HRP20191972T1 - Pripravci i postupci za aktiviranje signalizacije ovisne o "stimulatoru gena interferona" - Google Patents
Pripravci i postupci za aktiviranje signalizacije ovisne o "stimulatoru gena interferona" Download PDFInfo
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- HRP20191972T1 HRP20191972T1 HRP20191972TT HRP20191972T HRP20191972T1 HR P20191972 T1 HRP20191972 T1 HR P20191972T1 HR P20191972T T HRP20191972T T HR P20191972TT HR P20191972 T HRP20191972 T HR P20191972T HR P20191972 T1 HRP20191972 T1 HR P20191972T1
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- 238000000034 method Methods 0.000 title claims 5
- 239000000203 mixture Substances 0.000 title claims 4
- 230000001419 dependent effect Effects 0.000 title claims 2
- 108010050904 Interferons Proteins 0.000 title 1
- 230000003213 activating effect Effects 0.000 title 1
- 230000011664 signaling Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000009093 first-line therapy Methods 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100036848 C-C motif chemokine 20 Human genes 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000004700 cellular uptake Effects 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 108700014844 flt3 ligand Proteins 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000011229 interlayer Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
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- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000014567 type I interferon production Effects 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Dermatology (AREA)
Claims (15)
1. Spoj, naznačen time, da je predstavljen formulom
gdje svaki od R1 i R2 je H, ili njegova farmaceutski prihvatljiva sol.
2. Pripravak, naznačen time, da obuhvaća spoj u skladu s patentnim zahtjevom 1 i farmaceutski prihvatljivo pomoćno sredstvo.
3. Pripravak prema patentnom zahtjevu 2, naznačen time, da obuhvaća dostavni nosač koji pojačava stanično primanje i/ili stabilnost spoja.
4. Pripravak prema patentnom zahtjevu 3, naznačen time, da dostavni nosač sadrži jedno ili više sredstava odabranih iz skupine koja se sastoji od lipida, multilamelarnih vesikula križno povezanih dvostrukim međuslojevima, biorazgradivih nanočestica ili mikročestica na bazi poli(D,L-laktičke-ko-glikolne kiseline) [PLGA] ili na bazi polianhidrida te nanoporoznih dvostrukih slojeva lipida koji su poduprti česticama.
5. Pripravak prema bilo kojem od patentnih zahtjeva 2 do 4, naznačen time, da dodatno obuhvaća CTLA-4-antagonist, TLR-agonist, CpG, monofosforil-lipid A i/ili neaktiviranu tumorsku stanicu koja izražava i izlučuje jedan ili više citokina koji stimuliraju indukciju, osnaživanje i dozrijevanje dendritičke stanice.
6. Pripravak prema patentnom zahtjevu 5, naznačen time, da neaktivirana tumorska stanica izražava i izlučuje GM-CSF, CCL20, CCL3, IL-12p70 ili FLT-3-ligand.
7. Pripravak prema bilo kojem od patentnih zahtjeva 2 do 4, naznačen time, da dodatno obuhvaća jedan ili više antigena odabranih u svrhu induciranja imunološkog odgovora protiv antigena prilikom primjene pripravka na pojedincu.
8. Spoj prema patentnom zahtjevu 1 ili pripravak prema bilo kojem od patentnih zahtjeva 2 do 7, naznačen time, da se upotrebljava u postupku liječenja.
9. Spoj prema patentnom zahtjevu 1 ili pripravak prema bilo kojem od patentnih zahtjeva 2 do 7, naznačen time, da se upotrebljava u postupku liječenje pojedinca koji boluje od raka.
10. Spoj ili pripravak za uporabu prema patentnom zahtjevu 9, naznačen time, da se upotrebljava u postupku liječenja pojedinca koji boluje od raka, pri čemu je rak odabran iz skupine koja se sastoji od sljedećih:
kolorektalni rak, rak pluća, rak mozga, rak jetre, rak želuca, sarkom, leukemija, limfom, multipli mijelom, rak jajnika, rak maternice, rak dojke, melanom, rak prostate, karcinom gušterače, karcinom bubrega, rak glave i vrata i rak grlića maternice.
