PE20160080A1 - Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon - Google Patents

Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon

Info

Publication number
PE20160080A1
PE20160080A1 PE2015002414A PE2015002414A PE20160080A1 PE 20160080 A1 PE20160080 A1 PE 20160080A1 PE 2015002414 A PE2015002414 A PE 2015002414A PE 2015002414 A PE2015002414 A PE 2015002414A PE 20160080 A1 PE20160080 A1 PE 20160080A1
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PE
Peru
Prior art keywords
depends
signaling
activate
compositions
methods
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PE2015002414A
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English (en)
Inventor
Jr Thomas W Dubensky
Laura Hix Glickman
Russell E Vance
Edward Emile Lemmens
Meredith Lai Ling Leong
David B Kanne
Original Assignee
Aduro Biotech Inc
Univ California
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51934006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20160080(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aduro Biotech Inc, Univ California filed Critical Aduro Biotech Inc
Publication of PE20160080A1 publication Critical patent/PE20160080A1/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Dermatology (AREA)

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE UNO O MAS DINUCLEOTIDOS DE PURINA CICLICOS QUE INDUCEN LA PRODUCCION DEL INTERFERON TIPO I QUE DEPENDE DE STING (ESTIMULADOR DE GENES DE INTERFERON), DONDE EL DINUCLEOTIDO DE FORMULA (a) SE UNE COVALENTEMENTE AL DE FORMULA (b) EN DONDE R3 ES UN ENLACE COVALENTE PARA EL CARBONO 5' DE (b); R4 ES UN ENLACE COVALENTE PARA EL CARBONO 2' O 3' DE (b); R1 Y R5 SON UNA PURINA UNIDA A TRAVES DE SU NITROGENO N9 AL ANILLO DE RIBOSA DE (a) Y (b), RESPECTIVAMENTE; X1 Y X2 SON CADA UNO O U S; R2 ES H, ALQUILO C1-C18, ENTRE OTROS. DICHOS DINUCLEOTIDOS CICLICOS (CDN) SON CDN 2',5',2',5' Y 2',5',3',5' BASICAMENTE PUROS Y PREFERENTEMENTE ESTEREOISOMEROS RP,RP DE ESTOS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE CANCER
PE2015002414A 2013-05-18 2014-05-18 Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon PE20160080A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361825005P 2013-05-18 2013-05-18
US201361902125P 2013-11-08 2013-11-08

Publications (1)

Publication Number Publication Date
PE20160080A1 true PE20160080A1 (es) 2016-02-21

Family

ID=51934006

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015002414A PE20160080A1 (es) 2013-05-18 2014-05-18 Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon

Country Status (37)

Country Link
US (3) US9724408B2 (es)
EP (2) EP3653637A1 (es)
JP (1) JP6453855B2 (es)
KR (1) KR20160009039A (es)
CN (1) CN105228450B (es)
AP (1) AP2015008700A0 (es)
AU (1) AU2014268836B2 (es)
BR (1) BR112015028341A2 (es)
CA (1) CA2904536A1 (es)
CL (1) CL2015002522A1 (es)
CR (1) CR20150616A (es)
CU (1) CU24377B1 (es)
CY (1) CY1122274T1 (es)
DK (1) DK2996473T3 (es)
DO (1) DOP2015000281A (es)
EC (1) ECSP15052938A (es)
ES (1) ES2754269T3 (es)
GT (1) GT201500326A (es)
HK (2) HK1219024A1 (es)
HR (1) HRP20191972T1 (es)
HU (1) HUE046942T2 (es)
IL (1) IL242359B (es)
LT (1) LT2996473T (es)
ME (1) ME03586B (es)
MX (1) MX354057B (es)
MY (1) MY175308A (es)
NI (1) NI201500162A (es)
PE (1) PE20160080A1 (es)
PH (1) PH12015502438A1 (es)
PL (1) PL2996473T3 (es)
PT (1) PT2996473T (es)
RS (1) RS59500B1 (es)
SA (1) SA515370123B1 (es)
SG (1) SG11201508273RA (es)
SI (1) SI2996473T1 (es)
SV (1) SV2015005107A (es)
WO (1) WO2014189805A1 (es)

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