法及其在抗肿瘤中的应用
|
|
KR20190142767A
(ko)
|
2017-03-20 |
2019-12-27 |
제노세아 바이오사이언스, 인코퍼레이티드 |
치료 방법
|
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
CN118267470A
(zh)
|
2017-04-13 |
2024-07-02 |
赛罗帕私人有限公司 |
抗SIRPα抗体
|
|
MX2019012295A
(es)
|
2017-04-14 |
2020-02-07 |
Tollnine Inc |
Polinucleotidos inmunomoduladores, conjugados de anticuerpos de los mismos y metodos para su uso.
|
|
AR111651A1
(es)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
AR113224A1
(es)
*
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
US11466047B2
(en)
|
2017-05-12 |
2022-10-11 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
CN108853144A
(zh)
*
|
2017-05-16 |
2018-11-23 |
科济生物医药（上海）有限公司 |
Toll样受体激动剂与免疫效应细胞的联用
|
|
WO2022271995A1
(en)
*
|
2021-06-24 |
2022-12-29 |
University Of Miami |
Sting dependent adjuvants
|
|
WO2018229715A1
(en)
|
2017-06-16 |
2018-12-20 |
Novartis Ag |
Compositions comprising anti-cd32b antibodies and methods of use thereof
|
|
CN118307674A
(zh)
|
2017-06-22 |
2024-07-09 |
诺华股份有限公司 |
针对cd73的抗体分子及其用途
|
|
WO2018237173A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
MY201080A
(en)
|
2017-07-14 |
2024-02-03 |
Innate Tumor Immunity Inc |
Nlrp3 modulators
|
|
EP3431484A1
(en)
*
|
2017-07-21 |
2019-01-23 |
Ludwig-Maximilians-Universität München |
A fluorescent cyclic dinucleotide and its use in methods of identifying substances having an ability to modulate the cgas/sting pathway
|
|
KR102709265B1
(ko)
*
|
2017-07-28 |
2024-09-23 |
브리스톨-마이어스 스큅 컴퍼니 |
항암제로서의 시클릭 디뉴클레오티드
|
|
US11312772B2
(en)
|
2017-08-04 |
2022-04-26 |
Merck Sharp & Dohme Corp. |
Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment
|
|
US11285131B2
(en)
|
2017-08-04 |
2022-03-29 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene STING agonists for cancer treatment
|
|
WO2019043634A2
(en)
|
2017-08-30 |
2019-03-07 |
Beijing Xuanyi Pharmasciences Co., Ltd. |
CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS
|
|
JP7270608B2
(ja)
|
2017-08-31 |
2023-05-10 |
エフ－スター・セラピューティクス・インコーポレイテッド |
化合物、組成物、及び疾患の治療方法
|
|
US10947263B2
(en)
*
|
2017-08-31 |
2021-03-16 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
ES2904317T3
(es)
*
|
2017-08-31 |
2022-04-04 |
Bristol Myers Squibb Co |
Dinucleótidos cíclicos como agentes anticancerosos
|
|
IL302338B2
(en)
|
2017-09-08 |
2024-10-01 |
Univ Leland Stanford Junior |
Enpp1 inhibitors and their use for the treatment of cancer
|
|
WO2019051488A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
WO2019051489A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
US20210238172A1
(en)
|
2017-10-05 |
2021-08-05 |
Glaxosmithkline Intellectual Property Development Limited |
Heterocyclic amides useful as protein modulators and methods of using the same
|
|
CA3077337A1
(en)
|
2017-10-05 |
2019-04-11 |
Glaxosmithkline Intellectual Property Development Limited |
Modulators of stimulator of interferon genes (sting)
|
|
KR20260039788A
(ko)
|
2017-10-10 |
2026-03-20 |
시애틀 프로젝트 코포레이션 |
핫스팟을 이용한 신생항원 동정
|
|
EP3700933A1
(en)
|
2017-10-25 |
2020-09-02 |
Novartis AG |
Antibodies targeting cd32b and methods of use thereof
|