11. Spoj ili pripravak za uporabu prema bilo kojem od patentnih zahtjeva 9 do 10, naznačen time, da se upotrebljava u postupku liječenja, pri čemu navedeno liječenje obuhvaća:
induciranje imunološkog odgovora kod pojedinca;
induciranje proizvodnje interferona tipa I ovisnog o STING-u kod pojedinca;
davanje navedenog spoja ili pripravka pojedincu, pri čemu pojedinac izražava antigen raka, prije ili nakon primarne terapije koja se primjenjuje u svrhu odstranjivanja ili ubijanja stanica raka koje izražavaju navedeni antigen raka kod pojedinca;
parenteralno davanje navedenog spoja ili pripravka pojedincu, pri čemu pojedinac boluje od raka; ili
davanje navedenog spoja ili pripravka zajedno s jednim ili više terapeutskih protutijela koji induciraju staničnu citotoksičnost ovisnu o protutijelu, u svrhu stimuliranja stanične citotoksičnosti ovisne o protutijelu kod pojedinca.
12. Spoj ili pripravak za uporabu prema patentnom zahtjevu 11, naznačen time, da se spoj ili pripravak daje nakon primarne terapije.
13. Spoj ili pripravak za uporabu prema patentnom zahtjevu 11 ili zahtjevu 12, naznačen time, da primarna terapija obuhvaća kirurški zahvat za uklanjanje stanica raka iz sisavca, radijacijsku terapiju za ubijanje stanica raka kod sisavca, ili oboje, i kirurški zahvat i terapeutsko zračenje.
14. Spoj ili pripravak za uporabu prema patentnom zahtjevu 11, naznačen time, da parenteralna primjena je supkutana, intramuskularna ili intradermalna, i prema potrebi se daje izravno u tumorsku masu.
15. Spoj ili pripravak za uporabu prema bilo kojem od patentnih zahtjeva 11 do 14, naznačen time, da postupak nadalje obuhvaća primjenu na sisavcu jednog ili više od sljedećih sredstava: CTLA-4-antagonist, PD-1-antagonist puteva, TLR-agonist, ili jedno ili više terapeutskih protutijela.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361825005P | 2013-05-18 | 2013-05-18 | |
US201361902125P | 2013-11-08 | 2013-11-08 | |
PCT/US2014/038525 WO2014189805A1 (en) | 2013-05-18 | 2014-05-18 | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
EP14800848.5A EP2996473B1 (en) | 2013-05-18 | 2014-05-18 | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20191972T1 true HRP20191972T1 (hr) | 2020-02-07 |
Family
ID=51934006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191972TT HRP20191972T1 (hr) | 2013-05-18 | 2019-10-30 | Pripravci i postupci za aktiviranje signalizacije ovisne o "stimulatoru gena interferona" |
Country Status (37)
Country | Link |
---|---|
US (3) | US9724408B2 (hr) |
EP (2) | EP2996473B1 (hr) |
JP (1) | JP6453855B2 (hr) |
KR (1) | KR20160009039A (hr) |
CN (1) | CN105228450B (hr) |
AP (1) | AP2015008700A0 (hr) |
AU (1) | AU2014268836B2 (hr) |
BR (1) | BR112015028341A2 (hr) |
CA (1) | CA2904536A1 (hr) |
CL (1) | CL2015002522A1 (hr) |
CR (1) | CR20150616A (hr) |
CU (1) | CU24377B1 (hr) |
CY (1) | CY1122274T1 (hr) |
DK (1) | DK2996473T3 (hr) |
DO (1) | DOP2015000281A (hr) |
EC (1) | ECSP15052938A (hr) |
ES (1) | ES2754269T3 (hr) |
GT (1) | GT201500326A (hr) |
HK (2) | HK1219024A1 (hr) |
HR (1) | HRP20191972T1 (hr) |
HU (1) | HUE046942T2 (hr) |
IL (1) | IL242359B (hr) |
LT (1) | LT2996473T (hr) |
ME (1) | ME03586B (hr) |
MX (1) | MX354057B (hr) |
MY (1) | MY175308A (hr) |
NI (1) | NI201500162A (hr) |
PE (1) | PE20160080A1 (hr) |
PH (1) | PH12015502438B1 (hr) |
PL (1) | PL2996473T3 (hr) |
PT (1) | PT2996473T (hr) |
RS (1) | RS59500B1 (hr) |
SA (1) | SA515370123B1 (hr) |
SG (1) | SG11201508273RA (hr) |
