BR112023004819A2 - Composições de vacinas multivalentes e seus usos - Google Patents
Composições de vacinas multivalentes e seus usosInfo
- Publication number
- BR112023004819A2 BR112023004819A2 BR112023004819A BR112023004819A BR112023004819A2 BR 112023004819 A2 BR112023004819 A2 BR 112023004819A2 BR 112023004819 A BR112023004819 A BR 112023004819A BR 112023004819 A BR112023004819 A BR 112023004819A BR 112023004819 A2 BR112023004819 A2 BR 112023004819A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- expec
- multivalent vaccine
- vaccine compositions
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229940031348 multivalent vaccine Drugs 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 241000059478 Escherichia coli O75 Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
COMPOSIÇÕES DE VACINAS MULTIVALENTES E SEUS USOS. São descritas composições e métodos para induzir uma resposta imune contra Escherichia coli patogênica extraintestinal (ExPEC) para, desse modo, proporcionar proteção imune contra doenças associadas a ExPEC. Em particular, são descritas composições e métodos para usar conjugados de polissacarídeo antigênico O75 de E. coli covalentemente ligado a uma proteína transportadora para a prevenção de doença por ExPEC invasiva.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063079734P | 2020-09-17 | 2020-09-17 | |
EP21154782 | 2021-02-02 | ||
US202163191471P | 2021-05-21 | 2021-05-21 | |
PCT/IB2021/058485 WO2022058945A1 (en) | 2020-09-17 | 2021-09-17 | Multivalent vaccine compositions and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023004819A2 true BR112023004819A2 (pt) | 2023-04-18 |
Family
ID=77801756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023004819A BR112023004819A2 (pt) | 2020-09-17 | 2021-09-17 | Composições de vacinas multivalentes e seus usos |
Country Status (17)
Country | Link |
---|---|
US (1) | US20220088165A1 (pt) |
EP (1) | EP4213870A1 (pt) |
JP (1) | JP7481585B2 (pt) |
KR (1) | KR20230043157A (pt) |
CN (1) | CN115803087A (pt) |
AU (1) | AU2021342797B2 (pt) |
BR (1) | BR112023004819A2 (pt) |
CA (1) | CA3190820A1 (pt) |
CL (1) | CL2023000740A1 (pt) |
CO (1) | CO2023002114A2 (pt) |
EC (1) | ECSP23019295A (pt) |
IL (2) | IL301248B2 (pt) |
MX (1) | MX2023003169A (pt) |
PE (1) | PE20231385A1 (pt) |
TW (1) | TW202227128A (pt) |
UY (1) | UY39428A (pt) |
WO (1) | WO2022058945A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020191088A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof |
CA3134216A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
EP0911036A3 (en) | 1992-02-11 | 2001-05-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Dual carrier immunogenic construct |
SG90042A1 (en) | 1992-06-25 | 2002-07-23 | Smithkline Beecham Biolog | Vaccine composition containing adjuvants |
EP0616034B1 (en) | 1993-03-05 | 2004-10-20 | Wyeth Holdings Corporation | Plasmid for production of CRM protein and diphtheria toxin |
NZ274376A (en) | 1993-09-22 | 1997-11-24 | Jackson H M Found Military Med | Activating soluble carbohydrate using cyanylating reagents for the production of immunogenic constructs |
AU712981B2 (en) | 1995-03-22 | 1999-11-18 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents |
US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
PT971739E (pt) | 1997-04-01 | 2004-12-31 | Corixa Corp | Composicoes aquosas de adjuvante imunologico de monofosforil lipido a |
US6491919B2 (en) | 1997-04-01 | 2002-12-10 | Corixa Corporation | Aqueous immunologic adjuvant compostions of monophosphoryl lipid A |
EP1797896A1 (en) | 1998-10-16 | 2007-06-20 | GlaxoSmithKline Biologicals SA | Adjuvant systems and vaccines |
WO2001078777A2 (en) | 2000-04-13 | 2001-10-25 | Mossman, Sally | Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and qs-21 |
US6676958B2 (en) | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
IL163806A0 (en) | 2002-03-07 | 2005-12-18 | Eidgenoess Tech Hochschule | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
EP2311972B1 (en) | 2005-05-11 | 2015-01-21 | ETH Zurich | Recombinant N-glycosylated proteins from procaryotic cells |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
ES2536426T3 (es) | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