|
JP7195317B2
(ja)
|
2017-11-10 |
2022-12-23 |
武田薬品工業株式会社 |
Ｓｔｉｎｇ調節剤化合物、ならびに製造及び使用する方法
|
|
EA038805B1
(ru)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Циклические динуклеотиды в качестве агонистов sting (стимулятор генов интерферона)
|
|
CA3083097A1
(en)
|
2017-11-22 |
2019-05-31 |
Gritstone Oncology, Inc. |
Reducing junction epitope presentation for neoantigens
|
|
WO2019104353A1
(en)
*
|
2017-11-27 |
2019-05-31 |
Children's Medical Center Corporation |
Stimulator of interferon genes (sting) ligands and uses thereof
|
|
WO2019118839A1
(en)
*
|
2017-12-15 |
2019-06-20 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
CN111511754B
(zh)
|
2017-12-20 |
2023-09-12 |
捷克共和国有机化学与生物化学研究所 |
活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸
|
|
EP3727401A4
(en)
|
2017-12-20 |
2022-04-06 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
|
US10966999B2
(en)
|
2017-12-20 |
2021-04-06 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
JP7230035B2
(ja)
*
|
2018-01-04 |
2023-02-28 |
アカデミア シニカ |
治療を強化するための細胞会合免疫アジュバントならびに同アジュバントを含むキットおよび処方物
|
|
WO2019147509A1
(en)
*
|
2018-01-26 |
2019-08-01 |
The Regents Of The University Of California |
Intranasal delivery of a cyclic-di-nucleotide adjuvanted vaccine for tuberculosis
|
|
RU2020128830A
(ru)
|
2018-02-02 |
2022-03-03 |
Новартис Аг |
Комбинация агониста sting и il-15/il-15rа для лечения рака
|
|
EP3749681A1
(en)
*
|
2018-02-06 |
2020-12-16 |
STipe Therapeutics ApS |
Modulation of p62 and sting activity
|
|
US12220462B1
(en)
|
2018-02-13 |
2025-02-11 |
Abionyx Pharma Sa |
Complexes for delivery of cyclic dinucleotides
|
|
US20190275134A1
(en)
|
2018-03-12 |
2019-09-12 |
Janssen Pharmaceuticals, Inc |
Vaccines against urinary tract infections
|
|
CN110272462B
(zh)
*
|
2018-03-15 |
2023-03-10 |
南开大学 |
制备化合物的方法
|
|
SG11202008636YA
(en)
|
2018-03-23 |
2020-10-29 |
Codiak Biosciences Inc |
Extracellular vesicles comprising sting-agonist
|
|
EP3774834A1
(en)
|
2018-03-27 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]triazin-7-one as sting agonists
|
|
CN111989338A
(zh)
|
2018-03-27 |
2020-11-24 |
勃林格殷格翰国际有限公司 |
修饰的环二核苷酸化合物
|
|
US10793557B2
(en)
|
2018-04-03 |
2020-10-06 |
Merck Sharp & Dohme Corp. |
Sting agonist compounds
|
|
US11702430B2
(en)
|
2018-04-03 |
2023-07-18 |
Merck Sharp & Dohme Llc |
Aza-benzothiophene compounds as STING agonists
|
|
US11874276B2
(en)
|
2018-04-05 |
2024-01-16 |
Dana-Farber Cancer Institute, Inc. |
STING levels as a biomarker for cancer immunotherapy
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TW202005654A
(zh)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
２，２，─環二核苷酸
|
|
PE20210160A1
(es)
|
2018-04-25 |
2021-01-26 |
Innate Tumor Immunity Inc |
Moduladores de nlrp3
|
|
CN108310378A
(zh)
*
|
2018-04-28 |
2018-07-24 |
杭州星鳌生物科技有限公司 |
一类新型免疫联体抗肿瘤创新药物的制备及其应用
|
|
WO2019211799A1
(en)
|
2018-05-03 |
2019-11-07 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide
|
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
MX2020012964A
(es)
|
2018-06-01 |
2021-02-16 |
Eisai R&D Man Co Ltd |
Metodos para el tratamiento de cancer de vejiga.
