AR124604A1 - Mutantes de fimh, composiciones con los mismos y uso de los mismos - Google Patents

Mutantes de fimh, composiciones con los mismos y uso de los mismos

Info

Publication number
AR124604A1
AR124604A1 ARP220100049A ARP220100049A AR124604A1 AR 124604 A1 AR124604 A1 AR 124604A1 AR P220100049 A ARP220100049 A AR P220100049A AR P220100049 A ARP220100049 A AR P220100049A AR 124604 A1 AR124604 A1 AR 124604A1
Authority
AR
Argentina
Prior art keywords
fimh
lectin domain
compositions
mutants
polypeptides
Prior art date
Application number
ARP220100049A
Other languages
English (en)
Inventor
Jan Grijpstra
Eveline Marleen Weerdenbburg
Jeroen Geurtsen
Kellen Cristhina Fae
Louris Jakob Feitsma
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of AR124604A1 publication Critical patent/AR124604A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describen polipéptidos que comprenden un dominio de lectina de FimH que comprenden al menos una mutación de aminoácidos que hace que el dominio de lectina de FimH esté en la conformación de baja afinidad por manosa. Se describen adicionalmente composiciones farmacéuticas que comprenden dichos polipéptidos y métodos para estimular una respuesta inmunitaria en un sujeto que lo necesita mediante la administración del polipéptido. Reivindicación 1: Un polipéptido que comprende un dominio de lectina de FimH que comprende Tirosina (Y) o Triptófano (W) en la posición que corresponde a la posición 71 en la SEQ ID Nº 1.
ARP220100049A 2021-01-12 2022-01-11 Mutantes de fimh, composiciones con los mismos y uso de los mismos AR124604A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP21151126 2021-01-12

Publications (1)

Publication Number Publication Date
AR124604A1 true AR124604A1 (es) 2023-04-12

Family

ID=74175646

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220100049A AR124604A1 (es) 2021-01-12 2022-01-11 Mutantes de fimh, composiciones con los mismos y uso de los mismos

Country Status (12)

Country Link
US (2) US11725028B2 (es)
EP (1) EP4277921A1 (es)
JP (2) JP7532672B2 (es)
KR (1) KR20230125842A (es)
CN (1) CN116888140A (es)
AR (1) AR124604A1 (es)
AU (1) AU2022207740B2 (es)
CA (1) CA3207841A1 (es)
IL (1) IL303954A (es)
MX (1) MX2023008251A (es)
TW (1) TW202241929A (es)
WO (1) WO2022153166A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4090363B1 (en) 2020-01-16 2024-09-04 Janssen Pharmaceuticals, Inc. Fimh mutant, compositions therewith and use thereof
CA3242476A1 (en) * 2021-12-17 2023-06-22 Pfizer Inc. Polynucleotide compositions and uses thereof

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Also Published As

Publication number Publication date
JP2024109576A (ja) 2024-08-14
AU2022207740B2 (en) 2024-06-06
JP2024502854A (ja) 2024-01-23
MX2023008251A (es) 2023-07-26
US11725028B2 (en) 2023-08-15
WO2022153166A1 (en) 2022-07-21
CN116888140A (zh) 2023-10-13
AU2022207740A9 (en) 2024-09-05
EP4277921A1 (en) 2023-11-22
US20220220159A1 (en) 2022-07-14
TW202241929A (zh) 2022-11-01
US20230406890A1 (en) 2023-12-21
IL303954A (en) 2023-08-01
CA3207841A1 (en) 2022-07-21
KR20230125842A (ko) 2023-08-29
AU2022207740A1 (en) 2023-06-29
JP7532672B2 (ja) 2024-08-13

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