WO2007109812A2 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
JP5647899B2 (ja) | 2008-01-08 | 2015-01-07 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化 |
HUE039413T2 (hu) | 2008-02-20 | 2018-12-28 | Glaxosmithkline Biologicals Sa | Prokarióta sejtekbõl származó rekombináns N-glikozilált fehérjékbõl készített biokonjugátumok |
CN102481312B (zh) | 2009-06-05 | 2015-07-15 | 传染性疾病研究院 | 合成的吡喃葡萄糖脂佐剂 |
KR101742406B1 (ko) | 2012-08-16 | 2017-05-31 | 화이자 인코포레이티드 | 당접합 공정 및 조성물 |
AU2013311534A1 (en) | 2012-09-10 | 2015-03-12 | Glycovaxyn Ag | Bioconjugates comprising modified antigens and uses thereof |
EP2906681B1 (en) | 2012-10-12 | 2019-01-09 | GlaxoSmithKline Biologicals S.A. | Methods of host cell modification |
SI3363806T1 (sl) | 2012-12-20 | 2023-04-28 | Pfizer Inc. | Postopek glikokonjugacije |
AU2014268836B2 (en) | 2013-05-18 | 2018-08-02 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
CN103495161B (zh) | 2013-10-08 | 2019-06-18 | 江苏康泰生物医学技术有限公司 | 一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法 |
WO2015052344A1 (en) | 2013-10-11 | 2015-04-16 | Glycovaxyn Ag | Methods of host cell modification |
BR112016012599A2 (pt) | 2013-12-04 | 2017-09-26 | Glycovaxyn Ag | composição, e, método para tratamento ou prevenção de uma infecção por staphylococcus aureus |
AR100859A1 (es) | 2014-02-24 | 2016-11-09 | Glycovaxyn Ag | Polisacáridos y sus usos |
CN106794237B (zh) | 2014-04-17 | 2022-04-12 | 葛兰素史密丝克莱恩生物有限公司 | 经修饰的宿主细胞及其用途 |
CN105695497B (zh) | 2014-11-27 | 2019-09-24 | 中国人民解放军军事医学科学院生物工程研究所 | 一种细菌多糖修饰的重组融合蛋白的制备方法及其应用 |
EP3240895B1 (en) | 2014-12-30 | 2022-01-26 | GlaxoSmithKline Biologicals S.A. | Compositions and methods for protein glycosylation |
TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
GB201518668D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Immunogenic Comosition |
GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
AR109621A1 (es) * | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
WO2020120569A2 (en) | 2018-12-12 | 2020-06-18 | Glaxosmithkline Biologicals Sa | Modified carrier proteins for o-linked glycosylation |
CA3134216A1 (en) * | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
WO2020191088A1 (en) * | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof |
-
2021
- 2021-09-17 US US17/478,584 patent/US20220088165A1/en active Pending
- 2021-09-17 EP EP21772844.3A patent/EP4213870A1/en active Pending
- 2021-09-17 TW TW110135002A patent/TW202227128A/zh unknown
- 2021-09-17 KR KR1020237006127A patent/KR20230043157A/ko active Search and Examination
- 2021-09-17 IL IL301248A patent/IL301248B2/en unknown
- 2021-09-17 BR BR112023004819A patent/BR112023004819A2/pt unknown
- 2021-09-17 CA CA3190820A patent/CA3190820A1/en active Pending
- 2021-09-17 IL IL308201A patent/IL308201A/en unknown
- 2021-09-17 CN CN202180049038.6A patent/CN115803087A/zh active Pending
- 2021-09-17 JP JP2023517329A patent/JP7481585B2/ja active Active
- 2021-09-17 AU AU2021342797A patent/AU2021342797B2/en active Active
- 2021-09-17 UY UY0001039428A patent/UY39428A/es unknown
- 2021-09-17 MX MX2023003169A patent/MX2023003169A/es unknown
- 2021-09-17 PE PE2023001175A patent/PE20231385A1/es unknown
- 2021-09-17 WO PCT/IB2021/058485 patent/WO2022058945A1/en active Application Filing
-
2023
- 2023-02-27 CO CONC2023/0002114A patent/CO2023002114A2/es unknown
- 2023-03-15 CL CL2023000740A patent/CL2023000740A1/es unknown
- 2023-03-17 EC ECSENADI202319295A patent/ECSP23019295A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20230043157A (ko) | 2023-03-30 |
TW202227128A (zh) | 2022-07-16 |
AU2021342797B2 (en) | 2024-02-08 |
JP2023539943A (ja) | 2023-09-20 |
CO2023002114A2 (es) | 2023-03-07 |
CA3190820A1 (en) | 2022-03-24 |
IL308201A (en) | 2024-01-01 |
MX2023003169A (es) | 2023-03-27 |
US20220088165A1 (en) | 2022-03-24 |
ECSP23019295A (es) | 2023-04-28 |
PE20231385A1 (es) | 2023-09-12 |
JP7481585B2 (ja) | 2024-05-10 |
WO2022058945A1 (en) | 2022-03-24 |
IL301248B1 (en) | 2023-12-01 |
AU2021342797A1 (en) | 2023-02-16 |
CL2023000740A1 (es) | 2023-09-29 |
CN115803087A (zh) | 2023-03-14 |
IL301248A (en) | 2023-05-01 |
EP4213870A1 (en) | 2023-07-26 |
IL301248B2 (en) | 2024-04-01 |
UY39428A (es) | 2022-03-31 |
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