|
|
CA3110102A1
(en)
|
2018-06-20 |
2019-12-26 |
Yale University |
Rig-i agonists and treatments using same
|
|
CN112823036B
(zh)
|
2018-07-03 |
2024-11-08 |
艾福姆德尤股份有限公司 |
用于治疗与sting活性有关的疾病的化合物和组合物
|
|
US20210236466A1
(en)
|
2018-07-03 |
2021-08-05 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
EP3820477A4
(en)
|
2018-07-10 |
2022-07-13 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES
|
|
WO2020014543A2
(en)
|
2018-07-11 |
2020-01-16 |
Actym Therapeutics, Inc. |
Engineered immunostimulatory bacterial strains and uses thereof
|
|
JP7433291B2
(ja)
|
2018-08-16 |
2024-02-19 |
イネイト・テューマー・イミュニティ・インコーポレイテッド |
イミダゾ［４，５－ｃ］キノリン誘導体のＮＬＲＰ３モジュレーター
|
|
KR102768379B1
(ko)
|
2018-08-16 |
2025-02-13 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
이미다조[4,5-c]퀴놀린 유래 NLRP3-조정제
|
|
CN112888677A
(zh)
|
2018-08-16 |
2021-06-01 |
先天肿瘤免疫公司 |
被取代的4-氨基-1H-咪唑并[4,5-c]喹啉化合物及其改进的制备方法
|
|
MX2020013322A
(es)
|
2018-08-16 |
2021-02-22 |
Eisai R&D Man Co Ltd |
Sales de compuestos y cristales de los mismos.
|
|
EP3841112A1
(en)
|
2018-08-24 |
2021-06-30 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting dendritic cells and uses thereof
|
|
KR102567590B1
(ko)
|
2018-09-06 |
2023-08-17 |
다이이찌 산쿄 가부시키가이샤 |
신규 고리형 디뉴클레오티드 유도체 및 그 항체 약물 콘쥬게이트
|
|
WO2020049534A1
(en)
|
2018-09-07 |
2020-03-12 |
Novartis Ag |
Sting agonist and combination therapy thereof for the treatment of cancer
|
|
CN112770771A
(zh)
*
|
2018-09-17 |
2021-05-07 |
丘拉提斯股份有限公司 |
包含干扰素基因刺激蛋白激动剂的免疫佐剂及疫苗组合物
|
|
WO2020061129A1
(en)
|
2018-09-19 |
2020-03-26 |
President And Fellows Of Harvard College |
Compositions and methods for labeling and modulation of cells in vitro and in vivo
|
|
AU2019344398B2
(en)
*
|
2018-09-21 |
2022-09-22 |
Shanghai De Novo Pharmatech Co., Ltd. |
Cyclic dinucleotide analogue, pharmaceutical composition thereof, and application
|
|
AU2019373241A1
(en)
|
2018-10-29 |
2021-06-10 |
Genocea Biosciences, Inc. |
Treatment methods
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
AU2019371206A1
(en)
|
2018-10-29 |
2021-05-27 |
Venenum Biodesign, LLC |
Novel sting agonists
|
|
WO2020092633A1
(en)
|
2018-10-30 |
2020-05-07 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
|
WO2020092617A1
(en)
|
2018-10-31 |
2020-05-07 |
Novartis Ag |
Dc-sign antibody conjugates comprising sting agonists
|
|
US11596692B1
(en)
|
2018-11-21 |
2023-03-07 |
Incyte Corporation |
PD-L1/STING conjugates and methods of use
|
|
US20220024964A1
(en)
*
|
2018-12-07 |
2022-01-27 |
Merck Sharp & Dohme Corp. |
Cyclic Di-Nucleotide Compounds as STING Agonists
|
|
US20220033431A1
(en)
*
|
2018-12-07 |
2022-02-03 |
Merck Sharp & Dohme Corp. |
Cyclic Di-Nucleotide Compounds as STING Agonists