SI (1) | SI2996473T1 (hr) |
SV (1) | SV2015005107A (hr) |
WO (1) | WO2014189805A1 (hr) |
Families Citing this family (229)
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ES2804472T3 (es) | 2005-12-13 | 2021-02-08 | Harvard College | Estructuras para trasplante celular |
US11202759B2 (en) | 2010-10-06 | 2021-12-21 | President And Fellows Of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
ES2773895T3 (es) | 2012-04-16 | 2020-07-15 | Harvard College | Composiciones de sílice mesoporosa para modular las respuestas inmunitarias |
WO2013185052A1 (en) | 2012-06-08 | 2013-12-12 | Aduro Biotech | Compostions and methods for cancer immunotherapy |
MX361680B (es) | 2012-12-13 | 2018-12-13 | Aduro Biotech Inc | Composiciones que comprenden dinucleótidos de purina cíclicos que tienen estereoquímicas definidas y métodos para su preparación y uso. |
EP4398254A2 (en) | 2013-04-29 | 2024-07-10 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
EP2992000B1 (en) | 2013-05-03 | 2020-07-08 | The Regents of The University of California | Cyclic di-nucleotide induction of type i interferon |
PL2996473T3 (pl) | 2013-05-18 | 2020-06-01 | Aduro Biotech, Inc. | Kompozycje i sposoby aktywacji sygnałowania zależnego od „stymulatora genu interferonu” |
US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
EP3027227A4 (en) * | 2013-07-31 | 2018-05-23 | Memorial Sloan Kettering Cancer Center | Sting crystals and modulators |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
WO2015077354A1 (en) * | 2013-11-19 | 2015-05-28 | The University Of Chicago | Use of sting agonist as cancer treatment |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
JP7348708B2 (ja) | 2014-04-30 | 2023-09-21 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 組み合わせワクチン装置および癌細胞を殺滅する方法 |
PE20170198A1 (es) | 2014-06-04 | 2017-04-08 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos ciclicos como moduladores de sting |
WO2016040882A1 (en) | 2014-09-13 | 2016-03-17 | Novartis Ag | Combination therapies of egfr inhibitors |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
BR112017007379A2 (pt) | 2014-10-14 | 2017-12-19 | Dana Farber Cancer Inst Inc | moléculas de anticorpo para pd-l1 e usos das mesmas |
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ES2764178T3 (es) | 2014-12-16 | 2020-06-02 | Kayla Therapeutics | Dinucleótidos cíclicos fluorados para inducción de citocinas |
GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
US10130663B2 (en) | 2015-02-11 | 2018-11-20 | The John Hopkins University | Bacteria over-expressing c-di-AMP and therapeutic methods |
WO2016145102A1 (en) | 2015-03-10 | 2016-09-15 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene" -dependent signalling |
JP7094533B2 (ja) | 2015-04-10 | 2022-07-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
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EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
PL3317301T3 (pl) | 2015-07-29 | 2021-11-15 | Novartis Ag | Terapie skojarzone zawierające cząsteczki przeciwciał przeciw lag-3 |
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CN106540255A (zh) * | 2015-09-18 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 环二核苷酸cGAMP联合贝伐珠单抗在抗肿瘤中的应用 |
UY36969A (es) | 2015-10-28 | 2017-05-31 | Novartis Ag | Composiciones y métodos para activar la señalización dependiente del estimulador del gen de interferon |
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