|
|
US20220033435A1
(en)
*
|
2018-12-07 |
2022-02-03 |
Merck Sharp & Dohme Corp. |
Cyclic Di-Nucleotide Compounds as STING Agonists
|
|
KR102620495B1
(ko)
*
|
2019-01-10 |
2024-01-04 |
셴젠 잉 바이오파마수티칼 씨오., 엘티디. |
시클릭 디뉴클레오티드 프로드러그 분자 및 이의 제조 방법과 응용
|
|
WO2020150116A1
(en)
|
2019-01-14 |
2020-07-23 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
|
ES2930151T3
(es)
|
2019-01-14 |
2022-12-07 |
Innate Tumor Immunity Inc |
Moduladores heterocíclicos de NLRP3, para su uso en el tratamiento del cáncer
|
|
EP3911641A1
(en)
|
2019-01-14 |
2021-11-24 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
|
CN113301963A
(zh)
|
2019-01-14 |
2021-08-24 |
先天肿瘤免疫公司 |
用于治疗癌症的作为nlrp3调节剂的取代的喹唑啉类
|
|
TW202043198A
(zh)
|
2019-01-17 |
2020-12-01 |
美商Ｉｆｍ Ｄｕｅ有限公司 |
用於治療與sting活性相關之病況的化合物及組合物
|
|
US10998091B2
(en)
|
2019-02-07 |
2021-05-04 |
Sandeep Patil |
Systems for monitoring compliance with a patch dosage regimen and methods of using the same
|
|
US12024709B2
(en)
|
2019-02-27 |
2024-07-02 |
Actym Therapeutics, Inc. |
Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
|
|
KR102707808B1
(ko)
|
2019-03-07 |
2024-09-19 |
인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. |
2'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭
|
|
US11766447B2
(en)
|
2019-03-07 |
2023-09-26 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
|
EP3935066A1
(en)
|
2019-03-07 |
2022-01-12 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
3'3'-cyclic dinucleotides and prodrugs thereof
|
|
IL286467B2
(en)
|
2019-03-18 |
2026-02-01 |
Janssen Pharmaceuticals Inc |
Methods for producing bioconjugates of polysaccharides E. coli o-antigen, preparations thereof and methods for using them
|
|
CR20210522A
(es)
|
2019-03-18 |
2021-12-17 |
Janssen Pharmaceuticals Inc |
Bioconjugados de antígenos–polisacáridos de e. coli, métodos de producción y métodos de utilización de los mismos
|
|
WO2020191369A1
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
CN114080232A
(zh)
|
2019-03-21 |
2022-02-22 |
科迪亚克生物科学公司 |
用于疫苗递送的细胞外囊泡
|
|
KR20210141554A
(ko)
|
2019-03-21 |
2021-11-23 |
코디악 바이오사이언시즈, 인크. |
세포외 소포 접합체 및 이의 용도
|
|
US12281109B2
(en)
|
2019-04-04 |
2025-04-22 |
Merck Sharp & Dohme Llc |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
TW202104214A
(zh)
|
2019-04-05 |
2021-02-01 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
化合物
|
|
WO2020227159A2
(en)
|
2019-05-03 |
2020-11-12 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity
|
|
JP7621974B2
(ja)
*
|
2019-05-09 |
2025-01-27 |
アリゴス セラピューティクス インコーポレイテッド |
Ｓｔｉｎｇモジュレータとしての修飾環状ジヌクレオシド化合物
|
|
MX2021013657A
(es)
|
2019-05-10 |
2022-02-21 |
Takeda Pharmaceuticals Co |
Conjugados de anticuerpo y farmaco.
|
|
US20220227760A1
(en)
|
2019-05-29 |
2022-07-21 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
US20220251200A1
(en)
|
2019-07-03 |
2022-08-11 |
Codiak Biosciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
|
AU2020310853A1
(en)
|
2019-07-05 |
2022-01-27 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
GB201910304D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
WO2021013234A1
(en)
|
2019-07-25 |
2021-01-28 |
Beigene, Ltd. |
Cyclic dinucleotides as sting agonists
|
|
CA3149482A1
(en)
|
2019-08-02 |
2021-02-11 |
Mersana Therapeutics, Inc. |
Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer
|
|
KR20220061977A
(ko)
|
2019-08-12 |
2022-05-13 |
퓨리노미아 바이오테크, 아이엔씨. |
Cd39 발현 세포의 adcc 표적화를 통해 t 세포 매개 면역 반응을 촉진 및 강화하기 위한 방법 및 조성물
|
|
US20220305048A1
(en)
|
2019-08-26 |
2022-09-29 |
Dana-Farber Cancer Institute, Inc. |
Use of heparin to promote type 1 interferon signaling
|
|
EP3785719A1
(en)
*
|
2019-08-28 |
2021-03-03 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
New use of cyclic dinucleotides
|
|
WO2021061837A1
(en)
|
2019-09-23 |
2021-04-01 |
President And Fellows Of Harvard College |
Biomaterial-based antigen free vaccine and the use thereof
|
|
US20220395465A1
(en)
|
2019-09-25 |
2022-12-15 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour
|
|
EP4034247A1
(en)
|
2019-09-25 |
2022-08-03 |
Codiak BioSciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
|
US20230103726A1
(en)
|
2019-09-25 |
2023-04-06 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
|
CA3152478A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Extracellular vesicle compositions
|
|
MX2022004061A
(es)
|
2019-10-02 |
2022-07-19 |
Janssen Vaccines & Prevention Bv |
Peptidos de estafilococo y metodos de uso.
|
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
|
WO2021113679A1
(en)
|
2019-12-06 |
2021-06-10 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
CN114981265B
(zh)
|
2019-12-18 |
2025-01-03 |
Ctxt私人有限公司 |
化合物
|
|
CN115244052A
(zh)
|
2020-01-10 |
2022-10-25 |
先天肿瘤免疫公司 |
Nlrp3调节剂
|
|
LT4090363T
(lt)
|
2020-01-16 |
2024-09-25 |
Janssen Pharmaceuticals, Inc. |
Fimh mutantas, kompozicijos su juo ir jų panaudojimas
|
|
BR112022017136A2
(pt)
|
2020-02-28 |
2022-10-11 |
Tallac Therapeutics Inc |
Conjugação mediada por transglutaminase
|
|
CA3168368A1
(en)
|
2020-03-06 |
2021-09-10 |
Masayuki Ishizaki |
Antibody-drug conjugate including novel cyclic dinucleotide derivative
|
|
WO2021184017A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
|
JP2023518414A
(ja)
|
2020-03-20 |
2023-05-01 |
コディアック バイオサイエンシーズ， インコーポレイテッド |
治療のための細胞外小胞
|
|
WO2021202984A1
(en)
|
2020-04-02 |
2021-10-07 |
Mersana Therapeutics, Inc. |
Antibody drug conjugates comprising sting agonists
|
|
WO2021206158A1
(ja)
|
2020-04-10 |
2021-10-14 |
小野薬品工業株式会社 |
がん治療方法
|
|
US11857618B2
(en)
|
2020-04-17 |
2024-01-02 |
Emory University |
Boosting immunogenicity of vaccines using saponins and agonists of the intracellular stimulator of interferon genes pathway
|
|
JP7776145B2
(ja)
|
2020-05-13 |
2025-11-26 |
マサチューセッツ インスティテュート オブ テクノロジー |
ポリマーマイクロデバイスの組成物およびがん免疫療法におけるその使用
|
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
|
EP4295917A3
(en)
|
2020-08-07 |
2024-02-28 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
TW202227479A
(zh)
|
2020-09-02 |
2022-07-16 |
日商第一三共股份有限公司 |
新穎內－β－Ｎ－乙醯葡萄糖胺苷酶
|
|
CA3191593A1
(en)
|
2020-09-08 |
2022-03-17 |
Jinming Gao |
Polyvalent sting activating compositions and uses thereof
|
|
IL308201A
(en)
|
2020-09-17 |
2024-01-01 |
Janssen Pharmaceuticals Inc |
Multivalent vaccine compositions and uses thereof
|
|
US20230366794A1
(en)
|
2020-09-23 |
2023-11-16 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
US20240241020A1
(en)
|
2020-09-23 |
2024-07-18 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
|
WO2022066898A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
|
EP4228681A1
(en)
|
2020-10-14 |
2023-08-23 |
Boehringer Ingelheim International GmbH |
Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist
|
|
EP3984535A1
(en)
|
2020-10-16 |
2022-04-20 |
Albert-Ludwigs-Universität Freiburg |
Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome
|
|
CN115160392B
(zh)
*
|
2020-10-20 |
2026-01-30 |
泰励生物科技（上海）有限公司 |
多功能环二核苷酸及其用途
|
|
AU2021363267A1
(en)
|
2020-10-20 |
2023-06-22 |
Tyligand Bioscience (Shanghai) Limited |
Multifunctional cyclic dinucleotide and use thereof
|
|
WO2022094262A1
(en)
|
2020-10-30 |
2022-05-05 |
Avacta Life Sciences Limited |
Fap-activated serum extended half-life therapeutic conjugates
|
|
JP7397996B2
(ja)
|
2020-11-09 |
2023-12-13 |
武田薬品工業株式会社 |
抗体薬物コンジュゲート
|
|
TW202241516A
(zh)
|
2020-12-17 |
2022-11-01 |
美商杜夫特學院信託管理公司 |
經fap活化之放射性治療診斷(radiotheranostics)，與其相關用途
|
|
TW202235073A
(zh)
|
2021-01-08 |
2022-09-16 |
美商Ｉｆｍ Ｄｕｅ有限公司 |
用於治療與sting活性相關的病狀之化合物及組合物
|
|
US11725028B2
(en)
|
2021-01-12 |
2023-08-15 |
Janssen Pharmaceuticals, Inc. |
FimH mutants, compositions therewith and use thereof
|
|
TW202241454A
(zh)
|
2021-02-01 |
2022-11-01 |
日商第一三共股份有限公司 |
抗體－免疫賦活化劑共軛物之新穎製造方法
|
|
KR20230164108A
(ko)
|
2021-04-01 |
2023-12-01 |
얀센 파마슈티칼즈, 인코포레이티드 |
E. coli O18 생물접합체의 생산
|
|
EP4326321A1
(en)
|
2021-04-20 |
2024-02-28 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
|
EP4326769A1
(en)
|
2021-04-20 |
2024-02-28 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
|
US20220313724A1
(en)
*
|
2021-05-17 |
2022-10-06 |
Highlight Therapeutics, S.L. |
Compositions for intratumoral administration and related methods
|
|
UY39892A
(es)
|
2021-08-10 |
2023-03-31 |
Novartis Pharma Ag |
Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING
|
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
|
TW202334196A
(zh)
|
2021-10-07 |
2023-09-01 |
英商阿法克塔生命科學有限公司 |
Pd-l1結合多肽
|
|
CN114106140A
(zh)
*
|
2021-11-23 |
2022-03-01 |
哈尔滨医科大学附属肿瘤医院 |
一种表达特定sting异构体、细胞系、制备方法、用途
|
|
WO2023154799A1
(en)
|
2022-02-14 |
2023-08-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Combination immunotherapy for treating cancer
|
|
US20250207169A1
(en)
|
2022-03-02 |
2025-06-26 |
Daiichi Sankyo Company, Limited |
METHOD FOR PRODUCING Fc-CONTAINING MOLECULE
|
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
AU2023336004A1
(en)
|
2022-08-29 |
2025-03-06 |
Daiichi Sankyo Company, Limited |
Antibody-drug conjugate including mutant fc region
|
|
EP4687796A1
(en)
|
2023-04-05 |
2026-02-11 |
Massachusetts Institute of Technology |
Hybrid polymeric systems and methods of use thereof
|
|
WO2026027944A1
(en)
|
2024-07-30 |
2026-02-05 |
Sairopa B.V. |
Anti-sirp alpha antibody formulations and uses thereof
|